Publications by authors named "Shu Cui"

38 Publications

Experiences and attitudes of elementary school students and their parents toward online learning in China during the COVID-19 pandemic: Questionnaire Study.

J Med Internet Res 2021 Apr 16. Epub 2021 Apr 16.

Department of psychiatry, Chaohu Hospital, Anhui Medical University, 64 North Chaohu Road, Hefei, CN.

Background: Due to the widespread infection of COVID-19, an emergency homeschooling plan was rigorously implemented throughout China.

Objective: This study aimed to investigate the experiences and attitudes of elementary school students and their parents (two generations from the same family) toward online learning in China during the pandemic.

Methods: A 16-item questionnaire was distributed at the 10 day- and 40 day-mark after the first online course to 867 parent-child pairs and 141 parent-child pairs, respectively. The questionnaire comprised of questions pertaining to the course and homework's completeness, effectiveness, reliability, and abundance as well as the students' enthusiasm to take part in online classes and their satisfaction with the courses.

Results: The findings indicate that more than 91% of students exhibited high or moderate enthusiasm for participating in online classes. However, most students performed poorly in online learning classes and after school homework. Regarding satisfaction, parents' and students' average scores were 7.35 and 7.25, respectively (10-point scoring system). During the second stage of the study, parents' positive evaluations of online learning declined, including the effectiveness and reliability of the courses. Furthermore, the proportion of students who completed the courses and homework on time decreased; this difference proved statistically significant. The overall satisfaction of parents and students with online learning also declined during this second stage (7.21 vs. 7.23); however, the difference between the two stages was not statistically significant. Several of the parents (36.2%) indicated that assisting and supervising the students' online learning caused increased stress. Thirty-six percent of parents expressed dissatisfaction or suggestions concerning online learning; most parents and students hoped to return to face-to-face classes (94.9% vs. 93.5%). Finally, the results presented six main issues that parents are most concerned about: (1) disappointment regarding timely interaction in courses; (2) apprehensive about students understanding of the course; (3) increased burden of annoying adult responsibilities; (4) concern about the children's eyesight; (5) teachers' explanations were not detailed enough; (6) concerned about the decline of students' interest and attention.

Conclusions: Online learning could prevent the spread of infectious diseases while still allowing elementary school students to attain knowledge. However, children's completion of the courses and homework were not satisfactory. Furthermore, their parents often experienced stress and had many concerns and complaints. Measures such as increasing the interactivity of the courses and prohibiting teachers from assigning the task to parents could improve the effectiveness of these courses and the mental health level of parents and students.

Clinicaltrial:
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http://dx.doi.org/10.2196/24496DOI Listing
April 2021

Associations Between Childhood Trauma and the Age of First-Time Drug Use in Methamphetamine-Dependent Patients.

Front Psychiatry 2021 26;12:658205. Epub 2021 Mar 26.

Chaohu Hospital, Anhui Medical University, Hefei, China.

Childhood trauma is related to substance use disorder; however, few studies have examined the relationship between childhood trauma and the age at which the drug was first used. The aim of this study was to investigate the relationship between childhood trauma and the age of first-time drug use among methamphetamine-dependent patients. Moreover, we analyzed the characteristics of adverse family environment associated with severe childhood trauma and the risk factors for starting drugs in minors. A baseline interview was conducted with 110 participants who were in detoxification, including demographic information, past substance use, and age of first-time drug use. The participants' childhood trauma experience before 18 years of age was evaluated using the simplified version of the Childhood Trauma Questionnaire (CTQ-SF). The Chinese version of the Family Environment Scale (FES-CV) was used to assess the family environment of methamphetamine-dependent patients. Among 110 non-injecting methamphetamine-dependent patients, nearly half ( = 48, 43.6%) had moderate and severe childhood trauma. Correlation analysis showed that the age of first-time drug use negatively correlated with emotional abuse ( = -0.32, < 0.01) and physical abuse ( = -0.27, < 0.01). The age of first-time drug use negatively correlated with conflict ( = -0.20, < 0.05) and independence ( = -0.22, < 0.05) of family environment, but positively correlated with intellectual-cultural orientation ( = 0.28, < 0.01). Additionally, childhood trauma factors significantly correlated with many indexes of family environment, especially cohesion ( = -0.45, < 0.01), conflict ( = 0.49, < 0.01), and independence ( = 0.33, < 0.01). Additionally, the regression model showed that when emotional abuse increased by one point, the age of first-time drug use was 0.69 years earlier. These findings suggest that a detrimental family environment can aggravate childhood trauma, and the experience of childhood emotional or physical abuse may be an effective predictor of early drug use among methamphetamine-dependent patients.
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http://dx.doi.org/10.3389/fpsyt.2021.658205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044866PMC
March 2021

The mediating role of prenatal depression in adult attachment and maternal-fetal attachment in primigravida in the third trimester.

BMC Pregnancy Childbirth 2021 Apr 16;21(1):307. Epub 2021 Apr 16.

Chaohu Hospital, Anhui Medical University, Hefei, 238000, China.

Background: Prenatal depression and adult attachment are factors that affect the establishment of an intimate relationship between a mother and fetus. The study explored differences in prenatal depression and maternal-fetal attachment (MFA) scores between different types of adult attachment and the effects of maternal depression scores and attachment dimensions on maternal intimacy with the fetus.

Methods: The Edinburgh Postnatal Depression Scale (EPDS), Experience of Close Relationship (ECR) scale, Maternal Antenatal Attachment Scale (MAAS) and a general data scale were used to investigate 260 primigravida. An exploratory analysis was performed to analyze the effects of the depression score and adult attachment on MFA.

Results: The results showed that pregnant women with insecure attachment exhibited an increased prevalence of prenatal depression, lower total MFA scores, and lower MFA quality compared with those women with secure adult attachment. The explorative analysis showed that the depression scores mediated the relationship between adult attachment avoidance and MFA quality.

Conclusions: Primigravida who had insecure adult attachment exhibited an increased prevalence of prenatal depression and lower MFA. Maternal depression and adult attachment may affect the emotional bond between a mother and fetus. This finding should be seriously considered, and timely intervention needs to take personality traits into consideration.
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http://dx.doi.org/10.1186/s12884-021-03779-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052769PMC
April 2021

Self-esteem, social support and coping strategies of left-behind children in rural China, and the intermediary role of subjective support:a cross-sectional survey.

BMC Psychiatry 2021 03 17;21(1):158. Epub 2021 Mar 17.

Chaohu Hospital, Anhui Medical University, Hefei, 238000, China.

Background: Negative coping strategies and behavioral problems are common among Chinese left-behind children, which are relate to a variety of negative consequences. At this stage of development, the relevant factors of coping strategies need to be further studied, in which social support and self-esteem are worthy of our attention. The aim of this study is to detect the current situation of self-esteem, social support, and coping styles of left-behind children (LBC) in rural China.

Methods: 322 children from 3 schools in China enrolled in this study, including 236 LBC and 86 non-left-behind children (NLBC) to assess self-esteem, social support and coping strategies.

Results: The LBC group had lower self-esteem score and lower total social support (subjective support, objective support and support-seeking behavior) than the NLBC group. In terms of coping strategies, the LBC group was lower than the NLBC group in problem-solving and rationalization. The self-esteem score in LBC was significant positive associated with the subjective support score, objective support score, problem-solving and help-seeking score. In addition, self-esteem has significant mediating effect between subjective support and problem-solving, subjective support and help-seeking, respectively.

Conclusions: The finding indicate that Chinese LBC's self-esteem and social support need to be improved. Given the significant correlativity between self-esteem, subjective support and coping strategy, it is necessary to promote Chinese LBC's self-esteem and social support, especially subjective support.
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http://dx.doi.org/10.1186/s12888-021-03160-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7972224PMC
March 2021

Prenatal Depression in Women in the Third Trimester: Prevalence, Predictive Factors, and Relationship With Maternal-Fetal Attachment.

Front Public Health 2020 26;8:602005. Epub 2021 Jan 26.

College of Mental Health and Psychological Science, Anhui Medical University, Hefei, China.

The prevalence of prenatal depression in pregnant women has found to be high, which may adversely affect the intimacy of a mother to her fetus. Few studies have investigated the relationship between prenatal depression and maternal-fetal attachment in pregnant Chinese women. This study is thus designed to evaluate the prevalence rate, predictive factors of prenatal depression in Chinese pregnant women in the third trimester of pregnancy, and the effect of prenatal depression on maternal-fetal attachment. A total of 340 pregnant women in the third trimester of pregnancy were recruited from a hospital in Anhui Province. The Edinburgh Postpartum Depression Scale (EPDS) was rated to assess the prenatal depression; the Pittsburgh Sleep Quality Index (PSQI) and Zung Self-Rating Anxiety Scale (SAS) were used to assess sleep quality and anxiety level for all participants. The Maternal Antenatal Attachment Scale (MAAS) was used to assess maternal-fetal attachment. The prevalence of prenatal depression in the participants was high (19.1%) in our study. The scores of prenatal anxiety and sleep disorders were higher with prenatal depression than in those without prenatal depression (47.6 ± 9.5 vs. 38.9 ± 6.9; 8.3 ± 3.3 vs. 6.1 ± 2.7, all < 0.01). MAAS quality was lower in prenatal depression women than those in non-prenatal depression women (43.8 ± 5.6 vs. 46.4 ± 4.5, < 0.01). Correlation analysis showed that prenatal depression was associated with parity, prenatal education, education level, marital satisfaction, anxiety and sleep disorders (all < 0.05). Furthermore, binary logistic regression results showed that anxiety and sleep disorders were risk factors for prenatal depression. Prenatal education, higher marriage satisfaction were protective factors for prenatal depression. In addition, correlation analysis also showed that prenatal depression was positively correlated with MAAS intensity, but negatively correlated with MAAS quality. Our results indicated a high prevalence of prenatal depression in women in the third trimester. Prenatal education and higher marital satisfaction were protective factors for prenatal depression; antenatal anxiety and sleep disorders during pregnancy were risk factors for prenatal depression. Prenatal depression was negatively correlated with MAAS quality, but positively correlated with MAAS intensity.
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http://dx.doi.org/10.3389/fpubh.2020.602005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870992PMC
January 2021

Bayesian network analysis of open, laparoscopic, and robot-assisted radical cystectomy for bladder cancer.

Medicine (Baltimore) 2020 Dec;99(52):e23645

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan.

Background: We have performed the direct and network meta-analysis to evaluate the safety and efficacy of robot-assisted (RARC) versus laparoscopic (LRC) versus open radical cystectomy (ORC) for bladder cancer (BCa).

Methods: A systematic search of PubMed, Cochrane Library, and Embase was performed up until Dec 20, 2019. Outcome indexes include oncologic outcomes (the recurrence rate, mortality), pathologic outcomes (lymph node yield (LNY), positive lymph node (PLN), positive surgical margins (PSM)), perioperative outcomes (operating time (OP), estimated blood loss (EBL), blood transfusion rate, the length of hospital stay (LOS) and the time to regular diet) and postoperative 90-day complications.

Results: We have analyzed 6 RCTs, 23 prospective studies, and 25 retrospective studies (54 articles: 6382 patients). On one hand, the direct meta-analysis shows RARC is better than LRC or ORC. On the other hand, the clinical effects of the recurrence rate, Morbidity, PSM, LNY, PLN, and postoperative 90-day complications of RARC, LRC and ORC are all no statistical significance by network meta-analysis. Moreover, the probability rank shows that the comprehensive rank of RARC is better than LRC or ORC. The clinical effects of OP, EBL, LOS, blood transfusion rate and the time to regular diet are all statistical significance by network meta-analysis. There are ORC > LRC > RARC in the EBL ranking. Patients with RARC exhibited a decrease of LOS compared to those with LRC or ORC. Patients with RARC exhibited a decrease in blood transfusion rate and the time to regular diet compared to those with ORC. Patients with ORC exhibited an increase of OP compared to those with RARC or LRC. The heterogeneity tests of most studies are < 50%. Most studies have no publication bias and the quality of the selected studies is good.

Conclusion: The direct meta-analysis and network meta-analysis suggest that RARC is better than LRC or ORC according to comprehensive analysis. However, we need a large sample size and more high-quality studies to verify and improve in the further.
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http://dx.doi.org/10.1097/MD.0000000000023645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769378PMC
December 2020

Association Between Cognitive Function and Early Life Experiences in Patients with Alcohol Use Disorder.

Front Psychiatry 2020 13;11:792. Epub 2020 Aug 13.

Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, China.

Introduction: Early life experiences could be potential risk factors for the development of alcohol use disorder. In similar circumstances, it might also influence cognitive impairment in later life. However, the relationship between early life experience and cognitive function in people with alcohol use disorders is unclear. The current study examined the effects of early social environments and experiences on cognitive function in patients with alcohol use disorder.

Methods: A total of 37 adult male patients with alcohol use disorder and 30 healthy control (HC) subjects were enrolled. The MATRICS Cognitive Consensus Battery (MCCB) was used to evaluate cognitive function. The Childhood Trauma Questionnaire (CTQ) and the Revised Adult Attachment Scale (RAAS) were used to evaluate early life experiences of the participants. The RAAS was used to evaluate the attachment patterns of participants.

Results: Compared with the HC group, the alcohol use disorder group reported higher levels of childhood abuse and were more likely to form an insecure attachment style. Patients with alcohol use disorder who experienced trauma performed worse in terms of discrete cognitive parameters such as social cognition, reasoning and problem solving compared to patients without trauma. Importantly, emotional neglect and social comfort were significantly associated with individual social cognitive skills.

Conclusions: Our results suggest that the cognitive function of patients with alcohol use disorder, especially social cognitive function, is affected by early life experiences.
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http://dx.doi.org/10.3389/fpsyt.2020.00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438706PMC
August 2020

Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway.

Mol Med Rep 2020 Jul 24;22(1):219-226. Epub 2020 Apr 24.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Bladder outlet obstruction (BOO), which is primarily caused by benign prostatic hyperplasia, is a common chronic disease. However, previous studies have most commonly investigated BOO using the acute obstruction model. In the present study, a chronic obstruction model was established to investigate the different pathological alterations in the bladder between acute and chronic obstruction. Compared with chronic obstruction, acute obstruction led to increased expression of proliferating cell nuclear antigen and interleukin‑1β, which are markers of proliferation and inflammation, respectively. Furthermore, increased fibrosis in the bladder at week 2 was observed. Low pressure promoted mice bladder smooth muscle cell (MBSMC) proliferation, and pressure overload inhibited cell proliferation and increased the proportion of dead MBSMCs. Further investigation using serum/glucocorticoid regulated kinase 1 (SGK1) small interfering RNAs indicated that low pressure may promote MBSMC proliferation by upregulating SGK1 and nuclear factor of activated T‑cell expression levels. Therefore, the present study suggested that acute obstruction led to faster decompensation of bladder function and chronic bladder obstruction displayed an enhanced ability to progress to BOO.
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http://dx.doi.org/10.3892/mmr.2020.11092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248470PMC
July 2020

Effect of endostatin on Wnt pathway of stem-like cells in bladder cancer in tumor microenvironment.

Mol Biol Rep 2020 May 9;47(5):3937-3948. Epub 2020 May 9.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, People's Republic of China.

Wnt/β-catenin signaling pathway modulates miscellaneous biological events in cells including gene expression, cell growth, apoptosis, metabolism and transition. The aim of this study was to investigate the effect of endostatin on Wnt signaling pathway of stem-like cells in bladder cancer in tumor microenvironment. The qRT-PCR assay and western blot were conducted to evaluate related factors expressions of Wnt signaling pathway in both bladder cancer 5637 cells and stem cells. Loss of function assays were carried out to detect the influence of endostatin on the proliferation, migration, cell proliferation and apoptosis of bladder cancer cells. We demonstrated that endostatin triggered the degradation of β-catenin, a key mediator of Wnt signaling. The activation of the endostatin blocked β-catenin function and inhibited cell growth and migration of bladder cancer. In order to verify that the Wnt/β-catenin signaling pathway was inhibited by endostain in 5637 bladder cancer cells and stem cells, the Wnt/β-catenin signaling pathway-associated molecules, including DKK1, LRP5, TCF4, β-catenin, cyclin D1, and c-Myc, were evaluated in 5637 bladder cancer cells and stem cells. The western blotting results showed that expressions of these molecules were remarkably increased in the 5637 bladder cancer cells and stem cells compared to the control group. In summary, our study demonstrated that endostatin inhibited angiogenesis. The downregulation of the Wnt/β-catenin pathway may be engaged in the suppression of angiogenesis by endostatin in bladder cancer cells and cancer stem cells.
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http://dx.doi.org/10.1007/s11033-020-05487-3DOI Listing
May 2020

[Extracorporeal shock wave therapy for chronic prostatitis / chronic pelvic pain syndrome: A meta-analysis].

Zhonghua Nan Ke Xue 2019 Oct;25(10):914-922

Department of Urology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.

Objective: To systematically evaluate the clinical efficacy of the extracorporeal shock wave therapy (ESWT) in the treatment of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) and provide some evidence for the management of the disease.

Methods: We searched the PubMed, Cochrane Library, EMbase, CNKI, VIP, WanFang Data and CBM databases on the internet, as well as the Journal of Clinical Urology and Chinese Journal of Urology manually for randomized controlled trials (RCT) on the treatment of CP/CPPS by ESWT published from their establishment till February 1, 2019. Two reviewers independently screened the literature, extracted the data and assessed the risk of bias of the included studies, followed by a meta-analysis with the RevMan 5.3 software.

Results: Totally 12 RCTs involving 838 CP/CPPS patients were included in this study. Compared with the controls, the patients treated by ESWT showed a significantly higher rate of overall effectiveness (OR = 8.75, 95% CI: 5.16 to 14.86, P < 0.000 01) and lower NIH-CPSI scores (MD = -5.10, 95% CI: -6.13 to -4.06, P < 0.000 01). Subgroup analyses manifested that a higher number of shock wave pulses (≥2 000) had a better therapeutic effect (MD = -4.99, 95% CI: -6.20 to -3.38, P < 0.000 01 in the >2 000-pulse group; MD = -5.76, 95% CI: -7.09 to -4.42, P < 0.000 01 in the 2 000-pulse group).

Conclusions: ESWT can raise the rate of overall clinical effectiveness and improve the symptoms of chronic prostatitis in the treatment of CP/CPPS. This conclusion, however, is to be further supported by more RCTs with higher quality, larger sample size and better design.
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October 2019

1T- and 2H-mixed phase MoS nanosheets coated on hollow mesoporous TiO nanospheres with enhanced photocatalytic activity.

J Colloid Interface Sci 2020 May 28;567:10-17. Epub 2020 Jan 28.

Key Laboratory of Automobile Materials (Jilin University), Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130012, China. Electronic address:

Recently, photocatalysts with a hollow mesoporous structure have drawn increasing interest owing to their extensive application in environmental protection. Herein, we prepared hollow mesoporous TiO nanospheres decorated with few layer 1T- and 2H- mixed phase MoS nanosheets via a template-based method and a hydrothermal reaction. The as-synthesized samples are of hollow mesoporous structure and high specific surface area, providing abundant mass transport and active sites for photocatalytic reaction. 1T-MoS in the mixed phase MoS mainly play the role as a bridge that transfers photoexcited electrons. Besides, the heterojunction between MoS and TiO can also efficiently restrain the recombination of photogenerated charge carriers in photocatalysts. As a consequence, under UV-vis light irradiation, the hollow porous TiO/MoS presents a remarkable photocatalytic activity in rhodaming B degradation. Scavenger studies demonstrate that the primary active species in photocatalytic process are hydroxyl radicals. Moreover, a possible photocatalytic reaction mechanism has also been put forward.
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http://dx.doi.org/10.1016/j.jcis.2020.01.100DOI Listing
May 2020

Radical prostatectomy after previous transurethral resection of the prostate: oncological, surgical and functional outcomes-a meta-analysis.

World J Urol 2020 Aug 2;38(8):1919-1932. Epub 2019 Nov 2.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Wenhua Road 57, Shunqing District, Nanchong, 637000, Sichuan, People's Republic of China.

Background: The current study aimed to carry out a comprehensive meta-analysis on the existing evidence to quantify and compare the oncological, surgical and functional outcomes following radical prostatectomy between TURP group and Non-TURP group.

Methods: A systematic literature search was conducted using EMBASE, PubMed and Cochrane databases to identify relevant studies published in English up to March 2019. A meta-analysis was conducted using Review Manager.

Results: There were 13 studies included in the present study. Our results suggest that TURP group demonstrates a significantly higher positive surgical margin rate, bladder neck reconstruction rate and overall complication rate compared with Non-TURP group (OR = 1.31, 95% CI 1.09-1.58, P = 0.004, I = 0%; OR = 14.36, 95% CI 2.93-70.45, P = 0.001, I = 81%; OR = 2.63, 95% CI 1.87-3.71, P < 0.00001, I = 0%); whereas TURP group demonstrates a significantly lower nerve sparing rate compared with Non-TURP group (OR = 0.30, 95% CI 0.22-0.43, P < 0.00001, I = 40%); the operation time, blood loss and 1-year urinary continence rate are same between TURP group and Non-TURP group (MD = 4.25, 95% CI - 0.13 to 8.63, P = 0.06, I = 34%; MD = 27.29, 95% CI - 10.31 to 64.90, P = 0.15, I = 39%; OR = 0.68, 95% CI 0.43-1.06, P = 0.09, I = 0%).

Conclusion: This meta-analysis demonstrates that Non-TURP group may have a great advantage over TURP group in terms of positive surgical margin rate, bladder neck reconstruction rate, overall complication rate and sparing rate. The operation time, blood loss and 1-year urinary continence rate are comparable between TURP group and Non-TURP group. Therefore, important information should be given to those patients at risk of prostate cancer that TURP procedure may increase perioperative complications in case of a following radical prostatectomy. In the meantime, our meta-analysis found that each of these four subgroups (RARP, LRP, ORP and RARP/ORP) has its own advantages or disadvantages in every pool results. So when radical prostatectomy is performed on patients with TURP history, the appropriate operation method should be selected as per the conditions of patients, doctors and hospitals.
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http://dx.doi.org/10.1007/s00345-019-02986-2DOI Listing
August 2020

Efficacy and Safety of Microsurgical Subinguinal Varicocelectomy with and without Testicular Delivery for Varicocele Patients: A Systematic Review and Meta-Analysis.

Urol J 2019 10 21;16(5):417-426. Epub 2019 Oct 21.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, P.R. China.

Purpose: This study reviewed the efficacy and safety of the microsurgical subinguinal varicocelectomy (MSV) with and without testicular delivery (TD) for varicocele patients.

Materials And Methods: A systematic literature search was conducted in EMBASE, PubMed, MEDLINE, Cochrane databases, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Google Scholar databases to identify relevant studies that reported MSV with and without TD for varicocele patients published in English or Chinese up to October 2018. The Newcastle-Ottawa Scale (NOS) and the Jadad scores were used to evaluate the methodological quality of all the included studies. We also used the Cochrane Collaboration's tool for assessing risk of bias for each study. The Review Manager Software version 5.3 was used to conduct data analysis.

Results: Four RCTs and three retrospective studies consisting of 993 patients were included. Meta-analysis results indicated that both of the two treatments were effective and safe. MSV with TD had a lower recurrence rate (OR = 0.20, 95% CI: 0.06 - 0.65, P = .007, I2 = 0%) and postoperative serum testosterone level (MD = -39.07, 95% CI: -51.95 - -26.18, P = .00001, I2 = 0%) compared with MSV without TD but was associated with higher postopera-tive complications rate (OR=7.35, 95% CI: 2.92-18.53, P < .0001, I2 = 0%). We found no significant differences in operation time (MD = 12.46, 95% CI:0.11-24.81,P= .05, I2 = 87%), sperm concentration (MD = 3.73, 95% CI: -2.88 - 10.35, P = .27, I2 = 81%), sperm motility (MD = 10.96, 95% CI: -11.93 - 33.86, P = .35, I2 = 99%), and pregnancy rate(OR = 0.65, 95% CI: 0.37- 1.16, P = .15, I2 = 0%).

Conclusion: This meta-analysis compared efficacy and safety of MSV with and without TD for varicocele pa-tients. MSV with TD was associated with a higher postoperative complication rate but lower recurrence rate and postoperative serum testosterone level than MSV without TD. In terms of preoperative serum testosterone level, operation time, sperm concentration, sperm motility, and pregnancy rate, we found no significant differences.
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http://dx.doi.org/10.22037/uj.v0i0.5095DOI Listing
October 2019

Association of Interleukin-31 gene polymorphisms with risk of cryptorchidism in a Chinese population.

Medicine (Baltimore) 2019 May;98(22):e15861

Department of Urology.

This study aims to investigate the possible association between Interleukin-31 (IL-31) gene polymorphisms and cryptorchidism risk.Two single nucleotide polymorphisms of IL-31, rs7977932 (C/G) and rs4758680 (C/A), were selected to be investigated in this study. Polymerase chain reaction-restriction fragment length polymorphism methods were used to discriminate the selected single nucleotide polymorphisms of IL-31 gene. A hospital-based case-control study of 112 cryptorchidism patients and 425 healthy controls was conducted.The frequencies of the C allele of rs4758680 in the patients with cryptorchidism were significantly higher compared with those in controls (89% vs 83%, P = .02, OR = 0.58, 95% CI = 0. 37-0.92). Compared with CC genotype in dominant model, notable decreased frequencies of A carriers (CA/AA genotypes) were observed in cryptorchidism patients (P = . 03, OR = 0.58, 95% CI = 0.35-0.96).Results demonstrated that IL-31 gene polymorphisms were associated with the genetic susceptibility to cryptorchidism in a Chinese population. Compared with CC genotype, the A carriers (CA/AA genotypes) of rs4758680 were protect factors in cryptorchidism susceptibility.
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http://dx.doi.org/10.1097/MD.0000000000015861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709342PMC
May 2019

The effects of statins on benign prostatic hyperplasia and the lower urinary tract symptoms: A Meta-analysis.

Medicine (Baltimore) 2019 May;98(18):e15502

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China.

Background: The aim of this meta-analysis was to understand the relationship between statin with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).

Methods: A systematic literature search was conducted using PubMed, Embase, Cochrane Library, Chinese Medical and Biological Literature Database, China HowNet, Vip, and Wanfang. We calculated pooled odds ratios (OR) and 95% CI and standardized mean difference (SMD). Using Stata 12.0 and Review 5.3 for meta-analysis.

Results: This meta-analysis included 11 articles and 49,128 participants. Results show statins could not reduce the incidence of BPH [OR = 0.77 (0.57, 1.03, P = .08]. For patients over 60 years old, statins could reduce the incidence of BPH [OR = 0.35 (0.22, 0.55), P < .0001]. Statins can slow down the progression of LUTS in BPH [SMD = -0.32 (-0.54, -0.10), P = .004], but there is no significant correlation between them in patients taking drugs for less than 1 year.

Conclusion: Statins have no significant effect on the incidence of BPH, but statins can reduce the risk of BPH for patients over 60 years old. For patients with hyperlipidemia, the duration of medication is more than 1 year, which can slow down the progression of LUTS. However, more high-quality and large sample size studies are needed to further improve and verify.
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http://dx.doi.org/10.1097/MD.0000000000015502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504530PMC
May 2019

Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):512-523

a Department of Urology , Affiliated Hospital of North Sichuan Medical College , Nanchong , Sichuan , China.

In recent times, Gold nanoparticles (AuNPs) synthesized from plant extracts and their anticancer activity have attracted significant attention. We report the green approach for the synthesis of AuNPs using extract from Abies spectabilis plant. In this study, the reaction parameters were optimized to control the size of the nanoparticle, which was confirmed by Transmission Electron microscopy (TEM). Various characterization technique such as SAED pattern, UV visible spectroscopy, EDX, FTIR, and AFM were employed to analyze the synthesized AuNPs obtained from A. spectabilis plant extract. Furthermore, we investigated the anticancer activities using T24 cell lines. Interestingly, the results of extensive screening on the applications of newly synthesized AuNPs were tested for their cytotoxicity effects on anticancer activity against T24 cells by MTT assay. The cell apoptosis was studied using TUNEL, DAPI, caspase activity, cell invasion and migration. Nanoparticles at different concentrations ranging from 1 to 25 μg/ml exhibited a dose dependent cytotoxicity for 24 h. Condensation and DNA fragmentation are characteristic of apoptosis by DAPI, TUNEL staining, and the significant up regulations of Beclin-1, Bax and caspase 3, whereas the expressions of anti-apoptotic Bcl-2 and Bid were down regulated. However, this study, therefore attempts to report the synthesis, characterization, and anticancer activity of gold nanoparticles of A. spectabilis plant extract beneficial for cancer therapeutics.
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http://dx.doi.org/10.1080/21691401.2018.1560305DOI Listing
December 2019

Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer.

Free Radic Biol Med 2019 04 3;134:87-98. Epub 2019 Jan 3.

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

Although insulin-like growth factor-1 receptor (IGF-1R) has been accepted as a major determinant of cancers, its biological roles and corresponding mechanisms in tumorigenesis have remained elusive. Herein, we demonstrate that IGF-1R plays pivotal roles in the regulation of mitochondrial respiratory chain and functions during colitis and tumorigenesis. Heterozygous knockout IGF-1R attenuated azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis and colitis associated cancer (CAC) in Igf1r mice. Heterozygous knockout IGF-1R confers resistance to oxidative stress-induced damage on colorectal epithelial cells by protecting mitochondrial dynamics and structures. IGF-1R low expression improves the biological function of mitochondrial fusion under oxidative stress. Mechanically, an increase in respiratory coupling index (RCI) and oxidative phosphorylation index (ADP/O) was seen in colorectal epithelial cells of Igf1r mice. Seahorse XF-24 analyzer analysis of mitochondrial bioenergetics demonstrated an increase in oxygen consumption rate (OCR) and a decrease of extracellular acidification rate (ECAR) in Igf1r cells. Further analysis suggests the protection mechanisms of Igf1r cells from oxidative stress through the activation of the mitochondrial respiratory chain and LKB1/AMPK pathways. These results highlight the biological roles of IGF-1R at the nexus between oxidative damage and mitochondrial function and a connection between colitis and colorectal cancer.
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.035DOI Listing
April 2019

Different scoring systems to predict 6-week mortality in cirrhosis patients with acute variceal bleeding: a retrospective analysis of 202 patients.

Scand J Gastroenterol 2018 Jun - Jul;53(7):885-890. Epub 2018 Jun 17.

a Department of Gastroenterology and Hepatology of Tianjin Third Central Hospital , Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry , Tianjin , China.

Objective: Determine the optimal scoring system for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with acute variceal bleeding (AVB). Prediction effects of six scoring systems, AIMS65 score, Glasgow-Blatchford (GBS) score, full Rockall (FRS) score, the model for end-stage liver disease (MELD), the MELD-Na model and the Child-Turcotte-Pugh (CTP) score were analyzed in this study.

Methods: A total of 202 liver cirrhosis patients with AVB were enrolled between 1 January 2014, and 31 December 2014. All subjects were scored according to AIMS65, GBS, FRS, MELD, MELD-Na and CTP scoring systems on the first day of admission. The primary endpoint of the study was 6-week mortality. The prediction effect of these scoring systems for 6-week mortality was compared by ROC curve and the area under the curve (AUC).

Results: The scores of nonsurvival group evaluated by the AIMS65, GBS, FRS, MELD, MELD-Na and CTP (2.6 ± 1.1, 12.9 ± 2.7, 6.6 ± 1.8, 26.9 ± 6.5, 31.6 ± 9.3, 9.6 ± 2.2, respectively) were higher than those of the survival group (1.2 ± 1.1, 10.2 ± 3.4, 5.1 ± 1.6, 21.0 ± 6.4, 22.8 ± 8.2, 7.7 ± 2.0, respectively) (p < .01). The values of AUC and Youden index of AIMS65 and MELD-Na scoring systems [(0.808, 0.453) and (0.781, 0.516), respectively] were superior to those of MELD (0.761, 0.454), CTP (0.748, 0.399), FRS (0.738, 0.358) and GBS scoring systems (0.726, 0.370).

Conclusions: AIMS65 and MELD-Na scoring systems are recommended for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with AVB.
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http://dx.doi.org/10.1080/00365521.2018.1481518DOI Listing
November 2018

Synthesis of hierarchically meso-macroporous TiO/CdS heterojunction photocatalysts with excellent visible-light photocatalytic activity.

J Colloid Interface Sci 2018 Feb 5;512:47-54. Epub 2017 Oct 5.

Key Laboratory of Automobile Materials (Jilin University), Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130012, China. Electronic address:

Photocatalysts with a hierarchically porous structure have attracted considerable attention owing to their wide pore size distribution and high surface area, which enhance the efficiency of transporting species to active sites. In this study, hierarchically meso-macroporous TiO photocatalysts decorated with highly dispersed CdS nanoparticles were synthesized via hydrolysis, followed by a hydrothermal treatment. The textural mesopores and interconnected pore framework provided more accessible active sites and efficient mass transport for the photocatalytic process. The light collection efficiency was enhanced because of multiple scattering of incident light in the macropores. Moreover, the formation of a heterojunction between the CdS and TiO nanoparticles extended the photoresponse of TiO to the visible-light range and enhanced the charge separation efficiency. Therefore, the hierarchically meso-macroporous TiO/CdS photocatalysts exhibited excellent photocatalytic activity for the degradation of rhodaming B under visible-light irradiation. Trapping experiments demonstrated that superoxide radicals (O) and hydroxyl radicals (OH) were the main active species in photocatalysis. A reasonable photocatalytic mechanism of TiO/CdS heterojunction photocatalysts was also presented.
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http://dx.doi.org/10.1016/j.jcis.2017.10.011DOI Listing
February 2018

Is Electroacupuncture Treatment More Effective in Somatic Tinnitus Than in Nonsomatic Tinnitus?

Med Acupunct 2017 Jun;29(3):138-144

Health Services Research Unit, Singapore General Hospital, Outram Road, Singapore.

In recent years, evidence has been accumulating linking subjective tinnitus to the somatosensory system. Somatic tinnitus is defined as tinnitus in which forceful contractions of jaw and neck muscles modulate the psychoacoustic attributes of tinnitus, such as pitch and loudness. Being a somatosensory-based treatment modality, needling might well be more effective for treating somatic than nonsomatic tinnitus. The aim of this study was to compare the outcomes of electroacupuncture (EA) treatment between patients with somatic and nonsomatic tinnitus. A single-blinded prospective study was carried wherein 27 patients with tinnitus were divided into either a somatic or a nonsomatic group, based on whether their tinnitus could be modulated by at least one of a series of forceful jaw and neck muscular contraction maneuvers. Tinnitus responses were evaluated after a single session of EA on selected acupoints for 30 minutes. Seventeen of the 27 patients (63.0%) studied were found to have somatic tinnitus. Generalized estimating equation model analysis did not find any overall statistically significant difference in EA response between patients with somatic and nonsomatic tinnitus. However, patients with somatic tinnitus who were consistent in their responses to the muscular contraction maneuvers were more likely to improve with EA than variable responders to these maneuvers (62.5% versus 22.0%). EA did not provide increased benefits for patients with somatic tinnitus, compared to those with nonsomatic tinnitus overall. However, within the somatic tinnitus group, a subpopulation of patients appeared to be relatively more responsive to EA treatment.
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http://dx.doi.org/10.1089/acu.2017.1223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512328PMC
June 2017

Ultrasonography in Acupuncture-Uses in Education and Research.

J Acupunct Meridian Stud 2017 Jun 9;10(3):216-219. Epub 2017 Mar 9.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore.

This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound scan to ensure that the needle was in the desired location. Results suggested that ultrasound could be used to locate the acupuncture point and estimate the depth of needle insertion. The needle was inserted to a depth of 4.0 cm to reach the surface of the sacral foramen. Based on Pythagoras theorem, taking a needle insertion angle of 30° and a needle insertion depth of 4.0 cm, the estimated perpendicular depth is 1.8 cm. An ultrasound scan corroborated the depth of 1.85 cm. The use of an ultrasound-guided technique for needle insertion in acupuncture practice could help standardize the treatment. Clinicians and students would be able to visualize and measure the depth of the sacral foramen acupuncture point, to guide the depth of needle insertion. This methodological guide could also be used to create a standard treatment protocol for research. A similar mathematical guide could also be created for other acupuncture points in future.
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http://dx.doi.org/10.1016/j.jams.2017.03.001DOI Listing
June 2017

Measuring the effects of acupuncture on muscle stiffness with shear wave elastography.

Acupunct Med 2017 08 17;35(4):304-306. Epub 2017 Jun 17.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/acupmed-2016-011322DOI Listing
August 2017

Ureteroscopic Lithotripsy versus Laparoscopic Ureterolithotomy or Percutaneous Nephrolithotomy in the Management of Large Proximal Ureteral Stones: A Systematic Review and Meta-Analysis.

Urol Int 2017 7;99(3):308-319. Epub 2017 Jun 7.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Objectives: To provide a systematic review and meta-analysis of studies comparing ureterolithotripsy (URS) with percutaneous nephrolithotripsy (PCNL) or laparoscopic ureterolithotomy (LU) techniques for the management of large proximal ureteral stones (diameter greater than 10 mm).

Methods: A literature search was performed using PubMed, EMBASE, EBSCO, Web of Science, and Cochrane Library to identify suitable studies until November 2016. We used weighted mean difference to measure operative time and hospital stay, OR to measure stone free rate (SFR), and complication rate. Subgroup analyses were assessed for heterogeneity.

Results: Fourteen publications strictly met our eligibility criteria of which 7 were randomized control studies (RCTs) and 7 non-RCTs. Meta-analysis of extractable data showed that LU and PCNL had higher SFR than URS. URS led to a similar hospital stay like that of LU. However, it had a shorter operative time and lower complication rate than LU. When we compared URS with PCNL, we found a shorter hospital stay in the URS group. However, there was no significant difference in terms of the operative time and complication rate between URS and PCNL.

Conclusion: URS should be considered standard therapy for treating large proximal ureteral stones.
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http://dx.doi.org/10.1159/000471773DOI Listing
June 2018

Port-Site Metastases and Chimney Effect of B-Ultrasound-Guided and Laparoscopically-Assisted Hyperthermic Intraperitoneal Perfusion Chemotherapy.

Yonsei Med J 2017 May;58(3):497-504

Intracelom Hyperthermic Perfusion Therapy Center, Cancer Center of Guangzhou Medical University, Guangzhou, P.R. China.

Purpose: CO₂ leakage along the trocar (chimney effect) has been proposed to be an important factor underlying port-site metastasis after laparoscopic surgery. This study aimed to test this hypothesis by comparing the incidence of port-site metastasis between B-ultrasound-guided and laparoscopically-assisted hyperthermic intraperitoneal perfusion chemotherapy (HIPPC).

Materials And Methods: Sixty-two patients with malignant ascites induced by gastrointestinal or ovarian cancer were divided into two groups to receive either B-ultrasound-guided or laparoscopically-assisted HIPPC. Clinical efficacy was assessed from the objective remission rate (ORR), the Karnofsky Performance Status (KPS) score, and overall survival. The incidence of port-site metastasis was compared between the two groups.

Results: Patients in the B-ultrasound (n=32) and laparoscopy (n=30) groups were comparable in terms of age, sex, primary disease type, volume of ascites, and free cancer cell (FCC)-positive ascites. After HIPPC, there were no significant differences between the B-ultrasound and laparoscopy groups in the KPS score change, ORR, and median survival time. The incidence of port-site metastasis after HIPPC was not significantly different between the B-ultrasound (3 of 32, 9.36%) and laparoscopy (3 of 30, 10%) groups, but significantly different among pancreatic, gastric, ovarian, and colorectal cancer (33.33, 15.79, 10.00, and 0.00%, p<0.001).

Conclusion: The chimney effect may not be the key reason for port-site metastasis after laparoscopy. Other factors may play a role, including the local microenvironment at the trocar site and the delivery of viable FCCs (from the tumor or malignant ascites) to the trauma site during laparoscopic surgery.
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http://dx.doi.org/10.3349/ymj.2017.58.3.497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368133PMC
May 2017

Exploring the physiological and physical effects of acupuncture using ultrasound.

Acupunct Med 2017 06 13;35(3):231-233. Epub 2016 Dec 13.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/acupmed-2016-011274DOI Listing
June 2017

Quantifying needle motion during acupuncture: implications for education and future research.

Acupunct Med 2016 Dec 3;34(6):482-484. Epub 2016 Nov 3.

Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/acupmed-2016-011242DOI Listing
December 2016

Incidence and Characteristics of Meniscal Injuries in Cadets at a Military School, 2013-2015.

J Athl Train 2016 Nov 14;51(11):876-879. Epub 2016 Oct 14.

The Lab of Military Conditioning and Motor Function Assessment, the People's Liberation Army University of Science and Technology, Nanjing, Jiangsu Province, China.

Context:  Meniscal injury is common among military service members.

Objective:  To examine the incidence and characteristics of meniscal injuries in cadets at a single military institution between 2013 and 2015.

Design:  Cohort study.

Setting:  Meniscal-injury data were collected at the Center of Rehabilitation Training, the People's Liberation Army University of Science and Technology.

Patients Or Other Participants:  A total of 2479 cadets participating in physical activities between 2013 and 2015.

Main Outcome Measure(s):  Injury rates, injury proportions by body mass index, risk ratios (RRs), and injury proportion ratios were reported with 95% confidence intervals (CIs).

Results:  The overall incidence rate was 10.08 (95% CI = 6.84, 14.84) per 1000 person-years. A multiple-comparisons test revealed differences in the relative injury rate in overweight or obese cadets versus normal-weight cadets and underweight cadets (χ = 8.98, P = .01). No differences were found between injured normal-weight cadets and underweight cadets (P = .66, RR = 1.39, 95% CI = 0.32, 6.06) or between injured overweight or obese cadets and injured underweight cadets (P = .24, RR = 0.42, 95% CI = 0.09, 1.91). The absolute injury rate was higher for overweight and obese cadets compared with normal-weight cadets (P < .01, RR = 0.30, 95% CI = 0.13, 0.69). The overall proportional distribution for patterns of injury was 2:1 (medial to lateral) for meniscal injuries. Grade 2 injuries were the most common.

Conclusions:  The high frequency and level of severity of meniscal injuries may negatively affect the readiness and health of cadets. High body mass index was a risk factor for meniscal injury.
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http://dx.doi.org/10.4085/1062-6050-51.10.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224728PMC
November 2016

Laparoendoscopic single-site varicocelectomy compared with conventional laparoscopic surgery: a systematic review and meta-analysis.

Springerplus 2016 5;5(1):1483. Epub 2016 Sep 5.

Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 China.

Purpose: To present a systematic review and meta-analysis comparing laparoendoscopics single-site varicocelectomy (LESS-V) versus conventional laparoscopic surgery (CTL-V).

Methods: A literature search was performed using The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded and Google Scholar. Literature reviewed included meta-analyses, and randomized and nonrandomized prospective studies. We utilized weight mean difference (WMD) to measure hospital stay, time to return normal activity, postoperative pain and improvement of semen parameters and odds ratio (OR) to postoperative complications and cosmetic satisfaction. We used the Cochrane Collaboration's Review Manager 5.1 software for statistical analysis.

Results: We identified six publications which strictly met our eligibility criteria. Meta-analysis of extractable data showed that LESS-V was better than CTL-V in postoperative pain (WMD: -0.46; 95 % CI -0.75 to -0.17; p = 0.002), time to convalescence (WMD: -1.4 days; 95 % CI -2.55 to -0.25; p = 0.02) and cosmetic satisfaction (OR 6.86; 95 % CI 2.89-16.28; p < 0.00001). However, CTL-V was better than LESS-V in operative time (WMD 1.96 min, 95 % CI 0.96-2.96; p = 0.0001). There were no differences between LESS-V and CTL-V in hospital stay (WMD: -0.02 days, 95 % CI -0.39 to 0.35; p = 0.92) and postoperative complications (OR 1.13, 95 % CI 0.57-2.21; p = 0.73).

Conclusions: This meta-analysis comparing the efficacy of LESS-V and CTL-V showed that LESS-V was safe, with significantly reduced postoperative pain, shorter recovery time, and better cosmetic outcome.
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http://dx.doi.org/10.1186/s40064-016-3178-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011471PMC
September 2016

Ultrasonography in acupuncture: potential uses for education and research.

Acupunct Med 2016 Aug 1;34(4):320-2. Epub 2016 Jul 1.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/acupmed-2016-011182DOI Listing
August 2016