Dr Shravan Nadkarni, MBBS, MS - Tata Memorial Hospital - Senior resident

Dr Shravan Nadkarni

MBBS, MS

Tata Memorial Hospital

Senior resident

Mumbai, Maharashtra | India

Main Specialties: Oncology, Surgery, Thoracic Surgery

Additional Specialties: Surgical Oncology

ORCID logohttps://orcid.org/0000-0002-6811-0076

Dr Shravan Nadkarni, MBBS, MS - Tata Memorial Hospital - Senior resident

Dr Shravan Nadkarni

MBBS, MS

Introduction

Primary Affiliation: Tata Memorial Hospital - Mumbai, Maharashtra , India

Specialties:

Additional Specialties:

Publications

9Publications

77Reads

8Profile Views

4PubMed Central Citations

Hepatocellular carcinoma metastasis to the buccal mucosa masquerading as oral cavity malignancy: Case report of a rare entity.

Ann Hepatobiliary Pancreat Surg 2020 Feb 27;24(1):68-71. Epub 2020 Feb 27.

GI and HPB Services, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.

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http://dx.doi.org/10.14701/ahbps.2020.24.1.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061043PMC
February 2020

Mortality of emergency abdominal surgery in high-, middle- and low-income countries.

Authors:

Br J Surg 2016 Jul 4;103(8):971-988. Epub 2016 May 4.

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http://dx.doi.org/10.1002/bjs.10151DOI Listing
July 2016
45 Reads
5.542 Impact Factor

Metaplastic Carcinoma of Breast - The Basilisk among Breast Cancer

(2014), Abstracts. Asia-Pacific Journal of Clinical Oncology, 10: 1–264. doi: 10.1111/ajco.12332

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Background: Metaplastic carcinoma breast (MBC) is a rare & aggressive tumour, accounting for <1% of all breast cancers. 5-yr survival rate is 65% vs. 89% for conventional Invasive ductal cancer. Treatment paradigm is based on that of conventional IDC since available evidence is largely institutional case series-based. We aspire to add to the existing literature and study the clinico-epidemiologic and pathologic features in cases we came across Aim: To evaluate & study the clinico-epidemiologic parameters, tumour characteristics, hormone receptor status, & marker positivity of metaplastic carcinoma breast. Methods: Patients of breast lump presenting during the study period of 2009 – 2014, proven to have metaplastic carcinoma on histopathology were included in the study. Clinical presentation (age, menopausal status), tumour characteristics (size, grade, stage, margins, nodes, marker positivity) were studied. Results: We encountered 33 cases during the study. Of the total, 1 patient was male. The mean age was 48.55 yrs ranging from 23–88 yrs. Cases were clustered in the 4th–5th decade of life. Based on conclusive oncological diagnosis, 23 patients underwent Modified Radical Mastectomy (MRM). Resected tumour was more commonly a pT3 disease. Of the 4 patients with nodal disease 1 had N3, 1 had N2 and 2 had N1 disease. 19 cases were triple negative tumours (ER, PR, Her2neu) & most were positive for epithelial markers and sarcomatous markers. 1 case had lymphovascular invasion and none had perineural invasion. Conclusions: Metaplastic carcinoma at present, is at best a large pool of case series. With increasing recognition of its histopathological characteristics, known poor prognoses & a lack of uniform guidelines, it is pertinent that this entity is studied in its entirety.Increased awareness of its occurrence with subsequent data collection & analysis shall be the key in highlighting the natural history of the disease subset. This would further be instrumental in formulating management protocols. 1. Kuo S H, Chen C L, Huang C S. et al Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer. Anticancer Res 2000. 202219–202222. 2. Adem C, Reynolds C, Adlakha H. et al Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. Histopathology 2002. 40556–40562. 3. Kurian K M, Al-Nafussi A. Sarcomatoid/metaplastic carcinoma of the breast: a clinicopathological study of 12 cases. Histopathology 2002. 4058–4064.

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December 2014
6 Reads

Estrogen & Progesterone Receptors in Gallbladder disease - On the cusp of a discovery?

(2014), Abstracts. Asia-Pacific Journal of Clinical Oncology, 10: 1–264. doi: 10.1111/ajco.12332

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Background: Carcinoma Gallbladder is one of the most common malignancies of the gastrointestinal tract having a very poor prognosis with a high incidence in North India. Untreated chronic symptomatic cholelithiasis is one of the main risk factors with a female predilection. Impaired gallbladder emptying during menses & pregnancy & higher incidence of gallbladder diseases in females with high parity & prolonged fertility have all indicated the gallbladder to be female sex hormone responsive. This has been supported by some studies & refuted by others. Therefore a consensus is largely lacking, forming which, can further help in studying the therapeutic implications of hormone modulators in gallbladder pathology and its progression to malignancy Aim: To detect estrogen & progesterone receptors in gallbladder diseases Clinicopathologic significance of receptor expression with gender, menopausal status, association with gallstones, gallbladder malignancy & characteristics of gallbladder pathology Methods: Hospital-based descriptive type of observational study including all cases of gallbladder disease undergoing surgical management in the Sawai Man Singh Medical College, Jaipur, India during the study period. Resected specimen were evaluated for presence of the receptors by Immunohistochemistry and clinical significance was evaluated. Results: 92 cases of gallbladder disease were included. Age interval of the cases was from 18 yrs (youngest) to 80 yrs (oldest) with most of the cases clustered in the 4th decade of life. 72 cases had gallstone disease. 11 cases were malignant. Statistical significance for Estrogen receptor was not achieved but Progesterone receptor expression was statistically significant. Conclusions: We conclude that significant progesterone receptor expression was noted and confirm that gallbladder is a female sex hormone responsive organ. A multicentric trial involving larger number of cases of gallbladder malignancies would go a long way in potentiating therapeutic applications of hormone modulators in their prevention, treatment or palliation. 1. Singletary BK, Van Thiel DH, Eagon PK: Estro-gen and progesterone receptors in human gall-bladder. Hepatology 6:574–578, 1986 2. Hould FS, Fried GM, Fazekas AG, Tremblay S, Mersereau WA: Progesterone receptors regulate gallbladder motility. J Surg Res 45:505–512, 1988 3. Daignault PG, Fazekas AG, Rosenthall L, Fried GM: Relationship between gallbladder contrac-tion and progesterone receptors in patients with gallstones. Am J Surg 155:147–151, 1988 4. Ranelletti FO, Piantelli M, Farinon AM, Zanella E, Capelli A: Estrogen and progesterone recep-tors in the gallbladders from patients with gall-stones. Hepatology 14:608–612, 1991 5. Baskaran V, Vij U, Sahni P, Tandon RK, Nundy S: Do the progesterone receptors have a role to play in gallbladder cancer? Int J Gastrointest Cancer 35:61–68, 2005

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December 2014
2 Reads

Skin-sparing Mastectomy with Immediate Breast Reconstruction - When feasible, Why Not!

(2014), Abstracts. Asia-Pacific Journal of Clinical Oncology, 10: 1–264. doi: 10.1111/ajco.12332

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Background: Conventional breast cancer surgery is mutilating & impedes reconstructive procedures. Skin-sparing mastectomy (SSM) removes the breast tissue, nipple–areola complex (NAC), and previous biopsy incisions. It preserves the inframammary fold and native skin over the breast and is increasingly being employed in the treatment of breast cancer to improve the aesthetic results of immediate breast reconstruction. Aim: To evaluate the utility of Skin sparing Mastectomy with breast reconstruction in the same sitting as a procedure of choice in eligible patients of breast cancer To study the tumour characteristics, post-operative complications, aesthetic results and patient satisfaction using the BREAST-Q questionnaire. Methods: Patients with operable breast cancer, satisfying the inclusion and exclusion criteria were selected after proper evaluation. They underwent skin sparing mastectomy and immediate breast reconstruction. Their tumour characteristics (age, menopausal status, tumour size, grade, margin status and lymph nodal positivity) post-operative complications, aesthetic results and patient satisfaction were reviewed Results: 25 patients underwent SSM with IBR using Latissimus Dorsi pedicled flap. All patients were small to medium cup-size. 18 patients had multicentric tumour & the rest had unicentric tumour in whom breast conservation could not be offered. Resected margins were negative & lymph node clearance was adequate. 1 patient had local wound infection, 1 had local hematoma & 2 patients had skin envelope necrosis. Post operatively patient's aesthetic results and satisfaction were evaluated using Breast-Q questionnaire. 72% patients had scores denoting SATISFIED, 12% patients scored VERY SATISFIED. Conclusions: SSM with IBR has become increasingly popular as an effective treatment for patients with breast cancer where breast conservation is not possible. With SSM the endangered breast tissue could be removed with safe margins while the spared skin could still function cosmetically. This provides opportunity for enhanced aesthetic outcomes with immediate reconstruction without compromise of local oncological safety. Patient satisfaction remains high with low psychological trauma. 1. Carlson GW, Bostwick J 3rd, Styblo TM, Moore B, Bried JT, Murray DR. et al. Skin sparing mastectomy, oncologic and reconstructive considerations. Ann Surg. 1997;225:570–575 2. Simmons RM, Adamovich TL. Skin-sparing mastectomy. Surg Clin North Am. 2003;83:885–899 3. Lim W, et al. Oncological safety of skin sparing mastectomy followed by immediate reconstruction for locally advanced breast cancer. Journal of Surgical Oncology 2010;102(1):39–42 4. Malata CM, McIntosh SA, Purushotham AD. Immediate breast reconstruction after mastectomy for cancer. Br J Surg. 2000;87:1455–1472 5. Foster RD, Esserman LJ, Anthony JP, Hwang ES, Do H. Skin-sparing mastectomy and immediate breast reconstruction: a prospective cohort study for the treatment of advancd stages of breast carcinoma. Ann Surg Oncol. 2002;9:462–466

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December 2014
3 Reads

Abstracts - World Cancer Congress 2014, Melbourne Australia

(2014), Abstracts. Asia-Pacific Journal of Clinical Oncology, 10: 1–263. doi: 10.1111/ajco.12332

Asia-Pacific Journal of Clinical Oncology

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November 2014
2 Reads

Gastric glomus tumor.

J Surg Case Rep 2014 Jun 26;2014(6). Epub 2014 Jun 26.

Department of General Surgery, SMS Medical College, Jaipur, Rajasthan, India.

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http://dx.doi.org/10.1093/jscr/rju049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071341PMC
June 2014
14 Reads
4 Citations

Adrenocortical carcinoma posing as a pheochromocytoma: a diagnostic dilemma.

J Surg Case Rep 2014 May 12;2014(5). Epub 2014 May 12.

S.M.S Medical College and Attached Hospitals, Jaipur, Rajasthan, India.

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http://dx.doi.org/10.1093/jscr/rju030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017231PMC
May 2014
3 Reads

Top co-authors

Ashish Goyal
Ashish Goyal

Delhi University

2
Ranjan Kumar
Ranjan Kumar

University of Calgary

2
Lakshman Agarwal
Lakshman Agarwal

SMS Medical College

2
Atul Ameta
Atul Ameta

SMS Medical College

2
Kamalkant Gupta
Kamalkant Gupta

S.M.S Medical College and Attached Hospitals

1
Arjun Rao
Arjun Rao

Sydney Children's Hospitals Network - Randwick

1
Sumita Jain
Sumita Jain

University of Washington

1
Sumita A Jain
Sumita A Jain

SMS Medical College

1
Aekta Shah
Aekta Shah

Geetanjali Medical College and Hospital

1