Shraddha Thakkar

Shraddha Thakkar

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Shraddha Thakkar

Shraddha Thakkar

Publications by authors named "Shraddha Thakkar"

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Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference.

BMC Bioinformatics 2019 Mar 14;20(Suppl 2):95. Epub 2019 Mar 14.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1186/s12859-019-2618-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419330PMC
March 2019

Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration.

Macromol Biosci 2018 07 5;18(7):e1800004. Epub 2018 Jun 5.

Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1002/mabi.201800004DOI Listing
July 2018

Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans).

Antioxidants (Basel) 2018 Feb 23;7(2). Epub 2018 Feb 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.3390/antiox7020033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836023PMC
February 2018

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury.

Expert Rev Gastroenterol Hepatol 2018 Jan 9;12(1):31-38. Epub 2017 Oct 9.

a Division of Bioinformatics and Biostatistics , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA.

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http://dx.doi.org/10.1080/17474124.2018.1383154DOI Listing
January 2018

Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.

Sci Rep 2017 12 11;7(1):17311. Epub 2017 Dec 11.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, 72079, USA.

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http://dx.doi.org/10.1038/s41598-017-17701-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725422PMC
December 2017

Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.

BMC Bioinformatics 2017 12 28;18(Suppl 14):498. Epub 2017 Dec 28.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1186/s12859-017-1887-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751547PMC
December 2017

Scaling bioinformatics applications on HPC.

BMC Bioinformatics 2017 12 28;18(Suppl 14):501. Epub 2017 Dec 28.

Office of Science and Engineering Labs, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA.

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http://dx.doi.org/10.1186/s12859-017-1902-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751788PMC
December 2017

Succinamide derivatives of melampomagnolide B and their anti-cancer activities.

Bioorg Med Chem 2017 07 8;25(14):3694-3705. Epub 2017 May 8.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531864PMC
July 2017

PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance.

Pharm Res 2016 12 12;33(12):2954-2966. Epub 2016 Sep 12.

Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA.

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http://dx.doi.org/10.1007/s11095-016-2017-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097033PMC
December 2016

Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.

BMC Bioinformatics 2016 10 6;17(Suppl 13):356. Epub 2016 Oct 6.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.

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http://dx.doi.org/10.1186/s12859-016-1213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073803PMC
October 2016

The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future.

AAPS J 2016 07 26;18(4):814-8. Epub 2016 Apr 26.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.

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http://dx.doi.org/10.1208/s12248-016-9917-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973466PMC
July 2016

Decellularized Extracellular Matrix Scaffolds for Cartilage Regeneration.

Methods Mol Biol 2015 ;1340:133-51

Tissue Regeneration Department, University of Maastricht - MERLN Institute for Technology Inspired Regenerative Medicine Complex, Tissue Regeneration Department Universiteitsingel 40, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-2938-2_9DOI Listing
April 2016

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug Discov Today 2016 Apr 3;21(4):648-53. Epub 2016 Mar 3.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.02.015DOI Listing
April 2016

Comprehensive Assessments of RNA-seq by the SEQC Consortium: FDA-Led Efforts Advance Precision Medicine.

Pharmaceutics 2016 Mar 15;8(1). Epub 2016 Mar 15.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.3390/pharmaceutics8010008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810084PMC
March 2016

Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein.

Sci Rep 2015 Nov 18;5:16740. Epub 2015 Nov 18.

Department of Physiology and Biophysics College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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http://dx.doi.org/10.1038/srep16740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649741PMC
November 2015

Synthesis and anti-cancer screening of novel heterocyclic-(2)-1,2,3-triazoles as potential anti-cancer agents.

Medchemcomm 2015 Aug 30;6(8):1535-1543. Epub 2015 Jun 30.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1039/C5MD00219BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821443PMC
August 2015

Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.

Bioorg Med Chem Lett 2015 Jul 16;25(14):2763-7. Epub 2015 May 16.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459527PMC
July 2015

A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments.

Sci Rep 2015 Jul 10;5:12060. Epub 2015 Jul 10.

Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham St., # 611, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1038/srep12060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498229PMC
July 2015

Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.

Sci Rep 2014 Jan 14;4:3673. Epub 2014 Jan 14.

1] Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA [2].

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http://dx.doi.org/10.1038/srep03673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070344PMC
January 2014

Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes.

Biofabrication 2013 Jun 27;5(2):025003. Epub 2013 Feb 27.

Tissue Regeneration Department, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.

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http://dx.doi.org/10.1088/1758-5082/5/2/025003DOI Listing
June 2013