Shoukat Dedhar

Shoukat Dedhar

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Shoukat Dedhar

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Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.

Gastroenterology 2019 09 9;157(3):823-837. Epub 2019 May 9.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.05.004DOI Listing
September 2019

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism.

Heliyon 2019 Aug 16;5(8):e02294. Epub 2019 Aug 16.

Department of Biology, Trinity Western University, Langley, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.heliyon.2019.e02294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706370PMC
August 2019

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts.

Cancers (Basel) 2019 Jul 17;11(7). Epub 2019 Jul 17.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3, Canada.

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http://dx.doi.org/10.3390/cancers11071002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678951PMC
July 2019

Stat3 in mitosis: A new role in clustering excess centrosomes.

Cell Cycle 2017 7;16(17):1557-1559. Epub 2017 Aug 7.

a Department of Integrative Oncology , BC Cancer Research Centre, BC Cancer Agency , Vancouver , BC , Canada.

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http://dx.doi.org/10.1080/15384101.2017.1348064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587029PMC
May 2019

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

J Med Chem 2018 07 17;61(14):6328-6338. Epub 2018 Jul 17.

University of Florence , Department of Chemistry "Ugo Schiff" , Via della Lastruccia 3 , 50019 Sesto Fiorentino ( Florence ), Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00770DOI Listing
July 2018

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

Metabolites 2018 Mar 8;8(1). Epub 2018 Mar 8.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.3390/metabo8010020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876009PMC
March 2018

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Mol Cell 2017 Aug 27;67(3):512-527.e4. Epub 2017 Jul 27.

Department of Pharmacology, Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698809PMC
August 2017

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

Nat Commun 2017 05 5;8:15289. Epub 2017 May 5.

Department of Integrative Oncology, BC Cancer Research Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.

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http://dx.doi.org/10.1038/ncomms15289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424153PMC
May 2017

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

Sci Rep 2016 08 30;6:32118. Epub 2016 Aug 30.

Department of Biochemistry &Molecular Biology, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

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http://dx.doi.org/10.1038/srep32118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004178PMC
August 2016

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction.

Front Cell Dev Biol 2016 31;4:27. Epub 2016 Mar 31.

Department of Integrative Oncology, British Columbia Cancer Research CentreVancouver, BC, Canada; Department of Biochemistry and Molecular Biology, University of British ColumbiaVancouver, BC, Canada.

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http://journal.frontiersin.org/Article/10.3389/fcell.2016.00
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http://dx.doi.org/10.3389/fcell.2016.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814851PMC
April 2016

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

Oncoimmunology 2015 Dec 26;4(12):e1048955. Epub 2015 Jun 26.

Department of Integrative Oncology; BC Cancer Research Centre ; Vancouver, BC, Canada ; Department of Biochemistry and Molecular Biology; University of British Columbia ; Vancouver, BC, Canada.

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http://dx.doi.org/10.1080/2162402X.2015.1048955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635843PMC
December 2015

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.

Cancer Res 2015 Mar 26;75(6):996-1008. Epub 2015 Jan 26.

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3000DOI Listing
March 2015

Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum.

Sci Rep 2015 Feb 11;5:8389. Epub 2015 Feb 11.

1] Department of Integrative Oncology, BC Cancer Research Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3 [2] Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6E 4A2.

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http://dx.doi.org/10.1038/srep08389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323648PMC
February 2015

Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.

FASEB J 2014 Aug 1;28(8):3645-59. Epub 2014 May 1.

Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; Instituto Reina Sofia de Investigación Renal and Red de Investigación Renal (REDinREN), Instituto de Salud Carlos III, Madrid, Spain;

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http://dx.doi.org/10.1096/fj.13-249250DOI Listing
August 2014

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Nat Commun 2013 ;4:2976

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada V5Z 1L3.

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http://dx.doi.org/10.1038/ncomms3976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905719PMC
July 2014

Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

Subcell Biochem 2014 ;75:255-69

Department of Integrative Oncology, British Columbia Cancer Agency Centre, Vancouver, BC, Canada,

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http://dx.doi.org/10.1007/978-94-007-7359-2_13DOI Listing
May 2014

Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography.

J Enzyme Inhib Med Chem 2014 Apr 7;29(2):249-55. Epub 2013 Mar 7.

Department of Molecular Oncology, BC Cancer Agency , Vancouver, BC , Canada .

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http://dx.doi.org/10.3109/14756366.2013.773994DOI Listing
April 2014

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.

Exp Eye Res 2014 Apr 25;121:130-42. Epub 2014 Jan 25.

Ocular Development Laboratory, Anatomy and Neuroscience, University of Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.01.013DOI Listing
April 2014

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

Gene 2014 Jan 2;533(1):246-52. Epub 2013 Oct 2.

Research Unit, Shriners Hospital for Children, Montreal, Quebec H3G 1A6, Canada; Department of Human Genetics, McGill University, Montreal, Quebec H3A 2T5, Canada.

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http://dx.doi.org/10.1016/j.gene.2013.09.074DOI Listing
January 2014

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells.

Oncotarget 2013 Oct;4(10):1763-76

Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858562PMC
http://dx.doi.org/10.18632/oncotarget.1198DOI Listing
October 2013

Integrin-linked kinase regulates interphase and mitotic microtubule dynamics.

PLoS One 2013 21;8(1):e53702. Epub 2013 Jan 21.

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549953PMC
July 2013

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK).

Transl Oncogenomics 2007 23;2:85-97. Epub 2007 Jul 23.

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634623PMC
May 2013

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models.

Carcinogenesis 2012 Dec 1;33(12):2558-67. Epub 2012 Oct 1.

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada V5Z 1L3.

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http://dx.doi.org/10.1093/carcin/bgs285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510737PMC
December 2012

Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

Invest Ophthalmol Vis Sci 2012 May 17;53(6):3067-81. Epub 2012 May 17.

Department of Ophthalmology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1167/iovs.11-9128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378089PMC
May 2012

The importance of integrin-linked kinase in the regulation of bladder cancer invasion.

Int J Cancer 2012 Feb 28;130(3):521-31. Epub 2011 May 28.

The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/ijc.26008DOI Listing
February 2012

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.

Oncotarget 2012 Jan;3(1):84-97

Department of Integrative Oncology, British Columbia Cancer Research Centre and Cancer Agency, Vancouver, BC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292895PMC
http://dx.doi.org/10.18632/oncotarget.422DOI Listing
January 2012

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

J Med Chem 2011 Dec 22;54(24):8271-7. Epub 2011 Nov 22.

Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.

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http://dx.doi.org/10.1021/jm200983eDOI Listing
December 2011

Targeting hypoxic tumour cells to overcome metastasis.

BMC Cancer 2011 Nov 30;11:504. Epub 2011 Nov 30.

Integrative Oncology Department, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1186/1471-2407-11-504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247198PMC
November 2011

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

BMC Immunol 2011 Aug 1;12:42. Epub 2011 Aug 1.

Department of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada.

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http://bmcimmunol.biomedcentral.com/articles/10.1186/1471-21
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http://dx.doi.org/10.1186/1471-2172-12-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164617PMC
August 2011

Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.

Invest Ophthalmol Vis Sci 2011 Mar 25;52(3):1684-92. Epub 2011 Mar 25.

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1167/iovs.10-6397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101682PMC
March 2011

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

J Med Chem 2011 Mar 1;54(6):1896-902. Epub 2011 Mar 1.

Laboratorio di Chimica Bioinorganica, Rm. 188, Polo Scientifico, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1021/jm101541xDOI Listing
March 2011

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.

Breast Cancer Res 2010 21;12(3):R38. Epub 2010 Jun 21.

Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, 675 West 10th Ave., Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/bcr2592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917033PMC
November 2010

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.

Leuk Res 2010 Oct 2;34(10):1358-65. Epub 2010 Mar 2.

Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.leukres.2010.01.006DOI Listing
October 2010

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

Cancer Res 2010 Oct 20;70(19):7562-9. Epub 2010 Aug 20.

UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1584DOI Listing
October 2010

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration.

BMC Cell Biol 2010 Feb 23;11:16. Epub 2010 Feb 23.

Child & Family Research Institute, Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/1471-2121-11-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838830PMC
February 2010

The mitotic functions of integrin-linked kinase.

Cancer Metastasis Rev 2009 Jun;28(1-2):99-111

Department of Cancer Genetics, British Columbia Cancer Research Centre of the BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada V5Z1L3.

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http://dx.doi.org/10.1007/s10555-008-9177-0DOI Listing
June 2009

Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma.

J Clin Invest 2009 Jun;119(6):1452-5

Department of Cancer Genetics, British Columbia Cancer Research Centre, and British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689131PMC
http://dx.doi.org/10.1172/jci39457DOI Listing
June 2009

Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.

Exp Hematol 2009 Apr;37(4):450-60

British Columbia Cancer Research Centre, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.exphem.2009.01.002DOI Listing
April 2009

A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion.

Blood 2008 Dec 4;112(12):4523-31. Epub 2008 Sep 4.

Institute of Cardiovascular and Metabolic Research and School of Biological Sciences, University of Reading, Reading, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-03-148502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597126PMC
December 2008

Integrin-linked kinase regulates E-cadherin expression through PARP-1.

Dev Dyn 2008 Oct;237(10):2737-47

Genetics Graduate Program, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/dvdy.21685DOI Listing
October 2008

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

Dev Dyn 2008 Oct;237(10):2755-68

Department of Cancer Genetics, BC Cancer Research Centre, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/dvdy.21658DOI Listing
October 2008

Integrin-linked kinase--essential roles in physiology and cancer biology.

J Cell Sci 2008 Oct;121(Pt 19):3121-32

British Columbia Cancer Agency, BC Cancer Research Centre, Department of Cancer Genetics, Vancouver, BC, Canada.

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http://dx.doi.org/10.1242/jcs.017996DOI Listing
October 2008

Beyond focal adhesions: integrin-linked kinase associates with tubulin and regulates mitotic spindle organization.

Cell Cycle 2008 Jul 24;7(13):1899-906. Epub 2008 Apr 24.

Department of Cancer Genetics, British Columbia Cancer Research Centre of BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4161/cc.7.13.6204DOI Listing
July 2008

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.

Proc Natl Acad Sci U S A 2008 May 21;105(21):7582-7. Epub 2008 May 21.

Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.

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http://dx.doi.org/10.1073/pnas.0801105105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396701PMC
May 2008

Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis.

Mol Biol Cell 2008 Apr 30;19(4):1462-73. Epub 2008 Jan 30.

Department of Physiology and Pharmacology, and Regulatory Biology and Functional Genomics Research Group, Siebens-Drake Research Institute, University of Western Ontario, London, ON, N6A 5C1, Canada.

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http://www.molbiolcell.org/doi/10.1091/mbc.e07-06-0526
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http://dx.doi.org/10.1091/mbc.e07-06-0526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291395PMC
April 2008

Mapping the integrin-linked kinase interactome using SILAC.

J Proteome Res 2008 Apr 10;7(4):1740-9. Epub 2008 Mar 10.

Department of Cancer Genetics, British Columbia Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada.

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http://dx.doi.org/10.1021/pr700852rDOI Listing
April 2008

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.

Cancer Res 2008 Mar;68(6):1618-24

Department of Cancer Genetics, BC Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5869DOI Listing
March 2008

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization.

J Cell Biol 2008 Feb 18;180(4):681-9. Epub 2008 Feb 18.

Department of Cancer Genetics, British Columbia Cancer Research Centre of the British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1083/jcb.200710074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265580PMC
February 2008

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.

Cell Microbiol 2007 Jun 9;9(6):1519-28. Epub 2007 Feb 9.

Department of Microbiology, Medical School, University of Minnesota, 1460 Mayo Memorial Building, MMC 196, 420 Delaware Street SE. Minneapolis, MN 55455, USA.

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http://doi.wiley.com/10.1111/j.1462-5822.2007.00889.x
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http://dx.doi.org/10.1111/j.1462-5822.2007.00889.xDOI Listing
June 2007

Role of the integrin-linked kinase (ILK) in determining neuronal polarity.

Dev Biol 2007 Jun 20;306(2):457-68. Epub 2007 Mar 20.

Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060700220
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http://dx.doi.org/10.1016/j.ydbio.2007.03.019DOI Listing
June 2007

The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth.

Mol Cancer Ther 2007 Jun;6(6):1692-700

Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0134DOI Listing
June 2007

Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

Circ Res 2007 May;100(10):1408-14

Department of Laboratory Medicine & Pathobiology, University of Toronto, and Cell Biology Program, The Hospital for Sick Children MaRS Centre, Ontario, Canada.

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http://dx.doi.org/10.1161/01.RES.0000265233.40455.62DOI Listing
May 2007

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

Hepatology 2007 Apr;45(4):1025-34

Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://doi.wiley.com/10.1002/hep.21540
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http://dx.doi.org/10.1002/hep.21540DOI Listing
April 2007

Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

J Am Soc Nephrol 2007 Feb 3;18(2):449-60. Epub 2007 Jan 3.

Department of Pathology, University of Pittsburgh, S-405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2006030236
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http://dx.doi.org/10.1681/ASN.2006030236DOI Listing
February 2007

Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.

J Am Soc Nephrol 2006 Aug 12;17(8):2164-75. Epub 2006 Jul 12.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://jasn.asnjournals.org/content/early/2006/07/12/ASN.200
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http://www.jasn.org/cgi/doi/10.1681/ASN.2006010033
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http://dx.doi.org/10.1681/ASN.2006010033DOI Listing
August 2006

Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury.

Circ Res 2006 Aug 13;99(4):354-61. Epub 2006 Jul 13.

The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research/Providence Health Care Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1161/01.RES.0000237022.72726.01DOI Listing
August 2006

Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism.

J Cell Sci 2006 Jul 13;119(Pt 13):2787-96. Epub 2006 Jun 13.

Neuroscience Center, 8109 Neuroscience Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1242/jcs.03016DOI Listing
July 2006

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium.

Am J Physiol Cell Physiol 2006 Jun 4;290(6):C1532-42. Epub 2006 Jan 4.

Gynaecological Cancer Research Centre, Royal Women's Hospital, 132 Grattan St., Carlton, Victoria 3053, Australia.

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http://www.physiology.org/doi/10.1152/ajpcell.00478.2005
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http://dx.doi.org/10.1152/ajpcell.00478.2005DOI Listing
June 2006

Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis.

J Am Soc Nephrol 2006 May 12;17(5):1334-44. Epub 2006 Apr 12.

Division of Nephrology, Department of Internal Medicine, University of Michigan, 1570 MSRB II, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1681/ASN.2005090921DOI Listing
May 2006

Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.

Mol Cancer Ther 2006 Apr;5(4):833-42

Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi D'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0523DOI Listing
April 2006

The epithelial-mesenchymal transition: new insights in signaling, development, and disease.

J Cell Biol 2006 Mar;172(7):973-81

Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

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http://dx.doi.org/10.1083/jcb.200601018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063755PMC
March 2006

Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.

Cell Microbiol 2006 Feb;8(2):257-66

Department of Microbiology, Medical School, University of Minnesota, 1460 Mayo Memorial Building, MMC 196, 420 Delaware Street SE., Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2005.00618.xDOI Listing
February 2006

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

Endocr Rev 2005 Dec 26;26(7):898-915. Epub 2005 Aug 26.

Department of Molecular and Medical Pharmacology, 650 Charles E. Young Drive, Center for Health Sciences 23-234, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1210/er.2003-0034DOI Listing
December 2005

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.

Cancer Res 2005 Dec;65(24):11649-57

Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2123DOI Listing
December 2005

SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity.

J Biol Chem 2005 Oct 22;280(43):36483-93. Epub 2005 Aug 22.

Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA.

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http://dx.doi.org/10.1074/jbc.M504663200DOI Listing
October 2005

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.

Oncogene 2005 Apr;24(19):3154-65

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA.

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http://dx.doi.org/10.1038/sj.onc.1208525DOI Listing
April 2005

Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

Nat Rev Cancer 2005 Jan;5(1):51-63

Cancer Research Program, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

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http://www.nature.com/articles/nrc1524
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http://dx.doi.org/10.1038/nrc1524DOI Listing
January 2005