Shoshana Yakar

Shoshana Yakar

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Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer.

Oncotarget 2019 Jul 8;10(43):4437-4448. Epub 2019 Jul 8.

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.18632/oncotarget.27055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633887PMC
July 2019

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation.

Endocrinology 2019 Jun;160(6):1363-1376

Division of Endocrinology, Cincinnati Center for Growth Disorders, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1210/en.2018-00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507901PMC
June 2019

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.

Cells 2019 06 15;8(6). Epub 2019 Jun 15.

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010-4086, USA.

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http://dx.doi.org/10.3390/cells8060596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627189PMC
June 2019

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.

J Bone Miner Res 2019 Jan 14;34(1):106-122. Epub 2018 Sep 14.

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.

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http://dx.doi.org/10.1002/jbmr.3573DOI Listing
January 2019

Insulin-like growth factors: actions on the skeleton.

J Mol Endocrinol 2018 07 6;61(1):T115-T137. Epub 2018 Apr 6.

Maine Medical Center Research Institute, Scarborough, Maine, USA.

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http://dx.doi.org/10.1530/JME-17-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966339PMC
July 2018

Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency.

Oncotarget 2018 Mar 28;9(21):15691-15704. Epub 2018 Feb 28.

Departments of Surgery, McGill University and the McGill University Health Centre, Montréal, QC, Canada.

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http://dx.doi.org/10.18632/oncotarget.24593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884657PMC
March 2018

Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.

J Bone Miner Res 2018 01 6;33(1):123-136. Epub 2017 Nov 6.

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.

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http://dx.doi.org/10.1002/jbmr.3290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771972PMC
January 2018

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action.

Proc Natl Acad Sci U S A 2018 01 16;115(5):1045-1050. Epub 2018 Jan 16.

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel;

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http://dx.doi.org/10.1073/pnas.1715930115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798358PMC
January 2018

Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging.

Mol Cell Endocrinol 2017 Nov 23;455:115-130. Epub 2016 Dec 23.

Department of Pediatrics, University of Pittsburgh School of Medicine, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA 15224, USA; Children's Hospital of Pittsburgh of UPMC, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA 15224, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, 3500 Terrace Street, 5362 Biomedical Sciences Tower, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.12.022DOI Listing
November 2017

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis.

Growth Horm IGF Res 2017 06 28;34:13-21. Epub 2017 Apr 28.

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010-4086, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516798PMC
June 2017

Growth Hormone Control of Hepatic Lipid Metabolism.

Diabetes 2016 Dec 27;65(12):3598-3609. Epub 2016 Sep 27.

Department of Basic Science & Craniofacial Biology, David B. Kriser Dental Center, NYU College of Dentistry, New York, NY

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http://diabetes.diabetesjournals.org/content/diabetes/early/
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http://dx.doi.org/10.2337/db16-0649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127251PMC
December 2016

Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases.

Endocrinology 2016 Dec 26;157(12):4526-4533. Epub 2016 Oct 26.

Department of Urology (A.K.); Department of Genetics and Genomic Sciences (S.I.), Graduate School of Biomedical Sciences; and Division of Endocrinology, Diabetes and Bone Disease (S.Yao, K.L.O.-C., A.H., E.M.G., A.C.L.), Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029; and Departments of Basic Science and Craniofacial Biology (S.Yak.), New York University College of Dentistry, New York, New York 10010.

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http://dx.doi.org/10.1210/en.2016-1606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133341PMC
December 2016

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

J Clin Endocrinol Metab 2016 Nov 20;101(11):3879-3883. Epub 2016 Sep 20.

Department of Pediatrics and Pediatric Endocrinology (M.T.M.-C., V.B., J.P., J.A.C., G.A.M.-M., J.A.) Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Centro de Investigación Biomédica en Red (CIBEROBN), Instituto de Salud Carlos III, 28009 Madrid, Spain; Department of Endocrinology (F.H.), Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain; Cincinnati Center for Growth Disorders (A.D.), Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE) (H.M.D.), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), FEI, División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina; Department of Basic Science and Craniofacial Biology (S.Y.), New York University College of Dentistry, New York, New York 10010; Oregon Health and Science University (R.G.R.), Portland, Oregon 97239; Stat5 LLC (R.G.R.), Los Altos, California 94022; Genetics Unit (L.A.P.-J.), Universitat Pompeu Fabra, Hospital del Mar Research Institute (IMIM), and CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 08003 Barcelona, Spain; Department of Molecular Biology and Genetics (C.O.), Aarhus University, 8000 Aarhus, Denmark; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2016-2751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393598PMC
November 2016

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

Growth Horm IGF Res 2016 06 28;28:26-42. Epub 2015 Sep 28.

Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, SE-41345 Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.ghir.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809789PMC
June 2016

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.

Growth Horm IGF Res 2016 Apr 31;27:7-17. Epub 2015 Dec 31.

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology New York University College of Dentistry New York, NY 10010-408, US. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488285PMC
April 2016

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

EMBO Mol Med 2016 04;8(4):363-74

Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús Instituto de Investigación La Princesa Universidad Autónoma de Madrid, Madrid, Spain Program of Pediatric Obesity, CIBEROBN Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.15252/emmm.201506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818753PMC
April 2016

DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.

FASEB J 2016 Feb 19;30(2):635-52. Epub 2015 Oct 19.

*Department of Basic Science and Craniofacial Biology, David B. Kriser Dental Center, New York University College of Dentistry, New York, New York, USA; Department of Biomedical Engineering, City College of New York, New York, New York, USA; and Maine Medical Center Research Institute, Scarborough, Maine, USA

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http://dx.doi.org/10.1096/fj.15-275859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714547PMC
February 2016

Central effects of humanin on hepatic triglyceride secretion.

Am J Physiol Endocrinol Metab 2015 Aug 9;309(3):E283-92. Epub 2015 Jun 9.

Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;

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http://dx.doi.org/10.1152/ajpendo.00043.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525112PMC
August 2015

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes.

Diabetes Metab Res Rev 2014 Mar;30(3):191-200

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/dmrr.2466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496098PMC
March 2014

Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.

Endocrinology 2014 Mar 1;155(3):987-99. Epub 2014 Jan 1.

Department of Biomedical Engineering (O.D.K., L.C., J.B.-P., M.B.S.), City College of New York, New York 10031; David B. Kriser Dental Center (H.S., Y.W., G.A.W., S.Y.), Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010-4086; and Division of Endocrinology (H.-W.C., S.Y.), Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York 10029-6547.

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http://dx.doi.org/10.1210/en.2013-1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929729PMC
March 2014

Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging.

Age (Dordr) 2013 Oct 14;35(5):1691-703. Epub 2012 Sep 14.

Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s11357-012-9469-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776121PMC
October 2013

Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury.

Endocrinology 2013 Oct 16;154(10):3776-83. Epub 2013 Jul 16.

MD, PhD, Division of Endocrinology, Metabolism, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1055, New York, New York 10029.

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http://dx.doi.org/10.1210/en.2013-1209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398538PMC
October 2013

Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.

J Bone Miner Res 2013 Jul;28(7):1575-86

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.

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http://dx.doi.org/10.1002/jbmr.1920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843230PMC
July 2013

Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer.

Endocr Relat Cancer 2013 Jun 21;20(3):391-401. Epub 2013 May 21.

Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1530/ERC-12-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093836PMC
June 2013

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation.

PLoS One 2012 14;7(9):e44777. Epub 2012 Sep 14.

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044777PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443095PMC
February 2013

The intricate role of growth hormone in metabolism.

Front Endocrinol (Lausanne) 2011 27;2:32. Epub 2011 Sep 27.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine New York, NY, USA.

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http://journal.frontiersin.org/article/10.3389/fendo.2011.00
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http://dx.doi.org/10.3389/fendo.2011.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356038PMC
August 2012

Insulin-like growth factor 1 physiology: lessons from mouse models.

Endocrinol Metab Clin North Am 2012 Jun 15;41(2):231-47, v. Epub 2012 May 15.

Department of Basic Science and Craniofacial Biology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.

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http://dx.doi.org/10.1016/j.ecl.2012.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488279PMC
June 2012

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.

Diabetes 2012 Jan;61(1):94-103

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-08
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http://dx.doi.org/10.2337/db11-0814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237669PMC
January 2012

Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes.

Breast Cancer Res 2012 Jan 7;14(1):R8. Epub 2012 Jan 7.

Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr3089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496123PMC
January 2012

Unbound (bioavailable) IGF1 enhances somatic growth.

Dis Model Mech 2011 Sep 31;4(5):649-58. Epub 2011 May 31.

Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1242/dmm.006775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180229PMC
September 2011

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice.

J Clin Invest 2011 Jun 9;121(6):2422-6. Epub 2011 May 9.

Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://www.jci.org/articles/view/45027
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http://dx.doi.org/10.1172/JCI45027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104750PMC
June 2011

Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.

J Bone Miner Res 2011 Apr;26(4):761-8

Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1002/jbmr.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179330PMC
April 2011

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner.

PLoS One 2011 Mar 18;6(3):e14762. Epub 2011 Mar 18.

Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060807PMC
March 2011

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes.

Endocr Relat Cancer 2010 Dec 5;17(4):941-51. Epub 2010 Oct 5.

Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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https://erc.bioscientifica.com/view/journals/erc/17/4/941.xm
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http://dx.doi.org/10.1677/ERC-10-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082826PMC
December 2010

IGF-1 and bone: New discoveries from mouse models.

J Bone Miner Res 2010 Dec;25(12):2543-52

Division of Endocrinology, University of North Carolina, Chapel Hill, NC, USA.

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http://doi.wiley.com/10.1002/jbmr.234
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http://dx.doi.org/10.1002/jbmr.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179280PMC
December 2010

Elevated circulating IGF-I promotes mammary gland development and proliferation.

Endocrinology 2010 Dec 6;151(12):5751-61. Epub 2010 Oct 6.

Division of Endocrinology, Diabetes, and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-0792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999497PMC
December 2010

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact.

J Bone Miner Res 2010 Sep;25(9):2051-8

Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1002/jbmr.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118256PMC
September 2010

Sex-specific regulation of body size and bone slenderness by the acid labile subunit.

J Bone Miner Res 2010 Sep;25(9):2059-68

Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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http://dx.doi.org/10.1002/jbmr.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118255PMC
September 2010

Growth hormone regulates the balance between bone formation and bone marrow adiposity.

J Bone Miner Res 2010 Apr;25(4):757-68

Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.1359/jbmr.091015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153330PMC
April 2010

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression.

Diabetes 2010 Mar 3;59(3):686-93. Epub 2009 Dec 3.

Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-12
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http://dx.doi.org/10.2337/db09-1291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828655PMC
March 2010

Biological effects of growth hormone on carbohydrate and lipid metabolism.

Growth Horm IGF Res 2010 Feb 1;20(1):1-7. Epub 2009 Oct 1.

Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.ghir.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815161PMC
February 2010

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice.

Mol Carcinog 2009 Dec;48(12):1071-6

Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892-4258, USA.

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http://dx.doi.org/10.1002/mc.20577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951004PMC
December 2009

Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences.

Horm Res 2009 1;72(3):129-41. Epub 2009 Sep 1.

Centro de Investigaciones Endocrinológicas (CEDIE-CONICET), Hospital de Niños R. Gutiérrez, Buenos Aires 1425, Argentina.

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https://www.karger.com/Article/FullText/232486
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http://dx.doi.org/10.1159/000232486DOI Listing
November 2009

High-efficient FLPo deleter mice in C57BL/6J background.

PLoS One 2009 Nov 26;4(11):e8054. Epub 2009 Nov 26.

Endocrinology/Diabetes and Bone Disease Division, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777316PMC
November 2009

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.

Endocrinology 2009 Sep 4;150(9):4395-403. Epub 2009 Jun 4.

Division of Endocrinology, Diabetes, and Bone Disease, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2009-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819739PMC
September 2009

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Int J Cancer 2009 May;124(9):2042-9

Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.24169DOI Listing
May 2009

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.

Bone 2009 Apr 24;44(4):648-55. Epub 2008 Dec 24.

Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.bone.2008.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659558PMC
April 2009

The role of insulin receptor signaling in zebrafish embryogenesis.

Endocrinology 2008 Dec 7;149(12):5996-6005. Epub 2008 Aug 7.

Division of Endocrinology, Diabetes, and Bone Disease, Mount Sinai School of Medicine, New York, New York 10029, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2008-0329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613066PMC
December 2008

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.

Cancer Res 2008 May;68(10):3680-8

The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6271DOI Listing
May 2008

A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization.

J Clin Endocrinol Metab 2007 Apr 30;92(4):1542-8. Epub 2007 Jan 30.

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2006-2354DOI Listing
April 2007

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

Nat Clin Pract Endocrinol Metab 2007 Mar;3(3):302-10

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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http://www.nature.com/doifinder/10.1038/ncpendmet0427
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http://dx.doi.org/10.1038/ncpendmet0427DOI Listing
March 2007

The role of the IGF system in cancer growth and metastasis: overview and recent insights.

Endocr Rev 2007 Feb 24;28(1):20-47. Epub 2006 Aug 24.

Department of Medicine, McGill University Health Center, Royal Victoria Hospital, Room H6.25687, Pine Avenue West, Montreal, Québec, Canada H3A 1A1.

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https://academic.oup.com/edrv/article/28/1/20/2354970
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http://dx.doi.org/10.1210/er.2006-0001DOI Listing
February 2007

Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

Endocrinology 2006 Dec 7;147(12):5826-34. Epub 2006 Sep 7.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1210/en.2006-0311DOI Listing
December 2006

MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.

Am J Physiol Endocrinol Metab 2006 Aug 28;291(2):E298-305. Epub 2006 Feb 28.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00319.2005
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August 2006

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Cancer Res 2006 Jul;66(14):7151-7

Genetics of Development and Disease Branch and Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.

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July 2006

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Endocrinology 2006 Jun 2;147(6):2619-30. Epub 2006 Mar 2.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA.

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http://dx.doi.org/10.1210/en.2005-1556DOI Listing
June 2006

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.

Cytokine Growth Factor Rev 2005 Aug-Oct;16(4-5):407-20

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1758, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S135961010500047
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October 2005

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.

Endocrinology 2005 Sep 9;146(9):4024-35. Epub 2005 Jun 9.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8D12, Building 10, MSC 1758, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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September 2005

Metabolic effects of IGF-I deficiency: lessons from mouse models.

Pediatr Endocrinol Rev 2005 Sep;3(1):11-9

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2005

Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.

Cancer Res 2005 Aug;65(15):6864-73

Diabetes Branch and Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0181DOI Listing
August 2005

Clinical relevance of systemic and local IGF-I.

Endocr Dev 2005 ;9:11-16

Diabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USA.

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http://dx.doi.org/10.1159/000085718DOI Listing
July 2005

Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo.

Endocrinology 2005 Apr 23;146(4):1772-9. Epub 2004 Dec 23.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8D12, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.1210/en.2004-0906DOI Listing
April 2005

The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting.

Pediatr Nephrol 2005 Mar 12;20(3):251-4. Epub 2005 Jan 12.

Diabetes Branch, National Institutes of Health, MSC 1758, Bethesda, MD 20892-1758, USA.

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http://link.springer.com/10.1007/s00467-004-1613-y
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March 2005

Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

Novartis Found Symp 2004 ;262:3-9; discussion 9-18, 265-8

Diabetes Branch, Room 8D12, Building 10, National Institutes of Health, MSC 1758, Bethesda MD 20892-1758, USA.

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December 2004

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.

Diabetes 2004 Nov;53(11):2901-9

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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November 2004

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Endocrinology 2004 Oct 1;145(10):4667-76. Epub 2004 Jul 1.

Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.1210/en.2003-1543DOI Listing
October 2004

Role of growth hormone (GH) in liver regeneration.

Endocrinology 2004 Oct 8;145(10):4748-55. Epub 2004 Jul 8.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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October 2004

14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation.

J Biol Chem 2004 Aug 8;279(33):34353-60. Epub 2004 Jun 8.

Section on Molecular and Cellular Physiology, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, Bethesda, MD 20892-1758, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M401300200
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August 2004

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival.

J Biol Chem 2004 Jun 22;279(24):25898-904. Epub 2004 Mar 22.

Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.1074/jbc.M400661200DOI Listing
June 2004

Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells.

Mol Cell Biol 2004 Apr;24(8):3238-50

Eukaryotic Transcriptional Regulation Section, Laboratory of Protein Dynamics and Signaling, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381667PMC
http://dx.doi.org/10.1128/mcb.24.8.3238-3250.2004DOI Listing
April 2004

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

J Clin Invest 2004 Jan;113(1):96-105

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892-1758, USA.

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http://dx.doi.org/10.1172/JCI17763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC300761PMC
January 2004

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.

Oncogene 2004 Jan;23(3):786-94

Diabetes Branch, NIDDK, National Institute of Health, Room 8D12, Bldg 10, Bethesda, MD 20892-1758, USA.

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http://www.nature.com/articles/1207162
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January 2004

Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis.

Biol Blood Marrow Transplant 2004 Jan;10(1):32-9

Department of Microbiology & Immunology, University of Nevada School of Medicine, Reno 89557, USA.

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http://dx.doi.org/10.1016/j.bbmt.2003.09.008DOI Listing
January 2004

Regulation of the splenic somatotropic axis by dietary protein and insulin-like growth factor-I in the rat.

Growth Horm IGF Res 2003 Oct;13(5):254-63

Department of Chemistry, National University of Colombia, P.O. Box 14490, Bogota, Colombia.

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October 2003

Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance.

Diabetes 2003 Oct;52(10):2483-9

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.2337/diabetes.52.10.2483DOI Listing
October 2003

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

Cancer Res 2003 Aug;63(15):4384-8

Section on Cellular and Molecular Physiology, Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases/NIH, Building 10, Bethesda, MD 20892, USA.

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August 2003

Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance.

Mol Cell Endocrinol 2003 Jun;204(1-2):31-42

Fraser Laboratories, M3-15, Department of Medicine, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1.

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http://dx.doi.org/10.1016/s0303-7207(03)00145-xDOI Listing
June 2003