Shoichi Ishiura

Shoichi Ishiura

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Shoichi Ishiura

Publications by authors named "Shoichi Ishiura"

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Plant-based vaccines for Alzheimer's disease.

Proc Jpn Acad Ser B Phys Biol Sci 2019 ;95(6):290-294

MediHerb Co., Ltd.

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http://dx.doi.org/10.2183/pjab.95.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751297PMC
November 2019

Production of the herb Ruta chalepensis L. expressing amyloid β-GFP fusion protein.

Proc Jpn Acad Ser B Phys Biol Sci 2019 ;95(6):295-302

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University.

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http://dx.doi.org/10.2183/pjab.95.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751298PMC
November 2019

Exon Skipping by Ultrasound-Enhanced Delivery of Morpholino with Bubble Liposomes for Myotonic Dystrophy Model Mice.

Methods Mol Biol 2018 ;1828:481-487

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.

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http://dx.doi.org/10.1007/978-1-4939-8651-4_30DOI Listing
April 2019

RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells.

Angew Chem Int Ed Engl 2018 08 18;57(34):10873-10878. Epub 2018 Jul 18.

Cell Signaling Group, Waseda Bioscience Research Institute in Singapore (WABIOS), Singapore, 138667, Republic of Singapore.

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http://dx.doi.org/10.1002/anie.201804304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456769PMC
August 2018

Regulation of body size in Caenorhabditis elegans: effects of environmental factors and the nervous system.

Int J Dev Biol 2017 ;61(6-7):367-374

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1387/ijdb.160352ssDOI Listing
April 2018

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.

Biochem Biophys Res Commun 2016 09 5;478(4):1751-7. Epub 2016 Sep 5.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.018DOI Listing
September 2016

Data describing the effect of DRD4 promoter polymorphisms on promoter activity.

Data Brief 2016 Jun 1;7:1112-7. Epub 2016 Apr 1.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.dib.2016.03.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833125PMC
June 2016

Dopamine regulates body size in Caenorhabditis elegans.

Dev Biol 2016 Apr 24;412(1):128-138. Epub 2016 Feb 24.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.02.021DOI Listing
April 2016

Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice.

Biosci Biotechnol Biochem 2015 23;79(6):912-8. Epub 2015 Jan 23.

a Department of Biological Sciences, Graduate School of Science , The University of Tokyo , Tokyo , Japan.

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http://www.tandfonline.com/doi/full/10.1080/09168451.2014.10
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http://dx.doi.org/10.1080/09168451.2014.1002449DOI Listing
March 2016

Splicing of human chloride channel 1.

Biochem Biophys Rep 2016 Mar 11;5:63-69. Epub 2015 Nov 11.

Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrep.2015.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600464PMC
March 2016

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

J Biol Chem 2016 Jan 11;291(1):435-46. Epub 2015 Nov 11.

the Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences and Laboratory of Neuropathology and Neuroscience, Faculty of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M114.629287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697183PMC
January 2016

Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.

Biochim Biophys Acta 2015 Oct 11;1852(10 Pt A):2042-7. Epub 2015 Jul 11.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.07.006DOI Listing
October 2015

[Myotonic dystrophy].

Rinsho Shinkeigaku 2013 ;53(11):1109-11

Graduate School of Arts and Sciences, The University of Tokyo.

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http://dx.doi.org/10.5692/clinicalneurol.53.1109DOI Listing
August 2015

Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes.

Biochem Biophys Res Commun 2015 Jun 16;461(3):481-6. Epub 2015 Apr 16.

Department of Life-Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.04.035DOI Listing
June 2015

Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.

Hum Mol Genet 2015 Feb 30;24(3):740-56. Epub 2014 Sep 30.

Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan CREST (Core Research for Evolutionary Science and Technology), JST, Saitama 332-0012, Japan Laboratory for Structural Neuropathology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan

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http://dx.doi.org/10.1093/hmg/ddu492DOI Listing
February 2015

ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1.

Genes Cells 2015 Feb 18;20(2):121-34. Epub 2014 Nov 18.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.

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http://dx.doi.org/10.1111/gtc.12201DOI Listing
February 2015

Dopamine modulates acetylcholine release via octopamine and CREB signaling in Caenorhabditis elegans.

PLoS One 2013 16;8(8):e72578. Epub 2013 Aug 16.

Department of Life Sciences, Graduate School of Arts & Sciences, University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072578PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745381PMC
January 2015

Usefulness of monitoring γ-H2AX and cell cycle arrest in HepG2 cells for estimating genotoxicity using a high-content analysis system.

J Biomol Screen 2014 Oct 30;19(9):1246-54. Epub 2014 Jun 30.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1177/1087057114541147DOI Listing
October 2014

Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3.

Neurosci Lett 2014 Oct 6;582:120-4. Epub 2014 Sep 6.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.08.046DOI Listing
October 2014

Nonredundant function of two highly homologous octopamine receptors in food-deprivation-mediated signaling in Caenorhabditis elegans.

J Neurosci Res 2014 May 21;92(5):671-8. Epub 2014 Jan 21.

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/jnr.23345
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http://dx.doi.org/10.1002/jnr.23345DOI Listing
May 2014

Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice.

J Neurosci Res 2014 Mar 25;92(3):287-97. Epub 2013 Nov 25.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.23291DOI Listing
March 2014

[Current studies in myotonic dystrophy].

Brain Nerve 2014 Mar;66(3):259-64

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo.

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March 2014

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Bioorg Med Chem Lett 2014 Jan 8;24(2):618-23. Epub 2013 Dec 8.

Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan; Laboratory of Peptide Science, Nagahama Institute of Bio-Science and Technology, Tamura-cho, Nagahama 526-0829, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2013.12.007DOI Listing
January 2014

A high-salinity solution with calcium chloride enables RNase-free, easy plasmid isolation within 55 minutes.

Biosci Trends 2013 Dec;7(6):270-5

Department of Applied Biochemistry, School of Engineering, Tokai University, Kanagawa, Japan.

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December 2013

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice.

Sci Rep 2013 ;3:2142

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Tokyo, Japan.

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http://dx.doi.org/10.1038/srep02142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701899PMC
September 2013

The androgen receptor facilitates inhibition of human dopamine transporter (DAT1) reporter gene expression by HESR1 and HESR2 via the variable number of tandem repeats.

Neurosci Lett 2012 Sep 20;525(1):54-9. Epub 2012 Jul 20.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan.

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http://dx.doi.org/10.1016/j.neulet.2012.07.021DOI Listing
September 2012

CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.

Neurosci Lett 2012 Sep 23;526(2):96-9. Epub 2012 Aug 23.

Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.neulet.2012.08.029DOI Listing
September 2012

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Bioorg Med Chem Lett 2012 Jul 1;22(14):4640-4. Epub 2012 Jun 1.

Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2012.05.089DOI Listing
July 2012

Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.

Biochem Biophys Res Commun 2012 Jun 15;423(2):212-7. Epub 2012 May 15.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1200910
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http://dx.doi.org/10.1016/j.bbrc.2012.05.033DOI Listing
June 2012

Localization of mature neprilysin in lipid rafts.

J Neurosci Res 2012 Apr 20;90(4):870-7. Epub 2011 Dec 20.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.22796DOI Listing
April 2012

BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?

ACS Med Chem Lett 2012 Mar 26;3(3):193-7. Epub 2011 Dec 26.

Faculty of Pharmaceutical Sciences, Kobe Gakuin University , Minatojima, Chuo-ku, Kobe 650-8586, Japan ; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University , Yamashina-ku, Kyoto 607-8412, Japan ; Laboratory of Peptide Science, Nagahama Institute of Bio-Science and Technology , Tamura-cho, Nagahama 526-0829, Japan.

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http://dx.doi.org/10.1021/ml2002373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025764PMC
March 2012

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.

Bioorg Med Chem Lett 2012 Jan 1;22(2):1130-5. Epub 2011 Dec 1.

Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, Chuo-ku, Kobe 650-8586, Japan; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.102DOI Listing
January 2012

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.

J Biol Chem 2011 Dec 10;286(52):44569-75. Epub 2011 Nov 10.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1074/jbc.M111.270108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247977PMC
December 2011

An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

FASEB J 2011 Oct 11;25(10):3720-30. Epub 2011 Jul 11.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

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http://dx.doi.org/10.1096/fj.11-182154DOI Listing
October 2011

Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins.

Neurosci Lett 2011 Oct 27;503(3):234-9. Epub 2011 Aug 27.

Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.neulet.2011.08.043DOI Listing
October 2011

Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1.

Genes Cells 2011 Sep 28;16(9):961-72. Epub 2011 Jul 28.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2011.01542.xDOI Listing
September 2011

Effect of rice-expressed amyloid β in the Tg2576 Alzheimer's disease transgenic mouse model.

Vaccine 2011 Aug 2;29(37):6252-8. Epub 2011 Jul 2.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.vaccine.2011.06.073DOI Listing
August 2011

Production of anti-amyloid β antibodies in mice fed rice expressing amyloid β.

Biosci Biotechnol Biochem 2011 7;75(2):396-400. Epub 2011 Feb 7.

Department of Life Science, Graduate School of Arts and Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1271/bbb.100861DOI Listing
June 2011

Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy.

Biochem Biophys Res Commun 2011 May 28;409(1):64-9. Epub 2011 Apr 28.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1100704
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http://dx.doi.org/10.1016/j.bbrc.2011.04.106DOI Listing
May 2011

Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.

J Neurosci Res 2011 Apr 2;89(4):562-75. Epub 2011 Feb 2.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/jnr.22593
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http://dx.doi.org/10.1002/jnr.22593DOI Listing
April 2011

Transgenic rice expressing amyloid β-peptide for oral immunization.

Int J Biol Sci 2011 Mar 25;7(3):301-7. Epub 2011 Mar 25.

National Agricultural Research Center for Tohoku Region, National Agriculture and Food Research Organization, 4 Akahira, Shimo-kuriyagawa, Morioka, Iwate 020-0198, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065743PMC
http://dx.doi.org/10.7150/ijbs.7.301DOI Listing
March 2011

Polypyrimidine tract-binding protein 1 regulates the alternative splicing of dopamine receptor D2.

J Neurochem 2011 Jan 2;116(1):76-81. Epub 2010 Dec 2.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1111/j.1471-4159.2010.07086.x
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http://dx.doi.org/10.1111/j.1471-4159.2010.07086.xDOI Listing
January 2011

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.

J Neurosci Res 2010 Dec 1;88(16):3588-97. Epub 2010 Oct 1.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.1002/jnr.22503DOI Listing
December 2010

Inhibitory Smad proteins promote the differentiation of mouse embryonic stem cells into ependymal-like ciliated cells.

Biochem Biophys Res Commun 2010 Oct 31;401(1):1-6. Epub 2010 Aug 31.

Department of Biological Science, Graduate School of Science, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.08.099DOI Listing
October 2010

Reduction of amyloid beta-peptide accumulation in Tg2576 transgenic mice by oral vaccination.

Biochem Biophys Res Commun 2010 Sep 1;399(4):593-9. Epub 2010 Aug 1.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.07.120DOI Listing
September 2010

ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.

Biochem Biophys Res Commun 2010 Jun 9;396(4):927-32. Epub 2010 May 9.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.025DOI Listing
June 2010

BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin.

In Vitro Cell Dev Biol Anim 2010 May 24;46(5):416-30. Epub 2009 Dec 24.

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 153-8902, Japan.

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http://dx.doi.org/10.1007/s11626-009-9266-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862943PMC
May 2010

Zygotic VegT is required for Xenopus paraxial mesoderm formation and is regulated by Nodal signaling and Eomesodermin.

Int J Dev Biol 2010 ;54(1):81-92

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan.

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http://dx.doi.org/10.1387/ijdb.082837mfDOI Listing
April 2010

Alcoholism and alternative splicing of candidate genes.

Int J Environ Res Public Health 2010 04 30;7(4):1448-66. Epub 2010 Mar 30.

Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.

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http://www.mdpi.com/1660-4601/7/4/1448
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http://dx.doi.org/10.3390/ijerph7041448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872348PMC
April 2010

beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein.

J Biol Chem 2010 Jan 19;285(3):1634-42. Epub 2009 Nov 19.

From the Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1074/jbc.M109.066753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804321PMC
January 2010

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.

Nucleic Acids Res 2009 Oct 31;37(19):6477-90. Epub 2009 Aug 31.

Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1093/nar/gkp681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770659PMC
October 2009

Biochemical analysis of oligomerization of expanded polyalanine repeat proteins.

J Neurosci Res 2009 Aug;87(10):2290-6

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.22052DOI Listing
August 2009

Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse.

Neurochem Int 2009 May-Jun;54(5-6):330-8. Epub 2008 Dec 25.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S019701860800216
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http://dx.doi.org/10.1016/j.neuint.2008.12.012DOI Listing
July 2009

Polyalanine tracts directly induce the release of cytochrome c, independently of the mitochondrial permeability transition pore, leading to apoptosis.

Genes Cells 2009 Jun 22;14(6):751-7. Epub 2009 May 22.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2009.01307.xDOI Listing
June 2009

Oxytocin hypersensitivity in pregnant P-LAP deficient mice.

Life Sci 2009 May 26;84(19-20):668-72. Epub 2009 Feb 26.

Department of Medical Science of Proteases, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.

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http://dx.doi.org/10.1016/j.lfs.2009.02.018DOI Listing
May 2009

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

J Biol Chem 2009 May 2;284(19):13013-22. Epub 2009 Mar 2.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1074/jbc.M807653200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676034PMC
May 2009

Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.

Bioorg Med Chem Lett 2009 May 18;19(9):2435-9. Epub 2009 Mar 18.

Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.049DOI Listing
May 2009

Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.

J Neurosci Res 2009 Apr;87(5):1090-7

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.21942DOI Listing
April 2009

Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts.

J Neurosci Res 2009 Feb;87(2):360-8

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.21858DOI Listing
February 2009

1,3-Capryloyl-2-arachidonoyl glycerol activates alpha-secretase activity and suppresses Abeta40 secretion in A172 cells.

Neurosci Lett 2009 Feb 21;450(3):324-6. Epub 2008 Nov 21.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.neulet.2008.11.039DOI Listing
February 2009

Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.

FASEB J 2009 Jan 22;23(1):114-22. Epub 2008 Sep 22.

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.

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http://dx.doi.org/10.1096/fj.08-111203DOI Listing
January 2009

In vitro reconstitution of gamma-secretase activity using yeast microsomes.

Biochem Biophys Res Commun 2008 Dec 1;377(1):141-5. Epub 2008 Oct 1.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.09.090DOI Listing
December 2008

Physical interaction between Tbx6 and mespb is indispensable for the activation of bowline expression during Xenopus somitogenesis.

Biochem Biophys Res Commun 2008 Aug 27;372(4):607-12. Epub 2008 May 27.

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0800985
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http://dx.doi.org/10.1016/j.bbrc.2008.05.083DOI Listing
August 2008

MBNL1 associates with YB-1 in cytoplasmic stress granules.

J Neurosci Res 2008 Jul;86(9):1994-2002

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.21655DOI Listing
July 2008

Expression of polyalanine stretches induces mitochondrial dysfunction.

J Neurosci Res 2008 May;86(7):1529-37

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.21619DOI Listing
May 2008

Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.

J Neurochem 2008 Apr 12;105(1):101-12. Epub 2007 Nov 12.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05121.xDOI Listing
April 2008

Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression.

Proc Natl Acad Sci U S A 2008 Apr 2;105(14):5408-13. Epub 2008 Apr 2.

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1073/pnas.0710954105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291098PMC
April 2008

Quantitative analysis of CUG-BP1 binding to RNA repeats.

J Biochem 2008 Mar 26;143(3):377-83. Epub 2007 Nov 26.

Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1093/jb/mvm230DOI Listing
March 2008

BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Bioorg Med Chem Lett 2008 Mar 19;18(5):1649-53. Epub 2008 Jan 19.

Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.058DOI Listing
March 2008

Novel non-peptidic and small-sized BACE1 inhibitors.

Bioorg Med Chem Lett 2008 Mar 19;18(5):1643-7. Epub 2008 Jan 19.

Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.056DOI Listing
March 2008

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls.

Autophagy 2008 Jan 1;4(1):131-4. Epub 2007 Nov 1.

Department of Biochemistry and Cell Biology, National Institute of Infectious Disease, Tokyo, Japan.

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http://dx.doi.org/10.4161/auto.5233DOI Listing
January 2008

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.

J Biol Chem 2008 Jan 16;283(2):733-8. Epub 2007 Nov 16.

Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M707103200DOI Listing
January 2008

Identification of an estrogenic hormone receptor in Caenorhabditis elegans.

Biochem Biophys Res Commun 2007 Dec 24;364(4):883-8. Epub 2007 Oct 24.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.10.089DOI Listing
December 2007

Endoplasmic reticulum stress caused by aggregate-prone proteins containing homopolymeric amino acids.

FEBS J 2007 Nov 8;274(21):5619-27. Epub 2007 Oct 8.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2007.06085.xDOI Listing
November 2007

Interactions between homopolymeric amino acids (HPAAs).

Protein Sci 2007 Oct 31;16(10):2195-204. Epub 2007 Aug 31.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1110/ps.072955307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2204140PMC
October 2007

Degradation of nicastrin involves both proteasome and lysosome.

J Neurochem 2007 May 26;101(4):982-92. Epub 2007 Feb 26.

Department of Psychiatry, Brain Research Center, The University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04449.xDOI Listing
May 2007

Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy.

Neuromuscul Disord 2007 Apr 28;17(4):306-12. Epub 2007 Feb 28.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.nmd.2007.01.002DOI Listing
April 2007

Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay.

J Biol Chem 2007 Mar 17;282(11):7799-808. Epub 2007 Jan 17.

Department of Life Sciences, Graduate School of Arts and Science, The University of Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1074/jbc.M610159200DOI Listing
March 2007

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

Biochem Biophys Res Commun 2007 Mar 31;355(1):41-6. Epub 2007 Jan 31.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 3-8-1 Komaba, Meguro-ku 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.01.127DOI Listing
March 2007

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

J Neurosci Res 2007 Jan;85(1):153-65

Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/jnr.21104DOI Listing
January 2007

ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells.

Biochem Biophys Res Commun 2007 Jan 9;352(1):111-7. Epub 2006 Nov 9.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.181DOI Listing
January 2007

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.

Biochem Biophys Res Commun 2007 Jan 15;352(2):498-502. Epub 2006 Nov 15.

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Iruma-gun, Saitama 350-0495, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.043DOI Listing
January 2007

Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients.

Neurosci Lett 2007 Jan 15;412(2):139-42. Epub 2006 Dec 15.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.neulet.2006.10.064DOI Listing
January 2007

Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system.

J Neurosci Res 2006 Nov;84(7):1555-63

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.21062DOI Listing
November 2006

A simple, one-step cloning method to obtain long artificial triplet repeats.

Anal Biochem 2006 Oct 27;357(2):308-10. Epub 2006 Jun 27.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.

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http://dx.doi.org/10.1016/j.ab.2006.06.010DOI Listing
October 2006

BACE1 interacts with lipid raft proteins.

J Neurosci Res 2006 Sep;84(4):912-7

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/jnr.20981DOI Listing
September 2006

beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.

Bioorg Med Chem Lett 2006 Aug 6;16(16):4354-9. Epub 2006 Jun 6.

Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2006.05.046DOI Listing
August 2006

[Myotonic dystrophy as an RNA-mediated disease].

Authors:
Shoichi Ishiura

Rinsho Shinkeigaku 2005 Nov;45(11):828-30

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November 2005

Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.

J Neurochem 2005 Aug 7;94(4):1146-57. Epub 2005 Jul 7.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03268.xDOI Listing
August 2005

Denervation enhances the expression of SHPS-1 in rat skeletal muscle.

J Biochem 2005 Apr;137(4):495-502

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902.

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http://dx.doi.org/10.1093/jb/mvi058DOI Listing
April 2005