Publications by authors named "Shohreh Jahani"

14 Publications

  • Page 1 of 1

An electrochemical sensor based on hierarchical nickel oxide nanostructures doped with indium ions for voltammetric simultaneous determination of sunset yellow and tartrazine colorants in soft drink powders.

Anal Methods 2021 Jun 13;13(21):2396-2404. Epub 2021 May 13.

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

The current study was designed to develop a single-step and simple approach to effectively fabricate three-dimensional raspberry-like In/NiO hierarchical nanostructures (In/NiO RLHNSs) as a modifier, which was subsequently characterized by the techniques of X-ray diffraction (XRD), energy dispersive spectrometry (EDS) and field emission scanning electron microscopy (FE-SEM). The new prepared nano-modifier was practically used to co-detect electrochemically sunset yellow and tartrazine dyes. Potent sensitivity and acceptable selectivity were obtained for the produced In/NiO RLHNSs to co-detect both the food colorants, thus providing oxidation peaks in differential pulse voltammetry (DPV) with a peak potential separation of ca. 190 mV. The results showed a 5.14-fold and 8.07-fold increase in the electrochemical response of our modified electrode to sunset yellow and tartrazine, respectively, compared to the control (the unmodified electrode). Limits of detection of 2.7 and 3.1 nM were calculated for sunset yellow and tartrazine, respectively. The results from the interaction of common food additives showed satisfactory outcomes for the application of this method in determining sunset yellow and tartrazine in several beverage specimens. Other useful documentation was obtained for the production of portable food additive sensors.
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http://dx.doi.org/10.1039/d1ay00306bDOI Listing
June 2021

Simultaneous determination of theobromine, theophylline, and caffeine using a modified electrode with petal-like MnO nanostructure.

Talanta 2021 Jan 27;222:121563. Epub 2020 Aug 27.

Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. Electronic address:

This study substantially synthesized the β-type MnO nano-flowers assembled by the hierarchical nano-sheets using a simplified hydro-thermal procedure. According to the FESEM images, MnO nano-flower exhibited diameter of ∼800 nm and fabricated with a lot of irregular sheets as a petal-like structure with thickness of several nano-meters. Therefore, the study focused on the construction of an electro-chemical sensor to simultaneously determine theobromine (ThB), theophylline (ThP), as well as caffeine (CaF) on the basis of the β-type hierarchical structure of the MnO nano-flowers (βH-MnO-NF) modified electrode (βH-MnO-NF/GCE). Analysis showed an acceptable linear association between the oxidation peak current and ThB, ThP and CaF concentration within the ranges between 0.01 and 320.0 μM with a limit of detection (LOD) equal to 8.7, 5.9, and 10.1 nM (S/N = 3), respectively. Additionally, this study intended to investigate ThB, Thp and CaF bio-availability in the five commercially available brands of the chocolate products and drug.
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http://dx.doi.org/10.1016/j.talanta.2020.121563DOI Listing
January 2021

Synthesis of LaO/MWCNT nanocomposite as the sensing element for electrochemical determination of theophylline.

Anal Methods 2020 09;12(35):4319-4326

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

In this study, an electrochemical sensor was applied for the determination of theophylline, a bronchodilator drug, using differential pulse voltammetry (DPV). A glassy carbon electrode (GCE) surface was modified with the La2O3/MWCNT nanocomposite. The design is simplistic, efficient, greener and solvent-free microwave procedure for synthesizing La2O3/MWCNT nanocomposites. Fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) techniques are used to characterize the features of the La2O3/MWCNT nanocomposite morphology and structure. The use of the modified sensor remarkably enhanced the current density and displayed a linear response ranging between 0.1 and 400.0 μM, with a limit of detection of 0.01 μM (S/N = 3). Using optimized conditions, the modified sensor demonstrated very good stability, selectivity and improved accuracy. Acceptable outputs were achieved in the analysis of real specimens, indicating that it is possible to use the modified sensor for practical analyses.
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http://dx.doi.org/10.1039/d0ay01336fDOI Listing
September 2020

Experimental and computational interaction studies of terbium (III) and lanthanide (III) complexes containing 2,2'-bipyridine with bovine serum albumin and their anticancer and antimicrobial activities.

J Biomol Struct Dyn 2020 Jul 16:1-12. Epub 2020 Jul 16.

Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON, Canada.

To investigate the chemotherapeutic and pharmacokinetic aspects of two lanthanide complexes (Tb(III) and La(III) containing 2,2'-bipyridine ligand), binding studies were carried out with BSA by employing multiple biophysical methods and molecular modeling study. There are different techniques containing fluorescence, absorption spectroscopy and competitive experiments to determine the interaction mode between BSA and these complexes. These complexes efficiently quenched the BSA emission through a static procedure. The results showed that the terbium and lanthanum complexes exhibited a high propensity for BSA interaction van der Waals force. Further, competitive examination and docking study showed that the interaction site of these complexes on BSA is site III. The results of docking calculations were in good agreement with experimental examinations. Also, the energy transfer from BSA to these complexes has happened with high possibility. Moreover, antimicrobial studies of different bacterial and fungi indicated its promising antibacterial activity. cytotoxicity of the Tb complex and La complex was carried out in MCF-7 and A-549 cell lines, which revealed significantly good activity.Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2020.1792988DOI Listing
July 2020

Evaluation of parent and nano-encapsulated terbium(III) complex toward its photoluminescence properties, FS-DNA, BSA binding affinity, and biological applications.

J Trace Elem Med Biol 2020 May 21;61:126564. Epub 2020 May 21.

Department of Physical and Environmental Sciences, University of Toronto Scarborough 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. Electronic address:

Background: There is a crucial need for finding and developing new compounds as the anticancer and antimicrobial agents with better activity, specific target, and less toxic side effects.

Objectives: Base on the potential anticancer properties of lanthanide complexes, in the paper, the biological applications of terbium (Tb) complex, containing 2,9-dimethyl- 1,10-phenanthroline (MePhen) such as anticancer, antimicrobial, DNA cleavage ability, the interaction with FS-DNA (Fish-Salmon DNA) and BSA (Bovine Serum Albumin) was examined.

Methods: The interaction of Tb-complex with BSA and DNA was studied by emission spectroscopy, absorption titration, viscosity measurement, CD spectroscopy, competitive experiments, and docking calculation. Also, the ability of this complex to cleave DNA was reported by gel electrophoresis. Tb-complex was concurrently screened for its antibacterial activities by different methods. Besides, the nanocarriers of Tb-complex (lipid nanoencapsulation (LNEP) and the starch nanoencapsulation (SNEP)), as active anticancer candidates, were prepared. MTT technique was applied to measure the antitumor properties of these compounds on human cancer cell lines.

Results: The experimental and docking results suggest significant binding between DNA as well as BSA with terbium-complex. Besides, groove binding plays the main role in the binding of this compound with DNA and BSA. The competitive experiment with hemin demonstrated that the terbium complex was bound at site III of BSA, which was confirmed by the docking study. Also, Tb-complex was concurrently screened for its DNA cleavage, antimicrobial, and anticancer activities. The anticancer properties of LNEP and SNEP are more than the terbium compound.

Conclusions: Tb-complex can bond to DNA/BSA with high binding affinity. Base on biological applications of Tb-complex, it can be concluded that this complex and its nanocarriers can suggest as novel anticancer, antimicrobial candidates.
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http://dx.doi.org/10.1016/j.jtemb.2020.126564DOI Listing
May 2020

A review: Recent advances in ultrasensitive and highly specific recognition aptasensors with various detection strategies.

Int J Biol Macromol 2020 Jul 23;155:184-207. Epub 2020 Mar 23.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address:

One of the most studied topics in analytical chemistry and physics is to develop bio-sensors. Aptamers are small single-stranded RNA or DNA oligonucleotides (5-25 kDa), which have advantages in comparison to their antibodies such as physicochemical stability and high binding specificity. They are able to integrate with proteins or small molecules, including intact viral particles, plant lectins, gene-regulation factor, growth factors, antibodies and enzymes. The aptamers have reportedly shown some unique characteristics, including long shelf-life, simple modification to provide covalent bonds to material surfaces, minor batch variation, cost-effectiveness and slight denaturation susceptibility. These features led important efforts toward the development of aptamer-based sensors, known as apta-sensors classified into optical, electrical and mass-sensitive based on the signal transduction mode. This review provided a number of current advancements in selecting, development criteria, and aptamers application with the focus on the effect of apta-sensors, specifically for disease-associated analyses. The review concentrated on the current reports of apta-sensors that are used for evaluating different food and environmental pollutants.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.03.173DOI Listing
July 2020

Synthesis of bifunctional cabbage flower-like Ho/NiO nanostructures as a modifier for simultaneous determination of methotrexate and carbamazepine.

Anal Bioanal Chem 2020 Feb 2;412(4):1011-1024. Epub 2020 Jan 2.

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

Cabbage flower-like Ho/NiO nanostructure (CFL-Ho/NiO NSs) with significant electrocatalytic oxidation has been published for the first time. First, structure and morphology of CFL-Ho/NiO-NSs have been described by XRD, SEM, and EDX methods. Then, CFL-Ho/NiO-NSs have been applied as a modifier for simultaneous electrochemical detection of methotrexate (MTX) and carbamazepine (CBZ). Functions of the modified electrode have been dealt with through electrochemical impedance spectroscopy (EIS). It has been demonstrated that the electrode response has been linear from 0.001-310.0 μM with a limit of detection of 5.2 nM and 4.5 nM (3 s/m) through DPV for MTX and CBZ. Diffusion coefficient (D) and heterogeneous rate constant (k) have been detected for MTX and CBZ oxidation at the surface of the modified electrode. Moreover, CFL-Ho/NiO-NS/GCE has been employed for determining MTX and CBZ in urine and drug specimens. Outputs showed the analyte acceptable recovery. Therefore, the electrode could be applied to analyze both analytes in drug prescription and clinical laboratories. Graphical abstract Electrochemical sensor based on bifunctional cabbage flower-like Ho/NiO nanostructures modified glassy carbon electrode for simultaneous detecting methotrexate and carbamazepine was fabricated.
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http://dx.doi.org/10.1007/s00216-019-02326-8DOI Listing
February 2020

Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate.

Mikrochim Acta 2019 12 5;187(1):24. Epub 2019 Dec 5.

Department of Drug and Food Control, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/N = 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/N = 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens. Graphical abstractSchematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin.
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http://dx.doi.org/10.1007/s00604-019-4016-2DOI Listing
December 2019

Experimental and theoretical investigations of Dy(III) complex with 2,2'-bipyridine ligand: DNA and BSA interactions and antimicrobial activity study.

J Biomol Struct Dyn 2020 Oct 14;38(16):4746-4763. Epub 2019 Nov 14.

Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.

In this study, the interactions of a novel metal complex [Dy(bpy)Cl.OH] (bpy is 2,2'-bipyridine) with fish salmon DNA (FS-DNA) and bovine serum albumin (BSA) were investigated by experimental and theoretical methods. All results suggested significant binding between the Dy(III) complex with FS-DNA and BSA. The binding constants (), Stern-Volmer quenching constants () of Dy(III)-complex with FS-DNA and BSA at various temperatures as well as thermodynamic parameters using Van't Hoff equation were obtained. The experimental results from absorption, ionic strength, iodide ion quenching, ethidium bromide (EtBr) quenching studies and positive Δ˚ and Δ˚ suggested that hydrophobic groove-binding mode played a predominant role in the binding of Dy(III)-complex with FS-DNA. Indeed, the molecular docking results for DNA-binding were in agreement with experimental data. Besides, the results found from experimental and molecular modeling indicated that the Dy(III)complex bound to BSA Van der Waals interactions. Moreover, the results of competitive tests by phenylbutazone, ibuprofen, and hemin (as a site-I, site-II and site-III markers, respectively) considered that the site-III of BSA is the most possible binding site for Dy(III)-complex. In addition, Dy(III) complex was concurrently screened for its antimicrobial activities. The presented data provide a promising platform for the development of novel metal complexes that target nucleic acids and proteins with antimicrobial activity.Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2019.1689170DOI Listing
October 2020

Green and facile microwave solvent-free synthesis of CeO nanoparticle-decorated CNTs as a quadruplet electrochemical platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen.

Talanta 2020 Jan 9;207:120318. Epub 2019 Sep 9.

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

This study designed a simplistic, efficient, and greener procedure to synthesize CeO-CNTs. The analysis of structural and morphological characteristics of nano-composites has been done with regard to different procedures (e.g., EDX, XRD, & FESEM). In addition, simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA) and acetaminophen (AC) has been examined at the modified glassy carbon electrode with CeO-CNTs nano-composites. The surface area and electron transfer speed of the interplay between neuro-transmitters and electrode may be efficiently enhanced due to the existence of CeO nano-particles on CNTs surfaces. Moreover, electro-chemical behavior of electrodes has been dealt with by differential pulse voltammetry (DPV), impedance analysis (EIS), and cyclic voltammetry (CV). Acceptable linear response of AA, DA, UA and AC respectively have been ranged 0.01-900.0 μM, 0.01-700.0 μM, 0.01-900.0 μM, and 0.01-900.0 μM with determination limits (S/N = 3) of 3.1 nM, 2.6 nM, 2.4 nM and 4.4 nM. Ultimately, this procedure was used with successful results for determining AA, DA, UA and AC in real specimens, which suggested probable uses in other sensing studies.
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http://dx.doi.org/10.1016/j.talanta.2019.120318DOI Listing
January 2020

Evaluation of DNA, BSA binding, DNA cleavage and antimicrobial activity of ytterbium(III) complex containing 2,2'-bipyridine ligand.

J Biomol Struct Dyn 2020 Apr 27;38(6):1711-1725. Epub 2019 May 27.

Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran.

In order to estimate the biological potential of a synthesized complex [Yb(bpy)Cl.OH] where bpy is 2,2'-bipyridine, its binding behavior with fish salmon-DNA (FS-DNA) and bovine serum albumin (BSA) were studied by different kinds of spectroscopy and molecular modeling methods. This complex was selected for its antibacterial and antifungal activities as well as the DNA cleavage activities were examined by agarose gel electrophoresis. The analyses of fluorescence data at four temperatures were done in order to evaluate the binding and thermodynamic parameters of the interaction of Yb(III) complex with DNA and BSA. The experimental results indicated that the major binding modes were based on groove binding with DNA and BSA. In addition, iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, circular dichroism, and viscosity studies reflected the binding of Yb(III) complex explicitly with the FS-DNA mainly in a groove binding mode. Moreover, molecular docking studies indicated that this complex was bound to the minor groove of DNA and to polar and apolar residues located in the subdomain IB of BSA (site 3). Also, the results of competitive experiments assessed site 3 of BSA as the most probable binding site for this complex. The molecular docking results were in good agreement with our experimental results. From both experimental and docking results, the binding constant values displayed the remarkably high affinity of Yb(III) complex to DNA as well as BSA.Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2019.1617788DOI Listing
April 2020

The effect of ultrasonic irradiation on the morphology of NiO/CoO nanocomposite and its application to the simultaneous electrochemical determination of droxidopa and carbidopa.

Ultrason Sonochem 2019 Sep 2;56:183-192. Epub 2019 Apr 2.

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

The present work deals with the preparation of NiO/CoO nanocomposites in presence of ultrasonic irradiation, and its use in electrochemical determination of Parkinson's drugs. NiO/CoO nanocomposites are prepared using ultrasound assisted method. The impact of ultrasonic irradiation power (0, 75, 150, 300 and 600 W) on the structure and morphology of NiO/CoO nanocomposites was investigated. Various particle morphologies were attained because of the existence of ultrasonic irradiation. The nanoparticles' structure exhibited more uniformity whilst the particles sizes and nanoparticle accumulation was reduced when ultrasonic irradiation power was increased. The NiO/CoO nanocomposite was determined via X-ray diffraction, scanning electron microscopy i.e. SEM as well as energy dispersion X-ray spectroscopy (EDX). Drop casting NiO/CoO nanocomposites suspension on glassy carbon electrode was employed to fabricate the modified glassy carbon electrode (NiO/CoO/GCE). The electrochemical studies on the NiO/CoO nanocomposite towards droxidopa and carbidopa were experimented via cyclic voltammetry (CV), chronoamperometry (CHA) and differential pulse voltammetry (DPV). The CV examinations displayed increased catalytic behavior of droxidopa because of synergistic impact of the nanocomposite that was bolstered through enhanced material surface roughness. By using differential pulse voltammetry, the droxidopa detection limit and linear range was determined as 0.01 μM and 0.1-500.0 μM, respectively. Also, the adjusted electrode was implemented to ascertain droxidopa in the presence of carbidopa by differential pulse voltammetry. This sensor exhibited long term reproducibility and stability. Droxidopa and carbidopa quantification within biological specimens of fluids i.e. human urine and serum were conducted to validate the suitability in the application of this sensor.
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http://dx.doi.org/10.1016/j.ultsonch.2019.04.002DOI Listing
September 2019

cytotoxicity studies of parent and nanoencapsulated Holmium-2,9-dimethyl-1,10-phenanthroline complex toward fish-salmon DNA-binding properties and antibacterial activity.

J Biomol Struct Dyn 2019 10 16;37(17):4437-4449. Epub 2019 Jan 16.

Department of Biotechnology, Institute of Science, High Technology & Environmental Science, Graduate University of Advance Technology , Kerman , Iran.

In this study, the interaction of Holmium (Ho) complex including 2, 9-dimethyl-1,10-phenanthroline, also called Neocuproine (Neo), [Ho(Neo)Cl.HO], as fluorescence probe with fish-salmon DNA (FS-DNA) is studied during experimental investigations. Multi-spectroscopic methods are utilized to determine the affinity binding constants () of complex-FS-DNA. It is found that fluorescence of Ho complex is strongly quenched by the FS-DNA through a static quenching procedure. Under optimal conditions in Tris(trishydroxymethyl-aminomethane)-HCl buffer at 25 °C with pH ≈ 7.2, intrinsic binding constant of Ho complex is 6.12 ± 0.04 × 10 M. Also, the binding site number and Stern-Volmer quenching constant are calculated. There are different approaches, including iodide quenching assay, salt effect and thermodynamical assessment to determine the features of the binding mode between Ho complex and FS-DNA. Also, the parent and starch and lipid nanoencapsulated Ho complex, as potent antitumor candidates, were synthesized. The main structure of Ho complex is maintained after encapsulation using starch and lipid nanoparticles. 3-[4,5-Dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method was used to assess the anticancer properties of Ho complex and its encapsulated forms on human cancer cell lines of human lung carcinoma cell line and breast cancer cell line. In conclusion, these compounds could be considered as new antitumor candidates. Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2018.1557077DOI Listing
October 2019

DNA interaction of europium(III) complex containing 2,2'-bipyridine and its antimicrobial activity.

J Biomol Struct Dyn 2016 8;34(3):612-24. Epub 2015 Jun 8.

a Department of Chemistry , University of Sistan and Baluchestan , Zahedan , P.O. Box 98155-147, Iran.

The interaction of native fish salmon DNA (FS-DNA) with [Eu(bpy)3Cl2(H2O)]Cl, where bpy is 2,2'-bipyridine, is studied at physiological pH in Tris-HCl buffer by spectroscopic methods, viscometric techniques as well as circular dichroism (CD). These experiments reveal that Eu(III) complex has interaction with FS-DNA. Moreover, binding constant and binding site size have been determined. The value of Kb has been defined 2.46 ± .02 × 10(5) M(-1). The thermodynamic parameters are calculated by Van't Hoff equation, the results show that the interaction of the complex with FS-DNA is an entropically driven phenomenon. CD spectroscopy followed by viscosity as well as fluorescence and UV--Vis measurements indicate that the complex interacts with FS-DNA via groove binding mode. Also, the synthesized Eu(III) complex has been screened for antimicrobial activities.
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http://dx.doi.org/10.1080/07391102.2015.1048481DOI Listing
December 2016