Publications


Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.
Neuro Oncol 2017 Mar 30. Epub 2017 Mar 30.
Department of Neurosurgery, The University of Tokyo, Tokyo, Japan (S.T., A.M., S.T., M.N., M.O., S.Y., H.N., N.S.); Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan (S.Y., H.A.); Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan (K.I.); Department of Neurosurgery, Dokkyo Medical University, Mibu, Tochigi,Japan (K.U.).

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Cell Rep 2017 Feb;18(9):2228-2242
The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

A case of autoimmune pancreatitis effectively treated with an immunosuppressant (azathioprine).
Clin J Gastroenterol 2016 Oct 23;9(5):324-8. Epub 2016 Jul 23.
Department of Gastroenterology, Fukushima Medical University Aizu Medical Center, 21-2, Maeda, Tanisawa, Kawahigashi, Aizuwakamatsu, 969-3492, Japan.

Eosinophilic esophageal myositis diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy: a case report.
Clin J Gastroenterol 2016 Oct 9;9(5):285-8. Epub 2016 Aug 9.
Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, 21-2, Maeda, Tanisawa, Kawahigashi, Aizuwakamatsu, 969-3492, Japan.





Thermal and solvent stress cross-tolerance conferred to Corynebacterium glutamicum by adaptive laboratory evolution.
Appl Environ Microbiol 2015 Apr 16;81(7):2284-98. Epub 2015 Jan 16.
Research Institute of Innovative Technology for the Earth, Kizugawa, Kyoto, Japan Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan


Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.
Nat Genet 2014 Jun 11;46(6):583-7. Epub 2014 May 11.
1] Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. [2] Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [3] Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.



Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains.
Virus Res 2014 Feb 24;180:59-69. Epub 2013 Dec 24.
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan. Electronic address:

H3F3A K27M mutations in thalamic gliomas from young adult patients.
Neuro Oncol 2014 Jan 26;16(1):140-6. Epub 2013 Nov 26.
Corresponding authors: Akitake Mukasa, MD, PhD, Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Hiroyuki Aburatani, MD, PhD, Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan





Global transcriptome analysis of the tetrachloroethene-dechlorinating bacterium Desulfitobacterium hafniense Y51 in the presence of various electron donors and terminal electron acceptors.
J Ind Microbiol Biotechnol 2012 Feb 23;39(2):255-68. Epub 2011 Aug 23.
Molecular Microbiology and Biotechnology Group, Research Institute of Innovative Technology for the Earth (RITE), 9-2 Kizugawadai, Kizugawa, Kyoto 619-0292, Japan.



Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.
Hum Mol Genet 2011 Jul 19;20(14):2710-21. Epub 2011 Apr 19.
Genome Science Division, Research Center for Advanced Science and Technology and Department of Pathology, University of Tokyo, Tokyo, Japan.




Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.
Clin Cancer Res 2005 Mar;11(5):1776-85
Genome Science Division and Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, Graduate School of Medicine, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.


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