Shobhna Kapoor

Shobhna Kapoor

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Shobhna Kapoor

Shobhna Kapoor

Publications by authors named "Shobhna Kapoor"

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25Publications

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Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.

Biochim Biophys Acta Biomembr 2019 Jun 17;1861(6):1213-1227. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2019.04.004DOI Listing
June 2019

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.

Cell Chem Biol 2019 Apr 24;26(4):512-523.e5. Epub 2019 Jan 24.

Max Planck Institute for Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, Dortmund 44227, Germany; Technische Universität Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, Dortmund 44227, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183043
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http://dx.doi.org/10.1016/j.chembiol.2018.11.014DOI Listing
April 2019

The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens.

Front Biosci (Schol Ed) 2019 03 1;11:75-88. Epub 2019 Mar 1.

Department of Biology, International Consortium for Advancing Research on Triple Negative Breast Cancer, Georgia State University, Atlanta, GA 30303, USA,

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March 2019

Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint.

Biomed Res Int 2018 15;2018:6437371. Epub 2018 Aug 15.

Membrane Biophysics and Chemical Biology Lab, Department of Chemistry, Indian Institute of Technology Bombay, Powai 400076, India.

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http://dx.doi.org/10.1155/2018/6437371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114229PMC
December 2018

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Cell Chem Biol 2018 Sep 28;25(9):1095-1106.e23. Epub 2018 Jun 28.

Max Planck Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, Dortmund 44227, Germany; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, Dortmund 44227, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.05.016DOI Listing
September 2018

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.

Chembiochem 2017 09 31;18(18):1797-1806. Epub 2017 Jul 31.

Department of Chemical Biology, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/cbic.201700260DOI Listing
September 2017

Novel approaches to map small molecule-target interactions.

Bioorg Med Chem 2016 Aug 13;24(15):3232-45. Epub 2016 May 13.

Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.05.020DOI Listing
August 2016

Regulation of K-Ras4B Membrane Binding by Calmodulin.

Biophys J 2016 Jul;111(1):113-22

Physical Chemistry I - Biophysical Chemistry, TU Dortmund University, Dortmund, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945620PMC
July 2016

Pressure-A Gateway to Fundamental Insights into Protein Solvation, Dynamics, and Function.

Chemphyschem 2015 Dec 27;16(17):3555-71. Epub 2015 Oct 27.

Department of Chemistry and Chemical Biology, Physical Chemistry, TU Dortmund University, Dortmund, Otto-Hahn-Str. 6, d-44221, Dortmund, Germany.

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http://dx.doi.org/10.1002/cphc.201500669DOI Listing
December 2015

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Biophys J 2015 Oct;109(8):1619-29

Physical Chemistry I - Biophysical Chemistry, TU Dortmund University, Dortmund, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624342PMC
October 2015

In situ investigation of Geobacillus stearothermophilus spore germination and inactivation mechanisms under moderate high pressure.

Food Microbiol 2014 Aug 22;41:8-18. Epub 2014 Jan 22.

German Institute of Food Technologies (DIL), Prof.-von-Klitzing-Str. 7, 49610 Quakenbrück, Germany.

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http://dx.doi.org/10.1016/j.fm.2014.01.007DOI Listing
August 2014

Prebiotic cell membranes that survive extreme environmental pressure conditions.

Angew Chem Int Ed Engl 2014 Aug 20;53(32):8397-401. Epub 2014 Jun 20.

Physical Chemistry I-Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 6, 44227 Dortmund (Germany); Current address: Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany).

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http://dx.doi.org/10.1002/anie.201404254DOI Listing
August 2014

Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins.

Faraday Discuss 2013 ;161:549-61; discussion 563-89

Physical Chemistry I, Faculty of Chemistry, TU Dortmund University, Dortmund, Germany.

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September 2013

Misplaced helix slows down ultrafast pressure-jump protein folding.

Proc Natl Acad Sci U S A 2013 May 25;110(20):8087-92. Epub 2013 Apr 25.

Department of Chemistry, Center for the Physics of Living Cells and Beckman Institute, University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.1219163110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657825PMC
May 2013

Pressure modulation of Ras-membrane interactions and intervesicle transfer.

J Am Chem Soc 2013 Apr 16;135(16):6149-56. Epub 2013 Apr 16.

Physical Chemistry I-Biophysical Chemistry, Faculty of Chemistry, TU Dortmund University, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/ja312671jDOI Listing
April 2013

Investigation of structural changes of β-casein and lysozyme at the gas-liquid interface during foam fractionation.

J Biotechnol 2012 Oct 3;161(2):138-46. Epub 2012 Feb 3.

Technical University Dortmund, Faculty of Biochemical and Chemical Engineering, Laboratory of Plant and Process Design, Emil-Figge-Str. 70, 44227 Dortmund, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01681656120009
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http://dx.doi.org/10.1016/j.jbiotec.2012.01.030DOI Listing
October 2012

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction.

Eur Biophys J 2012 Oct 1;41(10):801-13. Epub 2012 Aug 1.

Physical Chemistry I, Biophysical Chemistry, Faculty of Chemistry, TU Dortmund University, Otto-Hahn-Str. 6, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1007/s00249-012-0841-5DOI Listing
October 2012

Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: membrane delivery instead of extraction.

J Am Chem Soc 2012 Jul 10;134(28):11503-10. Epub 2012 Jul 10.

Physical Chemistry I-Biophysical Chemistry, Faculty of Chemistry, TU Dortmund University, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://pubs.acs.org/doi/10.1021/ja305518h
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http://dx.doi.org/10.1021/ja305518hDOI Listing
July 2012

Cross-amyloid interaction of Aβ and IAPP at lipid membranes.

Angew Chem Int Ed Engl 2012 Jan 1;51(3):679-83. Epub 2011 Dec 1.

Physical Chemistry I-Biophysical Chemistry, Faculty of Chemistry, Technische Universität Dortmund, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.

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http://doi.wiley.com/10.1002/anie.201105877
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http://dx.doi.org/10.1002/anie.201105877DOI Listing
January 2012

Revealing conformational substates of lipidated N-Ras protein by pressure modulation.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):460-5. Epub 2011 Dec 27.

Physical Chemistry I-Biophysical Chemistry, Faculty of Chemistry, TU Dortmund University, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1073/pnas.1110553109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258604PMC
January 2012

Temperature-pressure phase diagram of a heterogeneous anionic model biomembrane system: results from a combined calorimetry, spectroscopy and microscopy study.

Biochim Biophys Acta 2011 Apr 22;1808(4):1187-95. Epub 2011 Jan 22.

Physical Chemistry I-Biophysical Chemistry, TU Dortmund University, Dortmund, Germany.

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http://dx.doi.org/10.1016/j.bbamem.2011.01.011DOI Listing
April 2011

Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms.

J Am Chem Soc 2011 Feb 9;133(4):880-7. Epub 2010 Dec 9.

Physical Chemistry I, Biophysical Chemistry, Faculty of Chemistry, TU Dortmund University , Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1021/ja107532qDOI Listing
February 2011

Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release.

J Control Release 2009 Nov 3;140(1):34-9. Epub 2009 Aug 3.

Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.

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http://linkinghub.elsevier.com/retrieve/pii/S016836590900541
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http://dx.doi.org/10.1016/j.jconrel.2009.07.015DOI Listing
November 2009

Structure and function of hemoglobin confined inside silica nanotubes.

J Phys Chem B 2009 Oct;113(43):14189-95

Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.

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http://dx.doi.org/10.1021/jp9032707DOI Listing
October 2009

Three-dimensional structures of apo- and holo-L-alanine dehydrogenase from Mycobacterium tuberculosis reveal conformational changes upon coenzyme binding.

J Mol Biol 2008 Apr 12;377(4):1161-73. Epub 2008 Feb 12.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2008.01.091DOI Listing
April 2008