Publications



Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial.
J Clin Lipidol 2018 Jan - Feb;12(1):173-184. Epub 2017 Oct 28.
Department of Community Medicine and Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiovascular Medicine, Rinku General Medical Center, Izumisano, Japan.




Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration.
Atheroscler Suppl 2016 Dec 7;22:1-32. Epub 2016 Dec 7.
Imperial Centre for Cardiovascular Disease Prevention (ICCP), School of Public Health, Imperial College London, London, UK.






Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial.
Atherosclerosis 2016 Jun 26;249:36-43. Epub 2016 Feb 26.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

Detrimental effects of high-fat diet loading on vascular endothelial function and therapeutic efficacy of ezetimibe and statins in patients with type 2 diabetes.
Endocr J 2016 May 3;63(5):431-40. Epub 2016 Feb 3.
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
Metabolism 2015 Sep 6;64(9):1165-74. Epub 2015 Jun 6.
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Community Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice.
Biochem Biophys Res Commun 2015 Sep 20;465(3):638-43. Epub 2015 Aug 20.
Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.


Effects of phenotypic and genotypic factors on the lipid responses to niacin in Chinese patients with dyslipidemia.
Medicine (Baltimore) 2015 May;94(20):e881
From the Department of Medicine and Therapeutics (MH, YLY, BT); Department of Surgery (CFN); School of Pharmacy, The Chinese University of Hong Kong, Hong Kong SAR (CPL, VWYL); Department of Medical Technology, Osaka University Hospital (HH); Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan (DM, SY); and Diabetes Center, Second Xiangya Hospital, Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan, China (YLY).

Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
Arterioscler Thromb Vasc Biol 2014 Aug 29;34(8):1756-62. Epub 2014 May 29.
From the Department of Genome Research and Clinical Application, Graduate School of Medicine (M.K., S.A., Y.A., H.B.) and Center for Advanced Medicine, Chiba University Hospital (M.K.), Chiba University, Chiba, Japan; Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (A.G.H., E.S.G.S.); Department of Nephrology in Internal Medicine, Kitasato University Hospital, Sagamihara, Japan (K.K.); Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Japan (S.Y.); Division of Endocrinology and Metabolism, Department of Medicine, Diabetes Center, Jichi Medical University, Shimotsuke, Japan (S.I.); Chiba University, Chiba, Japan (Y.S.); and Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Sakura, Japan (H.B.).

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan.
BMJ Open 2014 Jun 6;4(6):e005067. Epub 2014 Jun 6.
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.









Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits.
Tissue Eng Part C Methods 2011 Feb 26;17(2):145-54. Epub 2010 Oct 26.
Department of Somatic Stem Cell Therapy and Health Policy, Foundation for Biomedical Research and Innovation, Kobe, Japan.





Diagnosis and management of type I and type V hyperlipoproteinemia.
J Atheroscler Thromb 2012 1;19(1):1-12. Epub 2011 Dec 1.
Department of Clinical and Molecular Epidemiology, 22nd Century Medical and Research Center, University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.

Acute ST-segment elevation myocardial infarction is associated with decreased human antimicrobial peptide LL-37 and increased human neutrophil peptide-1 to 3 in plasma.
J Atheroscler Thromb 2012 21;19(4):357-68. Epub 2011 Dec 21.
State Key Laboratory of Cadiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Beijing, China.



Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease.
J Atheroscler Thromb 2012 4;19(10):890-6. Epub 2012 Jul 4.
Division of Laboratory for Clinical Investigation, Department of Medical Technology, Osaka University Hospital, Osaka, Japan.


Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan.
J Atheroscler Thromb 2012 25;19(11):1019-26. Epub 2012 Oct 25.
Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.


















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