Shizuo Akira

Shizuo Akira

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Shizuo Akira

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Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11bGr1MDSCs from bone marrow.

Biomed Pharmacother 2019 Nov 9;121:109581. Epub 2019 Nov 9.

Department of Pharmacology, Kitasato University School of Medicine, Japan; Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2019.109581DOI Listing
November 2019

ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity.

Int Immunol 2019 Oct 20. Epub 2019 Oct 20.

Laboratory of Adjuvant Innovation, Center for Vaccine and Adjuvant Research Center (CVAR), National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan.

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http://dx.doi.org/10.1093/intimm/dxz070DOI Listing
October 2019

Innate immunity in allergy.

Allergy 2019 Sep 14;74(9):1660-1674. Epub 2019 Apr 14.

Laboratory of Host Defense, The World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1111/all.13788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790574PMC
September 2019

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.

J Immunol 2019 Aug 26;203(4):783-788. Epub 2019 Jun 26.

Department of Molecular and Cellular Immunology, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.

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http://dx.doi.org/10.4049/jimmunol.1900202DOI Listing
August 2019

Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice.

Biochem Biophys Res Commun 2019 Jul 31;515(3):442-447. Epub 2019 May 31.

The School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Research Excellence, The James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590932PMC
July 2019

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

J Exp Med 2019 Jun 9;216(6):1431-1449. Epub 2019 May 9.

Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, Japan

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http://dx.doi.org/10.1084/jem.20181078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547859PMC
June 2019

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.

Neurobiol Dis 2019 04 10;124:81-92. Epub 2018 Nov 10.

Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Japan.

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http://dx.doi.org/10.1016/j.nbd.2018.11.004DOI Listing
April 2019

Autophagy Regulation of Metabolism Is Required for CD8 T Cell Anti-tumor Immunity.

Cell Rep 2019 Apr;27(2):502-513.e5

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.037DOI Listing
April 2019

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 03 12;1864(3):271-280. Epub 2018 Dec 12.

Key Laboratory of Pu-erh Tea Science, the Ministry of Education, Yunnan Agricultural University, Kunming 650201, China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China; Pu'erh Tea Research Institute, Pu'erh, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13881981183037
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http://dx.doi.org/10.1016/j.bbalip.2018.12.003DOI Listing
March 2019

Role of Akirin1 in the regulation of skeletal muscle fiber-type switch.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular Oncology, MVR Cancer Center and Research Institute, Kozhikode, India.

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http://dx.doi.org/10.1002/jcb.28406DOI Listing
February 2019

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.

Dev Cell 2019 01 10;48(2):151-166.e7. Epub 2019 Jan 10.

Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; Laboratory of Signal Transduction, World Premier Institute Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.12.002DOI Listing
January 2019

Beclin 1 regulates recycling endosome and is required for skin development in mice.

Commun Biol 2019 25;2:37. Epub 2019 Jan 25.

1Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 Japan.

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http://dx.doi.org/10.1038/s42003-018-0279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347619PMC
January 2019

Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.

Proc Natl Acad Sci U S A 2018 10 8;115(43):11036-11041. Epub 2018 Oct 8.

Laboratory of Host Defense, The World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, 565-0871 Osaka, Japan;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1809575115
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http://dx.doi.org/10.1073/pnas.1809575115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205455PMC
October 2018

The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.

iScience 2018 Aug 15;6:306-318. Epub 2018 Aug 15.

Thermal Biology group, Exploratory Research Center on Life and Living Systems National Institutes of Natural Sciences, Okazaki Aichi 444-8787, Japan; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan; Department of Physiological Sciences, the Graduate University for Advanced Studies, Aichi 444-8787, Japan; Institute for Environmental and Gender Specific Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137711PMC
August 2018

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.

J Hepatol 2018 07 16;69(1):110-120. Epub 2018 Feb 16.

Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.02.009DOI Listing
July 2018

Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.

J Invest Dermatol 2018 06 12;138(6):1439-1442. Epub 2018 Jan 12.

Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.12.033DOI Listing
June 2018

Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2.

J Immunol 2018 06 20;200(11):3814-3824. Epub 2018 Apr 20.

Laboratory of Molecular Immunobiology, Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan;

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http://dx.doi.org/10.4049/jimmunol.1701282DOI Listing
June 2018

Neutrophils alleviate fibrosis in the CCl-induced mouse chronic liver injury model.

Hepatol Commun 2018 Jun 12;2(6):703-717. Epub 2018 Apr 12.

Institute of Molecular and Cellular Biosciences University of Tokyo Tokyo Japan.

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http://dx.doi.org/10.1002/hep4.1178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983199PMC
June 2018

BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation.

Int Immunol 2018 05;30(6):255-265

Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, Osaka, Japan.

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http://dx.doi.org/10.1093/intimm/dxy023DOI Listing
May 2018

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.

J Immunol 2018 04 19;200(8):2987-2999. Epub 2018 Mar 19.

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan;

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http://dx.doi.org/10.4049/jimmunol.1700435DOI Listing
April 2018

Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proc Natl Acad Sci U S A 2018 03 6;115(12):E2676-E2685. Epub 2018 Mar 6.

Biophotonics Laboratory, Immunology Frontier Research Center, Osaka University, Suita, Osaka, 565-0871 Japan;

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http://dx.doi.org/10.1073/pnas.1711872115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866539PMC
March 2018

Autophagy limits activation of the inflammasomes.

Immunol Rev 2018 01;281(1):62-73

Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.

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http://dx.doi.org/10.1111/imr.12613DOI Listing
January 2018

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination.

Front Immunol 2017 6;8:1456. Epub 2017 Nov 6.

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.3389/fimmu.2017.01456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681732PMC
November 2017

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.

Cell Rep 2017 Sep;20(12):2944-2954

Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan; Laboratory of Host Defense, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614515PMC
September 2017

Netrins as prophylactic targets in skeletal diseases: A double-edged sword?

Pharmacol Res 2017 Aug 30;122:46-52. Epub 2017 May 30.

Laboratory of Host Defense Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan, Japan; WPI Immunology Frontier Research Center (IFReC), 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1016/j.phrs.2017.05.011DOI Listing
August 2017

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

Nat Immunol 2017 Aug 12;18(8):899-910. Epub 2017 Jun 12.

Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1038/ni.3767DOI Listing
August 2017

Antitumor effect of through IL-12 p40 up-regulation in tumor-associated macrophages.

Proc Natl Acad Sci U S A 2017 08 14;114(35):E7331-E7340. Epub 2017 Aug 14.

Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan;

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http://dx.doi.org/10.1073/pnas.1708598114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584452PMC
August 2017

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Cereb Cortex 2017 06;27(6):3378-3396

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/cercor/bhw270DOI Listing
June 2017

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

EMBO J 2017 06 22;36(12):1707-1718. Epub 2017 May 22.

Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), Nara, Japan

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http://dx.doi.org/10.15252/embj.201695528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470042PMC
June 2017

products persist in the bone marrow and promote chronic bone loss.

Sci Immunol 2017 Jun;2(12)

Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1126/sciimmunol.aam8093DOI Listing
June 2017

Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.

Int Immunol 2017 04;29(4):149-155

Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC).

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http://dx.doi.org/10.1093/intimm/dxx015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890888PMC
April 2017

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc Natl Acad Sci U S A 2017 03 17;114(10):2681-2686. Epub 2017 Feb 17.

Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan;

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http://dx.doi.org/10.1073/pnas.1621508114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347618PMC
March 2017

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity.

J Immunol 2017 02 9;198(4):1649-1659. Epub 2017 Jan 9.

Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan;

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http://dx.doi.org/10.4049/jimmunol.1601694DOI Listing
February 2017

Identification of an atypical monocyte and committed progenitor involved in fibrosis.

Nature 2017 01 21;541(7635):96-101. Epub 2016 Dec 21.

Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1038/nature20611DOI Listing
January 2017

Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation.

Am J Physiol Heart Circ Physiol 2016 12 21;311(6):H1485-H1497. Epub 2016 Oct 21.

Cardiovascular Division, King's College London British Heart Foundation Centre of Research Excellence, London, United Kingdom;

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http://dx.doi.org/10.1152/ajpheart.00481.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206340PMC
December 2016

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Authors:
Gunter Schumann Chunyu Liu Paul O'Reilly He Gao Parkyong Song Bing Xu Barbara Ruggeri Najaf Amin Tianye Jia Sarah Preis Marcelo Segura Lepe Shizuo Akira Caterina Barbieri Sebastian Baumeister Stephane Cauchi Toni-Kim Clarke Stefan Enroth Krista Fischer Jenni Hällfors Sarah E Harris Saskia Hieber Edith Hofer Jouke-Jan Hottenga Åsa Johansson Peter K Joshi Niina Kaartinen Jaana Laitinen Rozenn Lemaitre Anu Loukola Jian'an Luan Leo-Pekka Lyytikäinen Massimo Mangino Ani Manichaikul Hamdi Mbarek Yuri Milaneschi Alireza Moayyeri Kenneth Mukamal Christopher Nelson Jennifer Nettleton Eemil Partinen Rajesh Rawal Antonietta Robino Lynda Rose Cinzia Sala Takashi Satoh Reinhold Schmidt Katharina Schraut Robert Scott Albert Vernon Smith John M Starr Alexander Teumer Stella Trompet André G Uitterlinden Cristina Venturini Anne-Claire Vergnaud Niek Verweij Veronique Vitart Dragana Vuckovic Juho Wedenoja Loic Yengo Bing Yu Weihua Zhang Jing Hua Zhao Dorret I Boomsma John Chambers Daniel I Chasman Toniolo Daniela Eco de Geus Ian Deary Johan G Eriksson Tõnu Esko Volker Eulenburg Oscar H Franco Philippe Froguel Christian Gieger Hans J Grabe Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Anna-Liisa Hartikainen Andrew C Heath Lynne Hocking Albert Hofman Cornelia Huth Marjo-Riitta Jarvelin J Wouter Jukema Jaakko Kaprio Jaspal S Kooner Zoltan Kutalik Jari Lahti Claudia Langenberg Terho Lehtimäki Yongmei Liu Pamela A F Madden Nicholas Martin Alanna Morrison Brenda Penninx Nicola Pirastu Bruce Psaty Olli Raitakari Paul Ridker Richard Rose Jerome I Rotter Nilesh J Samani Helena Schmidt Tim D Spector David Stott David Strachan Ioanna Tzoulaki Pim van der Harst Cornelia M van Duijn Pedro Marques-Vidal Peter Vollenweider Nicholas J Wareham John B Whitfield James Wilson Bruce Wolffenbuttel Georgy Bakalkin Evangelos Evangelou Yun Liu Kenneth M Rice Sylvane Desrivières Steven A Kliewer David J Mangelsdorf Christian P Müller Daniel Levy Paul Elliott

Proc Natl Acad Sci U S A 2016 12 28;113(50):14372-14377. Epub 2016 Nov 28.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;

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http://www.pnas.org/content/113/50/14372.full.pdf
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http://dx.doi.org/10.1073/pnas.1611243113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167198PMC
December 2016

Important Announcement.

Authors:
Shizuo Akira

Int Immunol 2016 Dec;28(12):573

Editor-in-Chief in waiting, International Immunology.

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https://academic.oup.com/intimm/article-lookup/doi/10.1093/i
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http://dx.doi.org/10.1093/intimm/dxw087DOI Listing
December 2016

Toll-Like Receptor Signaling and Its Inducible Proteins.

Microbiol Spectr 2016 12;4(6)

Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0040-2016DOI Listing
December 2016

Genome-wide map of RNA degradation kinetics patterns in dendritic cells after LPS stimulation facilitates identification of primary sequence and secondary structure motifs in mRNAs.

BMC Genomics 2016 12 22;17(Suppl 13):1032. Epub 2016 Dec 22.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8561, Japan.

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http://dx.doi.org/10.1186/s12864-016-3325-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259865PMC
December 2016

Important Announcement.

Authors:
Shizuo Akira

Int Immunol 2016 Nov;28(11):521

Editor-in-Chief in waiting, International Immunology.

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http://dx.doi.org/10.1093/intimm/dxw043DOI Listing
November 2016

Impaired autophagy in macrophages promotes inflammatory eye disease.

Autophagy 2016 10 27;12(10):1876-1885. Epub 2016 Jul 27.

a Department of Ophthalmology and Visual Sciences , Washington University School of Medicine , St. Louis , MO , USA.

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http://dx.doi.org/10.1080/15548627.2016.1207857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066937PMC
October 2016

TLR7 Structure: Cut in Z-Loop.

Immunity 2016 10;45(4):705-707

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.10.003DOI Listing
October 2016

Regulation of inflammasomes by autophagy.

J Allergy Clin Immunol 2016 07 24;138(1):28-36. Epub 2016 May 24.

Laboratory of Host Defense, World Premier International Research Center Immunology Frontier Research Center, Osaka, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1016/j.jaci.2016.05.009DOI Listing
July 2016

Raman spectroscopy as a tool for label-free lymphocyte cell line discrimination.

Analyst 2016 Jun 12;141(12):3756-64. Epub 2016 Apr 12.

Biophotonics Laboratory, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1039/c6an00181eDOI Listing
June 2016

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency.

Immunity 2016 06 14;44(6):1434-43. Epub 2016 Jun 14.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.05.012DOI Listing
June 2016

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.

Int Immunol 2016 Mar 20;28(3):105-15. Epub 2015 Oct 20.

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan iPS Cell-Based Research Project on Hepatic Toxicity and Metabolism, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan Global Center for Medical Engineering and Informatics, Osaka University, Osaka 565-0871, Japan

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http://dx.doi.org/10.1093/intimm/dxv058DOI Listing
March 2016

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nat Commun 2016 Mar 22;7:11051. Epub 2016 Mar 22.

WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1038/ncomms11051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804175PMC
March 2016

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.

Life Sci 2015 Dec 14;142:1-7. Epub 2015 Oct 14.

Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; Department of Molecular Pharmacology, Graduate School of Medical Sciences, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.10.008DOI Listing
December 2015

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.

J Biol Chem 2015 Dec 16;290(50):29781-93. Epub 2015 Oct 16.

From the Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan, the Global Innovation Research Organization, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan,

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http://dx.doi.org/10.1074/jbc.M115.669481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706013PMC
December 2015

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.

J Exp Med 2015 Dec 16;212(13):2305-21. Epub 2015 Nov 16.

Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

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http://dx.doi.org/10.1084/jem.20150618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683997PMC
December 2015

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication.

Sci Signal 2015 Dec 8;8(406):ra126. Epub 2015 Dec 8.

Laboratory of Immunology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462066, India. Laboratory of Host Defense, WPI Immunology Frontier Research Centre, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1126/scisignal.aab3183DOI Listing
December 2015

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair.

Nat Commun 2015 Dec 9;6:10123. Epub 2015 Dec 9.

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1038/ncomms10123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682113PMC
December 2015

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

Cell Rep 2015 Oct 1;13(2):223-33. Epub 2015 Oct 1.

Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.005DOI Listing
October 2015

Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome.

Int Immunol 2015 Sep 7;27(9):425-34. Epub 2015 Apr 7.

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1093/intimm/dxv018DOI Listing
September 2015

Emerging molecules in the interface between skeletal system and innate immunity.

Pharmacol Res 2015 Sep 2;99:223-8. Epub 2015 Jul 2.

Laboratory of Host Defense, Osaka University, Osaka 565-0871, Japan; WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka 565-0871, Japan; Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.06.005DOI Listing
September 2015

Role of the Atg9a gene in intrauterine growth and survival of fetal mice.

Reprod Biol 2015 Sep 11;15(3):131-8. Epub 2015 Jun 11.

Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.1016/j.repbio.2015.05.001DOI Listing
September 2015

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation.

Biochem Biophys Res Commun 2015 Aug 20;463(4):1284-90. Epub 2015 Jun 20.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Cell Signaling, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.105DOI Listing
August 2015

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.

Nat Med 2015 Aug 20;21(8):927-31. Epub 2015 Jul 20.

1] Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. [2] Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1038/nm.3912DOI Listing
August 2015

Role of zinc-finger anti-viral protein in host defense against Sindbis virus.

Int Immunol 2015 Jul 10;27(7):357-64. Epub 2015 Mar 10.

Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1093/intimm/dxv010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565983PMC
July 2015

Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy.

Angew Chem Int Ed Engl 2015 Jul 26;54(28):8226-30. Epub 2015 May 26.

Institute for Protein Research, Osaka University, Osaka 565-0871 (Japan).

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http://dx.doi.org/10.1002/anie.201501847DOI Listing
July 2015

Glucocorticoid augments lipopolysaccharide-induced activation of the IκBζ-dependent genes encoding the anti-microbial glycoproteins lipocalin 2 and pentraxin 3.

J Biochem 2015 May 30;157(5):399-410. Epub 2014 Dec 30.

Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan; Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan; and Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

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http://dx.doi.org/10.1093/jb/mvu086DOI Listing
May 2015

Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes.

J Exp Med 2015 May 20;212(5):699-714. Epub 2015 Apr 20.

Centre for Respiratory Infection, Respiratory Infections Section, National Heart and Lung Institute, Imperial College London, London W2 1PG, England, UK

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http://dx.doi.org/10.1084/jem.20140825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419339PMC
May 2015

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

Cell 2015 May;161(5):1058-1073

Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Kyoto 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.029DOI Listing
May 2015

5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.

J Biol Chem 2015 Apr 17;290(15):9377-86. Epub 2015 Feb 17.

From the Laboratory of Host Defense, World Premier International (WPI) Immunology Frontier Research Center (IFReC), Osaka University, Osaka 565-0871, the Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871,

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http://www.jbc.org/content/290/15/9377.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392245PMC
April 2015

Toll-like receptors.

Curr Protoc Immunol 2015 Apr 1;109:14.12.1-14.12.10. Epub 2015 Apr 1.

WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1002/0471142735.im1412s109DOI Listing
April 2015

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nat Commun 2015 Mar 9;6:6514. Epub 2015 Mar 9.

Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1038/ncomms7514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366529PMC
March 2015

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Eur J Immunol 2015 Feb 8;45(2):513-24. Epub 2014 Dec 8.

Center for Comparative Medicine, Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA, USA.

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http://dx.doi.org/10.1002/eji.201444744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324162PMC
February 2015

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.

J Biol Chem 2015 Jan 1;290(2):1269-80. Epub 2014 Dec 1.

From the Laboratory of Molecular Immunobiology, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294491PMC
January 2015

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.

Nat Commun 2014 Nov 5;5:5425. Epub 2014 Nov 5.

Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncomms6425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232137PMC
November 2014

Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.

Cold Spring Harb Perspect Biol 2014 Oct 9;7(1):a016246. Epub 2014 Oct 9.

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1101/cshperspect.a016246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292165PMC
October 2014