Publications by authors named "Shiyu Xia"

19Publications

Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles.

AAPS PharmSciTech 2020 Nov 25;22(1). Epub 2020 Nov 25.

Center for Nanomedicine, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, Maryland, 21231, USA.

View Article and Find Full Text PDF
November 2020

Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats.

J Control Release 2020 Nov 18;327:456-466. Epub 2020 Aug 18.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Departments of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Ophthalmology, Massey Cancer Center, Center for Pharmaceutical Engineering, Institute for Structural Biology, Drug Discovery & Development, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:

View Article and Find Full Text PDF
November 2020

Biological mechanisms and therapeutic relevance of the gasdermin family.

Authors:
Shiyu Xia

Mol Aspects Med 2020 12 13;76:100890. Epub 2020 Aug 13.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

Regional cerebral activity abnormality in pregnant women with antenatal depression.

J Affect Disord 2020 09 23;274:381-388. Epub 2020 May 23.

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

View Article and Find Full Text PDF
September 2020

Monitoring gasdermin pore formation in vitro.

Methods Enzymol 2019 23;625:95-107. Epub 2019 May 23.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States. Electronic address:

View Article and Find Full Text PDF
June 2020

Mechanism and Regulation of Gasdermin-Mediated Cell Death.

Cold Spring Harb Perspect Biol 2020 03 2;12(3). Epub 2020 Mar 2.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article and Find Full Text PDF
March 2020

Mechanism of TRPM2 channel gating revealed by cryo-EM.

FEBS J 2019 09 10;286(17):3333-3339. Epub 2019 Jun 10.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, MA, USA.

View Article and Find Full Text PDF
September 2019

Structural and mechanistic elucidation of inflammasome signaling by cryo-EM.

Curr Opin Struct Biol 2019 10 22;58:18-25. Epub 2019 May 22.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

View Article and Find Full Text PDF
October 2019

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.

Nanomedicine 2019 04 21;17:119-123. Epub 2019 Jan 21.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA; Department of Ophthalmology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

View Article and Find Full Text PDF
April 2019

Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis.

J Control Release 2019 02 17;296:68-80. Epub 2019 Jan 17.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21231, USA; Departments of Oncology, Neurosurgery, and Pharmacology & Molecular Sciences, The Johns Hopkins University, Baltimore, MD 21231, USA. Electronic address:

View Article and Find Full Text PDF
February 2019

Structures and gating mechanism of human TRPM2.

Science 2018 12 22;362(6421). Epub 2018 Nov 22.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
December 2018

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Science 2018 11 25;362(6418):1064-1069. Epub 2018 Oct 25.

Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

View Article and Find Full Text PDF
November 2018

Clinical effect of lamivudine in treating liver function lesion caused by hepatitis B combined with Anti-TB drugs.

Pak J Pharm Sci 2018 Jul;31(4(Special)):1667-1670

Department of Pharmacy, Huai'an Second People's Hospital, Huai'an, China / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

View Article and Find Full Text PDF
July 2018

Cryo-EM structure of the gasdermin A3 membrane pore.

Nature 2018 05 25;557(7703):62-67. Epub 2018 Apr 25.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.

View Article and Find Full Text PDF
May 2018

Inflammation NODs to Antagonists of RIP2-XIAP Interaction.

Mol Cell 2018 02;69(4):535-536

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

View Article and Find Full Text PDF
February 2018

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Immunity 2018 01 28;48(1):35-44.e6. Epub 2017 Nov 28.

Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA; Program in Immunology, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
January 2018

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Proc Natl Acad Sci U S A 2016 09 24;113(36):E5328-36. Epub 2016 Aug 24.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

View Article and Find Full Text PDF
September 2016