Publications by authors named "Shiyan Yang"

19 Publications

  • Page 1 of 1

The Resting-State Electroencephalogram Microstate Correlations With Empathy and Their Moderating Effect on the Relationship Between Empathy and Disgust.

Front Hum Neurosci 2021 28;15:626507. Epub 2021 Jun 28.

School of Nursing, Xinxiang Medical University, Xinxiang, China.

Humans have a natural ability to understand the emotions and feelings of others, whether one actually witnesses the situation of another, perceives it from a photograph, reads about it in a fiction book, or merely imagines it. This is the phenomenon of empathy, which requires us to mentally represent external information to experience the emotions of others. Studies have shown that individuals with high empathy have high anterior insula and adjacent frontal operculum activation when they are aware of negative emotions in others. As a negative emotion, disgust processing involves insula coupling. What are the neurophysiological characteristics for regulating the levels of empathy and disgust? To answer this question, we collected electroencephalogram microstates (EEG-ms) of 196 college students at rest and used the Disgust Scale and Interpersonal Reactivity Index. The results showed that: (1) there was a significant positive correlation between empathy and disgust sensitivity; (2) the empathy score and the intensity of transition possibility between EEG-ms C and D were significantly positively correlated; and (3) the connection strength between the transition possibility of EEG-ms C and D could adjust the relationship between the disgust sensitivity score and the empathy score. This study provides new neurophysiological characteristics for an understanding of the regulate relationship between empathy and disgust and provides a new perspective on emotion and attention.
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http://dx.doi.org/10.3389/fnhum.2021.626507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273331PMC
June 2021

A synthesis framework using machine learning and spatial bivariate analysis to identify drivers and hotspots of heavy metal pollution of agricultural soils.

Environ Pollut 2021 Jun 17;287:117611. Epub 2021 Jun 17.

College of Environmental & Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou, 310058, China.

Source apportionment can be an effective tool in mitigating soil pollution but its efficacy is often limited by a lack of information on the factors that influence the accumulation of pollutants at a site. In response to this limitation and focusing on a suite of heavy metals identified as priorities for pollution control, the study established a comprehensive pollution control framework using factor identification coupled with spatial agglomeration for agricultural soils in an industrialized part of Zhejiang Province, China. In addition to elucidating the key role of industrial and traffic activities on heavy metal accumulation through implementing a receptor model, specific influencing factors were identified using a random forest model. The distance from the soil sample location to the nearest likely industrial source was the most important factor in determining cadmium and copper concentrations, while distance to the nearest road was more important for lead and zinc pollution. Soil parent materials, pH, organic matter, and clay particle size were the key factors influencing accumulation of arsenic, chromium, and nickel. Spatial auto-correlation between levels of soil metal pollution and industrial agglomeration can enable a more targeted approach to pollution control measures. Overall, the approach and results provide a basis for improved accuracy in source apportionment, and thus improved soil pollution control, at the regional scale.
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http://dx.doi.org/10.1016/j.envpol.2021.117611DOI Listing
June 2021

Co-benefits of biochar-supported nanoscale zero-valent iron in simultaneously stabilizing soil heavy metals and reducing their bioaccessibility.

J Hazard Mater 2021 Jun 6;418:126292. Epub 2021 Jun 6.

College of Environmental & Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China. Electronic address:

We investigated the performance and encapsulation mechanisms of novel biochar-supported nanoscale zero-valent iron (nZVI-BC) used for the remediation of soil co-contaminated with arsenic (As), cadmium (Cd), and lead (Pb) via incubation and column experiments. Compared with the control, 0.50% of nZVI-BC significantly decreased the leakage of As, Cd, and Pb by 97.94-98.45%, 42.86-81.12%, and 82.14-92.49%, respectively. In addition, 0.50% of nZVI-BC could transform the fraction of unstable heavy metals into a stable form, which substantially decreased the availability, leachability, and bioaccessibility of the heavy metals and hence greatly reduced the human health exposure risk. Column experiments showed that 0.50% of nZVI-BC effectively restrained the leaching of As, Cd, and Pb by 95.60-99.84%, 70.82-84.18%, and 91.68-99.81%, respectively. The predominant encapsulation mechanisms of nZVI-BC included complexation, precipitation/co-precipitation, reduction, and the formation of ternary surface complexes. Based on these insights, we can devise new strategies for the remediation of soil co-contaminated with As, Cd, and Pb.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126292DOI Listing
June 2021

Heavy metals in soil-vegetable system around E-waste site and the health risk assessment.

Sci Total Environ 2021 Jul 15;779:146438. Epub 2021 Mar 15.

College of Environmental and Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China.

Investigating the farmland quality around electronic waste (E-waste) dismantling site and taking positive measures to ensure local food safety are urgent. Eleven types of vegetables (n = 184) and their corresponding soils were collected from vegetable fields in a city with famous historical e-waste activities in China. Nemerow integrated pollution indices analysis revealed that local vegetable fields suffered from heavy metal pollution to a certain extent, especially with regards to Cd, Cu, and Zn. The human health risk models provided by USEPA have been used to evaluate the non-carcinogenic and carcinogenic risks associated with the consumption of vegetables by local residents. Results indicated that both adults and children were suffering potential health risks. And the consumption of lettuce and sweet potato caused the greatest health risk, whereas cabbage and cowpea were relatively safe. The bioaccumulation factors (BAF) of heavy metals in various vegetables were calculated, and different vegetables showed huge variance in metal accumulation. Considering both contamination status and health risk assessment, cabbage and cowpea were selected as low accumulators of heavy metals. This study reveals the need for adjusting plantation structure and applying amendments to current protocols to alleviate the adverse effects caused by soil pollution.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146438DOI Listing
July 2021

The Impacts of Temporal Variation and Individual Differences in Driver Cognitive Workload on ECG-Based Detection.

Hum Factors 2021 Aug 4;63(5):772-787. Epub 2021 Feb 4.

Volvo Trucks Australia, Brisbane, Australia.

Objective: This paper aimed to investigate the robustness of driver cognitive workload detection based on electrocardiogram (ECG) when considering temporal variation and individual differences in cognitive workload.

Background: Cognitive workload is a critical component to be monitored for error prevention in human-machine systems. It may fluctuate instantaneously over time even in the same tasks and differ across individuals.

Method: A driving simulation study was conducted to classify driver cognitive workload underlying four experimental conditions (baseline, N-back, texting, and N-back + texting distraction) in two repeated 1-hr blocks. Heart rate (HR) and heart rate variability (HRV) were compared among the experimental conditions and between the blocks. Random forests were built on HR and HRV to classify cognitive workload in different blocks and for different individuals.

Results: HR and HRV were significantly different between repeated blocks in the study, demonstrating the time-induced variation in cognitive workload. The performance of cognitive workload classification across blocks and across individuals was significantly improved after normalizing HR and HRV in each block by the corresponding baseline.

Conclusion: The temporal variation and individual differences in cognitive workload affects ECG-based cognitive workload detection. But normalization approaches relying on the choice of appropriate baselines help compensate for the effects of temporal variation and individual differences.

Application: The findings provide insight into the value and limitations of ECG-based driver cognitive workload monitoring during prolonged driving for individual drivers.
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http://dx.doi.org/10.1177/0018720821990484DOI Listing
August 2021

Measurement of therapeuticC beam in water phantom using CR-39.

J Radiol Prot 2021 Jan 5. Epub 2021 Jan 5.

Fudan University, Shanghai, 200433, CHINA.

The motivation of this study was to explore a new method to test the particle spatial distribution for a therapeutic carbon beam. The CR-39 plastic nuclear track detectors (PNTD) were irradiated to a 276.5 MeV/u mono-energy carbon beam at the heavy ion facility in SPHIC (Shanghai Proton and Heavy Ion Center). The spatial distribution of primary carbon beam and secondary fragments in a water phantom were systematically analyzed both in transverse direction (perpendicular to the projection direction of primary beam) and at different depths in longitudinal direction (along the projection direction of primary beam) with the measured tracks on the CR-39 detectors. Meanwhile, the theoretically spatial distribution and linear energy transfer (LET) spectra of primary beam and secondary fragments were calculated using the Monte Carlo toolkit Geant4. The results showed that the CR-39 detectors are capable to provide high lateral resolution of carbon ion at different depths. In the range of primary carbon beam, the beam width simulated with MC is in good agreement with that of experimental measurement. The track size registered in the CR-39 has a good correlation with the particle LET. These findings indicate that the CR-39 can be used for measuring both the particle flux and its spatial distribution of carbon ions.
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http://dx.doi.org/10.1088/1361-6498/abd88cDOI Listing
January 2021

Evaluating Driver Features for Cognitive Distraction Detection and Validation in Manual and Level 2 Automated Driving.

Hum Factors 2020 Oct 15:18720820964149. Epub 2020 Oct 15.

557108 Seeing Machines, Canberra, ACT, Australia.

Objective: This study aimed to investigate the impacts of feature selection on driver cognitive distraction (CD) detection and validation in real-world nonautomated and Level 2 automated driving scenarios.

Background: Real-time driver state monitoring is critical to promote road user safety.

Method: Twenty-four participants were recruited to drive a Tesla Model S in manual and Autopilot modes on the highway while engaging in the N-back task. In each driving mode, CD was classified by the random forest algorithm built on three "hand-crafted" glance features (i.e., percent road center [PRC], the standard deviation of gaze pitch, and yaw angles), or through a large number of features that were transformed from the output of a driver monitoring system (DMS) and other sensing systems.

Results: In manual driving, the small set of glance features was as effective as the large set of machine-generated features in terms of classification accuracy. Whereas in Level 2 automated driving, both glance and vehicle features were less sensitive to CD. The glance features also revealed that the misclassified driver state was the result of the dynamic fluctuations and individual differences of cognitive loads under CD.

Conclusion: Glance metrics are critical for the detection and validation of CD in on-road driving.

Applications: The paper suggests the practical value of human factors domain knowledge in feature selection and ground truth validation for the development of driver monitoring technologies.
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http://dx.doi.org/10.1177/0018720820964149DOI Listing
October 2020

Three-dimensional (3D)-printed titanium sternum replacement: A case report.

Thorac Cancer 2020 11 5;11(11):3375-3378. Epub 2020 Oct 5.

Yanda Hospital, Hebei Medical University, Sanhe, China.

After sternal tumor resection, reconstruction of chest wall defects is still a challenging part of thoracic surgery. Three-dimensional (3D)-printed titanium alloy prosthesis implants provide an effective solution. The bionic bone trabecular micropore structure, which is beneficial to the human body, increases stability and robustness of the prosthesis. Here, we report a successful case of a customized prosthesis using a 3D-printed titanium alloy to repair and reconstruct bone defects in a patient with sternal osteosarcoma who underwent radical resection of the whole sternum.
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http://dx.doi.org/10.1111/1759-7714.13655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606024PMC
November 2020

Effects of Distraction in On-Road Level 2 Automated Driving: Impacts on Glance Behavior and Takeover Performance.

Hum Factors 2020 Jul 17:18720820936793. Epub 2020 Jul 17.

557108 Seeing Machines, Canberra, ACT, Australia.

Objective: The paper aimed to investigate glance behaviors under different levels of distraction in automated driving (AD) and understand the impact of distraction levels on driver takeover performance.

Background: Driver distraction detrimentally affects takeover performance. Glance-based distraction measurement could be a promising method to remind drivers to maintain enough attentiveness before the takeover request in partially AD.

Method: Thirty-six participants were recruited to drive a Tesla Model S in manual and Autopilot modes on a test track while engaging in secondary tasks, including temperature-control, email-sorting, and music-selection, to impose low and high distractions. During the test drive, participants needed to quickly change the lane as if avoiding an immediate road hazard if they heard an unexpected takeover request (an auditory warning). Driver state and behavior over the test drive were recorded in real time by a driver monitoring system and several other sensors installed in the Tesla vehicle.

Results: The distribution of off-road glance duration was heavily skewed (with a long tail) by high distractions, with extreme glance duration more than 30 s. Moreover, being eyes-off-road before takeover could cause more delay in the urgent takeover reaction compared to being hands-off-wheel.

Conclusion: The study measured off-road glance duration under different levels of distraction and demonstrated the impacts of being eyes-off-road and hands-off-wheel on the following takeover performance.

Application: The findings provide new insights about engagement in Level 2 AD and are useful for the design of driver monitoring technologies for distraction management.
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http://dx.doi.org/10.1177/0018720820936793DOI Listing
July 2020

The electrophysiology correlation of the cognitive bias in anxiety under uncertainty.

Sci Rep 2020 07 9;10(1):11354. Epub 2020 Jul 9.

Department of Psychology, Xinxiang Medical University, Henan, 453003, China.

The intolerance of uncertainty (IU) model holds that excessive emotional response under uncertain conditions is conducive to the maintenance of anxiety, and individuals with a high anxiety level may exhibit a negative bias and experience anxiety when processing uncertain information. However, the dynamic electrophysiological correlation of this negative bias is not clear. Therefore, we used an adapted study-test paradigm to explore the changes in the electroencephalography (EEG) of subjects when processing uncertain cues and certain cues (certain neutral and certain threatening) and correlated the differences with anxiety level. The behavioral results showed that there was a significant positive correlation between the trait anxiety score and β value under the threatening condition, which indicated that individuals with high trait anxiety take a more conservative approach in the face of negative stimuli. The results of EEG showed that during the test stage, the components N1 and P2, which are related to early perception, had significant conditional main effects. Meanwhile, under uncertain conditions, the N1 peak was positively correlated with the state anxiety score. In the study stage, we found that the N400 component was significantly larger in the early study stage than in the late study stage under uncertain conditions. In sum, individuals with high anxiety levels had a negative bias in the early cue processing of the test stage, and anxiety did not affect the study stage.
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http://dx.doi.org/10.1038/s41598-020-68427-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347926PMC
July 2020

Policy adjustment impacts Cd, Cu, Ni, Pb and Zn contamination in soils around e-waste area: Concentrations, sources and health risks.

Sci Total Environ 2020 Nov 23;741:140442. Epub 2020 Jun 23.

College of Environmental and Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China. Electronic address:

Pollution control policies (PCP) have been implemented in some e-waste dismantling areas in China to curb metal contamination since 2012. We investigated the effects of policy intervention on the concentrations, sources and health risks of heavy metals in soils. Post-implementation, among Cd, Cu, Ni, Pb and Zn, Pb levels declined while the Cd, Cu, Ni and Zn concentrations in soils were not impacted. Changes in their pollution indices and health risks were also similar. After the PCP, the contribution of traffic emission significantly decreased, while natural and industrial contribution increased due to the heighten background input and relocation of small e-waste dismantling workshops. Risk assessment showed that total cancer risk of five metals also slightly increased. Thus, policy intervention might be effective in controlling the release of some metals from e-waste dismantling. However, the performance of control measures varied depending on both source emission and geochemical properties of the metals. This study reveal the ongoing need of stricter supervision, targeted emission reduction and more-effective soil remediation actions to alleviate soil contamination from e-waste dismantling.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140442DOI Listing
November 2020

Spatiotemporal modeling of soil heavy metals and early warnings from scenarios-based prediction.

Chemosphere 2020 Sep 29;255:126908. Epub 2020 Apr 29.

College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Prediction of soil heavy metal concentrations based on continuous site specific investigation can provide reference for soil metal contamination prevention and early warning of soil environmental quality. In this study, the spatiotemporal variations of soil heavy metals (Cd, Ni, Zn, Pb and Cu) in Wenling were analyzed with 132 and 169 soil samples gathered in 2011 and 2016. In addition, we adopted a scenario-simulation model to predict future dynamic concentrations of soil heavy metals under optimistic (the pollution inputs are zero under strict environmental policy) and default (the pollution status maintain constant) conditions. Results indicated that the paddy soil was contaminated mainly by Cd and Cu. Spatiotemporal maps revealed distinct patterns in the joint area, where soil Cd, Ni, Zn, Pb and Cu all increased in northwest. Soil heavy metal concentrations as well as the associated ecological risks would decline gradually under optimistic scenario, while sharply increase when no control acts are taken over long term in default condition. The percentages of soil Cd and Cu that exceeding their corresponding risk screening value (RSV) under the default condition would be 1.6 and 1.3 times higher than those under optimistic scenario 10 years later. The probability of high potential ecological risk in default condition would be twice higher than that under optimistic scenario in 2026. Overall, strengthening the control of pollution sources and strict environmental policy are very important for soil heavy metals contamination prevention and control.
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http://dx.doi.org/10.1016/j.chemosphere.2020.126908DOI Listing
September 2020

Simultaneous adsorption of Cd(II)andAs(III)by a novel biochar-supported nanoscale zero-valent iron in aqueous systems.

Sci Total Environ 2020 Mar 31;708:134823. Epub 2019 Oct 31.

College of Environmental & Resource Sciences of Zhejiang University, Hangzhou 310058, China; Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Hangzhou 310058, China.

Biochar-supported nanoscale zero-valent iron (nZVI-BC) is a promising material for Cd(II) and As(III) removal from aqueous systems. In this study, simplified nZVI-BC composites were successfully synthesized and characterized via scanning electron microscopy (SEM), X-ray diffraction spectroscopy (XRD), X-ray photoelectron spectrometry (XPS), and Fourier transform infrared spectroscopy (FTIR) to understand the underlying adsorption mechanism. SEM and FTIR confirmed that nZVI particles were distributed evenly on the biochar surface. XRD and XPS revealed that metal ions were separated from solutions via electrostatic adsorption, complexation, oxidation, precipitation/co-precipitation, and the formation of type B ternary surface complex. Batch experiments showed that nZVI-BC (1:1) had a high removal efficiency in a wide pH range of 5.0-8.0 for Cd(II) and 3.0-8.0 for As(III), the maximum Cd(II) and As(III) adsorption capacities were 33.81 and 148.5 mg/g within 2 and 1 h, respectively. Additionally, synergisticeffects considerably enhanced the adsorption capacity of nZVI-BC(1:1) in mixed adsorption systems, the adsorption capacities of Cd(II) and As(III) reached 179.9 and 158.5 mg/g, respectively. Hence, nZVI-BC(1:1) is an ideal candidate for Cd(II) and As(III) pollution treatment.
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http://dx.doi.org/10.1016/j.scitotenv.2019.134823DOI Listing
March 2020

An integrated analysis on source-exposure risk of heavy metals in agricultural soils near intense electronic waste recycling activities.

Environ Int 2019 12 19;133(Pt B):105239. Epub 2019 Oct 19.

College of Environmental and Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China.

Conducting integrated analysis of the source, exposure and health risk of heavy metals is critical for developing mitigation strategies of soil contamination. Taking the former electronic waste (e-waste) dismantling center in China as an example this study quantitatively apportioned source contribution of soil heavy metals in this area by statistical analysis and positive matrix factorization (PMF) model. Furthermore, the human health risk of identified sources were quantified by combining source profiles and exposure risk assessment. The seven heavy metals investigated were arsenic (As), cadmium (Cd), copper (Cu), chromium (Cr), nickel (Ni), lead (Pb) and Zinc (Zn). Results indicated that agricultural soils were mainly contaminated with Cd and Cu. Parent material and pesticide, fertilizer application, industrial discharge, and vehicle emission accounted for 46.6, 22.2, and 31.2%, respectively, of the accumulation of metals in the soil. Moreover, these sources contributed 52.9, 19.0, and 28.1%, respectively of the total non-cancer risk. For the total cancer risk, the contribution of these three sources was 39.2, 45.3, and 15.5%, respectively. Despite that industrial discharge contributed the least to the accumulation of metals (22.2%), it contributed the most to the total cancer risk (45.3%). Reducing industrial emission was crucial for minimizing the heavy metal input to agricultural soils and preventing potential health hazard. These findings could provide support for environmental protection authority to improve the management and risk prevention of contaminated farmland.
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http://dx.doi.org/10.1016/j.envint.2019.105239DOI Listing
December 2019

Reduction in the exposure risk of farmer from e-waste recycling site following environmental policy adjustment: A regional scale view of PAHs in paddy fields.

Environ Int 2019 12 3;133(Pt A):105136. Epub 2019 Sep 3.

College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China. Electronic address:

Farmland contamination by polycyclic aromatic hydrocarbons (PAHs) has drawn increasing attention across China with enhanced regulations and environmental policies proposed by government to protect soil environment safety. As the informal electronic waste (e-waste) dismantling activities were forbidden under recent environmental regulation, this study compared levels, compositions, spatial distributions, human health risks of PAHs in paddy soil within the vicinity of an e-waste recycling area in southeastern China, with 129 and 150 soil samples collected in 2011 and 2016, respectively. The soil contamination was dominated with high molecular weight PAHs. The mean concentration of EPA 16 PAHs decreased from 590.4 ± 337.2 μg kg in 2011 to 407.3 ± 232.2 μg kg in 2016. Distribution maps of soil PAHs concentration displayed the temporal change in spatial. Principal component analysis together with diagnostic ratios revealed the combustion of biomass and coal in industrial and unregulated e-waste dismantling were the main sources of PAHs in the study area. Both deterministic and probabilistic assessments demonstrated reduced exposure risk for farmers from 2011 to 2016. Sensitivity analysis revealed that exposure frequency (EF) is the most influential parameter for the total variance in the risk assessment model. This study implied that the more stringent environmental policy and regulation can lead reductions in soil contamination with PAHs.
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http://dx.doi.org/10.1016/j.envint.2019.105136DOI Listing
December 2019

The bHLH transcription factor gene AtUPB1 regulates growth by mediating cell cycle progression in Arabidopsis.

Biochem Biophys Res Commun 2019 10 21;518(3):565-572. Epub 2019 Aug 21.

Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu, 610064, China. Electronic address:

Plant growth, development and interaction with the environment involve the action of transcription factor. bHLH proteins play an essential and often conserved role in the plant kingdom. However, bHLH proteins that participate in the cell division process are less well known. Here, we report that the bHLH transcription factor gene AtUPB1 is involved in mediating cell cycle progression and root development. In yeast cells, AtUPB1 inhibits cells proliferation and the cells had increased numbers of nuclei. UPB1 overexpression decreased the expression of the cell division marker CYCB1-1, and CDKA1 expression could overcome the defect of UPB1 overexpression. Moreover, UPB1 could directly bind to the promoter region of the SIM and SMR1 genes to regulate cell cycle. These results support a new role for AtUPB1 regulating root meristem development by mediating the expression of SIM/SMR1 genes.
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http://dx.doi.org/10.1016/j.bbrc.2019.08.088DOI Listing
October 2019

Status assessment and probabilistic health risk modeling of metals accumulation in agriculture soils across China: A synthesis.

Environ Int 2019 07 3;128:165-174. Epub 2019 May 3.

College of Environmental Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China. Electronic address:

Heavy metal accumulation in agriculture soils is of particular concern in China, while the status and probabilistic health risks of metal contamination in Chinese agriculture soils have been rarely studied at the national scale. In this study, we compiled a database of heavy metal concentrations in Chinese agriculture soils and selected six heavy metals for pollution assessment and risk screening: arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb) and Zinc (Zn). Monte Carlo simulation was employed to assess the probabilistic health risks, the associated uncertainties, as well as variations in toxicity parameters, ingestion rate and body weight. Results indicated that the concentrations of Cd were elevated above their reference standard and Cd had the highest mean geo-accumulation index (I) of 1.79. Moreover, the mean hazard index (HI) through exposure to six heavy metals was 1.85E-01 and 2.87E-02 for children and adults, respectively, with 2.2% of non-cancer risks for children that exceeded the guideline value of 1. In contrast, 95.0% and 90.0% of the total cancer risks (TCR) through exposure to six heavy metals for children and adults, respectively, exceeded the guideline value of 1E-06. Six metals were ranked based on their percent of risk outputs exceeding the guideline values. Arsenic had the high exceedance of both cancer and non-cancer risks, while both Cr and Cd were metals with high concern that had high exceedance of cancer risk. Sensitivity analyses indicated that metal concentrations and ingestion rate of soil were the predominant contributors to total risk variance. Overall, the adverse health risks induced by exposure to heavy metals contaminated farmland were elevated. Results from this study may provide valuable implications for public health professionals and policy-makers to design effective strategy to manage nation-wide farmland and reduce heavy metal exposure.
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http://dx.doi.org/10.1016/j.envint.2019.04.044DOI Listing
July 2019

Docetaxel-decorated anticancer drug and gold nanoparticles encapsulated apatite carrier for the treatment of liver cancer.

J Photochem Photobiol B 2018 Aug 22;185:73-79. Epub 2018 May 22.

Gastroenterology Department, Huai'an Second People's Hospital, PR China; Jiangsu Province Hospital of TCM, 155 Hanzhong Lu, Nanjing, PR China. Electronic address:

Liver malignancy is one of serious sicknesses which undermine human life and wellbeing. Concentrates on the treatment of liver malignancy have attracted widespread consideration. Utilization of drug delivery system cannot just enhance particular medication conveyance to liver tissue and enhance the bioavailability of medication, yet additionally can lessen the reactions of medications when it is uniquely changed in the regards of structure adjustment or particular target particles improvement. Docetaxel (Dxtl) remains the favored decision of enhancing the survival of patients with hormone stubborn liver malignancy, however numerous patients experience the ill effects of humble medication reaction and huge lethality. In the present examination, we researched the productivity of novel Dtxl stacked gold doped apatite (Dtxl-GHANPs) and increase insights into the molecular mechanism of the apoptosis initiated by these novels Dxtl- stacked nanoparticles. In vitro anticancer tests demonstrated that Dtxl-GHANPs had a higher cytotoxicity against human liver cancer cells (HepG2). The dual staining and Hoechst measure uncovered the dynamic idea of Dtxl-GHANPs in the cell core of the HepG2 cells. The potential mitochondrial break by apoptosis in HepG2 cells enormously expanded cell passing. Our discoveries demonstrated that nanoparticles, more than basic medication carriers, may assume a dynamic part in intervening the organic impacts.
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http://dx.doi.org/10.1016/j.jphotobiol.2018.05.021DOI Listing
August 2018

MicroRNA-328 enhances cellular motility through posttranscriptional regulation of PTPRJ in human hepatocellular carcinoma.

Onco Targets Ther 2015 28;8:3159-67. Epub 2015 Oct 28.

Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, People's Republic of China.

Objective: Interaction between microRNA (miR-328) and PTPRJ (protein tyrosine phosphatase, receptor type, J) has been reported to be responsible for miR-328-dependent increase in epithelial cancer cell proliferation. However, the role of miR-328 and PTPRJ in hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to investigate the clinical significance of miR-328 and/or PTPRJ expression in human HCC and determine their precise biological functions in this malignancy.

Methods: Expression levels of miR-328 and PTPRJ messenger RNA (mRNA) in 100 pairs of HCC and adjacent noncancerous tissues were detected using quantitative real-time reverse transcription polymerase chain reaction. The associations between miR-328 and/or PTPRJ expression and various clinicopathological features of HCC patients were further statistically assessed. Then, the functions of miR-328 and PTPRJ in migration and invasion of two human HCC cell lines were determined by transwell assays.

Results: miR-328 and PTPRJ mRNA expression levels were markedly upregulated and down-regulated in HCC tissues, respectively, compared to adjacent noncancerous tissues. Notably, the upregulation of miR-328 in HCC tissues was significantly correlated with the downregulation of PTPRJ mRNA in HCC tissues (r=-0.362, P=0.01). In addition, miR-328-high and/or PTPRJ-low expression were found to be closely correlated with high Edmondson-Steiner grading (all P<0.05) and advanced tumor-node-metastasis stage (all P<0.05). Moreover, the restoration of miR-328 dramatically promoted HCC cell migration and invasion by repressing PTPRJ expression. Interestingly, the loss of PTPRJ expression could significantly attenuate the inhibitory effects of knockdown miR-328 on the migration and invasion of HCC cells.

Conclusion: These findings demonstrated that the dysregulation of miR-328 and PTPRJ may be associated with tumor progression of HCC patients. Functionally, miR-328 may serve as a crucial oncogene and be implicated in the motility of HCC cells at least in part by the suppression of PTPRJ.
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http://dx.doi.org/10.2147/OTT.S93056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630182PMC
November 2015