Dr Shiv Shankar Verma, PhD - Case Western Reserve University - Research Associate

Dr Shiv Shankar Verma

PhD

Case Western Reserve University

Research Associate

Cleveland, Ohio | United States

Additional Specialties: plytochemicals and human disease

Dr Shiv Shankar Verma, PhD - Case Western Reserve University - Research Associate

Dr Shiv Shankar Verma

PhD

Introduction

Primary Affiliation: Case Western Reserve University - Cleveland, Ohio , United States

Additional Specialties:

Research Interests:


View Dr Shiv Shankar Verma’s Resume / CV

Publications

8Publications

195Reads

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Oncogenic potential of BMI1: race-based evidence in prostate cancer

@article{{AMJ}{4699}, author = {Shankar, E., Verma, S., Gupta, S.}, title = {Oncogenic potential of BMI1: race-based evidence in prostate cancer}, journal = {AME Medical Journal}, volume = {3}, number = {0}, year = {2018}, url = {http://amj.amegroups.com/article/view/4699} }

AME Medical Journal

Oncogenic potential of BMI1: race-based evidence in prostate cancer

Eswar Shankar1,2, Shiv Verma1, Sanjay Gupta1,2,3,4,5

1Department of Urology, School of Medicine, Case Western Reserve UniversityCleveland, OH 44106USA; 2The Urology Institute, University Hospitals Cleveland Medical CenterCleveland, OH 44106USA; 3Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical CenterCleveland, OH 44106USA; 4Department of Nutrition, Case Western Reserve UniversityCleveland, OH 44106USA; 5Division of General Medical Sciences, Case Comprehensive Cancer CenterCleveland, OH 44106USA

Correspondence to: Sanjay Gupta, PhD. Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Email: sanjay.gupta@case.edu.

Provenance: This is an invited Editorial commissioned by Section Editor Xiao Li (Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University, Nanjing, China).

Comment onGanaie AA, Beigh FH, Astone M, et al. BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models. Clin Cancer Res 2018. [Epub ahead of print].


Received: 12 October 2018; Accepted: 02 November 2018; Published: 09 November 2018.

doi: 10.21037/amj.2018.11.01



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November 2019
2 Reads

Effects of lovastin, fosmidomycin and methyl jasmonate on andrographolide biosynthesis in the Andrographis panicula

Acta Physiologiae Plantarum

Andrographolide is a diterpene secondary metabolite product of Andrographis paniculata. It has been known to be a pharmaceutically important compound synthesized via the cytosolic mevalonate (MVA) and the plastidial 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways. To understand the biosynthetic pathway of andrographolide biosynthesis in Andrographis paniculata, lovastatin, fosmidomycin and methyl jasmonate (MeJA) were used to inhibit the key enzymes 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), and 1-deoxy-d-xylulose-5-phosphate reducto-isomerase (DXR) involved in the synthesis of andrographolide in the MVA and MEP pathways, respectively. The inhibition of andrographolide accumulation was linked with the expression level of the studied regulatory genes, 3-hydroxy-3-methyl glutaryl coenzyme A synthase (hmgs), 3-hydroxy-3-methyl glutaryl coenzyme A reductase (hmgr), 1-deoxyxylulose-5-phosphate synthase (dxs), 1-deoxyxylulose-5-phosphate reductoisomerase (dxr), 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate synthase (hds),1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (hdr), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase(isph), isopentenyl diphosphate isomerase (ipp), geranylgeranyl diphosphatesynthase (ggps) of the MVA and MEP pathways. The pathways associated transcript expression level, and andrographolide biosynthesis was significantly modulated by the inhibitors indicating that the andrographolide biosynthesis is strongly responsive at the transcriptional level. The results demonstrated that both pathways can contribute to the biosynthesis of andrographolide in A. paniculata. Both hmgr and dxr played a critical role consistent with some crossover between MVA and MEP pathways in andrographolide biosynthesis.

View Article
July 2019
1 Read

Differentially Expressed Genes and Molecular Pathways in an Autochthonous Mouse Prostate Cancer Model.

Front Genet 2019 26;10:235. Epub 2019 Mar 26.

Department of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fgene.2019.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445055PMC
March 2019
143 Reads

(E)-β-farnesene gene reduces Lipaphis erysimi colonization in transgenic Brassica juncea lines.

Plant Signal Behav 2015 ;10(7):e1042636

a Agricultural and Agri-Food Canada ; Lethbridge , Canada.

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http://dx.doi.org/10.1080/15592324.2015.1042636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623259PMC
May 2016
6 Reads

Differential expression of miRNAs in Brassica napus root following infection with Plasmodiophora brassicae.

PLoS One 2014 31;9(1):e86648. Epub 2014 Jan 31.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909011PMC
October 2014
8 Reads
3.234 Impact Factor

Functional characterization of four APETALA2-family genes (RAP2.6, RAP2.6L, DREB19 and DREB26) in Arabidopsis.

Plant Mol Biol 2011 Jan 11;75(1-2):107-27. Epub 2010 Nov 11.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada.

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http://dx.doi.org/10.1007/s11103-010-9711-7DOI Listing
January 2011
18 Reads
4.257 Impact Factor

Expression of anti-sclerotinia scFv in transgenic Brassica napus enhances tolerance against stem rot.

N Biotechnol 2010 Dec 7;27(6):816-21. Epub 2010 Oct 7.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.nbt.2010.09.010DOI Listing
December 2010
20 Reads
2.898 Impact Factor

Noncoding RNAs and Its Implication as Biomarkers in Renal Cell Carcinoma: A Systematic Analysis

Annals of Urology Oncology

Abstract

Renal cell carcinoma (RCC) is one of the most devastating disease with higher mortality rates. It comprises several subtypes exhibiting distinct histological features and clinical staging. Despite recent advancement in understanding the biology of RCC success in treatment rates remains dismal. This may be partly due to lack of specific biomarkers for early detection/prognosis and poor clinical outcome. Noncoding protein transcripts in the genome play important role in the initiation, evolution and progression of cancer. With the advancement in genomic analysis techniques, especially next-generation sequencing, a large number of new transcripts have been discovered, leading to better understanding of coding and noncoding RNAs. In the present review, we summarize recent advancement on renal cancer associated noncoding RNAs which includes long noncoding RNAs, microRNAs, and circular RNAs for their involvement in RCC along with their clinical implication as prognostic and diagnosis biomarkers.

Key words renal cell carcinoma, noncoding RNAs, biomarkers, diagnosis, prognosis

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November 1949
3 Reads