Shiv Pillai

Shiv Pillai

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Shiv Pillai

Publications by authors named "Shiv Pillai"

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Immune mechanisms of fibrosis and inflammation in IgG4-related disease.

Curr Opin Rheumatol 2020 Mar;32(2):146-151

Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Cambridge.

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http://dx.doi.org/10.1097/BOR.0000000000000686DOI Listing
March 2020

Winning with the B team?

Sci Immunol 2020 Feb;5(44)

Ragon Institute of MGH, MIT and Harvard Medical School, Cambridge, MA, USA. King Fahd Specialist Hospital-Dammam (KFSH-D), Dammam, Saudi Arabia.

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http://dx.doi.org/10.1126/sciimmunol.abb0236DOI Listing
February 2020

T and B lymphocytes in fibrosis and systemic sclerosis.

Authors:
Shiv Pillai

Curr Opin Rheumatol 2019 Nov;31(6):576-581

Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000644DOI Listing
November 2019

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

Glycobiology 2019 11;29(12):861-875

Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/glycob/cwz062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861835PMC
November 2019

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

Front Immunol 2018 17;9:2393. Epub 2018 Oct 17.

Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.02393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199389PMC
October 2019

Disease Severity Linked to Increase in Autoantibody Diversity in IgG4-Related Disease.

Arthritis Rheumatol 2019 Oct 15. Epub 2019 Oct 15.

Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/art.41140DOI Listing
October 2019

Induction of metabolic quiescence defines the transitional to follicular B cell switch.

Sci Signal 2019 Oct 22;12(604). Epub 2019 Oct 22.

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.aaw5573DOI Listing
October 2019

Sugar Mommy.

Authors:
Shiv Pillai

Sci Immunol 2019 Sep;4(39)

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aaz2439DOI Listing
September 2019

Luring T cells into a gray area.

Sci Immunol 2019 04;4(34)

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA. King Fahd Specialist Hospital-Dammam, Al Muraikabat, Dammam, Saudi Arabia. Email:

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http://dx.doi.org/10.1126/sciimmunol.aax3917DOI Listing
April 2019

Identification of galectin-3 as an autoantigen in patients with IgG-related disease.

J Allergy Clin Immunol 2019 02 29;143(2):736-745.e6. Epub 2018 May 29.

Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Ragon Institute of MGH, MIT and Harvard, Cambridge, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265117PMC
February 2019

The depth of mutational agony and the exuberance of tumoral T cell ecstasy predict checkpoint salvation.

Sci Immunol 2018 12;3(30)

Illawarra Health and Medical Research Institute, University of Wollongong, Keiraville, Australia. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aav9722DOI Listing
December 2018

Young and restless killer T cells keep infections at bay.

Sci Immunol 2018 08;3(26)

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aau8705DOI Listing
August 2018

The right angle on IL-2 therapy.

Sci Immunol 2018 04;3(22)

Division of Hematology-Oncology, Columbia University Medical Center, New York, NY 10032, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aat6418DOI Listing
April 2018

Getting with the program in type 1 diabetes mellitus.

Sci Immunol 2018 01;3(19)

Department of Medicine, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aar8621DOI Listing
January 2018

Editorial: Cytotoxic CD4+ T Cells in Viral Infections.

Front Immunol 2017 4;8:1729. Epub 2017 Dec 4.

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.3389/fimmu.2017.01729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723143PMC
December 2017

JAKing up resistance to immunotherapy.

Sci Immunol 2017 10;2(16)

Ragon Institute of MGH, MIT and Harvard Department of Medicine, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aaq0015DOI Listing
October 2017

Turning Charon around on the Styx?

Sci Immunol 2017 Jul;2(13)

Department of Medicine, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.aao2062DOI Listing
July 2017

Nurture trumps nature!

Sci Immunol 2017 Apr;2(10)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Email: and

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http://dx.doi.org/10.1126/sciimmunol.aan2236DOI Listing
April 2017

Viewing Siglecs through the lens of tumor immunology.

Immunol Rev 2017 03;276(1):178-191

Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/imr.12526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860639PMC
March 2017

Clonally expanded cytotoxic CD4 T cells and the pathogenesis of IgG4-related disease.

Autoimmunity 2017 Feb;50(1):19-24

a Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/08916934.2017.1280029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880292PMC
February 2017

B lymphocytes and cancer: a love-hate relationship.

Trends Cancer 2016 12;2(12):747-757

Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge MA 02139.

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https://linkinghub.elsevier.com/retrieve/pii/S24058033163014
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http://dx.doi.org/10.1016/j.trecan.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472356PMC
December 2016

Case Records of the Massachusetts General Hospital. Case 31-2016. A 53-Year-Old Man with Diplopia, Polydipsia, and Polyuria.

N Engl J Med 2016 10;375(15):1469-1480

From the Departments of Neurology (T.N.B.), Rheumatology (J.H.S.), Radiology (O.R.), and Pathology (V.D.), Massachusetts General Hospital, and the Departments of Neurology (T.N.B.), Rheumatology (J.H.S.), Radiology (O.R.), and Pathology (V.D.) and the Ragon Institute (S.S.P.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1610097DOI Listing
October 2016

Predictors of disease relapse in IgG4-related disease following rituximab.

Rheumatology (Oxford) 2016 Jun 16;55(6):1000-8. Epub 2016 Feb 16.

Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1093/rheumatology/kev438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900135PMC
June 2016

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain.

Cell Rep 2016 05 19;15(9):1901-9. Epub 2016 May 19.

Ragon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892502PMC
May 2016

Sialic acids and autoimmune disease.

Immunol Rev 2016 Jan;269(1):145-61

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/imr.12344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769436PMC
January 2016

IgG4-related disease.

Lancet 2015 Apr 4;385(9976):1460-71. Epub 2014 Dec 4.

Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736146072
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http://dx.doi.org/10.1016/S0140-6736(14)60720-0DOI Listing
April 2015

Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations.

Ann Rheum Dis 2015 Jan 9;74(1):190-5. Epub 2014 May 9.

Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2014-205233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656194PMC
January 2015

Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus and erosive arthritis.

J Allergy Clin Immunol 2015 Jan 11;135(1):272-3. Epub 2014 Oct 11.

Division of Immunology, Boston Children's Hospital, Boston, Mass; The Manton Center For Orphan Disease Research, Boston Children's Hospital, Boston, Mass; Harvard Stem Cell Institute, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2014.07.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289116PMC
January 2015

De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease.

J Allergy Clin Immunol 2014 Sep 6;134(3):679-87. Epub 2014 May 6.

Massachusetts General Hospital and Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149918PMC
September 2014

IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.

J Biol Chem 2014 Sep 8;289(39):26960-72. Epub 2014 Aug 8.

From the Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.598763
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http://dx.doi.org/10.1074/jbc.M114.598763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175336PMC
September 2014

IgG4-related midline destructive lesion.

Ann Rheum Dis 2014 Jul 20;73(7):1434-6. Epub 2014 Mar 20.

Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2014-205187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625399PMC
July 2014

IgG4-related disease.

Annu Rev Pathol 2014 2;9:315-47. Epub 2013 Oct 2.

Cancer Center.

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http://dx.doi.org/10.1146/annurev-pathol-012513-104708DOI Listing
March 2014

Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease.

Allergy 2014 02 25;69(2):269-272. Epub 2013 Nov 25.

Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston MA.

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http://dx.doi.org/10.1111/all.12320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638385PMC
February 2014

Rethinking mechanisms of autoimmune pathogenesis.

Authors:
Shiv Pillai

J Autoimmun 2013 Sep 25;45:97-103. Epub 2013 Jun 25.

Massachusetts General Hospital, Center for Cancer Research, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820393PMC
September 2013

Love the one you're with: the HIV, B cell and TFH cell triangle.

Authors:
Shiv Pillai

Nat Med 2013 Apr;19(4):401-2

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http://dx.doi.org/10.1038/nm.3141DOI Listing
April 2013

Siglecs and immune regulation.

Annu Rev Immunol 2012 3;30:357-92. Epub 2012 Jan 3.

Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-immunol-020
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http://dx.doi.org/10.1146/annurev-immunol-020711-075018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781015PMC
July 2012

B cells and autoimmunity.

Curr Opin Immunol 2011 Dec 24;23(6):721-31. Epub 2011 Nov 24.

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States.

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http://dx.doi.org/10.1016/j.coi.2011.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268048PMC
December 2011

Now you know your ABCs.

Authors:
Shiv Pillai

Blood 2011 Aug;118(5):1187-8

Massachusetts General Hospital, USA.

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http://dx.doi.org/10.1182/blood-2011-06-355131DOI Listing
August 2011

The follicular versus marginal zone B lymphocyte cell fate decision.

Nat Rev Immunol 2009 Nov;9(11):767-77

Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nri2656DOI Listing
November 2009

Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance.

Trends Immunol 2009 Oct 18;30(10):488-93. Epub 2009 Sep 18.

Cancer Center, Massachusetts General Hospital, Boston MA 02129, USA.

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http://dx.doi.org/10.1016/j.it.2009.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758290PMC
October 2009

The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes.

Immunol Cell Biol 2009 Jan 25;87(1):16-9. Epub 2008 Nov 25.

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 2129, USA.

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http://dx.doi.org/10.1038/icb.2008.89DOI Listing
January 2009

NK T cells provide lipid antigen-specific cognate help for B cells.

Proc Natl Acad Sci U S A 2008 Jun 11;105(24):8339-44. Epub 2008 Jun 11.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0801375105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448838PMC
June 2008

Peripheral B cell subsets.

Curr Opin Immunol 2008 Apr 21;20(2):149-57. Epub 2008 Apr 21.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09527915080003
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http://dx.doi.org/10.1016/j.coi.2008.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532490PMC
April 2008

Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies.

J Immunol 2008 Mar;180(6):3839-48

Transplantation Research Center, Brigham and Women's Hospital, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://www.jimmunol.org/content/180/6/3839.full.pdf
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http://dx.doi.org/10.4049/jimmunol.180.6.3839DOI Listing
March 2008

The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations.

J Immunol 2007 Aug;179(4):2270-81

Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2270DOI Listing
August 2007

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

J Immunol 2007 Jul;179(1):195-200

Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.179.1.195DOI Listing
July 2007

Naive recirculating B cells mature simultaneously in the spleen and bone marrow.

Blood 2007 Mar 21;109(6):2339-45. Epub 2006 Nov 21.

Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1182/blood-2006-05-021089DOI Listing
March 2007

Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.

Mol Immunol 2006 Apr 26;43(10):1694-9. Epub 2005 Oct 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

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http://www.jimmunol.org/content/171/4/1875.full.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S016158900500341
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http://dx.doi.org/10.1016/j.molimm.2005.09.009DOI Listing
April 2006

The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity.

J Immunol 2005 Sep;175(5):2925-30

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.175.5.2925DOI Listing
September 2005

Marginal zone B cells.

Annu Rev Immunol 2005 ;23:161-96

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115728DOI Listing
June 2005

Birth pangs: the stressful origins of lymphocytes.

Authors:
Shiv Pillai

J Clin Invest 2005 Feb;115(2):224-7

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1172/JCI24238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546430PMC
February 2005

Positive selection and lineage commitment during peripheral B-lymphocyte development.

Immunol Rev 2004 Feb;197:206-18

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1111/j.0105-2896.2003.097.xDOI Listing
February 2004

Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.

J Biol Chem 2003 Jun 3;278(24):21526-33. Epub 2003 Apr 3.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301575200
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http://dx.doi.org/10.1074/jbc.M301575200DOI Listing
June 2003

Tec kinase pathways in lymphocyte development and transformation.

Biochim Biophys Acta 2002 Jun;1602(2):162-7

Massachusetts General Hospital Cancer Center, Harvard Medical School, 13th Street, Charlestown, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/s0304-419x(02)00041-0DOI Listing
June 2002

Antigen-dependent B-cell development.

Curr Opin Immunol 2002 Apr;14(2):241-9

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/s0952-7915(02)00328-xDOI Listing
April 2002

Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin.

Mol Immunol 2002 Feb;38(9):701-8

Cancer Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown Navy Yard, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/s0161-5890(01)00101-8DOI Listing
February 2002