Shitij Kapur

Shitij Kapur

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Shitij Kapur

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Small Sample Sizes and a False Economy for Psychiatric Clinical Trials.

JAMA Psychiatry 2019 Jul;76(7):676-677

School of Psychological Science, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0095DOI Listing
July 2019

The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

Biol Psychiatry 2019 01 11;85(1):79-87. Epub 2018 Jul 11.

Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269123PMC
January 2019

Moment-to-moment associations between negative affect, aberrant salience, and paranoia.

Cogn Neuropsychiatry 2018 09 26;23(5):299-306. Epub 2018 Jul 26.

e Faculty of Medicine, Dentistry and Health Sciences , University of Melbourne , Melbourne , Australia.

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http://dx.doi.org/10.1080/13546805.2018.1503080DOI Listing
September 2018

Determinants of treatment response in first-episode psychosis: an F-DOPA PET study.

Mol Psychiatry 2018 Apr 20. Epub 2018 Apr 20.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

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http://dx.doi.org/10.1038/s41380-018-0042-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331038PMC
April 2018

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life.

Elife 2017 11 28;6. Epub 2017 Nov 28.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.29088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705207PMC
November 2017

Connectomic correlates of response to treatment in first-episode psychosis.

Brain 2017 02 21;140(2):487-496. Epub 2016 Dec 21.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1093/brain/aww297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841056PMC
February 2017

Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials.

Br J Psychiatry 2016 11 19;209(5):427-428. Epub 2016 May 19.

Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, University of Texas Health Science Center, Houston, Texas, USA; Shitij Kapur, MD, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.

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https://www.cambridge.org/core/product/identifier/S000712500
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http://dx.doi.org/10.1192/bjp.bp.115.173906DOI Listing
November 2016

Increasing Versus Maintaining the Dose of Olanzapine or Risperidone in Schizophrenia Patients Who Did Not Respond to a Modest Dosage: A Double-Blind Randomized Controlled Trial.

J Clin Psychiatry 2016 Oct;77(10):1381-1390

Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.4088/JCP.15m10490DOI Listing
October 2016

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers.

J Neurol Sci 2016 Sep 15;368:243-8. Epub 2016 Jul 15.

Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.07.033DOI Listing
September 2016

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

Am J Psychiatry 2016 07 19;173(7):714-21. Epub 2016 Feb 19.

From the Department of Psychosis Studies, the Neurodegeneration Imaging Group, the Department of Basic and Clinical Neuroscience, and the Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Division of Brain Sciences, Department of Medicine, and the Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London; and Imanova Ltd., Centre for Imaging Sciences, Hammersmith Hospital, London.

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http://dx.doi.org/10.1176/appi.ajp.2015.15040518DOI Listing
July 2016

Dopamine, Striatum, Antipsychotics, and Questions About Weight Gain.

JAMA Psychiatry 2016 Feb;73(2):107-8

Psychiatric Imaging Group, MRC (Medical Research Council) Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2015.2872DOI Listing
February 2016

Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero.

Eur Neuropsychopharmacol 2015 Dec 21;25(12):2210-20. Epub 2015 Oct 21.

King's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychosis Studies, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.022DOI Listing
December 2015

Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study.

Eur Neuropsychopharmacol 2015 Dec 9;25(12):2252-61. Epub 2015 Oct 9.

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Centre for Psychology, Kristianstad University, Kristianstad, Sweden.

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.016DOI Listing
December 2015

Calibration and cross-validation of MCCB and CogState in schizophrenia.

Psychopharmacology (Berl) 2015 Nov 29;232(21-22):3873-82. Epub 2015 May 29.

Institute of Brain, Behaviour & Mental Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s00213-015-3960-8DOI Listing
November 2015

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses.

Eur Neuropsychopharmacol 2015 Nov 17;25(11):2098-107. Epub 2015 Aug 17.

King׳s College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, PO63, De Crespigny Park, London SE5 8AF, UK; King׳s College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.08.004DOI Listing
November 2015

NEWMEDS special issue commentary.

Psychopharmacology (Berl) 2015 Nov;232(21-22):3849-51

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1007/s00213-015-4083-yDOI Listing
November 2015

Biomarkers of treatment outcome in schizophrenia: Defining a benchmark for clinical significance.

Eur Neuropsychopharmacol 2015 Oct 20;25(10):1578-85. Epub 2015 Jun 20.

King׳s College London, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2015.06.008DOI Listing
October 2015

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.

Brain 2015 Oct 21;138(Pt 10):3016-29. Epub 2015 Jul 21.

1 Neurodegeneration Imaging Group, Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv214DOI Listing
October 2015

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease.

Brain 2015 Oct 25;138(Pt 10):3003-15. Epub 2015 Jul 25.

1 Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv219DOI Listing
October 2015

Predicting clinical response in people at ultra-high risk of psychosis: a systematic and quantitative review.

Drug Discov Today 2015 Aug 18;20(8):924-7. Epub 2015 Mar 18.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.drudis.2015.03.003DOI Listing
August 2015

Modafinil combined with cognitive training: pharmacological augmentation of cognitive training in schizophrenia.

Eur Neuropsychopharmacol 2015 Aug 31;25(8):1178-89. Epub 2015 Mar 31.

Section on Schizophrenia, Imaging and Therapeutics, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, PO Box 053, 16 De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2015.03.009DOI Listing
August 2015

Changes in delusional dimensions and emotions over eight weeks of antipsychotic treatment in acute patients.

Psychiatry Res 2015 Aug 27;228(3):393-8. Epub 2015 Jun 27.

Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1016/j.psychres.2015.06.027DOI Listing
August 2015

Going beyond "trial-and-error" in psychiatric treatments: OPTiMiSE-ing the treatment of first episode of schizophrenia.

Schizophr Bull 2015 May;41(3):546-8

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands

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http://dx.doi.org/10.1093/schbul/sbv026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393707PMC
May 2015

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank.

Int J Neuropsychopharmacol 2015 Apr 21;18(10):pyv042. Epub 2015 Apr 21.

Department of Psychiatry, University of Melbourne, Victoria, Australia (Drs Scarr and Dean); The Molecular Psychiatry Laboratory, Florey Institute for Neuroscience and Mental Health, Victoria, Australia (Drs Scarr and Dean); Pole d'Innovation Thérapeutique en Neuropsychiatrie, Institut de Recherches Servier, Paris, France (Dr Millan); Cambridge Centre for Neuropsychiatric Research, University of Cambridge, UK (Dr Bahn); Pharma Research & Early Development, NORD, DTA, Hoffman - La Roche, Ltd., Basel, Switzerland (Dr Bertolino); School of Medicine, Basic Medical Sciences, Neuroscience and Sense Organs (DMBNOS), University of Bari, Italy (Dr Bertolino); Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany (Dr Turck); Institute of Psychiatry, Kings College London, London, UK (Dr Kapur); Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany (Dr Möller).

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http://dx.doi.org/10.1093/ijnp/pyv042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648162PMC
April 2015

The effects of a single dose of oxytocin on working memory in schizophrenia.

Schizophr Res 2015 Mar 8;162(1-3):62-3. Epub 2015 Jan 8.

Cognition, Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience King's College London, UK.

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http://dx.doi.org/10.1016/j.schres.2014.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101540PMC
March 2015

Re-examining the role of benzodiazepines in the treatment of schizophrenia: a systematic review.

J Psychopharmacol 2015 Feb 21;29(2):212-23. Epub 2014 Jul 21.

Institute of Psychiatry, King's College London, London, UK

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http://dx.doi.org/10.1177/0269881114541013DOI Listing
February 2015

Clinically meaningful biomarkers for psychosis: a systematic and quantitative review.

Neurosci Biobehav Rev 2014 Sep 27;45:134-41. Epub 2014 May 27.

Department of Psychosis Studies, Institute of Psychiatry, King' College London, King' Health Partners, 16 De Crespigny Park, SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neubiorev.2014.05.010DOI Listing
September 2014

How antipsychotics impact the different dimensions of Schizophrenia: a test of competing hypotheses.

Eur Neuropsychopharmacol 2014 Aug 24;24(8):1279-88. Epub 2014 Apr 24.

Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, PO Box 053, London SE5 8AF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2014.04.001DOI Listing
August 2014

Polypharmacy: the good, the bad and the ugly.

Int J Neuropsychopharmacol 2014 Jul 12;17(7):981. Epub 2013 Aug 12.

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http://dx.doi.org/10.1017/S1461145713000965DOI Listing
July 2014

A neurobiological hypothesis for the classification of schizophrenia: type A (hyperdopaminergic) and type B (normodopaminergic).

Br J Psychiatry 2014 Jul;205(1):1-3

Oliver D. Howes, BM, BCh, MA, MRCPsych, PhD, DM, Departments of Psychological Medicine and Psychosis Studies, Institute of Psychiatry, King's College London; Shitij Kapur, FRCPC, PhD, FMedSci, Institute of Psychiatry, King's College London, UK.

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https://www.cambridge.org/core/product/identifier/S000712500
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http://dx.doi.org/10.1192/bjp.bp.113.138578DOI Listing
July 2014

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study.

Psychopharmacology (Berl) 2014 Jun 3;231(11):2251-9. Epub 2014 Apr 3.

Psychiatric Imaging Group, Mansfield Building, Medical Research Council Clinical Sciences Centre, Institute of Clinical Sciences, Hammersmith Hospital, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://link.springer.com/content/pdf/10.1007%2Fs00213-014-35
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http://www.ecnp-congress.eu/presentationpdfs/7/P.6.f.004.pdf
Web Search
http://link.springer.com/10.1007/s00213-014-3523-4
Publisher Site
http://dx.doi.org/10.1007/s00213-014-3523-4DOI Listing
June 2014

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies.

Br J Psychiatry 2014 Jun;204(6):420-9

Joseph Kambeitz, MD, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK; Anissa Abi-Dargham, MD, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, USA;Shitij Kapur, MD, PhD, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK; Oliver D. Howes, BM, BCh, MA, MRCPsych, PhD, DM, Department of Psychosis Studies, Institute of Psychiatry, King's College London, and Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, UK.

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http://dx.doi.org/10.1192/bjp.bp.113.132308DOI Listing
June 2014

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

Biol Psychiatry 2014 Mar 29;75(6):470-8. Epub 2013 Jun 29.

Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Sciences, Hammersmith Hospital, Imperial College London; Department of Psychosis Studies, Institute of Psychiatry, King's College London (King's Health Partners), London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.05.027DOI Listing
March 2014

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.

Biol Psychiatry 2014 Mar 25;75(5):e11-3. Epub 2013 Jul 25.

Department of Psychosis Studies, Institute of Psychiatry, King's College London.

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http://dx.doi.org/10.1016/j.biopsych.2013.06.011DOI Listing
March 2014

Changes in delusions in the early phase of antipsychotic treatment - an experience sampling study.

Psychiatry Res 2014 Mar 24;215(3):568-73. Epub 2013 Dec 24.

National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, United Kingdom; Section on Schizophrenia, Imaging and Therapeutics, King's College London, Institute of Psychiatry, London, United Kingdom; Department of Psychological Medicine, King's College London, Institute of Psychiatry, London, United Kingdom.

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http://dx.doi.org/10.1016/j.psychres.2013.12.033DOI Listing
March 2014

Detecting improvements in acute psychotic symptoms using experience sampling methodology.

Psychiatry Res 2013 Nov 9;210(1):82-8. Epub 2013 Jul 9.

Department of Psychology, The Chinese University of Hong Kong, Shatin, New Territories, Room 321 Wong Foo Yuan Building, Hong Kong SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2013.05.010DOI Listing
November 2013

Clinical trials for negative symptoms--emerging directions and unresolved issues.

Schizophr Res 2013 Nov;150(2-3):327

Semel Institute for Neuroscience at UCLA and VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.schres.2013.10.005DOI Listing
November 2013

Molecular imaging as a guide for the treatment of central nervous system disorders.

Dialogues Clin Neurosci 2013 Sep;15(3):315-28

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811103PMC
September 2013

Treating impaired cognition in schizophrenia: the case for combining cognitive-enhancing drugs with cognitive remediation.

Eur Neuropsychopharmacol 2013 Aug 22;23(8):790-8. Epub 2013 Apr 22.

Section on Schizophrenia, Imaging and Therapeutics, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2013.03.012DOI Listing
August 2013

Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people.

J Cereb Blood Flow Metab 2013 Jul 17;33(7):1098-103. Epub 2013 Apr 17.

St Thomas' PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, UK.

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http://dx.doi.org/10.1038/jcbfm.2013.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705439PMC
July 2013

Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response.

J Clin Psychopharmacol 2013 Jun;33(3):329-35

Pharmacy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK.

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http://dx.doi.org/10.1097/JCP.0b013e31828b28d5DOI Listing
June 2013

The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole.

Psychopharmacology (Berl) 2013 May 28;227(2):221-9. Epub 2012 Dec 28.

Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul, 110-744, South Korea.

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http://dx.doi.org/10.1007/s00213-012-2953-0DOI Listing
May 2013

Role of dopamine D(2) receptors for antipsychotic activity.

Handb Exp Pharmacol 2012 (212):27-52

Department of Psychiatry, University of Geneva, Geneva, Switzerland.

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http://link.springer.com/10.1007/978-3-642-25761-2_2
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http://dx.doi.org/10.1007/978-3-642-25761-2_2DOI Listing
April 2013

Antipsychotic therapy over half a century: a tale of discovery from chlorpromazine to aripiprazole.

Natl Med J India 2012 Jul-Aug;25(4):193-5

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April 2013

Early improvement on antipsychotic treatment as a predictor of subsequent response in schizophrenia: analyses from ziprasidone clinical studies.

Hum Psychopharmacol 2011 Jun-Jul;26(4-5):282-90. Epub 2011 Jun 2.

Pfizer Inc., 235 East 42nd Street, New York, New York 10017, USA.

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http://dx.doi.org/10.1002/hup.1200DOI Listing
March 2013

Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study.

BMC Psychiatry 2013 Jan 23;13:34. Epub 2013 Jan 23.

Division of Clinical Psychology, School of Psychological Sciences, the University of Manchester, Oxford Road, Manchester, United Kingdom.

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http://dx.doi.org/10.1186/1471-244X-13-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562160PMC
January 2013

Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation.

Br J Psychiatry 2012 Dec 6;201(6):481-5. Epub 2012 Sep 6.

Department of Psychosis Studies, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1192/bjp.bp.111.105833DOI Listing
December 2012

Dopamine synthesis capacity in patients with treatment-resistant schizophrenia.

Am J Psychiatry 2012 Nov;169(11):1203-10

Department of Psychosis Studies, Biomedical Research Centre, Institute of Psychiatry, King's College, London, UK.

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http://dx.doi.org/10.1176/appi.ajp.2012.12010144DOI Listing
November 2012

Investigating schizophrenia in a "dish": possibilities, potential and limitations.

World Psychiatry 2012 Oct;11(3):153-5

Department of Neuroscience.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449342PMC
October 2012

The nature of dopamine dysfunction in schizophrenia and what this means for treatment.

Arch Gen Psychiatry 2012 Aug;69(8):776-86

Department of Psychosis Studies, Institute of Psychiatry, King's College London, Camberwell, UK.

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http://dx.doi.org/10.1001/archgenpsychiatry.2012.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730746PMC
August 2012

Contrasting effects of haloperidol and lithium on rodent brain structure: a magnetic resonance imaging study with postmortem confirmation.

Biol Psychiatry 2012 May 15;71(10):855-63. Epub 2012 Jan 15.

Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2011.12.004DOI Listing
May 2012

Alterations of the brain reward system in antipsychotic naïve schizophrenia patients.

Biol Psychiatry 2012 May 13;71(10):898-905. Epub 2012 Mar 13.

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Center for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Glostrup, Denmark.

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http://dx.doi.org/10.1016/j.biopsych.2012.02.007DOI Listing
May 2012

Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections.

Int J Geriatr Psychiatry 2011 Dec 23;26(12):1300-8. Epub 2011 Feb 23.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gps.2682DOI Listing
December 2011

Exploring the neural correlates of delusions of reference.

Biol Psychiatry 2011 Dec 10;70(12):1127-33. Epub 2011 Aug 10.

Department of Psychiatry, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2011.05.037DOI Listing
December 2011

Dynamic regulation of dopamine and serotonin responses to salient stimuli during chronic haloperidol treatment.

Int J Neuropsychopharmacol 2011 Nov 1;14(10):1327-39. Epub 2011 Feb 1.

Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.

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http://dx.doi.org/10.1017/S1461145711000010DOI Listing
November 2011

An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis.

J Clin Psychiatry 2011 Nov 8;72(11):1439-44. Epub 2011 Mar 8.

Schizophrenia Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada.

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http://dx.doi.org/10.4088/JCP.09m05785yelDOI Listing
November 2011

Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.

Int J Neuropsychopharmacol 2011 Oct 19;14(9):1165-78. Epub 2010 Nov 19.

King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1017/S1461145710001343DOI Listing
October 2011

The use of healthy volunteers instead of patients to inform drug dosing studies: a [¹¹C]raclopride PET study.

Psychopharmacology (Berl) 2011 Oct 19;217(4):515-23. Epub 2011 Apr 19.

Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, South Korea.

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http://dx.doi.org/10.1007/s00213-011-2306-4DOI Listing
October 2011

Relationship between daily dose, plasma concentrations, dopamine receptor occupancy, and clinical response to quetiapine: a review.

J Clin Psychiatry 2011 Aug 25;72(8):1108-23. Epub 2011 Jan 25.

Pharmacy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, and School of Biomedical & Health Sciences, King's College London.

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http://dx.doi.org/10.4088/JCP.09r05739yelDOI Listing
August 2011

Haloperidol modulates noradrenergic responses to aversive stimulation depending on treatment duration.

Behav Brain Res 2011 Aug 10;221(1):311-3. Epub 2011 Mar 10.

Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.

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http://dx.doi.org/10.1016/j.bbr.2011.03.011DOI Listing
August 2011

Calculating occupancy when one does not have baseline: a comparison of different options.

J Cereb Blood Flow Metab 2011 Aug 27;31(8):1760-7. Epub 2011 Apr 27.

Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1038/jcbfm.2011.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170949PMC
August 2011

The evolution of antipsychotic switch and polypharmacy in natural practice--a longitudinal perspective.

Schizophr Res 2011 Aug 31;130(1-3):40-6. Epub 2011 May 31.

Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1016/j.schres.2011.05.013DOI Listing
August 2011

Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation.

Biol Psychiatry 2011 May 31;69(10):936-44. Epub 2010 Dec 31.

Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2010.11.010DOI Listing
May 2011

What Kraepelin might say about schizophrenia: just the facts.

Authors:
Shitij Kapur

Schizophr Res 2011 May;128(1-3):1-2

Institute of Psychiatry, King's College London, UK.

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http://dx.doi.org/10.1016/j.schres.2011.02.012DOI Listing
May 2011

Looking for a "biological test" to diagnose"schizophrenia": are we chasing red herrings?

Authors:
Shitij Kapur

World Psychiatry 2011 Feb;10(1):32

King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048513PMC
February 2011

The neurobiology of schizophrenia: new leads and avenues for treatment.

Curr Opin Neurobiol 2010 Dec 8;20(6):810-5. Epub 2010 Oct 8.

Department of Neuroscience, Institute of Psychiatry, King's College London, UK.

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http://dx.doi.org/10.1016/j.conb.2010.09.008DOI Listing
December 2010