Publications

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J Med Chem 2017 Jun 12;60(12):4818-4839. Epub 2017 Jun 12.
Department of Medicinal Chemistry, ‡Department of Internal Medicine, §Comprehensive Cancer Center, ∥Department of Pathology, ⊥Howard Hughes Medical Institute, #Department of Biological Chemistry, ∇Department of Pharmaceutical Sciences, ○Department of Pharmacology, and ¶Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

Adapting Knowledge Translation Strategies for Rare Rheumatic Diseases.
J Rheumatol 2016 Aug 1;43(8):1462-8. Epub 2016 May 1.
From the Division of Pediatric Rheumatology, Department of Pediatrics, McMaster University, Hamilton; Department of Family and Community Medicine, and Institute of Health Policy Management and Evaluation, University of Toronto; Schwartz-Reisman Emergency Medicine Institute, Department of Emergency Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.T. Cellucci, MD, MScCH, FRCPC, Assistant Professor, Division of Pediatric Rheumatology, Department of Pediatrics, McMaster University; S. Lee, MD, MHSc (Ed), CCFP(EM), FCFP, Associate Professor, Department of Family and Community Medicine, University of Toronto, and Schwartz-Reisman Emergency Medicine Institute, Department of Emergency Medicine, Mount Sinai Hospital; F. Webster, PhD, Associate Professor, Department of Family and Community Medicine and Institute of Health Policy Management and Evaluation, University of Toronto.

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Nat Commun 2015 Aug 20;6:8045. Epub 2015 Aug 20.
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

One-pot refolding of core histones from bacterial inclusion bodies allows rapid reconstitution of histone octamer.
Protein Expr Purif 2015 Jun 14;110:89-94. Epub 2015 Feb 14.
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Mol Cell 2014 Jan 2;53(2):247-61. Epub 2014 Jan 2.
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Dose-dependent neuroprotection of VEGF₁₆₅ in Huntington's disease striatum.
Mol Ther 2013 Oct 25;21(10):1862-75. Epub 2013 Jun 25.
Division of Brain Sciences, Department of Gene Therapy, Faculty of Medicine, Centre for Neuroinflammation & Neurodegeneration, Imperial College London, Hammersmith Hospital Campus, London, UK.

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