Shiranee Sriskandan

Shiranee Sriskandan

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Shiranee Sriskandan

Publications by authors named "Shiranee Sriskandan"

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Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study.

Lancet Infect Dis 2019 Nov 10;19(11):1209-1218. Epub 2019 Sep 10.

Department of Infectious Diseases and Medical Research Council Centre for Molecular Bacteriology & Infection, Imperial College London, London, UK; Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, National Institute for Health Research, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30446-3DOI Listing
November 2019

Sepsis: Precision-Based Medicine for Pregnancy and the Puerperium.

Int J Mol Sci 2019 Oct 29;20(21). Epub 2019 Oct 29.

Imperial College London, Academic Department of Obstetrics & Gynaecology, Level 3, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.

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http://dx.doi.org/10.3390/ijms20215388DOI Listing
October 2019

Sampling and diversity of Escherichia coli from the enteric microbiota in patients with Escherichia coli bacteraemia.

BMC Res Notes 2019 Jun 13;12(1):335. Epub 2019 Jun 13.

Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13104-019-4369-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563364PMC
June 2019

Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR.

J Infect 2019 May 20;78(5):358-363. Epub 2019 Feb 20.

Department of Infectious Diseases, Imperial College London, London W12 0NN, UK; Department of Molecular Biology & Biotechnology, The Florey Institute, University of Sheffield, Sheffield S10 2TN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.02.005DOI Listing
May 2019

Treatment potential of pathogen-reactive antibodies sequentially purified from pooled human immunoglobulin.

BMC Res Notes 2019 Apr 15;12(1):228. Epub 2019 Apr 15.

Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13104-019-4262-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466806PMC
April 2019

High prevalence of 16S rRNA methyltransferases among carbapenemase-producing Enterobacteriaceae in the UK and Ireland.

Int J Antimicrob Agents 2018 Aug 27;52(2):278-282. Epub 2018 Mar 27.

National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK; Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, National Infection Service, Public Health England, London, UK.

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http://dx.doi.org/10.1016/j.ijantimicag.2018.03.016DOI Listing
August 2018

Development of an opsonophagocytic killing assay for group a streptococcus.

Vaccine 2018 06;36(26):3756-3763

Immunobiology, UCL Great Ormond Street Institute of Child Health Biomedical Research Centre, 30 Guilford Street, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1016/j.vaccine.2018.05.056DOI Listing
June 2018

Nosocomial Outbreak of Drug-Resistant Streptococcus pneumoniae Serotype 9V in an Adult Respiratory Medicine Ward.

J Clin Microbiol 2017 03 14;55(3):776-782. Epub 2016 Dec 14.

Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/JCM.02405-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328445PMC
March 2017

Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation.

J Microbiol Methods 2016 May 24;124:69-71. Epub 2016 Mar 24.

Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677012163005
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http://dx.doi.org/10.1016/j.mimet.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838658PMC
May 2016

Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG.

J Infect 2016 Apr 12;72(4):450-9. Epub 2016 Feb 12.

Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796040PMC
April 2016

Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically relevant UK isolates of .

Microb Genom 2016 02 23;2(2):e000049. Epub 2016 Feb 23.

1​Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1099/mgen.0.000049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320583PMC
February 2016

Identification of the Streptococcus pyogenes surface antigens recognised by pooled human immunoglobulin.

Sci Rep 2015 Oct 28;5:15825. Epub 2015 Oct 28.

Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom.

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http://dx.doi.org/10.1038/srep15825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623672PMC
October 2015

Panton-Valentine leucocidin expression by Staphylococcus aureus exposed to common antibiotics.

J Infect 2015 Sep 28;71(3):338-46. Epub 2015 May 28.

Infectious Diseases & Immunity, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2015.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535317PMC
September 2015

Corynebacterium ulcerans cutaneous diphtheria.

Lancet Infect Dis 2015 Sep 16;15(9):1100-1107. Epub 2015 Jul 16.

National Centre for Infection Prevention and Management, Imperial College London, London, UK; Department of Infectious Diseases, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1016/S1473-3099(15)00225-XDOI Listing
September 2015

Bromine, bear-claw scratch fasciotomies, and the Eagle effect: management of group A streptococcal necrotising fasciitis and its association with trauma.

Lancet Infect Dis 2015 Jan;15(1):109-21

Department of Medicine, Imperial College London, Hammersmith Campus, Hammersmith Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(14)70922-3DOI Listing
January 2015

Ebola and other viral haemorrhagic fevers: a local operational approach.

Br J Hosp Med (Lond) 2014 Sep;75(9):515-22

NIHR Clinical Research Fellow at the Imperial Biomedical Research Centre, Imperial College London, Hammersmith Campus, London W12 0HS.

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http://dx.doi.org/10.12968/hmed.2014.75.9.515DOI Listing
September 2014

Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.

PLoS One 2013 20;8(11):e82123. Epub 2013 Nov 20.

Infectious Diseases and Immunity, Department of Medicine, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835743PMC
August 2014

Editorial commentary: step on the GAS: are we almost there for clindamycin and intravenous immunoglobulin?

Clin Infect Dis 2014 Aug 29;59(3):366-8. Epub 2014 Apr 29.

Section of Infectious Diseases and Immunity, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciu307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096107PMC
August 2014

Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.

Vaccine 2014 Jun 14;32(30):3713-20. Epub 2014 May 14.

Department of Molecular Medicine and Pathology and Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.05.017DOI Listing
June 2014

Current views of haemolytic streptococcal pathogenesis.

Curr Opin Infect Dis 2014 Apr;27(2):155-64

aSection of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus bDepartment of Haematology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1097/QCO.0000000000000047DOI Listing
April 2014

The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.

Virulence 2014 Jan 9;5(1):127-36. Epub 2013 Oct 9.

Department of Infectious Disease and Immunity; Imperial College London; London, UK.

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http://dx.doi.org/10.4161/viru.26400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916366PMC
January 2014

Inactivation of the CovR/S virulence regulator impairs infection in an improved murine model of Streptococcus pyogenes naso-pharyngeal infection.

PLoS One 2013 25;8(4):e61655. Epub 2013 Apr 25.

Section of Infectious Diseases and Immunity, Department of Medicine, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061655PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636223PMC
November 2013

Molecular analysis of an outbreak of lethal postpartum sepsis caused by Streptococcus pyogenes.

J Clin Microbiol 2013 Jul 24;51(7):2089-95. Epub 2013 Apr 24.

Infectious Diseases & Immunity, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1128/JCM.00679-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697669PMC
July 2013

The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation.

Immunology 2012 Jul;136(3):325-33

Section of Infectious Diseases & Immunity, Imperial College, Hammersmith Hospital, London Centre for Infection & Immunity, Queen's University, Belfast, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2012.03584.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385032PMC
July 2012

Pro-inflammatory mechanisms in sepsis.

Contrib Microbiol 2011 9;17:86-107. Epub 2011 Jun 9.

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http://dx.doi.org/10.1159/000324022DOI Listing
September 2011

New understandings in Streptococcus pyogenes.

Curr Opin Infect Dis 2011 Jun;24(3):196-202

Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1097/QCO.0b013e3283458f7eDOI Listing
June 2011

Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency.

Microbes Infect 2010 Aug 22;12(8-9):626-34. Epub 2010 Apr 22.

Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom.

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http://dx.doi.org/10.1016/j.micinf.2010.04.004DOI Listing
August 2010

Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection.

J Infect Dis 2009 Aug;200(4):555-63

Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/6035
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http://dx.doi.org/10.1086/603541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820315PMC
August 2009

Rapid screen for epithelial internalization of Tn917-mutagenized Streptococcus pyogenes.

J Microbiol Methods 2009 Jul 14;78(1):34-9. Epub 2009 Apr 14.

Department of Infectious Diseases & Immunity, Hammersmith Campus, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.mimet.2009.04.002DOI Listing
July 2009

Toll-like receptor 2 is essential for the sensing of oxidants during inflammation.

Am J Respir Crit Care Med 2009 Feb 14;179(4):299-306. Epub 2008 Nov 14.

Cardiothoracic Pharmacology, Cardiothoracic and Stem Cell Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200707-1019OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643079PMC
February 2009

Gram-positive and Gram-negative bacteria synergize with oxidants to release CXCL8 from innate immune cells.

Mol Med 2008 May-Jun;14(5-6):238-46

Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, United Kingdom.

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http://www.molmed.org/vpdfstore/238_246.Paul_Clark.00098.PDF
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http://dx.doi.org/10.2119/2007-00098.Paul-ClarkDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215766PMC
August 2008

Superantigens SPEA and SMEZ do not affect secretome expression in Streptococcus pyogenes.

Microb Pathog 2008 Jun 6;44(6):537-43. Epub 2008 Feb 6.

Department of Infectious Diseases, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.micpath.2007.06.010DOI Listing
June 2008

Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells.

Respir Res 2008 Apr 1;9:30. Epub 2008 Apr 1.

Experimental Studies, Airway Disease Section, National Heart & Lung Institute, Imperial College London, London, SW3 6LY, UK.

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http://dx.doi.org/10.1186/1465-9921-9-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2324089PMC
April 2008

Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha induced hepatic apoptosis.

Am J Respir Crit Care Med 2007 Sep 15;176(5):473-82. Epub 2007 Jun 15.

Department of Infectious Diseases and Immunity, Imperial College, London, UK.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200611-1712O
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http://dx.doi.org/10.1164/rccm.200611-1712OCDOI Listing
September 2007

Streptococcus pyogenes under pressure.

Nat Med 2007 Aug;13(8):909-10

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http://www.nature.com/articles/nm0807-909
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http://dx.doi.org/10.1038/nm0807-909DOI Listing
August 2007

Streptococcus pyogenes: Insight into the function of the streptococcal superantigens.

Int J Biochem Cell Biol 2007 1;39(1):12-9. Epub 2006 Sep 1.

Gram-Positive Molecular Pathogenesis Group, Department of Infectious Diseases, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S135727250600236
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http://dx.doi.org/10.1016/j.biocel.2006.08.009DOI Listing
February 2007

The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength.

Int Immunol 2006 Oct 7;18(10):1433-41. Epub 2006 Aug 7.

Department of Infectious Diseases, Faculty of Medicine, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1093/intimm/dxl076DOI Listing
October 2006

Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two.

Br J Pharmacol 2006 Aug 19;148(8):1067-75. Epub 2006 Jun 19.

1Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY.

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http://doi.wiley.com/10.1038/sj.bjp.0706815
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http://dx.doi.org/10.1038/sj.bjp.0706815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752017PMC
August 2006

Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation.

J Antimicrob Chemother 2006 Jul 2;58(1):117-24. Epub 2006 May 2.

Department of Infectious Diseases, Imperial College London, Hammersmith Hospital Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1093/jac/dkl173DOI Listing
July 2006

Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the East?

PLoS Med 2006 May 11;3(5):e187. Epub 2006 Apr 11.

Department of Infectious Diseases, Hammersmith Hospital, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.0030187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1434506PMC
May 2006

Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes.

J Immunol 2006 May;176(10):6112-20

Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.176.10.6112DOI Listing
May 2006

The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm.

J Immunol 2005 Nov;175(10):6870-7

Department of Infectious Diseases, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.175.10.6870DOI Listing
November 2005

Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.

J Infect Dis 2005 Sep 18;192(5):783-90. Epub 2005 Jul 18.

Section of Experimental Medicine and Toxicology, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1086/432485DOI Listing
September 2005

Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin.

Blood 2005 May 11;105(9):3655-62. Epub 2005 Jan 11.

Department of Infectious Diseases, Imperial College, Du Cane Rd, London, UK.

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http://dx.doi.org/10.1182/blood-2004-07-2523DOI Listing
May 2005

Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle.

Proc Natl Acad Sci U S A 2005 Mar 8;102(12):4637-42. Epub 2005 Mar 8.

Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Royal Brompton Hospital, Faculty of Medicine, Imperial College, London SW3 6LY, UK.

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http://dx.doi.org/10.1073/pnas.0407655101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC555494PMC
March 2005

HLA class II polymorphisms determine responses to bacterial superantigens.

J Immunol 2004 Feb;172(3):1719-26

Department of Infectious Diseases, Faculty of Medicine, Imperial College, Department of Immunology, Guy's, Kings and St. Thomas' School of Medicine, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.3.1719DOI Listing
February 2004

Superantigens and streptococcal toxic shock syndrome.

Emerg Infect Dis 2003 Oct;9(10):1211-8

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033064PMC
http://dx.doi.org/10.3201/eid0910.030042DOI Listing
October 2003

Application of a rat model of streptococcal shock to evaluate on-line hemoperfusion and removal of circulating superantigens.

Crit Care Med 2003 Jan;31(1):171-8

Department of Infectious Diseases & Microbiology, Faculty of Medicine, Imperial College of Science Technology & Medicine, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1097/00003246-200301000-00027DOI Listing
January 2003

The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes.

J Immunol 2002 Sep;169(5):2561-9

Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, London, United Kingdom.

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http://www.jimmunol.org/content/169/5/2561.full.pdf
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http://dx.doi.org/10.4049/jimmunol.169.5.2561DOI Listing
September 2002