Shinya Yamanaka

Shinya Yamanaka

UNVERIFIED PROFILE

Are you Shinya Yamanaka?   Register this Author

Register author
Shinya Yamanaka

Shinya Yamanaka

Publications by authors named "Shinya Yamanaka"

Are you Shinya Yamanaka?   Register this Author

100Publications

2984Reads

37Profile Views

Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation.

Stem Cell Reports 2019 Oct 26;13(4):761-774. Epub 2019 Sep 26.

Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2019.08.014DOI Listing
October 2019

Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.

Stem Cell Reports 2019 Sep 8;13(3):485-498. Epub 2019 Aug 8.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Osaka 569-8686, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2019.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739768PMC
September 2019

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.

Circ Res 2019 Aug 29;125(6):653-658. Epub 2019 Aug 29.

Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, and Laboratory of Cardiovascular Genetics, Milan, Italy (P.J.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.119.315209DOI Listing
August 2019

Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.

Stem Cell Res 2019 Apr 12;36:101406. Epub 2019 Feb 12.

iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center, Kyoto, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2019.101406DOI Listing
April 2019

Application of induced pluripotent stem cells to primary immunodeficiency diseases.

Exp Hematol 2019 03 19;71:43-50. Epub 2019 Jan 19.

Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0301472X193005
Publisher Site
http://dx.doi.org/10.1016/j.exphem.2019.01.005DOI Listing
March 2019

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.

Cell Rep 2018 Apr;23(2):361-375

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.03.057DOI Listing
April 2018

Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.

Nat Commun 2017 11 20;8(1):1616. Epub 2017 Nov 20.

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01679-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696376PMC
November 2017

Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.

Lab Invest 2017 10 4;97(10):1133-1141. Epub 2017 Sep 4.

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/labinvest.2017.87
Publisher Site
http://dx.doi.org/10.1038/labinvest.2017.87DOI Listing
October 2017

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.

PLoS One 2016 21;11(10):e0165268. Epub 2016 Oct 21.

Division of Obstetrics and Gynecology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Huddinge, SE-141 86, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165268PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074499PMC
June 2017

Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications.

Circ Res 2017 Jun;120(12):1958-1968

From the Center for iPS Cell Research and Application, Kyoto University, Japan (Y.Y., S.Y.); and Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA (S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.117.311080DOI Listing
June 2017

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.

Cell Metab 2017 May;25(5):1103-1117.e6

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; AMED-CREST, AMED 1-7-1 Otemach, Chiyodaku, Tokyo, 100-0004, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2017.04.017DOI Listing
May 2017

New Models for Therapeutic Innovation from Japan.

EBioMedicine 2017 04 28;18:3-4. Epub 2017 Mar 28.

Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2017.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405189PMC
April 2017

Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.

N Engl J Med 2017 03;376(11):1038-1046

From the Division of Ophthalmology, Institute of Biomedical Research and Innovation Hospital, Foundation for Biomedical Research and Innovation (M.M., Y. Kurimoto, Y.H., M.F., M.Y., S. Ohta, M. Takahashi), Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology (M.M., C.M., H.A., N.S., Y.S., M. Terada, H.K., S.S., A.O., M.Y., M. Takahashi), the Department of Ophthalmology, Kobe City Medical Center General Hospital (Y.Kurimoto, Y.H., M.F.), the Department of Clinical Trial Management, Institute of Biomedical Research and Innovation Hospital, Foundation for Biomedical Research and Innovation (T.I., K.F.), and Research and Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation (S.K., M.J.G.), Kobe, Center for iPS Cell Research and Application (CiRA) (A.W., Y.N., M.N., J.K., Y. Kitano, N.A., M.U., F.K., A.T., N.T., S.Y.), Institute for Integrated Cell-Material Sciences (iCeMS) (A.W.), and Department of Pathology and Tumor Biology, Graduate School of Medicine (K.Y., S. Ogawa), Kyoto University, Kyoto, the Department of Biostatistics, Hyogo College of Medicine, Nishinomiya (T.D.), Platform of Therapeutics for Rare Disease, National Institutes of Biomedical Innovation, Health, and Nutrition, Ibaraki (H.A.), Mitsubishi Space Software, Tokyo (S.T., Y.O., C.O.), the Department of Ophthalmology, Kawasaki Medical School, Kurashiki (H.K.), Japan Tissue Engineering, Gamagori (C.S., K.H.), and HEALIOS K.K., Tokyo (M.S.) - all in Japan; and Gladstone Institute of Cardiovascular Disease, San Francisco (S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1608368DOI Listing
March 2017

Induced pluripotent stem cell technology: a decade of progress.

Nat Rev Drug Discov 2017 02 16;16(2):115-130. Epub 2016 Dec 16.

Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrd.2016.245
Publisher Site
http://dx.doi.org/10.1038/nrd.2016.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416143PMC
February 2017

Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.

Proc Natl Acad Sci U S A 2017 01 21;114(2):340-345. Epub 2016 Dec 21.

Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1617234114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240712PMC
January 2017

Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons.

Methods Mol Biol 2016 ;1357:111-31

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/7651_2015_251DOI Listing
October 2016

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing.

Annu Rev Genet 2015 25;49:47-70. Epub 2015 Sep 25.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8501, Japan; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-genet-112414-054926DOI Listing
September 2016

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells.

Sci Rep 2016 09 9;6:32532. Epub 2016 Sep 9.

Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep32532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016789PMC
September 2016

Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies.

Regen Ther 2016 Jun 1;4:36-47. Epub 2016 Mar 1.

Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reth.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581825PMC
June 2016

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins.

Stem Cells Int 2016 26;2016:7235757. Epub 2016 Apr 26.

Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan; Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2016/7235757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861799PMC
May 2016

When Myc's asleep, embryonic stem cells are dormant.

EMBO J 2016 Apr 10;35(8):801-2. Epub 2016 Mar 10.

Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201694095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972139PMC
April 2016

A decade of transcription factor-mediated reprogramming to pluripotency.

Nat Rev Mol Cell Biol 2016 Mar 17;17(3):183-93. Epub 2016 Feb 17.

Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan, and the Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm.2016.8DOI Listing
March 2016

Understanding Intracellular Signaling Advances Cardiac Reprogramming Technology Toward Clinical Applications.

Circ Res 2016 Feb;118(3):377-8

From the Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan (Y.Y., S.Y.); and Gladstone Institute of Cardiovascular Disease, San Francisco, CA (S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.115.308075DOI Listing
February 2016

Development of a global network of induced pluripotent stem cell haplobanks.

Regen Med 2015 ;10(3):235-8

MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5, Little France Drive, Edinburgh, EH16 4UU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/rme.15.1DOI Listing
January 2016

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2016 Jan 1;88:Unit 21.4. Epub 2016 Jan 1.

Gladstone Institute of Cardiovascular Disease, San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471142905.hg2104s88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726454PMC
January 2016

Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.

PLoS One 2014 15;9(8):e104957. Epub 2014 Aug 15.

Department of Reprogramming Science, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan; iCeMS, Kyoto University, Kyoto, Japan; PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104957PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134236PMC
December 2015

Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells.

Curr Protoc Hum Genet 2015 Oct 6;87:21.2.1-21. Epub 2015 Oct 6.

Gladstone Institute of Cardiovascular Disease, San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471142905.hg2102s87DOI Listing
October 2015

A developmental framework for induced pluripotency.

Development 2015 Oct;142(19):3274-85

Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.114249DOI Listing
October 2015

Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.

Stem Cells Transl Med 2015 Sep 21;4(9):980-92. Epub 2015 Jul 21.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan; Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Clinical Research Center, Chiba University of Medicine, Chiba, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5966/sctm.2014-0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542865PMC
September 2015

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.

Cell Stem Cell 2015 Aug 16;17(2):178-94. Epub 2015 Jul 16.

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2015.06.014DOI Listing
August 2015

KLF4 N-terminal variance modulates induced reprogramming to pluripotency.

Stem Cell Reports 2015 Apr 12;4(4):727-43. Epub 2015 Mar 12.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8507, Japan; Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2015.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400650PMC
April 2015

Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications.

Circ Res 2015 Apr;116(8):1378-91

From the Department of Cardiology, Keio University School of Medicine, Japan Science and Technology CREST, Tokyo, Japan (T.S., M.I.); Japan Science and Technology CREST, Tokyo, Japan (M.I.); Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan (S.Y.); and Gladstone Institute of Cardiovascular Disease, San Francisco, CA (S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.116.305374DOI Listing
April 2015

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

Stem Cell Reports 2015 Jan 26;4(1):143-154. Epub 2014 Nov 26.

Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; iCeMS, Kyoto University, Kyoto 606-8501, Japan; PRESTO, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0033
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221367111400335
Publisher Site
http://dx.doi.org/10.1016/j.stemcr.2014.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297888PMC
January 2015

The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells.

Sci Rep 2014 Dec 4;4:7283. Epub 2014 Dec 4.

Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep07283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255186PMC
December 2014

Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.

Sci Rep 2014 Nov 11;4:6996. Epub 2014 Nov 11.

1] Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep06996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227026PMC
November 2014

Induction of pluripotency by defined factors.

Proc Jpn Acad Ser B Phys Biol Sci 2014 ;90(3):83-96

Center for iPS Cell Research and Application (CiRA), Kyoto University.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997808PMC
http://dx.doi.org/10.2183/pjab.90.83DOI Listing
October 2014

The fate of cell reprogramming.

Nat Methods 2014 Oct;11(10):1006-8

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3109DOI Listing
October 2014

Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells.

Nat Biotechnol 2014 Aug;32(8):724-6

1] Kyoto Center for iPS Cell Research and Application, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan. [2] International Society for Stem Cell Research at the time of submission and acceptance of this work.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.2973DOI Listing
August 2014

Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.

Stem Cell Reports 2014 Aug 26;3(2):242-9. Epub 2014 Jun 26.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175543PMC
August 2014

Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Stem Cell Reports 2014 Aug 4;3(2):269-81. Epub 2014 Jul 4.

Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA; Departments of Medicine, Anatomy and Cellular and Molecular Pharmacology, University of California San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175159PMC
August 2014

Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.

Cell Stem Cell 2014 Apr 13;14(4):535-48. Epub 2014 Feb 13.

Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, 606-8507, Japan; Laboratory of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2014.01.011DOI Listing
April 2014

Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.

Nat Commun 2014 Apr 24;5:3678. Epub 2014 Apr 24.

1] Center for iPS cell Research and Application, Kyoto University, Kyoto 606-8507, Japan [2] Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4678DOI Listing
April 2014

Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.

Nature 2014 Mar 12;507(7490):99-103. Epub 2014 Jan 12.

1] Institute for Human Genetics and Department of Pediatrics, University of California, San Francisco, California 94143, USA [2] Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature12923
Publisher Site
http://dx.doi.org/10.1038/nature12923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030630PMC
March 2014

A chemical probe that labels human pluripotent stem cells.

Cell Rep 2014 Mar 6;6(6):1165-1174. Epub 2014 Mar 6.

Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.02.006DOI Listing
March 2014

Rethinking differentiation: stem cells, regeneration, and plasticity.

Cell 2014 Mar;157(1):110-9

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074550PMC
March 2014

iPS cell technologies: significance and applications to CNS regeneration and disease.

Mol Brain 2014 Mar 31;7:22. Epub 2014 Mar 31.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6606-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977688PMC
March 2014

Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation.

Cell 2014 Feb;156(4):663-77

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8507, Japan; PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, 332-0012, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.01.005DOI Listing
February 2014

The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.

Cell Stem Cell 2014 Jan 14;14(1):40-52. Epub 2013 Nov 14.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA; Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982312PMC
January 2014

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.

Sci Rep 2014 Jan 8;4:3594. Epub 2014 Jan 8.

1] Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan [2] Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep03594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884228PMC
January 2014

Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism.

Circ Res 2014 Jan;114(3):505-10

From the Department of Reprogramming Science, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan (N.N., S.Y.); and Gladstone Institute of Cardiovascular Disease, San Francisco, CA (S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.114.303043DOI Listing
January 2014

The winding road to pluripotency (Nobel Lecture).

Authors:
Shinya Yamanaka

Angew Chem Int Ed Engl 2013 Dec 19;52(52):13900-9. Epub 2013 Nov 19.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507 (Japan); Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158 (USA).

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/anie.201306721
Publisher Site
http://dx.doi.org/10.1002/anie.201306721DOI Listing
December 2013

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.

Proc Natl Acad Sci U S A 2013 Dec 20;110(51):20569-74. Epub 2013 Nov 20.

Center for iPS Cell Research and Application, Department of Biological Repair, Institute for Frontier Medical Sciences, and Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1319061110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870695PMC
December 2013

Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.

Mol Cell 2013 Dec 21;52(6):805-18. Epub 2013 Nov 21.

Howard Hughes Medical Institute, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2013.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950835PMC
December 2013

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.

Proc Natl Acad Sci U S A 2013 Oct 25;110(41):16492-7. Epub 2013 Sep 25.

European Molecular Biology Laboratory, Grenoble Outstation and Unit for Virus Host-Cell Interactions, Université Grenoble Alpes, European Molecular Biology Laboratory, Centre National de la Recherche Scientifique, 38042 Grenoble, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1316316110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799322PMC
October 2013

Global splicing pattern reversion during somatic cell reprogramming.

Cell Rep 2013 Oct 17;5(2):357-66. Epub 2013 Oct 17.

Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2013.09.016DOI Listing
October 2013

Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts.

Proc Natl Acad Sci U S A 2013 Jul 28;110(30):12172-9. Epub 2013 Jun 28.

Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1310291110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725041PMC
July 2013

Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo.

J Invest Dermatol 2013 Jun 15;133(6):1479-88. Epub 2013 Jan 15.

Department of Dermatology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022202X153628
Publisher Site
http://dx.doi.org/10.1038/jid.2013.7DOI Listing
June 2013

Induced pluripotent stem cells in medicine and biology.

Development 2013 Jun;140(12):2457-61

Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.092551DOI Listing
June 2013

Making steady progress on direct cardiac reprogramming toward clinical application.

Circ Res 2013 Jun;113(1):13-5

Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.113.301788DOI Listing
June 2013

To be immunogenic, or not to be: that's the iPSC question.

Cell Stem Cell 2013 Apr;12(4):385-6

Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2013.03.008DOI Listing
April 2013

Young researchers in Japan.

Science 2013 Apr;340(6131):407

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1239057DOI Listing
April 2013

An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.

Stem Cells 2013 Mar;31(3):458-66

Department of Reprogramming Science, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1293DOI Listing
March 2013

Steps toward safe cell therapy using induced pluripotent stem cells.

Circ Res 2013 Feb;112(3):523-33

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.111.256149DOI Listing
February 2013

Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monolithic silica columns.

J Proteome Res 2013 Jan 4;12(1):214-21. Epub 2012 Dec 4.

Department of Molecular & Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr300837uDOI Listing
January 2013

Shinya Yamanaka: purveyor of pluripotency. Interview by Ruth Williams.

Authors:
Shinya Yamanaka

Circ Res 2013 Jan 10;112(2):233-5. Epub 2012 Dec 10.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.112.281105DOI Listing
January 2013