Shingo Nakayamada

Shingo Nakayamada

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Shingo Nakayamada

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Regulatory Mechanism of The Induction of Regulatory T Cells through Growth Factors Released by Human Mesenchymal Stem Cells.

Crit Rev Immunol 2018 ;38(6):471-478

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan.

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http://dx.doi.org/10.1615/CritRevImmunol.2018027821DOI Listing
September 2019

Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.

Front Immunol 2018 28;9:1957. Epub 2018 Aug 28.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.3389/fimmu.2018.01957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121190PMC
September 2019

Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10.

Bone 2019 Aug 14;128:115034. Epub 2019 Aug 14.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu 807-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.115034DOI Listing
August 2019

IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.

Bone 2019 Jul 11;124:53-61. Epub 2019 Apr 11.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu 807-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.04.006DOI Listing
July 2019

Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update.

Expert Rev Clin Immunol 2019 Jul 25;15(7):693-700. Epub 2019 Apr 25.

a The First Department of Internal Medicine , University of Occupational and Environmental Health , Kitakyushu, Fukuoka , Japan.

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http://dx.doi.org/10.1080/1744666X.2019.1608821DOI Listing
July 2019

[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. Change in immune phenotype by the treatment of rheumatoid arthritis.]

Clin Calcium 2018;28(5):619-625

The First Department of Internal Medicine, School of Medicine,University of Occupational and Environmental Health, Japan.

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http://dx.doi.org/CliCa1805619625DOI Listing
June 2019

Lymphocyte phenotype and its application to precision medicine in systemic autoimmune diseases.

Semin Arthritis Rheum 2019 Jun 25;48(6):1146-1150. Epub 2019 Apr 25.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1016/j.semarthrit.2019.04.007DOI Listing
June 2019

Comparative study of corticosteroid monotherapy, and TNF inhibitors with or without corticosteroid in patients with refractory entero-Behcet's disease.

Arthritis Res Ther 2019 Jun 22;21(1):151. Epub 2019 Jun 22.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1186/s13075-019-1933-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589167PMC
June 2019

Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis.

Rheumatology (Oxford) 2019 Jun 23. Epub 2019 Jun 23.

First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1093/rheumatology/kez244DOI Listing
June 2019

Immunophenotype involved in IgG4-related disease.

Mod Rheumatol 2019 Mar 9;29(2):226-230. Epub 2019 Jan 9.

a The First Department of Internal Medicine , University of Occupational and Environmental Health, Japan , Kitakyushu , Fukuoka , Japan.

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1537962DOI Listing
March 2019

Effectiveness and safety of hydroxychloroquine therapy with or without corticosteroid in patients with systemic lupus erythematosus.

Int J Rheum Dis 2019 Mar 18;22(3):434-442. Epub 2018 Oct 18.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyush, Japan.

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http://doi.wiley.com/10.1111/1756-185X.13387
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http://dx.doi.org/10.1111/1756-185X.13387DOI Listing
March 2019

Type I and II interferons commit to abnormal expression of chemokine receptor on B cells in patients with systemic lupus erythematosus.

Clin Immunol 2019 Mar 19;200:1-9. Epub 2018 Dec 19.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.12.017DOI Listing
March 2019

Radiological patterns of pulmonary involvement may predict treatment response in rheumatoid arthritis: A retrospective study.

Respir Investig 2019 Mar 1;57(2):172-182. Epub 2019 Feb 1.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.

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http://dx.doi.org/10.1016/j.resinv.2018.12.006DOI Listing
March 2019

Optimal Biologic Selection for Treatment of Psoriatic Arthritis: the Approach to Precision Medicine.

Curr Rheumatol Rep 2019 Mar 20;21(5):21. Epub 2019 Mar 20.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s11926-019-0817-xDOI Listing
March 2019

Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis.

Rheumatology (Oxford) 2019 Feb;58(2):336-344

The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1093/rheumatology/key069DOI Listing
February 2019

Janus kinases to jakinibs: from basic insights to clinical practice.

Rheumatology (Oxford) 2019 Feb;58(Supplement_1):i4-i16

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/rheumatology/key432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657570PMC
February 2019

Mediastinal and axillar lymphadenopathy in patients with rheumatoid arthritis: prevalence and clinical significance.

Clin Imaging 2019 May - Jun;55:140-143. Epub 2019 Feb 20.

Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1016/j.clinimag.2019.02.014DOI Listing
February 2019

Th22 Cells Promote Osteoclast Differentiation Production of IL-22 in Rheumatoid Arthritis.

Front Immunol 2018 10;9:2901. Epub 2018 Dec 10.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02901
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http://dx.doi.org/10.3389/fimmu.2018.02901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295478PMC
December 2018

Intracranial vessel wall lesions in patients with systematic lupus erythematosus.

J Magn Reson Imaging 2018 11 23;48(5):1237-1246. Epub 2018 Feb 23.

University of Occupational and Environmental Health School of Medicine, Department of Radiology, Yahatanishi-ku Kitakyushu-shi, Fukuoka, Japan.

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http://dx.doi.org/10.1002/jmri.25966DOI Listing
November 2018

Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition.

Clin Immunol 2018 10 4;195:1-7. Epub 2018 Jul 4.

The First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Japan, Kitakyushu 807-8555, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.07.003DOI Listing
October 2018

Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis.

Arthritis Res Ther 2018 Oct 26;20(1):240. Epub 2018 Oct 26.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu City, 807-8555, Japan.

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1737-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235206PMC
October 2018

Expansion of T follicular helper-T helper 1 like cells through epigenetic regulation by signal transducer and activator of transcription factors.

Ann Rheum Dis 2018 09 31;77(9):1354-1361. Epub 2018 May 31.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2017-212652DOI Listing
September 2018

IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion.

Intern Med 2018 Aug 9;57(15):2251-2257. Epub 2018 Mar 9.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.

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http://dx.doi.org/10.2169/internalmedicine.0387-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120838PMC
August 2018

Comparison of efficacy of TNF inhibitors and abatacept in patients with rheumatoid arthritis; Adjusted with propensity score matching.

Clin Immunol 2018 06 31;191:67-74. Epub 2018 Mar 31.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.03.018DOI Listing
June 2018

Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System.

Front Immunol 2018 28;9:1510. Epub 2018 Jun 28.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.3389/fimmu.2018.01510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031708PMC
June 2018

Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair.

Inflamm Regen 2018 12;38. Epub 2018 Mar 12.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, 807-8555 Japan.

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http://dx.doi.org/10.1186/s41232-018-0061-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846298PMC
March 2018

Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis.

Rheumatology (Oxford) 2018 01;57(1):164-174

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1093/rheumatology/kex012DOI Listing
January 2018

B cell phenotypes, signaling and their roles in secretion of antibodies in systemic lupus erythematosus.

Clin Immunol 2018 01 5;186:21-25. Epub 2017 Aug 5.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

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http://dx.doi.org/10.1016/j.clim.2017.07.010DOI Listing
January 2018

Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.

Arthritis Rheumatol 2017 10 25;69(10):2029-2037. Epub 2017 Aug 25.

University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1002/art.40180DOI Listing
October 2017

Anti-PD-1 Antibody Therapy Induces Hashimoto's Disease with an Increase in Peripheral Blood Follicular Helper T Cells.

Thyroid 2017 10 3;27(10):1335-1336. Epub 2017 Aug 3.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health , Kitakyushyu, Japan .

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http://dx.doi.org/10.1089/thy.2017.0062DOI Listing
October 2017

Enlarged perivascular spaces are associated with the disease activity in systemic lupus erythematosus.

Sci Rep 2017 10 3;7(1):12566. Epub 2017 Oct 3.

Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://www.nature.com/articles/s41598-017-12966-4
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http://dx.doi.org/10.1038/s41598-017-12966-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626765PMC
October 2017

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.

J Immunol 2017 09 19;199(5):1616-1625. Epub 2017 Jul 19.

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan;

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http://dx.doi.org/10.4049/jimmunol.1600230DOI Listing
September 2017

Abatacept therapy reduces CD28+CXCR5+ follicular helper-like T cells in patients with rheumatoid arthritis.

Clin Exp Rheumatol 2017 Jul-Aug;35(4):562-570. Epub 2017 Apr 27.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.

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August 2017

Metabolic Reprogramming Commits Differentiation of Human CD27IgD B Cells to Plasmablasts or CD27IgD Cells.

J Immunol 2017 07 16;199(2):425-434. Epub 2017 Jun 16.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807-8555, Japan;

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http://dx.doi.org/10.4049/jimmunol.1601908DOI Listing
July 2017

T follicular helper (Tfh) cells in autoimmune diseases.

Nihon Rinsho Meneki Gakkai Kaishi 2016 ;39(1):1-7

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.

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http://dx.doi.org/10.2177/jsci.39.1DOI Listing
March 2017

Clinical, radiographic and functional efficacy of abatacept in routine care for rheumatoid arthritis patients: Abatacept Leading Trial for RA on Imaging Remission (ALTAIR) study.

Clin Exp Rheumatol 2016 Sep-Oct;34(5):834-841. Epub 2016 Aug 31.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.

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January 2017

Chemical JAK inhibitors for the treatment of rheumatoid arthritis.

Expert Opin Pharmacother 2016 Nov 8;17(16):2215-2225. Epub 2016 Oct 8.

a The First Department of Internal Medicine, School of Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

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http://dx.doi.org/10.1080/14656566.2016.1241237DOI Listing
November 2016

Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis.

BioDrugs 2016 Oct;30(5):407-419

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan.

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http://link.springer.com/10.1007/s40259-016-0190-5
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http://dx.doi.org/10.1007/s40259-016-0190-5DOI Listing
October 2016

Erratum to: Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis.

BioDrugs 2016 Oct;30(5):483

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s40259-016-0198-xDOI Listing
October 2016

[Abnormal expression of chemokine receptor on B cells in patients with SLE].

Nihon Rinsho Meneki Gakkai Kaishi 2015 ;38(1):65-8

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.

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http://dx.doi.org/10.2177/jsci.38.65DOI Listing
September 2016

Baricitinib for the treatment of rheumatoid arthritis.

Expert Rev Clin Immunol 2016 Sep 5;12(9):911-9. Epub 2016 Aug 5.

a The First Department of Internal Medicine , University of Occupational and Environmental Health , Fukuoka , Japan.

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http://dx.doi.org/10.1080/1744666X.2016.1214576DOI Listing
September 2016

Comparison of the efficacies of abatacept and tocilizumab in patients with rheumatoid arthritis by propensity score matching.

Ann Rheum Dis 2016 Jul 5;75(7):1321-7. Epub 2015 Aug 5.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://ard.bmj.com/content/early/2015/08/05/annrheumdis-2015
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http://dx.doi.org/10.1136/annrheumdis-2015-207784DOI Listing
July 2016

BAFF- and APRIL-targeted therapy in systemic autoimmune diseases.

Inflamm Regen 2016 21;36. Epub 2016 Jul 21.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555 Japan.

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http://dx.doi.org/10.1186/s41232-016-0015-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725651PMC
July 2016

Pancreas-protective effect of rituximab for acute-onset type 1 diabetes in the honeymoon period: a case report.

Endocrinol Diabetes Metab Case Rep 2016 1;2016:160020. Epub 2016 May 1.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health , Japan, Kitakyushu , Japan.

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http://dx.doi.org/10.1530/EDM-16-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870497PMC
June 2016

Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia.

Eur Radiol 2016 Apr 1;26(4):1056-63. Epub 2015 Aug 1.

Department of Radiology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s00330-015-3929-3DOI Listing
April 2016

[Anti-RANKL antibody for the treatment of bone and cartilage destruction in rheumatoid arthritis].

Clin Calcium 2015 Dec;25(12):1787-93

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.

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http://dx.doi.org/CliCa151217871793DOI Listing
December 2015

Amplification of IL-21 signalling pathway through Bruton's tyrosine kinase in human B cell activation.

Rheumatology (Oxford) 2015 Aug 26;54(8):1488-97. Epub 2015 Feb 26.

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu and

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http://dx.doi.org/10.1093/rheumatology/keu532DOI Listing
August 2015

Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.

Biochem Biophys Res Commun 2015 Jul 31;463(3):434-9. Epub 2015 May 31.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu 807-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X153001
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http://dx.doi.org/10.1016/j.bbrc.2015.05.094DOI Listing
July 2015

Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study.

Ann Rheum Dis 2015 Feb 28;74(2):389-95. Epub 2013 Nov 28.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2013-204016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316845PMC
February 2015

Relevance of lymphocyte subsets to B cell-targeted therapy in systemic lupus erythematosus.

Int J Rheum Dis 2015 Feb 3;18(2):208-18. Epub 2015 Jan 3.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/1756-185X.12534DOI Listing
February 2015

Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro.

Ann Rheum Dis 2014 Dec 25;73(12):2213-5. Epub 2014 Aug 25.

The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2014-205615DOI Listing
December 2014

Study on the safety and efficacy of tocilizumab, an anti-IL-6 receptor antibody, in patients with rheumatoid arthritis complicated with AA amyloidosis.

Mod Rheumatol 2014 May 21;24(3):405-9. Epub 2013 Oct 21.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health , Kitakyushu , Japan.

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http://www.tandfonline.com/doi/full/10.3109/14397595.2013.84
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http://dx.doi.org/10.3109/14397595.2013.844294DOI Listing
May 2014

Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

J Immunol 2014 Mar 31;192(5):2156-66. Epub 2014 Jan 31.

Lymphocyte Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300675
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http://dx.doi.org/10.4049/jimmunol.1300675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967131PMC
March 2014

Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.

Genome Res 2013 Mar 3;23(3):462-72. Epub 2012 Dec 3.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1101/gr.147652.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589535PMC
March 2013

STATs shape the active enhancer landscape of T cell populations.

Cell 2012 Nov;151(5):981-93

Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1930, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674120129
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http://dx.doi.org/10.1016/j.cell.2012.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509201PMC
November 2012

Helper T cell diversity and plasticity.

Curr Opin Immunol 2012 Jun 15;24(3):297-302. Epub 2012 Feb 15.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.coi.2012.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383341PMC
June 2012

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

Nat Immunol 2012 Apr 29;13(6):587-95. Epub 2012 Apr 29.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ni.2286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499969PMC
April 2012

Early Th1 cell differentiation is marked by a Tfh cell-like transition.

Immunity 2011 Dec;35(6):919-31

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613110051
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http://dx.doi.org/10.1016/j.immuni.2011.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244883PMC
December 2011

Helper T-cell differentiation and plasticity: insights from epigenetics.

Immunology 2011 Nov;134(3):235-45

Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1930, USA.

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http://doi.wiley.com/10.1111/j.1365-2567.2011.03483.x
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http://dx.doi.org/10.1111/j.1365-2567.2011.03483.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209564PMC
November 2011

Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis.

Mod Rheumatol 2010 Apr 14;20(2):139-46. Epub 2009 Nov 14.

The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-009-0247-0DOI Listing
April 2010

Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling.

Arthritis Rheum 2010 Apr;62(4):952-9

University of Occupational and Environmental Health, Kitakyushu, Japan, and University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/art.27331DOI Listing
April 2010

Usefulness of initial histological features for stratifying Sjogren's syndrome responders to mizoribine therapy.

Rheumatology (Oxford) 2009 Oct 11;48(10):1279-82. Epub 2009 Aug 11.

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1093/rheumatology/kep228DOI Listing
October 2009

Discontinuation of infliximab in rheumatoid arthritis patients in clinical remission.

Mod Rheumatol 2008 6;18(5):460-4. Epub 2008 Jun 6.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-008-0089-1DOI Listing
April 2009

Alendronate protects premenopausal women from bone loss and fracture associated with high-dose glucocorticoid therapy.

J Rheumatol 2008 Nov;35(11):2249-54

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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November 2008

Efficacy and safety of mizoribine for the treatment of Sjögren's syndrome: a multicenter open-label clinical trial.

Mod Rheumatol 2007 20;17(6):464-9. Epub 2007 Dec 20.

First Department of Internal Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-007-0627-2DOI Listing
February 2008

Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.

J Immunol 2007 Nov;179(10):6479-84

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.4049/jimmunol.179.10.6479DOI Listing
November 2007

Clinical images: Takayasu arteritis diagnosed by positron emission tomography.

Arthritis Rheum 2007 Jul;56(7):2466

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1002/art.22723DOI Listing
July 2007

Overcoming treatment unresponsiveness mediated by P-glycoprotein overexpression on lymphocytes in refractory active systemic lupus erythematosus.

Mod Rheumatol 2005 ;15(1):28-32

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-004-0354-xDOI Listing
June 2007

Human urinary trypsin inhibitor bolus infusion improved severe interstitial pneumonia in mixed connective tissue disease.

Mod Rheumatol 2005 ;15(5):374-80

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-005-0421-yDOI Listing
June 2007

A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate.

Mod Rheumatol 2007 20;17(2):144-7. Epub 2007 Apr 20.

First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1007/s10165-006-0548-5DOI Listing
June 2007

Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus.

Arthritis Rheum 2007 May;56(5):1559-68

University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1002/art.22581DOI Listing
May 2007

Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system.

Ann Rheum Dis 2007 Apr 15;66(4):470-5. Epub 2006 Nov 15.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka Yahata-nishi, Kitakyushu 807-8555 Japan.

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http://dx.doi.org/10.1136/ard.2006.057885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856059PMC
April 2007

Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation.

Biochem Biophys Res Commun 2007 Apr 1;356(1):279-85. Epub 2007 Mar 1.

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.02.121DOI Listing
April 2007

Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts.

Arthritis Res Ther 2005 18;7(3):R476-84. Epub 2005 Feb 18.

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1186/ar1694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174939PMC
January 2006

Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading.

J Bone Miner Res 2005 Jun 4;20(6):1002-10. Epub 2005 Jan 4.

Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan.

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http://dx.doi.org/10.1359/JBMR.050102DOI Listing
June 2005

Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus.

Arthritis Rheum 2005 Jun;52(6):1676-83

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

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http://dx.doi.org/10.1002/art.21032DOI Listing
June 2005

Osteoblasts and osteoclasts in bone remodeling and inflammation.

Curr Drug Targets Inflamm Allergy 2005 Jun;4(3):325-8

First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu 807-8555, Japan.

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June 2005

Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes.

Genes Cells 2004 Dec;9(12):1265-73

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Yahata-nishi, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2004.00803.xDOI Listing
December 2004

[Successful treatment of intravenous cyclophosphamide pulse therapy for lupus myelitis with urinary disturbance and acute confusional state].

Nihon Rinsho Meneki Gakkai Kaishi 2004 Oct;27(5):338-44

The First Department of Internal Medicine, University of Occupational and Environmental Hearth, Japan, School of Medicine.

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October 2004

[Active arthritis due to cryoglobulinemia based on HCV infection in a patient with RA improvement of arthritis with IFN-alpha].

Nihon Rinsho Meneki Gakkai Kaishi 2004 Feb;27(1):48-53

First Department of Internal Medicine, University of Occupational & Environmental Health, School of Medicine.

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February 2004

Etidronate prevents high dose glucocorticoid induced bone loss in premenopausal individuals with systemic autoimmune diseases.

J Rheumatol 2004 Jan;31(1):163-6

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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January 2004

Efficacy of mizoribine treatment in patients with Sjögren's syndrome: an open pilot trial.

Mod Rheumatol 2003 Dec;13(4):339-45

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine , 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555 , Japan.

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http://dx.doi.org/10.3109/s10165-003-0247-4DOI Listing
December 2003

Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation.

J Biol Chem 2003 Nov 3;278(46):45368-74. Epub 2003 Sep 3.

First and Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, 807-8555, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M308786200
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http://dx.doi.org/10.1074/jbc.M308786200DOI Listing
November 2003

[Successful treatment of intravenous cyclophosphamide pulse therapy for systemic lupus erythematosus complicated with steroid-resistant hemolytic anemia].

Nihon Rinsho Meneki Gakkai Kaishi 2003 Oct;26(5):304-9

First Department of Internal Medicine, University of Occupational and Environmental Hearth, School of Medicine, Japan.

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October 2003

High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.

Kidney Int 2003 Feb;63(2):722-31

The Second Department of Internal Medicine, and The First Department of Internal Medicine,University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

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http://dx.doi.org/10.1046/j.1523-1755.2003.00772.xDOI Listing
February 2003

[A case of Paragonimiasis westermanii complicated with migrating subcutaneous induration and multiple involvements in the liver].

Kansenshogaku Zasshi 2002 Aug;76(8):594-9

First Department of Internal Medicine, Environmental Health, School of Medicine, Kitakyushu, Japan.

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http://dx.doi.org/10.11150/kansenshogakuzasshi1970.76.594DOI Listing
August 2002

H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.

J Biol Chem 2002 Jun 4;277(24):21446-52. Epub 2002 Apr 4.

First Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1074/jbc.M202238200DOI Listing
June 2002

[A case of rheumatoid arthritis with secondary amyloidosis in urinary bladder].

Ryumachi 2002 Jun;42(3):618-23

First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu-city.

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June 2002