Shin Hamada

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Shin Hamada

Publications by authors named "Shin Hamada"

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99Publications

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Elucidating the link between collagen and pancreatic cancer: what's next?

Expert Rev Gastroenterol Hepatol 2018 04 8;12(4):315-317. Epub 2018 Mar 8.

a Division of Gastroenterology , Tohoku University Graduate School of Medicine , Sendai , Japan.

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April 2018

Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.

Dig Dis Sci 2018 Apr 4. Epub 2018 Apr 4.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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April 2018

Estrogen-Dependent Nrf2 Expression Protects Against Reflux-Induced Esophagitis.

Dig Dis Sci 2018 02 27;63(2):345-355. Epub 2017 Dec 27.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

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February 2018

Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis.

Tohoku J Exp Med 2018 02;244(2):113-117

Division of Gastroenterology, Tohoku University Graduate School of Medicine.

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February 2018

Nationwide survey of hereditary pancreatitis in Japan.

J Gastroenterol 2018 Jan 31;53(1):152-160. Epub 2017 Aug 31.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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January 2018

Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.

Am J Physiol Gastrointest Liver Physiol 2018 01 28;314(1):G65-G74. Epub 2017 Sep 28.

Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , Japan.

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January 2018

Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells.

Biochem Biophys Res Commun 2018 01 28;495(1):71-77. Epub 2017 Oct 28.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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January 2018

Severity assessment of acute pancreatitis using four prognostic factors - a nationwide multicenter study of 3682 cases in Japan.

United European Gastroenterol J 2017 Dec 3;5(8):1136-1137. Epub 2017 Aug 3.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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December 2017

Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis.

Carcinogenesis 2017 06;38(6):661-670

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

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June 2017

Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer.

Cancer Lett 2017 04 16;390:103-114. Epub 2017 Jan 16.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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April 2017

Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey.

World J Gastroenterol 2017 Apr;23(16):2826-2831

Shin Hamada, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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April 2017

Variants in the UBR1 gene are not associated with chronic pancreatitis in Japan.

Pancreatology 2016 Sep-Oct;16(5):814-8. Epub 2016 Jul 2.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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March 2017

Exosomes Derived From Pancreatic Stellate Cells: MicroRNA Signature and Effects on Pancreatic Cancer Cells.

Pancreas 2017 01;46(1):19-27

From the Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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January 2017

Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society.

Pancreas 2016 11;45(10):1411-1417

From the *Japan Pancreas Society, Sendai; †Department of Surgery, Graduate School of Medicine, Osaka University, Osaka; ‡Second Department of Surgery, Wakayama Medical University, Wakayama; §Department of Surgery and ∥Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; ¶Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; #Department of Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki; **Department of Surgery, Kansai Medical University, Osaka; ††Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya; ‡‡Department of Surgery, Shiga University of Medical Science, Otsu; §§Department of Gastroenterology, IMS Sapporo Digestive Center General Hospital, Sapporo; ∥∥Department of Endoscopy, Nagoya University Hospital; and ¶¶Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya; ##Kyushu University Hospital Cancer Center, Fukuoka; ***Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo; †††Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto; and ‡‡‡Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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November 2016

MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6.

World J Gastrointest Oncol 2016 Jul;8(7):532-42

Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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July 2016

Management of acute pancreatitis in Japan: Analysis of nationwide epidemiological survey.

World J Gastroenterol 2016 Jul;22(28):6335-44

Shin Hamada, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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July 2016

IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells.

Dig Dis Sci 2016 06 6;61(6):1561-71. Epub 2016 Jan 6.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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June 2016

No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.

Gastroenterology 2016 06 3;150(7):1558-1560.e5. Epub 2016 Mar 3.

Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address:

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June 2016

Clinical Impact of Elevated Serum Triglycerides in Acute Pancreatitis: Validation from the Nationwide Epidemiological Survey in Japan.

Am J Gastroenterol 2016 04;111(4):575-6

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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April 2016

Comprehensive Analysis of Serum microRNAs in Autoimmune Pancreatitis.

Digestion 2015 11;91(4):263-71. Epub 2015 Apr 11.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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March 2016

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2015 Oct 27;309(8):G688-94. Epub 2015 Aug 27.

Pediatric Nutritional Medicine, Klinikum rechts der Isar; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin & Zentralinstitut für Ernährungs-und Lebensmittelforschung, Technische Universität München, Munich, Germany; and.

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October 2015

IgG4-unrelated type 1 autoimmune pancreatitis.

World J Gastroenterol 2015 Sep;21(33):9808-16

Eriko Nakano, Atsushi Kanno, Atsushi Masamune, Naoki Yoshida, Seiji Hongo, Shin Miura, Tetsuya Takikawa, Shin Hamada, Kiyoshi Kume, Kazuhiro Kikuta, Morihisa Hirota, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

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September 2015

The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients.

Pancreatology 2014 Nov-Dec;14(6):490-6. Epub 2014 Sep 3.

Molecular Epidemiology, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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August 2015

Common variants at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with chronic pancreatitis in Japan.

Gut 2015 Aug 22;64(8):1345-6. Epub 2015 May 22.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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August 2015

[Chronic pancreatitis is a risk factor of pancreatic cancer].

Nihon Shokakibyo Gakkai Zasshi 2015 Aug;112(8):1464-73

Division of Gastroenterology, Tohoku University Graduate School of Medicine.

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August 2015

Targeted next-generation sequencing effectively analyzed the cystic fibrosis transmembrane conductance regulator gene in pancreatitis.

Dig Dis Sci 2015 May 10;60(5):1297-307. Epub 2014 Dec 10.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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May 2015

Involvement of epithelial to mesenchymal transition in the development of pancreatic ductal adenocarcinoma.

J Gastroenterol 2015 Feb 14;50(2):140-6. Epub 2014 Sep 14.

Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1 Nodayama, Medeshima-Shiote, Natori, Miyagi, Japan,

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February 2015

Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer.

Int J Oncol 2015 Feb 10;46(2):539-47. Epub 2014 Nov 10.

Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Miyagi 981-1293, Japan.

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February 2015

Nationwide epidemiological survey of acute pancreatitis in Japan.

Pancreas 2014 Nov;43(8):1244-8

From the *Division of Gastroenterology, and †Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Seiryomachi, Aoba-ku, Sendai, Miyagi, Japan.

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November 2014

Inflammation and pancreatic cancer: disease promoter and new therapeutic target.

J Gastroenterol 2014 Apr 30;49(4):605-17. Epub 2013 Nov 30.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aobaku, Sendai, Miyagi, 980-8574, Japan,

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April 2014

Alteration of the microRNA expression profile during the activation of pancreatic stellate cells.

Scand J Gastroenterol 2014 Mar 10;49(3):323-31. Epub 2014 Jan 10.

Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , Japan.

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March 2014

MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX.

Cell Signal 2014 Feb 9;26(2):179-85. Epub 2013 Nov 9.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan.

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February 2014

The zinc transporter LIV-1 is a novel regulator of stemness in pancreatic cancer cells.

Scand J Gastroenterol 2014 Feb 2;49(2):215-21. Epub 2013 Dec 2.

Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , Japan.

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February 2014

CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells.

Exp Cell Res 2014 Feb 30;321(2):209-18. Epub 2013 Dec 30.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai city, Miyagi 980-8574, Japan.

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February 2014

Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction.

Front Physiol 2013 Nov 1;4:318. Epub 2013 Nov 1.

Division of Gastroenterology, Tohoku University Graduate School of Medicine Sendai, Japan.

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November 2013

Novel therapeutic strategies targeting tumor-stromal interactions in pancreatic cancer.

Front Physiol 2013 11;4:331. Epub 2013 Nov 11.

Division of Gastroenterology, Tohoku University Graduate School of Medicine Sendai, Miyagi, Japan.

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November 2013

miR-210 regulates the interaction between pancreatic cancer cells and stellate cells.

Biochem Biophys Res Commun 2013 Aug 4;437(3):433-9. Epub 2013 Jul 4.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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August 2013

The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice.

Scand J Gastroenterol 2013 May 11;48(5):602-9. Epub 2013 Mar 11.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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May 2013

Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells.

Biochem Biophys Res Commun 2013 Apr 13;433(3):292-7. Epub 2013 Mar 13.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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April 2013

The sixth nationwide epidemiological survey of chronic pancreatitis in Japan.

Pancreatology 2012 Mar-Apr;12(2):79-84. Epub 2012 Feb 16.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai City, Miyagi 980-8574, Japan.

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November 2012

Do genetic variants in the SPINK1 gene affect the level of serum PSTI?

J Gastroenterol 2012 Nov 20;47(11):1267-74. Epub 2012 Apr 20.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.

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November 2012

MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.

Front Physiol 2012 14;3:430. Epub 2012 Nov 14.

Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute Natori, Miyagi, Japan.

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November 2012

Regulators of epithelial mesenchymal transition in pancreatic cancer.

Front Physiol 2012 10;3:254. Epub 2012 Jul 10.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai Miyagi, Japan.

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October 2012

Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.

Biochem Biophys Res Commun 2012 May 9;421(2):349-54. Epub 2012 Apr 9.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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May 2012

MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9.

Mol Cancer Res 2012 Jan 7;10(1):3-10. Epub 2011 Nov 7.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Tokyo, Japan.

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January 2012

Biomarkers of pancreatic cancer.

Pancreatology 2011 5;11 Suppl 2:14-9. Epub 2011 Apr 5.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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June 2011

Nationwide epidemiological survey of acute pancreatitis in Japan.

Pancreas 2011 May;40(4):503-7

Division of Gastroenterology Sendai, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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May 2011

Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis.

Cancer Sci 2011 Jan 21;102(1):157-61. Epub 2010 Oct 21.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan.

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January 2011

Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma.

Cancer Sci 2011 Jan 13;102(1):150-6. Epub 2010 Oct 13.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan.

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January 2011

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells.

Biochem Biophys Res Commun 2010 Dec 20;403(3-4):380-4. Epub 2010 Nov 20.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

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December 2010

Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas.

J Gastroenterol 2010 Sep 10;45(9):952-9. Epub 2010 Apr 10.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, Japan.

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September 2010

Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas.

J Gastroenterol 2010 Jul 28;45(7):763-70. Epub 2010 Jan 28.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi, 980-8574, Japan.

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July 2010

Granular cell tumor of the pancreas: A case report and review of literature.

World J Gastrointest Oncol 2010 Feb;2(2):121-4

Atsushi Kanno, Kennichi Satoh, Morihisa Hirota, Shin Hamada, Jun Umino, Hiromichi Itoh, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan.

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February 2010

Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.

J Cell Physiol 2008 Apr;215(1):192-203

Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20832, USA.

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April 2008

Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line.

J Cell Physiol 2007 Dec;213(3):768-74

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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December 2007

Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor.

J Biol Chem 2007 Dec 9;282(49):35772-86. Epub 2007 Oct 9.

Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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December 2007

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.

J Biol Chem 2007 Oct 24;282(43):31643-55. Epub 2007 Aug 24.

Tumor Growth Factor Section, Mammary Biology & Tumorigenesis Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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October 2007

beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.

Biochem Biophys Res Commun 2007 Mar 2;355(1):240-4. Epub 2007 Feb 2.

Mammary Biology and Tumorigenesis Laboratory, NCI/CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA.

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March 2007

Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice.

Cancer Sci 2007 Feb;98(2):155-62

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai City, Miyagi, 980-8574, Japan.

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February 2007

MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells.

World J Gastroenterol 2005 Nov;11(43):6867-70

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai city, Miyagi 980-8574, Japan.

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November 2005

Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.

J Cell Sci 2005 Oct 21;118(Pt 20):4633-43. Epub 2005 Sep 21.

Mammary Biology and Tumorigenesis Laboratory, NCI/CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA.

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October 2005