Publications by authors named "Shimin Wang"

66 Publications

A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thunb.

J Ethnopharmacol 2021 Nov 28;280:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb., and Rosa rugosa Thunb. are used in local and traditional medicine to treat inflammation-related diseases. While the constituents and bioactivities of EOs of the above four Chinese herbals have been reported previously, but their anti-inflammatory and antioxidant activities have not been systematically evaluated.

Aim Of The Study: The purpose of this study was to research the chemical constituents, anti-inflammatory activities, and antioxidant activities of EOs of four Chinese herbal medicines.

Materials And Methods: Fresh plant materials were collected both in August 2018. The compositions of EOs were determined by the gas chromatography-mass spectrometry (GC-MS) method. TPA (12-O-tetradecylphophenol-13-acetate)-induced mouse ear model was evaluated the anti-inflammatory activities of EOs. The reduction of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and RelA protein of the nuclear factor kappa-B (NF-κB) in the signal pathway (P65) were measured. The antioxidant activities of EOs from four plants were determined by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.

Results: A total of 217 compounds were separated and identified from four EOs, mainly including trans-cinnamylaldehyde (68.75%), citronellal (38.16%), linalool (1.02-33.73%), geraniol (19.39%) and citronellol (17.18%). All four EOs reduced the damage of the ear tissue and had certain anti-inflammatory effects, and the EOs of C. citratus (CyCEOs) and S. japonica (SJEOs) had the best anti-inflammatory activities among others, even better than ibuprofen. The four EOs exhibited different DPPH radical-scavenging activities (IC, 0.101-1.017%), where most of them were much lower than that of EOs of C. citratus (CiCEOs) (IC, 0.101%) and EOs of R. rugosa (RREOs) (IC, 0.142%).

Conclusions: The main components determine diverse propertise of these four EOs, our results suggested that four EOs presented anti-inflammatory and antioxidant effect via reducing the expression of TNF-a, IL-6, COX-2, and NF-κB p65, which may provide a new approach for development of new anti-inflammatory drugs.
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http://dx.doi.org/10.1016/j.jep.2021.114472DOI Listing
November 2021

A technique to fabricate a custom CAD-CAM periapical radiographic film holder for implant assessment.

J Prosthet Dent 2021 Jul 19. Epub 2021 Jul 19.

Professor, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, PR China. Electronic address:

Standardized radiographs produced by using the paralleling technique play an important role in monitoring prosthetic misfit and marginal bone levels around endosseous implants. Under clinical conditions, parallel adjustment of the film with respect to the implant requires the use of positioning devices. This article describes the fabrication of a custom computer-aided design and computer-aided manufacturing (CAD-CAM) device suitable for implants adjacent to natural teeth.
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http://dx.doi.org/10.1016/j.prosdent.2021.05.016DOI Listing
July 2021

Levels of serum ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) predicts severity of abdominal aortic calcification in end-stage renal disease patients receiving regular dialysis.

Hemodial Int 2021 Jul 7. Epub 2021 Jul 7.

Department of Nephrology, Shaoxing People's Hospital, (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.

Objective: To investigate the correlation between serum ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) level and severity of abdominal vascular calcification in end-stage renal disease (ESRD) patients receiving dialysis.

Methods: A total of 124 patients were consecutively enrolled into the study in our local institution. Based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines and recommendations, abdomen lateral X-ray was used to determine abdominal aortic calcification score (AACS) for each patient at enrollment. Patients were divided into three groups based on AACS: no or mild calcification group, moderate calcification group, and severe calcification group. The relationships between ENPP1 levels and AACS were assessed by Spearman analysis and the value of ENPP1 in predicting severity of abdominal aortic calcification was evaluated by receiver operating characteristic (ROC).

Results: The level of ENPP1 in dialysis patients was (7.68 ± 1.67) ng/ml. There was no significant difference in serum ENPP1 level between peritoneal dialysis patients and hemodialysis patients (p > 0.05). The AACS of dialysis patients was negatively correlated with ENPP1 value (r = -0.70). Compared to no/mild calcification patients, the levels of serum ENPP1 in patients with moderate/severe calcification were decreased significantly (p < 0.01). The severity of vascular calcification was correlated with serum ENPP1 value, the severer the vascular calcification, the lower the serum ENPP1 level, and the difference was statistically significant (all p < 0.05). The area under ROC curve of ENPP1 was 0.90, the corresponding sensitivity was 0.86, and the specificity was 0.87.

Conclusion: Levels of serum ENPP1 in non-diabetic ESRD patients are negatively related to the severity of abdominal aortic vascular calcification.
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http://dx.doi.org/10.1111/hdi.12969DOI Listing
July 2021

PDGFR-β fibroblasts deteriorate survival in human solid tumors: a meta-analysis.

Aging (Albany NY) 2021 05 3;13(10):13693-13707. Epub 2021 May 3.

Department of General Surgery III, Affiliated Hospital of Shaoxing University, Zhejiang 312000, China.

Fibroblasts are a highly heterogeneous population in tumor microenvironment. PDGFR-β fibroblasts, a subpopulation of activated fibroblasts, have proven to correlate with cancer progression through multiple of mechanisms including inducing angiogenesis and immune evasion. However, the prognostic role of these cells in solid tumors is still not conclusive. Herein, we carried out a meta-analysis including 24 published studies with 6752 patients searched from PubMed, Embase and EBSCO to better comprehend the value of such subpopulation in prognosis prediction for solid tumors. We noted that elevated density of intratumoral PDGFR-β fibroblasts was remarkably associated with worse overall survival (OS) and disease-free survival (DFS) of patients. In subgroup analyses, the data showed that PDGFR-β fibroblast infiltration considerably decreased OS in non-small cell lung cancer (NSCLC), breast and pancreatic cancer, and reduced DFS in breast cancer. In addition, increased number of PDGFR-β fibroblasts appreciably correlated with advanced TNM stage of patients. In conclusion, PDGFR-β fibroblast infiltration deteriorates survival in human solid tumors especially in NSCLC, breast and pancreatic cancer. Hence, they may offer a practicable prognostic biomarker and a potential therapeutic strategy for these patients.
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http://dx.doi.org/10.18632/aging.202952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202854PMC
May 2021

RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling.

J Cell Biol 2021 05;220(5)

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cargo sorting and the subsequent membrane carrier formation require a properly organized endosomal actin network. To better understand the actin dynamics during endocytic recycling, we performed a genetic screen in C. elegans and identified RTKN-1/Rhotekin as a requisite to sustain endosome-associated actin integrity. Loss of RTKN-1 led to a prominent decrease in actin structures and basolateral recycling defects. Furthermore, we showed that the presence of RTKN-1 thwarts the actin disassembly competence of UNC-60A/cofilin. Consistently, in RTKN-1-deficient cells, UNC-60A knockdown replenished actin structures and alleviated the recycling defects. Notably, an intramolecular interaction within RTKN-1 could mediate the formation of oligomers. Overexpression of an RTKN-1 mutant form that lacks self-binding capacity failed to restore actin structures and recycling flow in rtkn-1 mutants. Finally, we demonstrated that SDPN-1/Syndapin acts to direct the recycling endosomal dwelling of RTKN-1 and promotes actin integrity there. Taken together, these findings consolidated the role of SDPN-1 in organizing the endosomal actin network architecture and introduced RTKN-1 as a novel regulatory protein involved in this process.
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http://dx.doi.org/10.1083/jcb.202007149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047894PMC
May 2021

An open protocol for evaluating the accuracy of guided implant surgery by using digital casts.

J Prosthet Dent 2020 Oct 15. Epub 2020 Oct 15.

Professor, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, PR China. Electronic address:

An open protocol is described for the evaluation of implant deviation by using digital casts. A digital surgical planning cast and a definitive cast are imported into a reverse engineering software program, and cylinders are created as simplifications of the implants. After superimposing the digital casts, implant deviations can be calculated by using the coordinates of the cylinders. This protocol only requires routine clinical data from the guided implant surgery and digital prosthodontic workflow; it can therefore be easily embedded into the clinical procedure. Any dental software program providing access to implant coordinates can be integrated with this protocol to overcome the shortcomings of various closed-loop workflows used by dental software programs.
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http://dx.doi.org/10.1016/j.prosdent.2020.05.039DOI Listing
October 2020

LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes.

Cell Rep 2020 09;32(12):108173

Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 Hubei, China. Electronic address:

To explore the mechanism of Rab5/RAB-5 activation during endocytic recycling, we perform a genome-wide RNAi screen and identify a recycling regulator, LET-502/ROCK. LET-502 preferentially interacts with RAB-5(GDP) and activates RABX-5 GEF activity toward RAB-5, presumably by disrupting the self-inhibiting conformation of RABX-5. Furthermore, we find that the concomitant loss of LET-502 and another CED-10 effector, TBC-2/RAB-5-GAP, results in an endosomal buildup of RAB-5, indicating that CED-10 directs TBC-2-mediated RAB-5 inactivation and re-activates RAB-5 via LET-502 afterward. Then, we compare the functional position of LET-502 with that of RME-6/RAB-5-GEF. Loss of LET-502-RABX-5 module or RME-6 leads to diminished RAB-5 presence in spatially distinct endosome groups. We conclude that in the intestine of C. elegans, RAB-5 resides in discrete endosome subpopulations. Under the oversight of CED-10, LET-502 synergizes with RABX-5 to revitalize RAB-5 on a subset of endosomes in the deep cytosol, ensuring the progress of basolateral recycling.
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http://dx.doi.org/10.1016/j.celrep.2020.108173DOI Listing
September 2020

An IL6-Adenosine Positive Feedback Loop between CD73 γδTregs and CAFs Promotes Tumor Progression in Human Breast Cancer.

Cancer Immunol Res 2020 10 27;8(10):1273-1286. Epub 2020 Jul 27.

Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), Zhejiang University, Hangzhou, China.

The tumor microenvironment induces immunosuppression via recruiting and expanding suppressive immune cells such as regulatory T cells (Treg) to promote cancer progression. In this study, we documented that tumor-infiltrating CD73 γδTregs were the predominant Tregs in human breast cancer and exerted more potent immunosuppressive activity than CD4 or CD8 Tregs. We further demonstrated that cancer-associated fibroblast (CAF)-derived IL6, rather than TGFβ1, induced CD73 γδTreg differentiation from paired normal breast tissues via the IL6/STAT3 pathway to produce more adenosine and become potent immunosuppressive T cells. CD73 γδTregs could in turn promote IL6 secretion by CAFs through adenosine/A2BRp38MAPK signaling, thereby forming an IL6-adenosine positive feedback loop. CD73 γδTreg infiltration also impaired the tumoricidal functions of CD8 T cells and significantly correlated with worse prognosis of patients. The data indicate that the IL6-adenosine loop between CD73 γδTregs and CAFs is important to promote immunosuppression and tumor progression in human breast cancer, which may be critical for tumor immunotherapy.
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http://dx.doi.org/10.1158/2326-6066.CIR-19-0923DOI Listing
October 2020

Preliminary clinical evaluation of traditional and a new digital PEEK occlusal splints for the management of sleep bruxism.

J Oral Rehabil 2020 Dec 28;47(12):1530-1537. Epub 2020 Oct 28.

Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.

Objective: To compare the manual time and preliminary clinical effects between the digital manufactured occlusal splints for sleep bruxism patients with those of traditional hard splints.

Methods: Sixteen individuals (18 to 44 y/o) with clinically diagnosed sleep bruxism were selected based on the inclusion criteria. All patients were divided into two groups, and a random control method was applied. Digital splints (test group) were designed and milled using CAD/CAM. Hard splints (control group) were made of transparent acrylic resin in laboratory office. The manual time spent including impression obtaining, splint production and clinical occlusal adjustment was recorded. A visual analog scale was used to report the subjective evaluations. The maximum depth loss and volumetric loss of the occlusal surface of splints in posterior tooth were measured. SPSS software was used for statistical analysis (P = .05).

Results: Comparing with control group, the manual time spent in test group was significantly less in all of three procedures (P < .001). The VAS scores for retention were not significantly different (P = .086), but the wearing comfort scores of test group were significantly higher (P < .001). Both maximum depth loss (P = .007) and volumetric loss in test group were significantly less than control group (P = .005).

Conclusion: In the current study, the digitally manufactured splints exhibit significantly improved comfort and time efficiency than traditional hard splints. Moreover, the new milling material (PEEK) has better wear resistance than acrylic resins.
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http://dx.doi.org/10.1111/joor.13083DOI Listing
December 2020

Cellular immunotherapy plus chemotherapy ameliorates survival in gastric cancer patients: a meta-analysis.

Int J Clin Oncol 2020 Oct 30;25(10):1747-1756. Epub 2020 Jul 30.

Department of General Surgery (Breast and Thyroid Surgery), Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, 568 Zhongxing Road, Shaoxing, 312000, Zhejiang, China.

The efficacy of cellular immunotherapy plus chemotherapy in treatment of gastric cancer (GC) remains inconsistent even controversial. Hence, we performed a meta-analysis to better comprehend the clinical value of cellular immunotherapy plus chemotherapy for GC patients. We searched PubMed, Embase and EBSCO databases to identify the studies evaluating the association of cellular immunotherapy plus chemotherapy and overall survival (OS) and/or disease-free survival (DFS) in patients with GC, and then combined relevant data into hazard ratios (HRs) for OS, DFS and clinicopathological features such as TNM stage, etc. with STATA 12.0. Eleven studies with 1244 patients were included in this meta-analysis. We found that cellular immunotherapy plus chemotherapy remarkably improved overall survival (OS) and diseases-free survival (DFS) as compared to the chemotherapy for GC patients. In subgroup analyses, pooled data showed that the combined therapy was significantly associated with better 3-year and 5-year survival rate, but not with 1-year survival rate of patients; the application of cellular immunotherapy based on either CIK or DC-CIK cells could enhance survival as well as NK, γδT and CIK cells-based immunotherapy. More importantly, the addition of cellular immunotherapy considerably improved OS and DFS only in patients with stage III rather than stage II. In addition, we also discovered that the combined therapy did not cause intolerable side effects to patients. Cellular immunotherapy plus chemotherapy ameliorates survival in GC, especially in patients with stage III, implicating that it is a valuable therapeutic strategy for these patients.
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http://dx.doi.org/10.1007/s10147-020-01750-6DOI Listing
October 2020

Validation of a novel swine model for training in EUS-FNA (with videos).

Endosc Ultrasound 2020 Jul-Aug;9(4):232-237

Department of Gastroenterology, Changhai Hospital, Navy Medical University, Shanghai, China.

Background And Objectives: EUS-FNA is applied widely in clinical practice, but there remains a lack of authentic training models. The present study aimed to develop a novel swine training model and to perform a preliminary assessment of its feasibility and efficacy.

Materials And Methods: To create an internal lesion-like target, empty shells of iodine-125 seeds were implanted into the caudate lobe of the liver in Bama minipigs. A training program involving 10 trainees was subsequently carried out, in which a total of 60 needlings were performed, composed of 6 for each trainee obtained during two training steps. Comparisons of procedure-related variables were conducted between the two. Trainees completed a questionnaire to assess their basic endoscopic experiences and reasonability of the model.

Results: A target region of 2.0 cm × 2.0 cm in diameter was successfully established on the caudate lobe in all implanted pigs. In the training program, the average procedure time decreased from the first to the second step and the average time for the total 30 needlings' obtainment was significantly shorter for the second training step (23.8 ± 4.5 min vs. 40.9 ± 9.0 min, P < 0.001). For the second step, there was also a significant improvement in total success rate (86.7% vs. 56.7%, P = 0.020) and accuracy rate (76.7% vs. 43.3%, P = 0.017). All trainees scored the effectiveness of the model highly and all reported improved confidence after the training.

Conclusion: This novel swine training model could authentically mimic clinical EUS-FNA, providing an effective in vivo practice tool for novices before clinical practice.
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http://dx.doi.org/10.4103/eus.eus_13_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529007PMC
July 2020

Heart sound classification based on improved MFCC features and convolutional recurrent neural networks.

Neural Netw 2020 Oct 23;130:22-32. Epub 2020 Jun 23.

Center of Preventive Disease, The People's Hospital of Yangjiang, Yangjiang, China. Electronic address:

Heart sound classification plays a vital role in the early detection of cardiovascular disorders, especially for small primary health care clinics. Despite that much progress has been made for heart sound classification in recent years, most of them are based on conventional segmented features and shallow structure based classifiers. These conventional acoustic representation and classification methods may be insufficient in characterizing heart sound, and generally suffer from a degraded performance due to the complicated and changeable cardiac acoustic environment. In this paper, we propose a new heart sound classification method based on improved Mel-frequency cepstrum coefficient (MFCC) features and convolutional recurrent neural networks. The Mel-frequency cepstrums are firstly calculated without dividing the heart sound signal. A new improved feature extraction scheme based on MFCC is proposed to elaborate the dynamic characteristics among consecutive heart sound signals. Finally, the MFCC-based features are fed to a deep convolutional and recurrent neural network (CRNN) for feature learning and later classification task. The proposed deep learning framework can take advantage of the encoded local characteristics extracted from the convolutional neural network (CNN) and the long-term dependencies captured by the recurrent neural network (RNN). Comprehensive studies on the performance of different network parameters and different network connection strategies are presented in this paper. Performance comparisons with state-of-the-art algorithms are given for discussions. Experiments show that, for the two-class classification problem (pathological or non-pathological), a classification accuracy of 98% has been achieved on the 2016 PhysioNet/CinC Challenge database.
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http://dx.doi.org/10.1016/j.neunet.2020.06.015DOI Listing
October 2020

Determining the Topic Evolution and Sentiment Polarity for Albinism in a Chinese Online Health Community: Machine Learning and Social Network Analysis.

JMIR Med Inform 2020 May 29;8(5):e17813. Epub 2020 May 29.

School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Background: There are more than 6000 rare diseases in existence today, with the number of patients with these conditions rapidly increasing. Most research to date has focused on the diagnosis, treatment, and development of orphan drugs, while few studies have examined the topics and emotions expressed by patients living with rare diseases on social media platforms, especially in online health communities (OHCs).

Objective: This study aimed to determine the topic categorizations and sentiment polarity for albinism in a Chinese OHC, Baidu Tieba, using multiple methods. The OHC was deeply mined using topic mining, social network analysis, and sentiment polarity analysis. Through these methods, we determined the current situation of community construction, identifying the ongoing needs and problems experienced by people with albinism in their daily lives.

Methods: We used the albinism community on the Baidu Tieba platform as the data source in this study. Term frequency-inverse document frequency, latent dirichlet allocation models, and naive Bayes were employed to mine the various topic categories. Social network analysis, which was completed using the Gephi tool, was employed to analyze the evolution of the albinism community. Sentiment polarity analysis was performed using a long short-term memory algorithm.

Results: We identified 8 main topics discussed in the community: daily sharing, family, interpersonal communication, social life and security, medical care, occupation and education, beauty, and self-care. Among these topics, daily sharing represented the largest proportion of the discussions. From 2012 to 2019, the average degree and clustering coefficient of the albinism community continued to decline, while the network center transferred from core communities to core users. A total of 68.43% of the corpus was emotional, with 35.88% being positive and 32.55% negative. There were statistically significant differences in the distribution of sentiment polarity between topics (P<.001). Negative emotions were twice as high as positive emotions in the social life and security topic.

Conclusions: The study reveals insights into the emotions expressed by people with albinism in the Chinese OHC, Baidu Tieba, providing health care practitioners with greater appreciation of the current emotional support needed by patients and the patient experience. Current OHCs do not exert enough influence due to limited effective organization and development. Health care sectors should take greater advantage of OHCs to support vulnerable patients with rare diseases to meet their evidence-based needs.
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http://dx.doi.org/10.2196/17813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293058PMC
May 2020

Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis.

BMC Cancer 2020 May 20;20(1):454. Epub 2020 May 20.

Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TATE) in human cancers remains controversial. Therefore, we conducted this meta-analysis to better comprehend the association between TATE and clinical outcomes of patients.

Methods: We searched PubMed, Embase and EBSCO to determine the researches assessing the association between TATE and overall survival (OS) and/or disease-free survival (DFS) in patients with cancer, then combined relevant data into hazard ratios (HRs) or odds ratio (OR) for OS, DFS and clinicopathological features including lymph node metastasis etc. with STATA 12.0.

Results: Twenty six researches with 6384 patients were included in this meta-analysis. We found that the presence of TATE was significantly associated with improved OS, but not with DFS in all types of cancers. In stratified analyses based on cancer types, pooled results manifested that the infiltration of eosinophils was remarkably associated with better OS in esophageal carcinoma and colorectal cancer. In addition, TATE significantly inversely correlated with lymph node metastasis, tumor stage and lymphatic invasion of cancer.

Conclusion: TATE promotes survival in cancer patients, suggesting that it is a valuable prognostic biomarker and clinical application of biological response modifiers or agonists promoting TATE may be the novel therapeutic strategy for patients.
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http://dx.doi.org/10.1186/s12885-020-06966-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240929PMC
May 2020

Extrinsic Ion Distribution Induced Field Effect in CsPbIBr Perovskite Solar Cells.

Small 2020 Apr 6;16(17):e1907283. Epub 2020 Apr 6.

Dalian National Laboratory for Clean Energy, iChEM, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, P. R. China.

Excellent power conversion efficiency (PCE) and stability are the primary forces that propel the all-inorganic cesium-based halide perovskite solar cells (PSCs) toward commercialization. However, the intrinsic high density of trap state and internal nonradiative recombination of CsPbIBr perovskite film are the barriers that limit its development. In the present study, a facile additive strategy is introduced to fabricate highly efficient CsPbIBr PSCs by incorporating sulfamic acid sodium salt (SAS) into the perovskite layer. The additive can control the crystallization behaviors and optimize morphology, as well as effectively passivate defects in the bulk perovskite film, thereby resulting in a high-quality perovskite. In addition, SAS in perovskite has possibly introduced an additional internal electric field effect that favors electron transport and injection due to inhomogeneous ion distribution. A champion PCE of 10.57% (steady-output efficiency is 9.99%) is achieved under 1 Sun illumination, which surpasses that of the contrast sample by 16.84%. The modified perovskite film also exhibits improved moisture stability. The unencapsulated device maintains over 80% initial PCE after aging for 198 h in air. The results provide a suitable additive for inorganic perovskite and introduce a new conjecture to explain the function of additives in PSCs more rationally.
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http://dx.doi.org/10.1002/smll.201907283DOI Listing
April 2020

Lola regulates adult midgut homeostasis via non-canonical hippo signaling.

Elife 2020 01 14;9. Epub 2020 Jan 14.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Tissue homeostasis and regeneration in the midgut is regulated by a diverse array of signaling pathways including the Hippo pathway. Hippo signaling restricts intestinal stem cell (ISC) proliferation by sequestering the transcription co-factor Yorkie (Yki) in the cytoplasm, a factor required for rapid ISC proliferation under injury-induced regeneration. Nonetheless, the mechanism of Hippo-mediated midgut homeostasis and whether canonical Hippo signaling is involved in ISC basal proliferation are less characterized. Here we identify Lola as a transcription factor acting downstream of Hippo signaling to restrict ISC proliferation in a Yki-independent manner. Not only that Lola interacts with and is stabilized by the Hippo signaling core kinase Warts (Wts), Lola rescues the enhanced ISC proliferation upon Wts depletion via suppressing and expressions. Our findings reveal that Lola is a non-canonical Hippo signaling component in regulating midgut homeostasis, providing insights on the mechanism of tissue maintenance and intestinal function.
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http://dx.doi.org/10.7554/eLife.47542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299341PMC
January 2020

The development of a 3D colour reproduction system of digital impressions with an intraoral scanner and a 3D printer: a preliminary study.

Sci Rep 2019 12 27;9(1):20052. Epub 2019 Dec 27.

Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.

This study aimed to develop a three-dimensional (3D) colour reproduction system to improve the aesthetic effects of dental prostheses. The system's colour accuracy was also evaluated. Based on the concept of colour management, 96 colour patches were selected to develop colour profiles for an intraoral scanner and a 3D printer using polynomial regression. The colour differences Δ[Formula: see text] between colour patches reproduced using different colour profiles and the original colour patches were analysed to select the best combinations of colour profiles. The 3D colour reproduction system with the best-performing (i.e. third-order polynomial regression) colour profiles was finally evaluated using tooth and gum shades. The median Δ[Formula: see text] was 6.940 ranging from 1.504 to 32.660. In terms of tooth and gum shade, the median Δ[Formula: see text] was 6.313, and half of the shade blocks were above the mismatch threshold (Δ[Formula: see text] > 6.80). In conclusion, the colour management based on polynomial regression can decrease the colour difference of the 3D colour reproduction system, but not to clinically acceptable levels. Further advances are needed to improve the methods and hardware.
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http://dx.doi.org/10.1038/s41598-019-56624-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934843PMC
December 2019

Preliminary Clinical Application of Complete Workflow of Digitally Designed and Manufactured Sports Mouthguards.

Int J Prosthodont 2020 Jan/Feb;33(1):99-104

Purpose: To establish a complete digital workflow for the design and manufacture of sports mouthguards and to observe preliminary clinical effects.

Materials And Methods: Eighteen healthy participants were included in this study. The self-controlled method was applied, and all participants were provided with two types of mouthguards. Digital mouthguards were designed and milled using CAD/CAM with polyetheretherketone, and conventional mouthguards were fabricated using the vacuum pressure-forming method with ethylene vinyl acetate. The order of wearing was determined using a random number table, and the washout period between was set as 1 month. Degrees of satisfaction in terms of retention, appearance, occlusal comfort, and labial comfort were evaluated. Distribution of occlusal force was tested using the T-scan analysis system. Participants were also asked to choose one mouthguard for future use.

Results: The complete workflow of digitally designed and manufactured sports mouthguards was successfully established. No significant difference was noted in retention between the types of mouthguard. The appearance score (P = .025), occlusal comfort score (P = .030), and labial side comfort score (P = .003) of the digital mouthguard group were significantly higher compared to the conventional mouthguard group. T-scan analysis results showed that in centric occlusion, participants exhibited occlusal contact in the second molar alone while wearing conventional mouthguards, while the occlusal force was uniformly distributed with digital mouthguards. Sixteen participants selected the digital mouthguard for future use.

Conclusion: Digital design and manufacture of sports mouthguards improved the occlusal design and greatly simplified and optimized the conventional fabrication process.
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http://dx.doi.org/10.11607/ijp.6348DOI Listing
December 2019

Understanding the Function Constitution and Influence Factors on Communication for the WeChat Official Account of Top Tertiary Hospitals in China: Cross-Sectional Study.

J Med Internet Res 2019 12 9;21(12):e13025. Epub 2019 Dec 9.

School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Background: Widespread adoption and continued developments in mobile health care technologies have led to the improved accessibility and quality of medical services. In China, WeChat, an instant messaging and social networking app released by the company Tencent, has developed a specific type of user account called WeChat official account (WOA), which is now widely adopted by hospitals in China. It enables health care providers to connect with local citizens, allowing them to, among other actions, send regular updates through mass circulation. However, with the diversity in function provided by WOA, little is known about its major constitution as well as the influence factors on the WeChat communication index (WCI). The WCI has been widely used in social media impact ranking with various types of WeChat content to fully reflect the dissemination and coverage of tweets as well as the maturity and impact of WOA.

Objective: There are two typical WOAs available to users, namely, WeChat subscription account (WSSA) and WeChat service account (WSVA). The biggest difference between them is the frequency of messages transmitted. This study aimed to explore the function constitution of WSVA adopted by top tertiary hospitals in China and the major contributors of the WCI score.

Methods: A total of 681 top tertiary hospitals were selected from the Hospital Quality Monitoring System; the WOA of every top tertiary hospital was retrieved in the WeChat app. We divided core functional items of WSVAs using categorical principal component analysis. To elicit the factors that influenced the use of WSVA, quantile regression was employed to analyze the WCI score.

Results: From the 668 WOAs identified, adoption of WSVAs (543/668, 81.3%) was more than that of WSSAs (125/668, 18.7%). Functional items of WSVAs were categorized into four clusters: (1) hospital introduction, (2) medical services, (3) visiting assistants, and (4) others. With regard to the influence factors on the WCI, the impact of the activity index of WSVA and the total visiting number of outpatients and emergencies on WCI were statistically significant and positive in all quantiles. However, the year of certification, the type of hospital, the year of public hospital reform, and the number of beds merely affected the WCI at some quantiles.

Conclusions: Our findings are considered helpful to tertiary hospitals in developing in-depth functional items that improve patient experience. The tertiary hospitals should take full advantage of times of posting and provide high-quality tweets to meet the various needs of patients.
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http://dx.doi.org/10.2196/13025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928700PMC
December 2019

Novel Quasi-Solid-State Electrolytes based on Electrospun Poly(vinylidene fluoride) Fiber Membranes for Highly Efficient and Stable Dye-Sensitized Solar Cells.

Nanomaterials (Basel) 2019 May 22;9(5). Epub 2019 May 22.

College of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000, China.

To obtain new highly efficient and stable quasi-solid dye-sensitized solar cells (QS-DSSCs) that can meet the requirements for the large-scale commercial application of solar cells, we have developed a novel quasi-solid-state electrolyte, based on an electrospun polyvinylidene fluoride (PVDF) membrane. The structure and properties of electrospun PVDF membranes were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), thermogravimetric (TG), and mechanical testing. The results indicate that the electrospun PVDF membrane has a three-dimensional network structure with extremely high porosity, which not only acts as a barrier to prevent electrolyte leakage but also provides a channel for the transmission of ions in the electrolyte, thereby effectively guaranteeing the high photoelectric conversion efficiency of the cells. The membrane was observed to withstand the conditions of hot-press (110 °C), and exhibited good thermal stability and mechanical strength, which are critical for the long-term stability and safety of the cells. The photovoltaic characteristics and stabilities of QS-DSSCs were compared with DSSCs based on an ionic liquid electrolyte (L-DSSC). QS-DSSCs with an 80 μm thick nanofiber electrolyte membrane showed a conversion efficiency of 8.63%, whereas an identical cell based on the corresponding ionic liquid electrolyte showed an efficiency of 9.30%. The stability test showed that, under indoor and outdoor conditions, after 390 h, the L-DSSCs failed. Meanwhile, the QS-DSSCs also maintained 84% and 77% of the original efficiency. The results show that, compared to the liquid electrolyte, the design of the quasi-solid electrolytes based on electrospun PVDF nanofiber membrane not only demonstrates the high conversion efficiency of DSSCs but also enhances the stability of the DSSCs, which provides the possibility for the fabrication of solar cells with higher efficiency and stability.
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http://dx.doi.org/10.3390/nano9050783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567040PMC
May 2019

Detecting the Interdisciplinary Nature and Topic Hotspots of Robotics in Surgery: Social Network Analysis and Bibliometric Study.

J Med Internet Res 2019 03 26;21(3):e12625. Epub 2019 Mar 26.

School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Background: With the widespread application of a robot to surgery, growing literature related to robotics in surgery (RS) documents widespread concerns from scientific researchers worldwide. Although such application is helpful to considerably improve the accuracy of surgery, we still lack the understanding of the multidiscipline-crossing status and topic distribution related to RS.

Objective: The aim of this study was to detect the interdisciplinary nature and topic hotspots on RS by analyzing the current publication outputs related to RS.

Methods: The authors collected publications related to RS in the last 21 years, indexed by the Web of Science Core Collection. Various bibliometric methods and tools were used, including literature distribution analysis at the country and institution level and interdisciplinary collaboration analysis in the different periods of time. Co-word analysis was performed based on the keywords with high frequency. The temporal visualization bar presented the evolution of topics over time.

Results: A total of 7732 bibliographic records related to RS were identified. The United States plays a leading role in the publication output related to RS, followed by Italy and Germany. It should be noted that the Yonsei University in South Korea published the highest number of RS-related publications. Furthermore, the interdisciplinary collaboration is uneven; the number of disciplines involved in each paper dropped from the initial 1.60 to the current 1.31. Surgery; Engineering; Radiology, Nuclear Medicine, and Medical Imaging; and Neurosciences and Neurology are the 4 core disciplines in the field of RS, all of which have extensive cooperation with other disciplines. The distribution of topic hotspots is in imbalanced status, which can be categorized into 7 clusters. Moreover, 3 areas about the evolution of topic were identified, namely (1) the exploration of techniques that make RS implemented, (2) rapid development of robotic systems and related applications in surgery, and (3) application of a robot to excision of tissues or organs targeted at various specific diseases.

Conclusions: This study provided important insights into the interdisciplinary nature related to RS, which indicates that the researchers with different disciplinary backgrounds should strengthen cooperation to publish a high-quality output. The research topic hotspots related to RS are relatively scattered, which has begun to turn to the application of RS targeted at specific diseases. Our study is helpful to provide a potential guide to the direction of the field of RS for future research in the field of RS.
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http://dx.doi.org/10.2196/12625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454338PMC
March 2019

The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

World J Urol 2019 Sep 3;37(9):1817-1825. Epub 2018 Dec 3.

Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains controversial. Hence, we performed this meta-analysis to better understand the role of preoperative circulating NLR in prognosis prediction for primary BC patients undergoing RC.

Methods: We searched PubMed, Embase and EBSCO to identify the studies and computed extracted data with STATA 12.0.

Results: A total of 11,945 patients with BC from 18 published studies were incorporated into this meta-analysis. We found that elevated NLR was significantly associated with decreased 3-year and 5-year overall survival (OS), 1-year, 3-year and 5-year recurrence-free survival (RFS), but not with 1-year or 10-year OS, or 10-year RFS in primary BC patients who underwent RC. The results also showed that neoadjuvant chemotherapy (NAC) had a significant impact on the negative prognostic effect of NLR. In addition, high NLR significantly correlated with unfavorable clinicopathological features of BC.

Conclusion: Elevated preoperative circulating NLR leads to an unfavorable outcome in primary BC undergoing RC, especially in patients without NAC, implicating that it might be a valuable prognostic index for these patients.
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http://dx.doi.org/10.1007/s00345-018-2593-zDOI Listing
September 2019

Adaptive Leader-Following Consensus for Multiple Euler-Lagrange Systems With an Uncertain Leader System.

IEEE Trans Neural Netw Learn Syst 2019 Jul 22;30(7):2188-2196. Epub 2018 Nov 22.

In this paper, we study the leader-following consensus problem of multiple Euler-Lagrange (EL) systems subject to an uncertain leader system. We first establish an adaptive distributed observer for a neutrally stable linear leader system whose system matrix is not known exactly. Under standard assumptions, this adaptive distributed observer can estimate and pass the leader's state to each follower through the communication network of the system without knowing the leader's system matrix exactly. Under the additional assumption that the leader's state is persistently exciting, this adaptive distributed observer can also asymptotically learn the parameters of the leader's system matrix. On the basis of this adaptive distributed observer, we further synthesize an adaptive distributed control law to solve our problem via the certainty equivalence principle. Our result allows the leader-following consensus problem of multiple EL systems to be solved even if none of the followers knows the system matrix of the leader system exactly.
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http://dx.doi.org/10.1109/TNNLS.2018.2878463DOI Listing
July 2019

Tumor-Infiltrating Podoplanin+ Fibroblasts Predict Worse Outcome in Solid Tumors.

Cell Physiol Biochem 2018 26;51(3):1041-1050. Epub 2018 Nov 26.

Department of Surgical Oncology, Shaoxing Second Hospital, Zhejiang,

Background/aims: Tumor-infiltrating fibroblasts are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. However, the prognostic role of podoplanin+ fibroblasts in human solid tumors still remains controversial. Therefore, we performed the meta-analysis to better understand the role of this subpopulation in prognosis prediction for patients with solid tumor.

Methods: We searched PubMed and EBSCO to identify the studies evaluating the association of intratumoral podoplanin+ fibroblast density detected by immunohistochemical method and overall survival (OS) and/or disease-free survival (DFS) in patients with solid tumor, then computed extracted data into hazard ratios for OS, DFS and clinicopathological features with STATA 12.0.

Results: A total of 4883 patients from 29 published studies were incorporated into this meta-analysis. We found that podoplanin+ fibroblast infiltration significantly decreased OS and DFS in all types of solid tumors. In stratified analyses, podoplanin+ fibroblast infiltration was significantly associated with worse OS in cholangiocarcinoma, breast, lung and pancreatic cancer. And these cells were inversely associated with DFS in breast, lung and pancreatic cancer. In addition, high density of these cells significantly correlated with unfavorable clinicopathological features such as lymph node metastasis, TNM stage, lymphatic and vascular invasion of solid tumor.

Conclusion: Podoplanin+ fibroblast infiltration leads to worse clinical outcome in solid tumors, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.
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http://dx.doi.org/10.1159/000495484DOI Listing
January 2019

Synergic effects of upconversion nanoparticles NaYbF:Ho and ZrO enhanced the efficiency in hole-conductor-free perovskite solar cells.

Nanoscale 2018 Nov;10(46):22003-22011

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062, PR China.

Extending the spectral absorption of organic-inorganic mixed-cation perovskite solar cells (PSCs) from visible light to the near-infrared (NIR) range minimizes the nonabsorption loss of solar photons. Few studies have focused on the application of high-fluorescence NaYbF4:Ho3+ upconversion nanoparticles (UCNPs) in solar cells. In this study, NaYbF4:Ho3+ UCNPs were successfully prepared using a solvothermal method. We incorporated the NaYbF4:Ho3+ UCNPs into ZrO2 as the scaffold layer for FA0.4MA0.6PbI3 perovskite solar cells. This design enabled the dual-functional effects, that is, the harvesting of NIR light and its conversion to visible light and the reduction of the electron-hole recombination rate. The effect of different amounts of NaYbF4:Ho3+ UCNPs on the device performance was investigated in detail. The best-performance devices based on optimized addition of UCNPs (40 wt%) could achieve a power conversion efficiency as high as 14.32%, an increase of 28.8% compared with conventional ZrO2 nanoparticle-based PSCs (11.12%). The design of the synergetic operation of UCNPs and ZrO2 in the mesoporous structure of PSCs enhanced the photocurrent and photovoltage. The results offered the flexibility for the device architecture and broaden the solar spectral use of UCNP-based devices.
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http://dx.doi.org/10.1039/c8nr07225fDOI Listing
November 2018

Activated Tumor-infiltrating Fibroblasts Predict Worse Prognosis in Breast Cancer Patients.

J Cancer 2018 8;9(20):3736-3742. Epub 2018 Sep 8.

Department of General Surgery (Breast and Thyroid Surgery), Shaoxing People's Hospital; Shaoxing Hospital, Zhejiang University School of Medicine, 312000, Zhejiang, China.

Activated tumor-infiltrating fibroblasts were significantly associated with survival of cancer patients. However, they are heterogeneous population, and the prognostic role of these cells in human breast cancer still remains controversial. Herein, we performed the meta-analysis to better understand the role of these cells in prognosis prediction for breast cancer patients. We searched PubMed and EBSCO to identify the studies evaluating the association of intratumoral activated fibroblast density detected by immunohistochemical (IHC) method and overall survival (OS) and/or disease-free survival (DFS) in breast cancer patients, then computed extracted data into hazard ratios (HRs) for OS, DFS and clinicopathological features such as lymph node metastasis, TNM stage with STATA 12.0. A total of 3680 patients with breast cancer from 15 published studies were incorporated into this meta-analysis. We found that the infiltration of activated fibroblasts significantly decreased overall survival (OS) and disease-free survival (DFS) in patients. In stratified analyses, high density of FSP-1 or podoplanin fibroblasts was significantly associated with worse OS; while α-SMA or podoplanin fibroblast infiltration was associated with worse DFS in breast cancer. In addition, elevated number of activated tumor-infiltrating fibroblasts significantly correlated with lymph node metastasis and poor tumor differentiation of patients. The infiltration of activated fibroblasts, especially the FSP-1 or podoplanin fibroblasts leads to worse clinical outcome in breast cancer patients, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.
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http://dx.doi.org/10.7150/jca.28054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216016PMC
September 2018

Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients.

Onco Targets Ther 2018 10;11:5607-5619. Epub 2018 Sep 10.

Department of General Surgery (Breast and Thyroid Surgery),

Background: Cancer-associated fibroblasts (CAFs) are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. However, the prognostic role of podoplanin-positive CAFs in human lung cancer still remains controversial.

Methods: Herein, we performed a meta-analysis including 12 published studies with 1,802 patients identified from PubMed and EBSCO to assess the prognostic impact of podoplanin-positive CAFs in lung cancer patients.

Results: We found that podoplanin fibroblast infiltration significantly decreased overall survival (OS), disease-free survival (DFS), and progression-free survival in patients. In stratified analyses, podoplanin fibroblast infiltration was significantly associated with worse OS and DFS in both squamous cell carcinoma and adenocarcinoma of lung. In addition, high density of podoplanin-positive CAFs significantly correlated with unfavorable clinicopathological features such as lymph node metastasis, and lymphatic, vascular, and pleural invasion of patients.

Conclusion: Podoplanin fibroblast infiltration leads to worse clinical outcome in lung cancer patients, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.
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http://dx.doi.org/10.2147/OTT.S175566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141120PMC
September 2018

Selection of an anti-solvent for efficient and stable cesium-containing triple cation planar perovskite solar cells.

Nanoscale 2018 Jul;10(25):12141-12148

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Wuhan 430062, PR China.

The perovskite layer is a crucial component influencing high-performance perovskite solar cells (PSCs). In the one-step solution method, anti-solvents are important for obtaining smooth and uniform perovskite active layers. This work explored the effect of various anti-solvents on the preparation of triple cation perovskite active layers. In general, anti-solvents with low dielectric constants, low polarity, and low boiling point are suitable for the preparation of perovskite films. Microstructural and elemental analyses of the perovskite films were systematically conducted by scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The photoelectric properties, carrier transfer, and recombination process in the PSCs were investigated using photocurrent-voltage characteristic curves and electrochemical impedance spectroscopy. Optimum performance was obtained when the anti-solvent was diethyl ether (DEE) and the ratio of the optimum amount of DEE to the volume of the precursor was 1 : 10. Meanwhile, we found that the partial replacement of formamidinium/methylammonium by cesium could increase the stability of the PSCs and enhance the power conversion efficiency from 15.49% to over 17.38%.
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http://dx.doi.org/10.1039/c8nr03580fDOI Listing
July 2018

Process identification of the SCR system of coal-fired power plant for de-NO based on historical operation data.

Environ Technol 2019 Nov 8;40(25):3287-3296. Epub 2018 May 8.

Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University , Nanjing , People's Republic of China.

The selective catalytic reduction (SCR) system, as one principal flue gas treatment method employed for the NO emission control of the coal-fired power plant, is nonlinear and time-varying with great inertia and large time delay. It is difficult for the present SCR control system to achieve satisfactory performance with the traditional feedback and feedforward control strategies. Although some improved control strategies, such as the Smith predictor control and the model predictive control, have been proposed for this issue, a well-matched identification model is essentially required to realize a superior control of the SCR system. Industrial field experiment is an alternative way to identify the SCR system model in the coal-fired power plant. But it undesirably disturbs the operation system and is costly in time and manpower. In this paper, a process identification model of the SCR system is proposed and developed by applying the asymptotic method to the sufficiently excited data, selected from the original historical operation database of a 350 MW coal-fired power plant according to the condition number of the Fisher information matrix. Numerical simulations are carried out based on the practical historical operation data to evaluate the performance of the proposed model. Results show that the proposed model can efficiently achieve the process identification of the SCR system.
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http://dx.doi.org/10.1080/09593330.2018.1470678DOI Listing
November 2019

Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis.

Oncotarget 2018 Jan 22;9(8):8111-8119. Epub 2017 Dec 22.

Department of Nephrology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Zhejiang, China.

The prognostic role of tumor-infiltrating CD57-positive lymphocytes (CD57 lymphocytes) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 26 published studies with 7656 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD57 lymphocytes in human solid tumors. We found that CD57 lymphocyte infiltration significantly improved overall survival (OS) including 1 - year, 3 - year and 5 - year survival, and disease - free survival (DFS) in all types of solid tumors. In stratified analyses, CD57 lymphocyte infiltration was significantly associated with better OS in hepatocellular, esophageal, head and neck carcinoma, non-small cell lung cancer, 5 - year survival in colorectal cancer, and 3 - year and 5 - year survival in gastric cancer, but not with 1 - year survival in gastric cancer, or 1 - year or 3 - year survival in colorectal cancer. In addition, high density of intratumoral CD57 lymphocytes was significantly inversely correlated with lymph node metastasis and TNM stage of solid tumor. In conclusion, CD57 lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a useful biomarker for prognosis and adoptive immunotherapy based on these cells may be a promising choice for treatment.
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http://dx.doi.org/10.18632/oncotarget.23621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814286PMC
January 2018
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