Publications by authors named "Shikha Jaiswal"

16 Publications

  • Page 1 of 1

Effect of mechanical alteration of enamel surface on shear bond strength of different bonding techniques.

J Conserv Dent 2020 Mar-Apr;23(2):141-144. Epub 2020 Nov 5.

Department of Conservative Dentistry and Endodontics, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.

Aim: This study was conducted to evaluate the effect of mechanical alteration of enamel surface on shear bond strength in different bonding techniques.

Materials And Methods: Seventy samples were fabricated and randomly divided into three groups: Group A ( = 30) - prepared enamel surfaces, Group B ( = 30) - unprepared enamel surfaces, and Group C ( = 10) - prepared enamel surfaces + etch and rinse which served as a control group. Group A and Group B were further divided into three subgroups ( = 10), sub-Group A1, B1 (nanohybrid composite + self-etch), sub-Group A2, B2 (self-adhering composite), and A3, B3 (self-adhering composite + self-etch). Teflon ring molds were used to make composite resin cylinders with the specific bonding protocol of each group. Shear bond strength testing was conducted, and data were analyzed.

Results: Mean shear bond strength values were as follows: C> A1> A3>A2>B1> B3> B2.

Conclusions: Prepared enamel surfaces resulted in higher shear bond strength values as compared to unprepared enamel surfaces. Prior application of self-etch agent resulted in higher shear bond strength values of self-adhering composite in prepared and unprepared enamel surfaces.
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http://dx.doi.org/10.4103/JCD.JCD_163_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720762PMC
November 2020

Effect of Different Finishing and Polishing Systems on the Surface Roughness of Resin Composite and Enamel: An Profilometric and Scanning Electron Microscopy Study.

Int J Appl Basic Med Res 2019 Jul-Sep;9(3):154-158

Department of Pedodontics and Preventive Dentistry, Private Practioner, Bathinda, Punjab, India.

Aim: The aim is to compare and evaluate the different finishing and polishing systems for the change in surface roughness of resin composites and enamel.

Materials And Methods: To conduct the study, 30 extracted human maxillary central incisors were selected, decoronated, and molded in self-cure acrylic molds. A box-shaped cavity of dimensions 3 mm × 3 mm × 2 mm was prepared in all the teeth. A nanohybrid composite resin (Filtek Z250) was then used to restore the prepared cavities. Thirty samples were divided into two groups, control group (Group A, = 10) and experimental group (Group B, = 20). The samples in Group A were cured through the Mylar matrix. The experimental group, i.e., Group B was divided into two subgroups, i.e., Subgroup BX, = 10 in which Sof-Lex polishing system was used for polishing the tooth surface and Subgroup BF, = 10 in which Shofu composite polishing system was used. The mean surface roughness (Ra in μm) of the composite restoration as well as for the enamel surface of all the samples before and after polishing was measured with a contact profilometer, and the values were correlated with scanning electron microscopy.

Results: The statistical analysis was carried out using paired -test. The results exhibited a significant decrease in the surface roughness of the resin composite and enamel surface irrespective of the finishing and polishing system used. The mean surface roughness values demonstrated by Mylar matrix was the lowest followed by Sof-Lex polishing system. Shofu polishing system demonstrated the highest surface roughness values.

Conclusion: Finishing and polishing of composite restoration can achieve a surface roughness similar to that of enamel. Involvement of marginal enamel in finishing and polishing procedures carried out for composite restoration results in smoother enamel surface.
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http://dx.doi.org/10.4103/ijabmr.IJABMR_11_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652279PMC
August 2019

Comparison of fluoride ion release and alkalizing potential of a new bulk-fill alkasite.

J Conserv Dent 2019 May-Jun;22(3):296-299

Department of Conservative Dentistry and Endodontics, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.

Aim: This study was conducted to evaluate and compare fluoride ion release by Cention-N (self-cure and light-cure) and conventional glass-ionomer cement (GIC) at different pH and time intervals.

Methodology: Cavities of similar dimensions were prepared in mandibular molars and restored with Cention-N (by self-cure and light-cure techniques) and GIC. Samples were stored in deionized water, and the cumulative fluoride ion release and change in pH were assessed utilizing spectrophotometer and pH meter, respectively, at the end of 7 days, 14 days, and 21 days. The data thus obtained were statistically analyzed.

Results: All the tested materials released fluoride ions in both acidic and neutral pH at all time intervals, and the fluoride ion release was significantly higher (<0.05) in acidic pH as compared to neutral pH except in GIC. All the groups showed a statistically significant increase in pH in acidic medium, whereas no significant increase was observed in neutral medium.

Conclusions: Cention-N (self-cure) has the highest fluoride ion release and alkalizing potential in acidic pH as compared to Cention-N (light-cure) and GIC.
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http://dx.doi.org/10.4103/JCD.JCD_74_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632620PMC
August 2019

Evaluation of marginal sealing ability of self-adhesive flowable composite resin in Class II composite restoration: An study.

J Conserv Dent 2018 Jul-Aug;21(4):363-368

Department of Conservative Dentistry and Endodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.

Aim: The aim of this study is to evaluate the marginal sealing ability of self-adhesive flowable composite resin when used as a liner in Class II composite restoration with and without aging.

Materials And Methods: A total of 120 standardized Class II tooth preparations with gingival margins 1 mm coronal and apical to cementenamel junction (CEJ) were prepared on 60 extracted permanent mandibular molars and were randomly divided into eight equal Groups: Group 1: cavities coronal to CEJ and restored with Dyad flow liner + Herculite ultra, Group 2: same as Group 1 but cavities margins apical to CEJ, Group 5: cavities coronal to CEJ and restored with only Herculite ultra, and Group 6: same as Group 5 but cavities apical to CEJ. Groups 3,4,7,8 were similar to Groups 1,2,5,6, respectively, but were aged for 6 months. After thermocycling, microleakage testing was done using 0.5% basic fuchsin dye.

Result: At cervical level, Group 5 exhibited statistically lower ( = 0.006) microleakage than Group 6, and Group 1 showed lesser microleakage than Group 5 ( = 0.162). Group 2 exhibited significantly less microleakage than Group 6 ( = 0.002). Increased microleakage was observed in aging Groups; however, the difference with nonaging Groups was not statistically significant ( > 0.005).

Conclusion: Margins of the cavity in cementum can be better sealed by placing self-adhesive liner and is not affected by aging.
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http://dx.doi.org/10.4103/JCD.JCD_94_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080182PMC
August 2018

evaluation of the contact angle formed between AH Plus, Hybrid Root Seal and mineral trioxide aggregate Plus sealer with dentin and gutta-percha.

J Conserv Dent 2018 Mar-Apr;21(2):180-183

Department of Conservative and Endodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.

Aim: The purpose of this study was evaluation and comparison of the contact angle of new root canal sealers - Hybrid Root Seal, mineral trioxide aggregate (MTA) Plus, and the conventional AH Plus sealer with dentin and gutta-percha.

Materials And Methods: Two groups (Group D - dentin and Group G - gutta-percha) of 18 samples each were further randomly divided into 3 subgroups based on the type of sealer used, that is, AH Plus, Hybrid Root Seal, and MTA Plus. Contact angle measurement device (Phoenix 300) was used to measure the contact angle of the sealers on both dentin and gutta-percha. The results thus obtained were analyzed using one-way analysis of variance and Student's -test.

Results: MTA Plus recorded significantly higher values of contact angle on both the substrates, that is, dentin and gutta-percha when compared to AH Plus and Hybrid root canal sealer. The lowest value of contact angle in gutta-percha and dentin was shown by Hybrid root canal sealer and AH Plus, respectively.

Conclusion: Both AH Plus and Hybrid Root Seal exhibited lower contact angle values, and hence, better wettability on both dentin and gutta-percha as compared to MTA Plus.
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http://dx.doi.org/10.4103/JCD.JCD_300_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890409PMC
April 2018

Efficacy of Deferasirox as an Oral Iron Chelator in Paediatric Thalassaemia Patients.

J Clin Diagn Res 2017 Feb 1;11(2):FC01-FC03. Epub 2017 Feb 1.

Consultant Diabetologist and Non Invasive Cardiologist, Lifeline Hospital , Raipur, Chhattisgarh, India .

Introduction: Thalassaemia Major patients require frequent blood transfusion leading to iron overload. Excessive iron gets deposited in vital organs and leads to dysfunction of the heart, liver, anterior pituitary, pancreas, and joints. Our body has limited mechanism to excrete iron, so patients with iron overload and its complications need safe and effective iron chelation therapy.

Aim: To assess the efficacy of Deferasirox (DFX) as an iron chelator, with specific reference to reduction in serum ferritin level.

Materials And Methods: This is a prospective; observational study done in 45 multitransfused Thalassaemia Major Children receiving DFX therapy at registered Thalassaemia society Raipur Chhattisgarh. DFX was given in an initial dose of 20 mg/kg/day and according to response increased to a maximum of 40 mg/kg/day. Serum ferritin level was estimated at time of registration and at every three monthly intervals (four times during study period). The primary end point of the study was change in serum ferritin level after 12 months of DFX therapy.

Results: The mean serum ferritin before DFX therapy of all cases was 3727.02 ng/mL. After 12 months of mean dose of 38 mg/kg/day of DFX, the mean decline in serum ferritin was 1207.11 ng/mL (drop by 32.38%, p-value <0.001).

Conclusion: DFX monotherapy has a good safety profile and effectively chelates total body iron in Thalassaemia major patients.
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http://dx.doi.org/10.7860/JCDR/2017/22650.9395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376891PMC
February 2017

CDC Group EO-4 and Candida tropicalis Peritonitis in a Patient on Peritoneal Dialysis after Upper Endoscopy, Colonoscopy and Coil Embolization of the Gastroduodenal Artery.

Case Rep Gastroenterol 2016 Sep-Dec;10(3):728-732. Epub 2016 Nov 25.

Thomas Jefferson University, Philadelphia, PA, USA.

Peritoneal dialysis (PD) is an excellent form of renal replacement therapy for many patients with end-stage renal disease (ESRD). Over 10,000 patients receive PD in the United States [United States Renal Data System: 2015]. PD has superior outcomes compared to hemodialysis in the first 2 years of ESRD [Sinnakirouchenan and Holley: Adv Chronic Kidney Dis 2011;18: 428-432]. However, peritonitis is a known complication and may result in significant morbidity and necessitate transition to hemodialysis, which increases medical costs [Holley and Piraino: Semin Dial 1990;3: 245-248]. We report the first case of a PD patient who underwent endoscopy, colonoscopy and CT angiogram with coil embolization for gastrointestinal bleeding without antibiotic prophylaxis and subsequently developed CDC group EO-4 organism and fungal peritonitis.
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http://dx.doi.org/10.1159/000452201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216208PMC
November 2016

Effect of phytic acid, ethylenediaminetetraacetic acid, and chitosan solutions on microhardness of the human radicular dentin.

J Conserv Dent 2016 Mar-Apr;19(2):179-83

Department of Conservative Dentistry and Endodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.

Aim: The purpose of this study was to evaluate the effect of phytic acid, ethylenediaminetetraacetic acid (EDTA), and chitosan solutions on the microhardness of human radicular dentin.

Materials And Methods: Thirty dentin specimens were randomly divided into three groups of 10 specimens each according to the irrigant used: G1 - 1% phytic acid, G2 - 17% EDTA, and G3 - 0.2% chitosan. A standardized volume of each chelating solution was used for 3 min. Dentin microhardness was measured before and after application at the cervical, middle, and apical levels with a Vickers indenter under a 200-g load and a 10-s dwell time. The results were analyzed using one-way analysis of variance (ANOVA) and Student's t test.

Results: Microhardness of the radicular dentin varied at the cervical, middle, and apical levels. EDTA had the greatest overall effect, causing a sharp percentage reduction in dentin microhardness with a significant difference from phytic acid and chitosan (P = 0.002). However, phytic acid and chitosan differed insignificantly from each other (P = 0.887).

Conclusion: All tested chelating solutions reduced microhardness of the radicular dentin layer at all the levels. However, reduction was least at the apical level. EDTA caused more reduction in dentin microhardness than chitosan while phytic acid reduced the least.
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http://dx.doi.org/10.4103/0972-0707.178705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815550PMC
April 2016

Evaluation of effect of addition of 2% chlorhexidine on the sealing ability of Biodentine: An in vitro study.

J Conserv Dent 2015 Nov-Dec;18(6):479-82

Department of Conservative Dentistry and Endodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.

Aim: To evaluate the effect of the addition of 2% chlorhexidine on the sealing ability of Biodentine.

Materials And Methods: Forty-six extracted human premolar teeth with single canal and apical foramen were selected, cleaned, and decoronated to standardize the length of 17 mm. Canals were prepared using ProTaper rotary files till size F4. The samples were divided into 2 experimental groups of 20 samples each on the basis of absence/presence of 2% chlorhexidine in liquid: Group BM = Biodentine mixed with the provided liquid, Group BC = Biodentine mixed with 2% chlorhexidine in provided liquid. Three samples, each were assigned to control groups: Group BP (positive control) = No root end filling was placed, Group BN (negative control) = Root ends were filled as in Group BM, and entire external surface was coated with sticky wax. The samples were then evaluated for the apical sealing using fluid filtration method.

Results: Results were analyzed using Student's t-test (P ≤ 0.05). Group BC showed the better sealing ability (3.06) as compared to Group BM (3.85). However, the difference was statistically insignificant (P > 0.05).

Conclusion: Addition of 2% chlorhexidine to the liquid enhanced the sealing ability of Biodentine.
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http://dx.doi.org/10.4103/0972-0707.168816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693323PMC
January 2016

Prostate Cancer for the Internist.

N Am J Med Sci 2015 Oct;7(10):429-35

PGY-2, Department of Internal Medicine, West Virginia University, Morgantown, West Virginia, 26505, USA.

In the United States, approximately 240,000 men are diagnosed annually with prostate cancer. Although effective treatment options are available for clinically localized cancer, the potential burdensome co-morbidities and attendant healthcare costs from over diagnosis and over treatment have escalated the discussion and controversy regarding appropriate screening, diagnosis, and optimal management of prostate cancer. Although the lifetime risk of developing prostate cancer is approximately 1 in 6 (~16%), the risk of dying from the disease is only ~2%. The discrepancy between the cancer incidence and lethality has led to widespread scrutiny of prostate cancer patient management, particularly for low-grade, low-stage (indolent) disease. The vast majority of men diagnosed with clinically localized prostate cancer are treated with interventional therapies despite studies demonstrating that even without treatment, prostate cancer-specific mortality is low. A MedLine/PubMed search was performed using PICO format (Patient, Intervention, Comparison and Outcome) identifying all relevant articles. No restrictions were used for publication dates. The terms "Prostate Cancer", "Screening", "Mortality", "Morbidity" yielded 307 results. "Diagnosis", "Prognosis" and "Survival" yielded 1504 results. Further filters were applied to narrow down the results using keywords "Prostate cancer screening guidelines 2014", "Beyond PSA", "NCCN Guidelines prostate", "MRI guided Prostate biopsy" yielding 72, 274, 54 and 568 results respectively. Of these, approximately 137 articles were found relevant and were reviewed. References from the reviewed articles were included in the final article.
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http://dx.doi.org/10.4103/1947-2714.168660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677466PMC
October 2015

Comparing gray and white mineral trioxide aggregate as a repair material for furcation perforation: an in vitro dye extraction study.

J Clin Diagn Res 2014 Oct 20;8(10):ZC70-3. Epub 2014 Oct 20.

Post-Graduate Student, Department of Oral & Maxillofacial Surgery, College of Dental Sciences , Manipur, Ahmedabad, India .

Introduction: Furcation perforation can have a negative impact on the prognosis of the affected tooth by compromising the attached apparatus. Hence these perforations require immediate repair. A variety of materials have been suggested for repair, of that MTA is the most promising material. The purpose of this study was to compare the ability of Gray and White MTA to seal furcation perforations using a dye extraction method under spectrophotometer.

Materials And Methods: A total of 60 permanent mandibular molars were randomly divided into four experimental groups of 15 samples each as follows: Group A: Perforation repaired with White MTA. Group B: Perforation repaired with Gray MTA. Group C: Perforation left unsealed (positive). Group D: without perforation (negative). Dye extraction was performed using full concentration nitric acid. Dye absorbance was measured at 550 nm using spectrophotometer. The data analyzed using one-way-Anova Ratio and Unpaired t-test showing statistically significance difference among the groups.

Result: It was seen that Group D samples without perforation showed least absorbance followed by Group A (perforation repaired with White MTA) and Group B (perforation repaired with Gray MTA). Group C (perforation left unsealed) showed highest absorbance.

Conclusion: The White and Gray Mineral Trioxide Aggregate performed similarly as a furcation perforation repair material. There was no significant difference between the Gray MTA and White MTA.
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http://dx.doi.org/10.7860/JCDR/2014/9517.5046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253270PMC
October 2014

Severe resistant hypocalcemia in multiple myeloma after zoledronic acid administration: a case report.

J Med Case Rep 2014 Oct 23;8:353. Epub 2014 Oct 23.

UAB Health Center Montgomery, 2055 East South Boulevard, Suite 202, Montgomery, AL 36116, USA.

Introduction: Hypercalcemia is one of the most common metabolic abnormalities encountered in any form of malignancy. Hypocalcemia, however, is a rare manifestation, especially in cancers with bone involvement. Here we present a case of hypocalcemia in a patient with multiple myeloma that was refractory to treatment.

Case Presentation: A 73-year-old African American woman recently diagnosed with multiple myeloma, presented with a 2-day history of fever, vomiting and hypocalcemia. Ten days prior to admission she received zoledronic acid, Velcade® (bortezomib), Revlimid® (lenalidomide) and dexamethasone. Treatment was started with intravenous antibiotics and calcium gluconate boluses. After 24 hours of treatment her calcium level became undetectable (<5mg/dL). Continuous intravenous calcium gluconate infusions in addition to boluses were started. She remained persistently hypocalcemic and eventually developed tonic-clonic seizures. Vitamin D levels were found to be low and intravenous paricalcitol was initiated, which improved her calcium level.

Conclusions: Underlying vitamin D deficiency can precipitate severe hypocalcemia in patients with multiple myeloma receiving bisphosphonates. This warrants baseline screening for vitamin D deficiency in these patients.
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http://dx.doi.org/10.1186/1752-1947-8-353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227449PMC
October 2014

Marginal zone mucosa associated lymphoid tissue diffuse large B cell lymphoma.

N Am J Med Sci 2014 Aug;6(8):422-4

Department of Internal Medicine, University of Alabama at Birmingham Health Center Montgomery, Alabama, United States.

Context: Non-Hodgkin's lymphomas (NHL) primarily involving the orbit, is relatively uncommon. Rarely two pathologically different NHL cell types have been found to be coexistent.

Case Report: We report a case of orbital lymphoma in a 62-year-old male with rare histopathological findings secondary to transformation of once cell type into another. Tissue diagnosis and molecular studies led to revelation of diffuse large B cell lymphoma evolving from MALT lymphoma.

Conclusion: Proliferation of two morphologically and phenotypically different B cells resulting in malignancy has not been found in the orbit so far. They are usually aggressive tumors and require chemo-immunotherapy.
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http://dx.doi.org/10.4103/1947-2714.139307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158653PMC
August 2014

Comparative evaluation of microleakage in Class II restorations using open vs. closed centripetal build-up techniques with different lining materials.

J Conserv Dent 2014 Jul;17(4):344-8

Department of Conservative Dentistry and Endodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.

Background: Evaluation of microleakage is important for assessing the success of new restorative materials and methods.

Aim And Objectives: Comparative evaluation of microleakage in Class II restorations using open vs. closed centripetal build-up techniques with different lining materials.

Materials And Methods: Standardized mesi-occlusal (MO) and distoocclusal (DO) Class II tooth preparations were preparedon 53 molars and samples were randomly divided into six experimental groups and one control group for restorations. Group 1: Open-Sandwich technique (OST) with flowable composite at the gingival seat. Group 2: OST with resin-modified glass ionomer cement (RMGIC) at the gingival seat. Group 3: Closed-Sandwich technique (CST) with flowable composite at the pulpal floor and axial wall. Group 4: CST with RMGIC at the pulpal floor and axial wall. Group 5: OST with flowable composite at the pulpal floor, axial wall, and gingival seat. Group 6: OST with RMGIC at the pulpal floor, axial wall, and gingival seat. Group 7: Control - no lining material, centripetal technique only. After restorations and thermocycling, apices were sealed and samples were immersed in 0.5% basic fuchsin dye. Sectioning was followed by stereomicroscopic evaluation.

Results: Results were analyzed using Post Hoc Bonferroni test (statistics is not a form of tabulation). Cervical scores of control were more than the exprimental groups (P < 0.05). Less microleakage was observed in CST than OST in all experimental groups (P < 0.05). However, insignificant differences were observed among occlusal scores of different groups (P > 0.05).

Conclusion: Class II composite restorations with centripetal build-up alone or when placed with CST reduces the cervical microleakage when compared to OST.
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http://dx.doi.org/10.4103/0972-0707.136450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127693PMC
July 2014

Ventricular standstill: An uncommon electrophysiological abnormality caused by profound vagal tone.

N Am J Med Sci 2014 Apr;6(4):178-80

Internal Medicine, Cardiology and Nuclear Cardiology, University of Alabama at Birmingham Health Center Montgomery, Montgomery, Alabama 36116, US.

Context: Ventricular standstill (VS) is an uncommon electrophysiological phenomenon and usually manifests as syncope. Rarely has a case been reported where the patient has been totally asymptomatic, and it has resolved spontaneously.

Case Report: We report a case of complete VS and high-degree atrioventricular (AV) block in a 50-year-old female, who was admitted for nausea, vomiting, and chest pain. The patient never had a syncopal episode, even though she was in VS for more than 10 s.

Conclusion: Such degree of conduction abnormality without any syncope has not been reported so far. Her electrophysiological abnormality was attributed to profound vagotonic effect and was treated with a permanent pacemaker.
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http://dx.doi.org/10.4103/1947-2714.131245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024585PMC
April 2014

Endodontic management of permanent mandibular left first molar with six root canals.

Contemp Clin Dent 2012 Apr;3(Suppl 1):S130-3

Department of Conservative Dentistry and Endodontics, Subharti Dental College, NH-58 Delhi Haridwar Bypass Road, Subhartipuram, Meerut, Uttar Pradesh, India.

The endodontic treatment of a mandibular molar with aberrant canal configuration can be diagnostically and clinically challenging. This case report presents the treatment of a mandibular first molar with six root canals, of which three canals were located in the mesial root and three in distal root. Third canals were found between the two main root canals. This case presents a rare anatomic configuration and points to the importance of expecting and searching for additional canals.
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http://dx.doi.org/10.4103/0976-237X.95124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354780PMC
April 2012
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