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Publications Authored by Shigeyoshi Harada | PubFacts
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Soluble-type small-molecule CD4 mimics as HIV entry inhibitors.

Bioorg Med Chem Lett 2019 Mar 11;29(5):719-723. Epub 2019 Jan 11.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193001
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http://dx.doi.org/10.1016/j.bmcl.2019.01.011DOI Listing
March 2019

Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.

Sci Rep 2019 Mar 18;9(1):4828. Epub 2019 Mar 18.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892-1868, USA.

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http://www.nature.com/articles/s41598-019-41080-w
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http://dx.doi.org/10.1038/s41598-019-41080-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423129PMC
March 2019

Isolation and structure determination of a new lasso peptide specialicin based on genome mining.

Bioorg Med Chem 2018 12 9;26(23-24):6050-6055. Epub 2018 Nov 9.

Graduate School of Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, 432-8561 Shizuoka, Japan; Academic Institute, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183165
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http://dx.doi.org/10.1016/j.bmc.2018.11.007DOI Listing
December 2018

Flexibility of small molecular CD4 mimics as HIV entry inhibitors.

Bioorg Med Chem 2018 11 16;26(21):5664-5671. Epub 2018 Oct 16.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.10.011DOI Listing
November 2018

[Clinical Significance of Circulating Tumor DNA and Its Future Prospects].

Gan To Kagaku Ryoho 2017 May;44(5):357-361

Product Development, Life Science Product Engineering, LS Business Unit, Sysmex Corporation.

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May 2017

Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.

Front Microbiol 2017 16;8:390. Epub 2017 Mar 16.

AIDS Research Center, National Institute of Infectious Diseases Tokyo, Japan.

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http://dx.doi.org/10.3389/fmicb.2017.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352695PMC
March 2017

A novel dual luciferase assay for the simultaneous monitoring of HIV infection and cell viability.

J Virol Methods 2016 May 17;231:25-33. Epub 2016 Feb 17.

Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.02.006DOI Listing
May 2016

Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.

ChemMedChem 2016 Apr 17;11(8):940-6. Epub 2016 Feb 17.

Institute of Biomaterials & Bioengineering, Tokyo Medical & Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.

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http://dx.doi.org/10.1002/cmdc.201500590DOI Listing
April 2016

A minimally cytotoxic CD4 mimic as an HIV entry inhibitor.

Bioorg Med Chem Lett 2016 Jan 30;26(2):397-400. Epub 2015 Nov 30.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.11.103DOI Listing
January 2016

Fibrocytes Differ from Macrophages but Can Be Infected with HIV-1.

J Immunol 2015 Nov 28;195(9):4341-50. Epub 2015 Sep 28.

Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan; International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1500955
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http://dx.doi.org/10.4049/jimmunol.1500955DOI Listing
November 2015

Impact of maraviroc-resistant and low-CCR5-adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.

J Gen Virol 2014 Aug 2;95(Pt 8):1816-26. Epub 2014 May 2.

Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan

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http://dx.doi.org/10.1099/vir.0.062885-0DOI Listing
August 2014

A CD4 mimic as an HIV entry inhibitor: pharmacokinetics.

Bioorg Med Chem 2013 Dec 17;21(24):7884-9. Epub 2013 Oct 17.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bmc.2013.10.005DOI Listing
December 2013

Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.

J Gen Virol 2013 May 3;94(Pt 5):933-43. Epub 2013 Jan 3.

Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1099/vir.0.047167-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093781PMC
May 2013

CD4 mimics as HIV entry inhibitors: lead optimization studies of the aromatic substituents.

Bioorg Med Chem 2013 May 7;21(9):2518-26. Epub 2013 Mar 7.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bmc.2013.02.041DOI Listing
May 2013

Small molecular CD4 mimics as HIV entry inhibitors.

Bioorg Med Chem 2011 Nov 29;19(22):6735-42. Epub 2011 Sep 29.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bmc.2011.09.045DOI Listing
November 2011

The cell cycle profile test is a prognostic indicator for breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy.

Jpn J Clin Oncol 2011 Jun 27;41(6):739-46. Epub 2011 Apr 27.

Department of Breast and Thyroid Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan.

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http://dx.doi.org/10.1093/jjco/hyr042DOI Listing
June 2011

CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.

Bioorg Med Chem Lett 2010 Oct 3;20(19):5853-8. Epub 2010 Aug 3.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2010.07.106DOI Listing
October 2010

Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.

J Virol 2010 Aug 26;84(15):7558-68. Epub 2010 May 26.

Division of Clinical Retrovirology and Infectious Diseases, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1128/JVI.00227-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897603PMC
August 2010

Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2.

J Gen Virol 2010 May 23;91(Pt 5):1335-45. Epub 2009 Dec 23.

Division of Clinical Retrovirology and Infectious Diseases, Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1099/vir.0.017426-0DOI Listing
May 2010

CD4 mimics targeting the mechanism of HIV entry.

Bioorg Med Chem Lett 2010 Jan 4;20(1):354-8. Epub 2009 Nov 4.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.098DOI Listing
January 2010

Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy.

Antiviral Res 2007 Aug 21;75(2):159-66. Epub 2007 Mar 21.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.antiviral.2007.02.004DOI Listing
August 2007

Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

Antiviral Res 2006 Nov 21;72(2):89-99. Epub 2006 Apr 21.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Building 10, Room 10S255, NIH, Bethesda MD 20892-1868, USA.

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http://dx.doi.org/10.1016/j.antiviral.2006.03.015DOI Listing
November 2006

Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.

J Med Chem 2003 Oct;46(22):4799-802

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm030048y
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http://dx.doi.org/10.1021/jm030048yDOI Listing
October 2003

Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants.

AIDS 2003 May;17(8):1127-37

The Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1097/00002030-200305230-00003DOI Listing
May 2003

Identification of amino acid residues critical for LD78beta, a variant of human macrophage inflammatory protein-1alpha, binding to CCR5 and inhibition of R5 human immunodeficiency virus type 1 replication.

J Biol Chem 2002 Feb 4;277(7):4649-55. Epub 2001 Dec 4.

Department of Internal Medicine II, Kumamoto University School of Medicine, Honjo 1-1-1, Kumamoto 860-0811, Japan.

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http://dx.doi.org/10.1074/jbc.M109198200DOI Listing
February 2002