Publications

Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
Kidney Int 2017 Dec 11. Epub 2017 Dec 11.
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Japan. Electronic address:






High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.
J Clin Virol 2016 Sep 21;82:101-107. Epub 2016 Jul 21.
Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kochi, Japan. Electronic address:

Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.
Hum Pathol 2015 Feb 23;46(2):210-6. Epub 2014 Oct 23.
Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine, Tottori, Japan, 683-8503. Electronic address:

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nat Commun 2015 Feb 4;6:6119. Epub 2015 Feb 4.
1] Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan [2] Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan.


Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.
Cancer Immunol Res 2014 Nov 12;2(11):1071-9. Epub 2014 Aug 12.
Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington. Department of Pathology, University of Washington, Seattle, Washington. Fred Hutchinson Cancer Research Center, Seattle, Washington.


Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 gene sequences derived from neoplastic tumours in Japanese patients.
J Gen Virol 2014 Jan 9;95(Pt 1):135-41. Epub 2013 Oct 9.
Department of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan.



Usefulness of significant morphologic characteristics in distinguishing between Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative Merkel cell carcinomas.
Hum Pathol 2013 Sep 10;44(9):1912-7. Epub 2013 May 10.
Division of Molecular Pathology, Department of Microbiology and Pathology, Tottori University Faculty of Medicine, Yonago, 683-8503 Japan.




Safety and effectiveness of a new enzyme-targeting radiosensitization treatment (KORTUC II) for intratumoral injection for low-LET radioresistant tumors.
Int J Oncol 2011 Sep 6;39(3):553-60. Epub 2011 Jun 6.
Department of Diagnostic Radiology and Radiation Oncology, Medical School, Kochi University, Oko-cho, Nankoku-shi, Kochi Prefecture 783-8505, Japan.



Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.
PLoS One 2012 15;7(11):e49519. Epub 2012 Nov 15.
Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan.

Guanosine and its modified derivatives are endogenous ligands for TLR7.
Int Immunol 2016 05 20;28(5):211-22. Epub 2015 Oct 20.
Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan


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