Shigenori Nagai

Shigenori Nagai

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Shigenori Nagai

Shigenori Nagai

Publications by authors named "Shigenori Nagai"

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61Publications

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Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contact Hypersensitivity.

J Invest Dermatol 2019 Oct 9;139(10):2164-2173.e1. Epub 2019 Apr 9.

Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.037DOI Listing
October 2019

Endogenous IL-33 exerts CD8 T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model.

Biochem Biophys Res Commun 2019 Oct 14;518(2):331-336. Epub 2019 Aug 14.

Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.08.058DOI Listing
October 2019

Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade.

Oral Oncol 2019 Apr 20;91:21-28. Epub 2019 Feb 20.

Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193005
Publisher Site
http://dx.doi.org/10.1016/j.oraloncology.2019.02.014DOI Listing
April 2019

PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells.

Immunology 2017 11 31;152(3):507-516. Epub 2017 Jul 31.

Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/imm.12789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629445PMC
November 2017

TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation.

Biochem Biophys Res Commun 2016 Nov 1;480(1):114-119. Epub 2016 Oct 1.

Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.153DOI Listing
November 2016

The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.

Cell Rep 2016 08 18;16(9):2456-71. Epub 2016 Aug 18.

Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.062DOI Listing
August 2016

Impact of immediate breast reconstruction on postoperative adjuvant chemotherapy: a single center study.

Breast Cancer 2015 May 12;22(3):287-91. Epub 2013 Jun 12.

Division of Plastic and Reconstructive Surgery, Saitama Cancer Center, 818 Komuro, Inamachi, Kitaadachigunn, Saitama, Japan,

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http://dx.doi.org/10.1007/s12282-013-0480-4DOI Listing
May 2015

A unique dermal dendritic cell subset that skews the immune response toward Th2.

PLoS One 2013 9;8(9):e73270. Epub 2013 Sep 9.

Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767795PMC
June 2014

CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.

Biochem Biophys Res Commun 2013 Jun 9;435(3):378-84. Epub 2013 May 9.

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.04.096DOI Listing
June 2013

Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells.

Genes Cells 2013 Apr 5;18(4):247-65. Epub 2013 Feb 5.

Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1111/gtc.12039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657121PMC
April 2013

Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo.

PLoS One 2012 17;7(9):e44770. Epub 2012 Sep 17.

Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444443PMC
March 2013

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation.

Ann N Y Acad Sci 2013 Mar;1280:30-4

Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/nyas.12059DOI Listing
March 2013

Analysis of complete response by MRI following neoadjuvant chemotherapy predicts pathological tumor responses differently for molecular subtypes of breast cancer.

Oncol Lett 2013 Jan 30;5(1):83-89. Epub 2012 Oct 30.

Division of Breast Surgery, Saitama Cancer Center, Saitama 362-0806; ; Department of Thoracic and Visceral Organ Surgery, Graduate School of Medicine, Gunma University, Gunma 371-8511;

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http://dx.doi.org/10.3892/ol.2012.1004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525359PMC
January 2013

[Prognostic significance of the number of axillary lymph nodes examined in breast cancer].

Nihon Rinsho 2012 Sep;70 Suppl 7:154-7

Department of Breast Medical Oncology, Saitama Cancer Center.

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September 2012

Dynamic regulation of Th17 differentiation by oxygen concentrations.

Int Immunol 2012 Mar 29;24(3):137-46. Epub 2011 Dec 29.

Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1093/intimm/dxr111DOI Listing
March 2012

Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection.

J Clin Invest 2012 Mar 6;122(3):801-4. Epub 2012 Feb 6.

Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://www.jci.org/articles/view/61466
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http://dx.doi.org/10.1172/JCI61466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287236PMC
March 2012

Neoadjuvant endocrine therapy of breast cancer: which patients would benefit and what are the advantages?

Breast Cancer 2011 Apr 23;18(2):85-91. Epub 2010 Nov 23.

Division of Breast Surgery, Saitama Cancer Center, 818 Komuro, Ina, Kita-Adachi, Saitama, Japan.

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http://dx.doi.org/10.1007/s12282-010-0239-0DOI Listing
April 2011

Listerial invasion protein internalin B promotes entry into ileal Peyer's patches in vivo.

Microbiol Immunol 2011 Feb;55(2):123-9

Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1111/j.1348-0421.2010.00292.xDOI Listing
February 2011

Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN.

J Exp Med 2009 Dec 14;206(13):3073-88. Epub 2009 Dec 14.

Laboratory of Bacterial Infection, Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108-8641, Japan.

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http://dx.doi.org/10.1084/jem.20090494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806459PMC
December 2009

Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms.

J Exp Med 2009 Jun 11;206(6):1317-26. Epub 2009 May 11.

Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1084/jem.20082614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715055PMC
June 2009

Critical roles of NK and CD8+ T cells in central nervous system listeriosis.

J Immunol 2009 May;182(10):6360-8

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo,Japan.

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http://dx.doi.org/10.4049/jimmunol.0803798DOI Listing
May 2009

Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation.

Cell Host Microbe 2009 Jan;5(1):23-34

Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1016/j.chom.2008.11.010DOI Listing
January 2009

The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.

Int Immunol 2008 Oct 24;20(10):1259-68. Epub 2008 Jul 24.

Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1093/intimm/dxn082DOI Listing
October 2008

Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin.

Glycobiology 2008 Jan 31;18(1):74-83. Epub 2007 Oct 31.

Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1093/glycob/cwm118DOI Listing
January 2008

Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.

Proc Natl Acad Sci U S A 2007 May 14;104(21):8971-6. Epub 2007 May 14.

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1073/pnas.0609014104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885612PMC
May 2007

TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression.

J Immunol 2006 May;176(10):6194-201

Epithelial Pathobiology Division, Department of Pathology, Emory University School of Medicine, 6156 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.4049/jimmunol.176.10.6194DOI Listing
May 2006

Cancer gene therapy using in vivo electroporation of Flt3-ligand.

Int J Oncol 2005 Aug;27(2):457-63

Department of Surgery and Bioengineering Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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August 2005

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

Nat Immunol 2005 Jun 1;6(6):587-92. Epub 2005 May 1.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/ni1200DOI Listing
June 2005

Identification of a host gene subset related to disease prognosis of HIV-1 infected individuals.

Int Immunopharmacol 2004 Dec;4(14):1829-36

Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1016/j.intimp.2004.07.031DOI Listing
December 2004

Survival benefit of KRN7000 immune therapy in combination with TNP470 in hamster liver metastasis model of pancreatic cancer.

Oncol Rep 2003 Sep-Oct;10(5):1201-6

Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan.

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April 2004

Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues.

Oncol Rep 2003 Jul-Aug;10(4):791-6

Department of Surgery II, Hospital, Kumamoto University Medical School, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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February 2004

Gene expression profile in human leukocytes.

Blood 2003 May 9;101(9):3509-13. Epub 2003 Jan 9.

Department of Molecular Preventive Medicine, Graduate School of Frontier Science, University of Tokyo, Japan.

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http://dx.doi.org/10.1182/blood-2002-06-1866DOI Listing
May 2003

Comprehensive gene expression analysis of human NK cells and CD8(+) T lymphocytes.

Int Immunol 2002 Oct;14(10):1085-98

Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1093/intimm/dxf086DOI Listing
October 2002

Molecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model.

Int J Cancer 2002 Sep;101(1):37-45

Environmental Science Center, University of Tokyo, Japan.

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http://dx.doi.org/10.1002/ijc.10578DOI Listing
September 2002

The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells.

J Biol Chem 2002 Jun 27;277(23):20686-93. Epub 2002 Mar 27.

Graduate School of Pharmaceutical Sciences and the Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M202104200DOI Listing
June 2002