Shigeki Umemura

Shigeki Umemura

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Shigeki Umemura

Publications by authors named "Shigeki Umemura"

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Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study.

Eur J Cancer 2019 May 13;113:78-86. Epub 2019 Apr 13.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1016/j.ejca.2019.03.012DOI Listing
May 2019

Publication of lung cancer clinical trials in the Japanese Clinical Trial Registry.

Jpn J Clin Oncol 2018 Nov;48(11):995-1000

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1093/jjco/hyy131DOI Listing
November 2018

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

Cancer Res 2018 05 28;78(9):2179-2190. Epub 2018 Feb 28.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-2109DOI Listing
May 2018

Impact of denosumab use on the survival of untreated non-squamous non-small cell lung cancer patients with bone metastases.

J Cancer Res Clin Oncol 2017 Jun 20;143(6):1075-1082. Epub 2017 Feb 20.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.

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http://link.springer.com/10.1007/s00432-017-2350-5
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http://dx.doi.org/10.1007/s00432-017-2350-5DOI Listing
June 2017

Switch maintenance chemotherapy using S-1 with or without bevacizumab in patients with advanced non-small cell lung cancer: a phase II study.

Lung Cancer 2017 06 1;108:66-71. Epub 2017 Mar 1.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2017.02.018DOI Listing
June 2017

Prognostic Factor Analysis in Patients With Small-Cell Lung Cancer Treated With Third-Line Chemotherapy.

Clin Lung Cancer 2016 11 16;17(6):581-587. Epub 2016 Jun 16.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1016/j.cllc.2016.05.022DOI Listing
November 2016

Clinical Impact of Gastric Acid-Suppressing Medication Use on the Efficacy of Erlotinib and Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations.

Clin Lung Cancer 2016 09 5;17(5):412-418. Epub 2016 Feb 5.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.cllc.2016.01.006DOI Listing
September 2016

Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma.

Lung Cancer 2016 Apr 22;94:1-6. Epub 2016 Jan 22.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.01.009DOI Listing
April 2016

Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma.

J Cancer Res Clin Oncol 2016 Mar 31;142(3):593-600. Epub 2015 Oct 31.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-015-2068-1DOI Listing
March 2016

RECIST progression patterns during EGFR tyrosine kinase inhibitor treatment of advanced non-small cell lung cancer patients harboring an EGFR mutation.

Lung Cancer 2015 Dec 9;90(3):477-83. Epub 2015 Oct 9.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2015.09.025DOI Listing
December 2015

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung.

J Cancer Res Clin Oncol 2015 Aug 9;141(8):1417-25. Epub 2015 Jan 9.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/10.1007/s00432-015-1912-7
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http://dx.doi.org/10.1007/s00432-015-1912-7DOI Listing
August 2015

Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.

J Cancer Res Clin Oncol 2015 Jul 2;141(7):1163-70. Epub 2014 Dec 2.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s00432-014-1891-0DOI Listing
July 2015

Docetaxel for platinum-refractory advanced thymic carcinoma.

Jpn J Clin Oncol 2015 Jul 2;45(7):665-9. Epub 2015 Apr 2.

Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1093/jjco/hyv046DOI Listing
July 2015

Second-line docetaxel for patients with platinum-refractory advanced non-small cell lung cancer and interstitial pneumonia.

Cancer Chemother Pharmacol 2015 Jul 15;76(1):69-74. Epub 2015 May 15.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/10.1007/s00280-015-2775-y
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http://dx.doi.org/10.1007/s00280-015-2775-yDOI Listing
July 2015

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

J Biol Chem 2015 Jul 28;290(28):17495-504. Epub 2015 May 28.

From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.

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http://dx.doi.org/10.1074/jbc.M115.660498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498084PMC
July 2015

Genomic profiling of small-cell lung cancer: the era of targeted therapies.

Jpn J Clin Oncol 2015 Jun 10;45(6):513-9. Epub 2015 Feb 10.

Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
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http://dx.doi.org/10.1093/jjco/hyv017DOI Listing
June 2015

Vinorelbine and cisplatin in patients with advanced non-small cell lung cancer with interstitial pneumonia.

Anticancer Res 2015 Mar;35(3):1697-701

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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March 2015

Low-dose irinotecan as a second-line chemotherapy for recurrent small cell lung cancer.

Jpn J Clin Oncol 2014 Sep 23;44(9):846-51. Epub 2014 Jul 23.

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

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http://dx.doi.org/10.1093/jjco/hyu094DOI Listing
September 2014

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

J Thorac Oncol 2014 Sep;9(9):1324-31

*Division of Thoracic Oncology, National Cancer Center Hospital East; †Exploratory Oncology Research and Clinical Trial Center, National Cancer Center; ‡Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East; §Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; and ‖Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1097/JTO.0000000000000250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154841PMC
September 2014

Protective effect of magnesium preloading on cisplatin-induced nephrotoxicity: a retrospective study.

Jpn J Clin Oncol 2014 Apr 5;44(4):346-54. Epub 2014 Feb 5.

*Division of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
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http://dx.doi.org/10.1093/jjco/hyu004DOI Listing
April 2014

Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.

Pathol Int 2013 Dec;63(12):599-606

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Hospital East, Kashiwa, Chiba, Japan; Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/pin.12122DOI Listing
December 2013

Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung.

J Cancer Res Clin Oncol 2013 Nov 7;139(11):1869-78. Epub 2013 Sep 7.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-City, Chiba, 277-8577, Japan.

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http://link.springer.com/content/pdf/10.1007/s00432-013-1502
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http://link.springer.com/10.1007/s00432-013-1502-5
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http://dx.doi.org/10.1007/s00432-013-1502-5DOI Listing
November 2013

Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung adenocarcinoma.

J Cancer Res Clin Oncol 2013 Oct 22;139(10):1691-700. Epub 2013 Aug 22.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://link.springer.com/content/pdf/10.1007/s00432-013-1495
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http://link.springer.com/10.1007/s00432-013-1495-0
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http://dx.doi.org/10.1007/s00432-013-1495-0DOI Listing
October 2013

Renal toxicity caused by brand-name versus generic cisplatin: a comparative analysis.

Jpn J Clin Oncol 2013 Apr 26;43(4):390-5. Epub 2013 Feb 26.

Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

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http://dx.doi.org/10.1093/jjco/hyt020DOI Listing
April 2013

Safety and efficacy of platinum agents plus etoposide for patients with small cell lung cancer with interstitial lung disease.

Anticancer Res 2013 Mar;33(3):1175-9

Division of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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March 2013

Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type.

Clin J Gastroenterol 2011 Dec 4;4(6):401-6. Epub 2011 Oct 4.

Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

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http://dx.doi.org/10.1007/s12328-011-0259-0DOI Listing
December 2011

Variant angina pectoris associated with FOLFOX4 therapy.

World J Gastrointest Oncol 2011 Nov;3(11):165-8

Hiromichi Yamane, Shigeki Umemura, Toshimitsu Suwaki, Haruhito Kamei, Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1Ohji-cho, Niihama, Ehime 792-8543, Japan.

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http://dx.doi.org/10.4251/wjgo.v3.i11.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220725PMC
November 2011

Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer.

J Cancer Res Clin Oncol 2011 Oct 5;137(10):1469-75. Epub 2011 Aug 5.

Department of Clinical Oncology, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, 792-8543, Japan.

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http://dx.doi.org/10.1007/s00432-011-1013-1DOI Listing
October 2011

An oral fluoropyrimidine agent S-1 induced interstitial lung disease: A case report.

World J Clin Oncol 2011 Jul;2(7):299-302

Hiromichi Yamane, Masahide Kinugawa, Shigeki Umemura, Yasuhiro Shiote, Kenichiro Kudo, Toshimitsu Suwaki, Haruhito Kamei, Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Ohji-cho, Niihama, Ehime 792-8543, Japan.

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http://dx.doi.org/10.5306/wjco.v2.i7.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139033PMC
July 2011

Synchronous double primary lung cancers with different response to pemetrexed.

Anticancer Drugs 2011 Jun;22(5):473-6

Department of Clinical Oncology, Sumitomo-Besshi Hospital, Niihama, Japan.

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http://dx.doi.org/10.1097/CAD.0b013e328344a964DOI Listing
June 2011

Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer.

Acta Med Okayama 2010 Feb;64(1):33-7

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama 700-8558, Japan.

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http://dx.doi.org/10.18926/AMO/32866DOI Listing
February 2010

Centrally located squamous cell carcinoma of the lung mimicking endobronchial tuberculosis.

J Thorac Oncol 2009 Sep;4(9):1178-9

Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, Sumitomo-Besshi Hospital, Niihama, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3181b28f2fDOI Listing
September 2009

Efficacy of a lumbo-peritoneal shunt for meningeal carcinomatosis refractory to gefitinib treatment.

Anticancer Res 2009 Jul;29(7):2759-60

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

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July 2009

Aberrant promoter hypermethylation in serum DNA from patients with silicosis.

Carcinogenesis 2008 Sep 16;29(9):1845-9. Epub 2008 Jul 16.

Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan.

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http://dx.doi.org/10.1093/carcin/bgn169DOI Listing
September 2008

Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test.

World J Gastroenterol 2008 Sep;14(35):5481-3

Department of Internal Medicine, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744902PMC
http://dx.doi.org/10.3748/wjg.14.5481DOI Listing
September 2008

Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.

Anticancer Drugs 2008 Apr;19(4):431-3

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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https://insights.ovid.com/crossref?an=00001813-200804000-000
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http://dx.doi.org/10.1097/CAD.0b013e3282f5d336DOI Listing
April 2008

Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer.

J Cancer Res Clin Oncol 2007 Aug 17;133(8):519-24. Epub 2007 Mar 17.

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

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http://dx.doi.org/10.1007/s00432-007-0196-yDOI Listing
August 2007

Radiation necrosis mimicking progressive brain metastasis in a patient with non-small cell lung cancer.

J Thorac Oncol 2007 Aug;2(8):762-3

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences & Okayama University Hospital, Okayama, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e31811f3abbDOI Listing
August 2007

Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer.

Anticancer Res 2007 May-Jun;27(3B):1737-41

Department of Respiratory Medicine, Okayama University Hospital, 2-5-1, Shikata-cho, Okayama 700-8558, Japan.

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July 2007

Clinical factors affecting acquired resistance to gefitinib in previously treated Japanese patients with advanced nonsmall cell lung cancer.

Cancer 2006 Oct;107(8):1866-72

Department of Medicine and Thoracic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.

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http://dx.doi.org/10.1002/cncr.22207DOI Listing
October 2006

A phase I study of 3-day topotecan and cisplatin in elderly patients with small-cell lung cancer.

Cancer Chemother Pharmacol 2006 Jun 6;57(6):755-60. Epub 2005 Oct 6.

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Okayama 701-1192, Japan.

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http://dx.doi.org/10.1007/s00280-005-0117-1DOI Listing
June 2006

Phase I study of irinotecan and amrubicin in patients with advanced non-small-cell lung cancer.

Anticancer Res 2005 May-Jun;25(3c):2429-34

Department of Medicine II, Okayama University Medical School, 2-5-1, Shikata-cho, Okayama, 700-8558, Japan.

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September 2005

Systemic tumor embolism mimicking gefitinib ('IRESSA')-induced interstitial lung disease in a patient with lung cancer.

Intern Med 2005 Sep;44(9):979-82

Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine and Dentistry, Japan.

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http://dx.doi.org/10.2169/internalmedicine.44.979DOI Listing
September 2005

A case of recurrent metastatic thymoma showing a marked response to paclitaxel monotherapy.

Jpn J Clin Oncol 2002 Jul;32(7):262-5

Department of Internal Medicine, National Shikoku Cancer Center Hospital, Matsuyama, Japan.

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http://dx.doi.org/10.1093/jjco/hyf059DOI Listing
July 2002