Shigeki Umemura

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA; Meyer Cancer Center, Weill Cornel Medicine, NY, USA. Electronic address:

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September 2020

Phase I/II study of carboplatin plus weekly nab-paclitaxel in patients aged ≥75 years with squamous-cell lung cancer: TORG1322.

Lung Cancer 2020 08 19;146:182-188. Epub 2020 May 19.

Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.

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August 2020

Non-small cell lung cancer with loss of expression of the SWI/SNF complex is associated with aggressive clinicopathological features, PD-L1-positive status, and high tumor mutation burden.

Authors:

Tomoyuki Naito Hibiki Udagawa Shigeki Umemura Tetsuya Sakai Yoshitaka Zenke Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Masahiro Tsuboi Genichiro Ishii Koichi Goto

Lung Cancer 2019 12 13;138:35-42. Epub 2019 Oct 13.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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December 2019

Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report.

Authors:

Takashi Sakai Tomohiro Miyoshi Shigeki Umemura Jun Suzuki Shoko Nakasone Satoshi Okada Kenta Tane Keiju Aokage Koichi Goto Noriko Motoi Genichiro Ishii Masahiro Tsuboi

Oxf Med Case Reports 2019 Jul;2019(7)

Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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July 2019

The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV.

Int J Clin Oncol 2019 Jul 2;24(7):731-770. Epub 2019 May 2.

Internal Medicine III, Wakayama Medical University, Wakayama, Japan.

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July 2019

Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study.

Authors:

Yuki Katsuya Hidehito Horinouchi Takashi Seto Shigeki Umemura Yukio Hosomi Miyako Satouchi Makoto Nishio Toshiyuki Kozuki Toyoaki Hida Tamie Sukigara Kenichi Nakamura Aya Kuchiba Yuichiro Ohe

Eur J Cancer 2019 05 13;113:78-86. Epub 2019 Apr 13.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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May 2019

Successful treatment with nivolumab for SMARCA4-deficient non-small cell lung carcinoma with a high tumor mutation burden: A case report.

Authors:

Tomoyuki Naito Shigeki Umemura Hiroshi Nakamura Yoshitaka Zenke Hibiki Udagawa Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Noriko Motoi Keijyu Aokage Masahiro Tsuboi Genichiro Ishii Koichi Goto

Thorac Cancer 2019 05 10;10(5):1285-1288. Epub 2019 Apr 10.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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May 2019

Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study.

Authors:

Seiji Niho Yukio Hosomi Hiroaki Okamoto Keiji Nihei Hiroshi Tanaka Toyoaki Hida Shigeki Umemura Koichi Goto Tetsuo Akimoto Yuichiro Ohe

Jpn J Clin Oncol 2019 Jul;49(7):614-619

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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July 2019

Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing.

Lung Cancer 2019 02 4;128:20-25. Epub 2018 Dec 4.

Departments of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.

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February 2019

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis.

Authors:

Hibiki Udagawa Shigeki Umemura Isao Murakami Sachiyo Mimaki Hideki Makinoshima Genichiro Ishii Tomohiro Miyoshi Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Katsuya Tsuchihara Koichi Goto

Lung Cancer 2018 12 12;126:182-188. Epub 2018 Nov 12.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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December 2018

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.

Authors:

Yuzo Sato Shiori Matsuda Ami Maruyama Joji Nakayama Tomoyuki Miyashita Hibiki Udagawa Shigeki Umemura Kazuyoshi Yanagihara Atsushi Ochiai Masaru Tomita Tomoyoshi Soga Katsuya Tsuchihara Hideki Makinoshima

Front Pharmacol 2018 12;9:1129. Epub 2018 Oct 12.

Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.

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October 2018

Publication of lung cancer clinical trials in the Japanese Clinical Trial Registry.

Authors:

Nobuaki Ochi Tatsuyuki Kawahara Yasunari Nagasaki Nozomu Nakagawa Tomoko Yamagishi Shigeki Umemura Yoshihiro Honda Hidekazu Nakanishi Hiromichi Yamane Nagio Takigawa

Jpn J Clin Oncol 2018 Nov;48(11):995-1000

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.

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November 2018

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0).

Cancer Sci 2018 Sep;109(9):2980-2985

Department of Genome Biology, Kindai University, Faculty of Medicine, Osaka, Japan.

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September 2018

Impact of prophylactic cranial irradiation on pattern of brain metastases as a first recurrence site for limited-disease small-cell lung cancer.

Authors:

Masaki Nakamura Masakatsu Onozawa Atsushi Motegi Hidehiro Hojo Sadamoto Zenda Naoki Nakamura Hibiki Udagawa Keisuke Kirita Shingo Matsumoto Shigeki Umemura Kiyotaka Yoh Seiji Niho Koichi Goto Tetsuo Akimoto

J Radiat Res 2018 Nov;59(6):767-773

Division of Radiation Oncology and Particle therapy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, Japan.

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November 2018

Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions.

Authors:

Yuka Kato Kiichiro Ninomiya Kadoaki Ohashi Shuta Tomida Go Makimoto Hiromi Watanabe Kenichiro Kudo Shingo Matsumoto Shigeki Umemura Koichi Goto Eiki Ichihara Takashi Ninomiya Toshio Kubo Akiko Sato Katsuyuki Hotta Masahiro Tabata Shinichi Toyooka Yoshinobu Maeda Katsuyuki Kiura

Cancer Sci 2018 Oct 11;109(10):3149-3158. Epub 2018 Sep 11.

Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

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October 2018

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

Authors:

Hideki Makinoshima Shigeki Umemura Ayako Suzuki Hiroki Nakanishi Ami Maruyama Hibiki Udagawa Sachiyo Mimaki Shingo Matsumoto Seiji Niho Genichiro Ishii Masahiro Tsuboi Atsushi Ochiai Hiroyasu Esumi Takehiko Sasaki Koichi Goto Katsuya Tsuchihara

Cancer Res 2018 05 28;78(9):2179-2190. Epub 2018 Feb 28.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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May 2018

Salvage chemoradiotherapy with cisplatin and vinorelbine for postoperative locoregional recurrence of non-small cell lung cancer.

Authors:

Kakeru Hisakane Kiyotaka Yoh Naoki Nakamura Hibiki Udagawa Keisuke Kirita Shigeki Umemura Shingo Matsumoto Seiji Niho Tetsuo Akimoto Masahiro Tsuboi Koichi Goto

Medicine (Baltimore) 2017 Nov;96(47):e8635

Department of Thoracic Oncology Department of Radiation Oncology Department of Thoracic Surgery, National Cancer Center, Kashiwa, Japan.

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November 2017

Efficacy of Cell-Free and Concentrated Ascites Reinfusion Therapy for Palliative Care in a Patient with Malignant Pleural Mesothelioma: A Case Report.

Authors:

Kakeru Hisakane Hironobu Ohmatsu Shigeki Umemura Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Koichi Goto

J Nippon Med Sch 2017 ;84(5):231-236

Department of Thoracic Oncology, National Cancer Center Hospital East.

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February 2018

Switch maintenance chemotherapy using S-1 with or without bevacizumab in patients with advanced non-small cell lung cancer: a phase II study.

Authors:

Seiji Niho Yuichiro Ohe Hironobu Ohmatsu Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Koichi Goto

Lung Cancer 2017 06 1;108:66-71. Epub 2017 Mar 1.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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June 2017

CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors.

Authors:

Masayuki Ishibashi Shinya Neri Hiroko Hashimoto Tomoyuki Miyashita Tatsuya Yoshida Yuka Nakamura Hibiki Udagawa Keisuke Kirita Shingo Matsumoto Shigeki Umemura Kiyotaka Yoh Seiji Niho Masahiro Tsuboi Kenkichi Masutomi Koichi Goto Atsushi Ochiai Genichiro Ishii

Sci Rep 2017 04 21;7:46662. Epub 2017 Apr 21.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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April 2017

Impact of denosumab use on the survival of untreated non-squamous non-small cell lung cancer patients with bone metastases.

Authors:

Hibiki Udagawa Seiji Niho Keisuke Kirita Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Koichi Goto

J Cancer Res Clin Oncol 2017 Jun 20;143(6):1075-1082. Epub 2017 Feb 20.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.

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June 2017

Association of Serum Anti-GAD Antibody and HLA Haplotypes with Type 1 Diabetes Mellitus Triggered by Nivolumab in Patients with Non-Small Cell Lung Cancer.

Authors:

Yuko Usui Hibiki Udagawa Shingo Matsumoto Kenjiro Imai Ken Ohashi Masayuki Ishibashi Keisuke Kirita Shigeki Umemura Kiyotaka Yoh Seiji Niho Keiichiro Osame Koichi Goto

J Thorac Oncol 2017 05 23;12(5):e41-e43. Epub 2016 Dec 23.

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

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May 2017

Prognostic Factor Analysis in Patients With Small-Cell Lung Cancer Treated With Third-Line Chemotherapy.

Authors:

Koichi Saruwatari Shigeki Umemura Shogo Nomura Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Yuichiro Ohe Koichi Goto

Clin Lung Cancer 2016 11 16;17(6):581-587. Epub 2016 Jun 16.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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November 2016

Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma.

Authors:

Shinnosuke Ikemura Nao Aramaki Satoshi Fujii Keisuke Kirita Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Takeshi Kuwata Motohiro Kojima Atsushi Ochiai Tomoko Betsuyaku Masahiro Tsuboi Koichi Goto Genichiro Ishii

Cancer Sci 2017 Jan 21;108(1):136-142. Epub 2017 Jan 21.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

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January 2017

Successful treatment with afatinib after grade 3 hepatotoxicity induced by both gefitinib and erlotinib in EGFR mutation-positive non-small cell lung cancer.

Authors:

Yoshitaka Zenke Shigeki Umemura Eri Sugiyama Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Koichi Goto

Lung Cancer 2016 09 6;99:1-3. Epub 2016 Jun 6.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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September 2016

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.

Authors:

Tomohiro Miyoshi Shigeki Umemura Yuki Matsumura Sachiyo Mimaki Satoshi Tada Hideki Makinoshima Genichiro Ishii Hibiki Udagawa Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Keiju Aokage Tomoyuki Hishida Junji Yoshida Kanji Nagai Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara

Clin Cancer Res 2017 Feb 9;23(3):757-765. Epub 2016 Aug 9.

Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

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February 2017

Acute and Progressive Tracheal Stenosis after Proton Beam Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer.

Authors:

Yoshitaka Zenke Shigeki Umemura Atsushi Motegi Kinya Furukawa Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Masahiro Tsuboi Tetsuo Akimoto Koichi Goto

J Thorac Oncol 2016 07 22;11(7):1181-3. Epub 2016 Apr 22.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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July 2016

Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma.

Authors:

Reiko Matsuzawa Keisuke Kirita Takeshi Kuwata Shigeki Umemura Shingo Matsumoto Satoshi Fujii Kiyotaka Yoh Motohiro Kojima Seiji Niho Hironobu Ohmatsu Atsushi Ochiai Masahiro Tsuboi Koichi Goto Genichiro Ishii

Lung Cancer 2016 Apr 22;94:1-6. Epub 2016 Jan 22.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Japan. Electronic address:

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April 2016

Clinical Impact of Gastric Acid-Suppressing Medication Use on the Efficacy of Erlotinib and Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations.

Authors:

Yoshitaka Zenke Kiyotaka Yoh Shingo Matsumoto Shigeki Umemura Seiji Niho Hironobu Ohmatsu Koichi Goto Yuichiro Ohe

Clin Lung Cancer 2016 09 5;17(5):412-418. Epub 2016 Feb 5.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Juntendo University Graduate School of Medicine, Tokyo, Japan.

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September 2016

Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations.

Authors:

Koichi Saruwatari Shinnosuke Ikemura Keigo Sekihara Takeshi Kuwata Satoshi Fujii Shigeki Umemura Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Atsushi Ochiai Hirotsugu Kohrogi Masahiro Tsuboi Koichi Goto Genichiro Ishii

Lung Cancer 2016 Jan 15;91:7-14. Epub 2015 Nov 15.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, Japan. Electronic address:

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January 2016

RECIST progression patterns during EGFR tyrosine kinase inhibitor treatment of advanced non-small cell lung cancer patients harboring an EGFR mutation.

Authors:

Tatsuya Yoshida Kiyotaka Yoh Seiji Niho Shigeki Umemura Shingo Matsumoto Hironobu Ohmatsu Yuichiro Ohe Koichi Goto

Lung Cancer 2015 Dec 9;90(3):477-83. Epub 2015 Oct 9.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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December 2015

Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma.

Authors:

Kakeru Hisakane Koichi Saruwatari Satoshi Fujii Keisuke Kirita Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Takeshi Kuwata Atsushi Ochiai Akihiko Gemma Masahiro Tsuboi Koichi Goto Genichiro Ishii

J Cancer Res Clin Oncol 2016 Mar 31;142(3):593-600. Epub 2015 Oct 31.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.

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March 2016

Impact of single nucleotide polymorphisms on severe hepatotoxicity induced by EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring EGFR mutations.

Authors:

Eri Sugiyama Shigeki Umemura Shogo Nomura Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Masahiro Tsuboi Yuichiro Ohe Koichi Goto

Lung Cancer 2015 Nov 12;90(2):307-13. Epub 2015 Aug 12.

Department of Thoracic Oncology, National Cancer Center Hospital East, Japan.

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November 2015

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

Authors:

Hideki Makinoshima Masahiro Takita Koichi Saruwatari Shigeki Umemura Yuuki Obata Genichiro Ishii Shingo Matsumoto Eri Sugiyama Atsushi Ochiai Ryo Abe Koichi Goto Hiroyasu Esumi Katsuya Tsuchihara

J Biol Chem 2015 Jul 28;290(28):17495-504. Epub 2015 May 28.

From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.

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July 2015

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma.

Authors:

Yuki Matsumura Shigeki Umemura Genichiro Ishii Koji Tsuta Shingo Matsumoto Keiju Aokage Tomoyuki Hishida Junji Yoshida Yuichiro Ohe Hiroyuki Suzuki Atsushi Ochiai Koichi Goto Kanji Nagai Katsuya Tsuchihara

J Cancer Res Clin Oncol 2015 Dec 20;141(12):2159-70. Epub 2015 May 20.

Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

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December 2015

Second-line docetaxel for patients with platinum-refractory advanced non-small cell lung cancer and interstitial pneumonia.

Authors:

Naohiro Watanabe Seiji Niho Keisuke Kirita Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Hironobu Ohmatsu Koichi Goto

Cancer Chemother Pharmacol 2015 Jul 15;76(1):69-74. Epub 2015 May 15.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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July 2015

Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth.

Authors:

Akiko Takahashi Genichiro Ishii Shinya Neri Tatsuya Yoshida Hiroko Hashimoto Shigeki Suzuki Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Seiji Niho Koichi Goto Hironobu Ohmatsu Kanji Nagai Akihiko Gemma Yuichiro Ohe Atsushi Ochiai

Oncotarget 2015 Apr;6(11):9531-41

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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April 2015

Docetaxel for platinum-refractory advanced thymic carcinoma.

Authors:

Naohiro Watanabe Shigeki Umemura Seiji Niho Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Hironobu Ohmatsu Koichi Goto

Jpn J Clin Oncol 2015 Jul 2;45(7):665-9. Epub 2015 Apr 2.

Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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July 2015

Vinorelbine and cisplatin in patients with advanced non-small cell lung cancer with interstitial pneumonia.

Authors:

Naohiro Watanabe Seiji Niho Keisuke Kirita Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Hironobu Ohmatsu Koichi Goto

Anticancer Res 2015 Mar;35(3):1697-701

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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March 2015

Genomic profiling of small-cell lung cancer: the era of targeted therapies.

Authors:

Shigeki Umemura Katsuya Tsuchihara Koichi Goto

Jpn J Clin Oncol 2015 Jun 10;45(6):513-9. Epub 2015 Feb 10.

Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa.

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June 2015

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung.

Authors:

Hibiki Udagawa Genichiro Ishii Masahiro Morise Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Masahiro Tsuboi Koichi Goto Atsushi Ochiai Yuichiro Ohe

J Cancer Res Clin Oncol 2015 Aug 9;141(8):1417-25. Epub 2015 Jan 9.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.

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August 2015

Presence of podoplanin-positive cancer-associated fibroblasts in surgically resected primary lung adenocarcinoma predicts a shorter progression-free survival period in patients with recurrences who received platinum-based chemotherapy.

Authors:

Haruki Koriyama Genichiro Ishii Kiyotaka Yoh Shinya Neri Masahiro Morise Shigeki Umemura Shingo Matsumoto Seiji Niho Hironobu Ohmatsu Masahiro Tsuboi Koichi Goto Atsushi Ochiai

J Cancer Res Clin Oncol 2015 Jul 2;141(7):1163-70. Epub 2014 Dec 2.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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July 2015

Podoplanin-positive cancer-associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation.

Authors:

Tatsuya Yoshida Genichiro Ishii Koichi Goto Shinya Neri Hiroko Hashimoto Kiyotaka Yoh Seiji Niho Shigeki Umemura Shingo Matsumoto Hironobu Ohmatsu Shinsuke Iida Akio Niimi Kanji Nagai Yuichiro Ohe Atsushi Ochiai

Clin Cancer Res 2015 Feb 11;21(3):642-51. Epub 2014 Nov 11.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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February 2015

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

J Thorac Oncol 2014 Sep;9(9):1324-31

*Division of Thoracic Oncology, National Cancer Center Hospital East; †Exploratory Oncology Research and Clinical Trial Center, National Cancer Center; ‡Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East; §Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; and ‖Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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September 2014

Low-dose irinotecan as a second-line chemotherapy for recurrent small cell lung cancer.

Authors:

Masahiro Morise Seiji Niho Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Koichi Goto Hironobu Ohmatsu Yuichiro Ohe

Jpn J Clin Oncol 2014 Sep 23;44(9):846-51. Epub 2014 Jul 23.

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

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September 2014

Protective effect of magnesium preloading on cisplatin-induced nephrotoxicity: a retrospective study.

Authors:

Tatsuya Yoshida Seiji Niho Mayuko Toda Koichi Goto Kiyotaka Yoh Shigeki Umemura Shingo Matsumoto Hironobu Ohmatsu Yuichiro Ohe

Jpn J Clin Oncol 2014 Apr 5;44(4):346-54. Epub 2014 Feb 5.

*Division of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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April 2014

Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.

Authors:

Yoshitaka Zenke Genichiro Ishii Yuichiro Ohe Kaoru Kaseda Tatsuya Yoshida Shingo Matsumoto Shigeki Umemura Kiyotaka Yoh Seiji Niho Koichi Goto Hironobu Ohmatsu Takeshi Kuwata Kanji Nagai Atsushi Ochiai

Pathol Int 2013 Dec;63(12):599-606

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Hospital East, Kashiwa, Chiba, Japan; Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Juntendo University Graduate School of Medicine, Tokyo, Japan.

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December 2013

Identification of biological properties of intralymphatic tumor related to the development of lymph node metastasis in lung adenocarcinoma.

Authors:

Keisuke Kirita Genichiro Ishii Rie Matsuwaki Yuki Matsumura Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Seiji Niho Koichi Goto Hironobu Ohmatsu Yuichiro Ohe Kanji Nagai Atsushi Ochiai

PLoS One 2013 23;8(12):e83537. Epub 2013 Dec 23.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan.

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March 2015

Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung.

Authors:

Akiko Takahashi Genichiro Ishii Tomonari Kinoshita Tatsuya Yoshida Shigeki Umemura Tomoyuki Hishida Kiyotaka Yoh Seiji Niho Koichi Goto Hironobu Ohmatsu Yuichiro Ohe Kanji Nagai Atsushi Ochiai

J Cancer Res Clin Oncol 2013 Nov 7;139(11):1869-78. Epub 2013 Sep 7.

Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-City, Chiba, 277-8577, Japan.

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November 2013

Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung adenocarcinoma.

Authors:

Tatsuya Yoshida Genichiro Ishii Koichi Goto Kiyotaka Yoh Seiji Niho Shigeki Umemura Shingo Matsumoto Hironobu Ohmatsu Kanji Nagai Yuichiro Ohe Atsushi Ochiai

J Cancer Res Clin Oncol 2013 Oct 22;139(10):1691-700. Epub 2013 Aug 22.

Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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October 2013

Safety and efficacy of platinum agents plus etoposide for patients with small cell lung cancer with interstitial lung disease.

Authors:

Tatsuya Yoshida Kiyotaka Yoh Koichi Goto Seiji Niho Shigeki Umemura Hironobu Ohmatsu Yuichiro Ohe

Anticancer Res 2013 Mar;33(3):1175-9

Division of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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March 2013

Renal toxicity caused by brand-name versus generic cisplatin: a comparative analysis.

Authors:

Seiji Niho Takeharu Yamanaka Shigeki Umemura Shingo Matsumoto Kiyotaka Yoh Koichi Goto Hironobu Ohmatsu Yuichiro Ohe

Jpn J Clin Oncol 2013 Apr 26;43(4):390-5. Epub 2013 Feb 26.

Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

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April 2013

Clinical outcome in patients with leptomeningeal metastasis from non-small cell lung cancer: Okayama Lung Cancer Study Group.

Authors:

Shigeki Umemura Kazuya Tsubouchi Hiroshige Yoshioka Katsuyuki Hotta Nagio Takigawa Keiichi Fujiwara Naokatsu Horita Yoshihiko Segawa Noboru Hamada Ichiro Takata Hiromichi Yamane Haruhito Kamei Katsuyuki Kiura Mitsune Tanimoto

Lung Cancer 2012 Jul 7;77(1):134-9. Epub 2012 Apr 7.

Division of Clinical Oncology, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, Japan.

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July 2012

Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.

Authors:

Masanori Fujii Nobukazu Fujimoto Akio Hiraki Kenichi Gemba Keisuke Aoe Shigeki Umemura Hideki Katayama Nagio Takigawa Katsuyuki Kiura Mitsune Tanimoto Takumi Kishimoto

Cancer Sci 2012 Mar 13;103(3):510-4. Epub 2012 Jan 13.

Department of Respiratory Medicine, Okayama Rosai Hospital, Okayama, Japan.

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March 2012

Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type.

Authors:

Hiromichi Yamane Masahiro Ohsawa Yasuhiro Shiote Shigeki Umemura Toshimitsu Suwaki Atsuko Shirakawa Haruhito Kamei Nagio Takigawa Katsuyuki Kiura

Clin J Gastroenterol 2011 Dec 4;4(6):401-6. Epub 2011 Oct 4.

Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

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December 2011

Variant angina pectoris associated with FOLFOX4 therapy.

Authors:

Hiromichi Yamane Minoru Matsubara Shigeki Umemura Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura Mitsune Tanimoto

World J Gastrointest Oncol 2011 Nov;3(11):165-8

Hiromichi Yamane, Shigeki Umemura, Toshimitsu Suwaki, Haruhito Kamei, Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1Ohji-cho, Niihama, Ehime 792-8543, Japan.

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November 2011

Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer.

Authors:

Shigeki Umemura Hiromichi Yamane Toshimitsu Suwaki Tsutomu Katoh Takuya Yano Yasuhiro Shiote Nagio Takigawa Katsuyuki Kiura Haruhito Kamei

J Cancer Res Clin Oncol 2011 Oct 5;137(10):1469-75. Epub 2011 Aug 5.

Department of Clinical Oncology, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, 792-8543, Japan.

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October 2011

An oral fluoropyrimidine agent S-1 induced interstitial lung disease: A case report.

Authors:

Hiromichi Yamane Masahide Kinugawa Shigeki Umemura Yasuhiro Shiote Kenichiro Kudo Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura

World J Clin Oncol 2011 Jul;2(7):299-302

Hiromichi Yamane, Masahide Kinugawa, Shigeki Umemura, Yasuhiro Shiote, Kenichiro Kudo, Toshimitsu Suwaki, Haruhito Kamei, Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Ohji-cho, Niihama, Ehime 792-8543, Japan.

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July 2011

Synchronous double primary lung cancers with different response to pemetrexed.

Authors:

Shigeki Umemura Hiromichi Yamane Takuya Yano Toshiko Hoshika Yasuhiro Shiote Nagio Takigawa Toshimitsu Suwaki Atsuko Shirakawa Haruhito Kamei

Anticancer Drugs 2011 Jun;22(5):473-6

Department of Clinical Oncology, Sumitomo-Besshi Hospital, Niihama, Japan.

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June 2011

Desire for information and involvement in treatment decisions: lung cancer patients' preferences and their physicians' perceptions: results from Okayama Lung Cancer Study Group Trial 0705.

Authors:

Katsuyuki Hotta Katsuyuki Kiura Nagio Takigawa Hiroshige Yoshioka Hidetoshi Hayashi Hajime Fukuyama Akihiro Nishiyama Toshihide Yokoyama Shoichi Kuyama Shigeki Umemura Yuka Kato Naoyuki Nogami Yoshihiko Segawa Masayuki Yasugi Masahiro Tabata Mitsune Tanimoto

J Thorac Oncol 2010 Oct;5(10):1668-72

Department of Respiratory Medicine, Okayama University Hospital, Kitaku, Okayama, Japan.

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October 2010

Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer.

Authors:

Nobukazu Fujimoto Katsuyuki Kiura Nagio Takigawa Yoshiro Fujiwara Shinichi Toyooka Shigeki Umemura Masahiro Tabata Hiroshi Ueoka Mitsune Tanimoto

Acta Med Okayama 2010 Feb;64(1):33-7

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama 700-8558, Japan.

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February 2010

Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer: the Okayama Lung Cancer Study Group experience.

J Thorac Oncol 2010 Feb;5(2):179-84

Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

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February 2010

A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705.

Authors:

Hiroshige Yoshioka Katsuyuki Hotta Katsuyuki Kiura Nagio Takigawa Hidetoshi Hayashi Shingo Harita Shoichi Kuyama Yoshihiko Segawa Haruhito Kamei Shigeki Umemura Akihiro Bessho Masahiro Tabata Mitsune Tanimoto

J Thorac Oncol 2010 Jan;5(1):99-104

Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.

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January 2010

Centrally located squamous cell carcinoma of the lung mimicking endobronchial tuberculosis.

Authors:

Shigeki Umemura Kenichiro Kudo Takashi Ninomiya Yasuhiro Shiote Hiromichi Yamane Toshimitsu Suwaki Atsuko Shirakawa Haruhito Kamei

J Thorac Oncol 2009 Sep;4(9):1178-9

Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, Sumitomo-Besshi Hospital, Niihama, Japan.

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September 2009

Efficacy of a lumbo-peritoneal shunt for meningeal carcinomatosis refractory to gefitinib treatment.

Authors:

Toshio Kubo Nagio Takigawa Katsuyuki Kiura Ayumi Nishida Nobuaki Ochi Hiromi Kashihara Shigeki Umemura Akiko Hisamoto Mitsune Tanimoto

Anticancer Res 2009 Jul;29(7):2759-60

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

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July 2009

[Evaluation of efficacy and safety of adjuvant analgesics for peripheral neuropathy induced by cancer chemotherapy in digestive cancer patients-a pilot study].

Authors:

Takuya Yano Hiromichi Yamane Ryuichi Fukuoka Takashi Ninomiya Shigeki Umemura Seiyuu Suzuki Hideyuki Saeki Toshihito Hanaoka Tsutomu Katou Kaori Itoh Takane Fujita Haruhito Kamei

Gan To Kagaku Ryoho 2009 Jan;36(1):83-7

Division of Pharmacology, Sumitomo-Besshi Hospital, Japan.

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January 2009

Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test.

Authors:

Shoji Hirasaki Seiyuu Suzuki Shigeki Umemura Haruhito Kamei Masato Okuda Kenichiro Kudo

World J Gastroenterol 2008 Sep;14(35):5481-3

Department of Internal Medicine, Sumitomo Besshi Hospital, 3-1 Ohji-cho, Niihama, Japan.

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September 2008

Aberrant promoter hypermethylation in serum DNA from patients with silicosis.

Authors:

Shigeki Umemura Nobukazu Fujimoto Akio Hiraki Kenichi Gemba Nagio Takigawa Keiichi Fujiwara Masanori Fujii Hiroshi Umemura Mamoru Satoh Masahiro Tabata Hiroshi Ueoka Katsuyuki Kiura Takumi Kishimoto Mitsune Tanimoto

Carcinogenesis 2008 Sep 16;29(9):1845-9. Epub 2008 Jul 16.

Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan.

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September 2008

Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine.

Authors:

Yoshiro Fujiwara Katsuyuki Kiura Masahiro Tabata Nagio Takigawa Katsuyuki Hotta Shigeki Umemura Masako Omori Kenichi Gemba Hiroshi Ueoka Mitsune Tanimoto

Anticancer Drugs 2008 Apr;19(4):431-3

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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April 2008

Radiation necrosis mimicking progressive brain metastasis in a patient with non-small cell lung cancer.

Authors:

Kadoaki Ohashi Kastuyuki Kiura Nagio Takigawa Shigeki Umemura Naruhito Kondo Mistuhiro Takemoto Kensuke Onoda Motoi Aoe Masahiro Tabata Mistune Tanimoto

J Thorac Oncol 2007 Aug;2(8):762-3

Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences & Okayama University Hospital, Okayama, Japan.

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August 2007

Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer.

Authors:

Katsuyuki Hotta Katsuyuki Kiura Masahiro Tabata Nagio Takigawa Yoshiro Fujiwara Shigeki Umemura Mitsune Tanimoto

Anticancer Res 2007 May-Jun;27(3B):1737-41

Department of Respiratory Medicine, Okayama University Hospital, 2-5-1, Shikata-cho, Okayama 700-8558, Japan.

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July 2007

Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells.

Authors:

Nagio Takigawa Masami Takeyama Toshiyuki Kozuki Takuo Shibayama Akiko Hisamoto Katsuyuki Kiura Atsuhiko Tada Katsuyuki Hotta Shigeki Umemura Kadoaki Ohashi Yoshiro Fujiwara Saburo Takata Eiki Ichihara Masahiro Osawa Masahiro Tabata Mitsune Tanimoto Kiyoshi Takahashi

Oncol Rep 2007 May;17(5):983-7

Department of Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan.

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May 2007

Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer.

Authors:

Shigeki Umemura Yoshihiko Segawa Hiroshi Ueoka Katsuyuki Hotta Katsuyuki Kiura Nagio Takigawa Masahiro Tabata Akihiro Bessho Tetsu Shinkai Mitsune Tanimoto

J Cancer Res Clin Oncol 2007 Aug 17;133(8):519-24. Epub 2007 Mar 17.

Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

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August 2007