Publications by authors named "Shigeki Higashiyama"

100Publications

Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion.

Food Funct 2020 Nov 13. Epub 2020 Nov 13.

The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan and Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo02442bDOI Listing
November 2020

ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway.

Biochem Biophys Res Commun 2020 Oct 20. Epub 2020 Oct 20.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2020.10.032DOI Listing
October 2020

The Roles of SPOP in DNA Damage Response and DNA Replication.

Int J Mol Sci 2020 Oct 2;21(19). Epub 2020 Oct 2.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21197293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582541PMC
October 2020

Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation.

J Cell Physiol 2020 Sep 27. Epub 2020 Sep 27.

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.30077DOI Listing
September 2020

Development of Human CBF1-Targeting Single-Stranded DNA Aptamers with Antiangiogenic Activity .

Nucleic Acid Ther 2020 Sep 2. Epub 2020 Sep 2.

Department of Biochemistry and Molecular Genetics and Ehime University Graduate School of Medicine, Toon, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2020.0875DOI Listing
September 2020

KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates: Emerging Divergent Roles of the cullin-3/KCTD10 E3 Ubiquitin Ligase Complex in Various Cell Lines.

Bioessays 2020 Aug 2;42(8):e1900256. Epub 2020 Jun 2.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime, 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bies.201900256DOI Listing
August 2020

SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.

Mol Biol Cell 2020 03 22;31(6):478-490. Epub 2020 Jan 22.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E19-08-0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185892PMC
March 2020

Automated collective motion analysis validates human keratinocyte stem cell cultures.

Sci Rep 2019 12 10;9(1):18725. Epub 2019 Dec 10.

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-55279-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904747PMC
December 2019

Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.

Ann Thorac Surg 2020 07 22;110(1):40-49. Epub 2019 Nov 22.

Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2019.09.085DOI Listing
July 2020

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.

Biochem Biophys Res Commun 2019 09 5;516(4):1116-1122. Epub 2019 Jul 5.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Shitsukawa, Toon, Ehime, 791-0295, Japan; Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.07.010DOI Listing
September 2019

Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism.

Biochem Biophys Rep 2019 Mar 3;17:132-138. Epub 2019 Jan 3.

Lipid Biofunction Section, Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24055808183014
Publisher Site
http://dx.doi.org/10.1016/j.bbrep.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319021PMC
March 2019

Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment.

Front Physiol 2018 23;9:1662. Epub 2018 Nov 23.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.01662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265511PMC
November 2018

Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells.

J Cell Physiol 2019 05 11;234(5):6865-6875. Epub 2018 Nov 11.

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.27443DOI Listing
May 2019

Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.

Oncogene 2018 10 4;37(40):5416-5434. Epub 2018 Jun 4.

Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Otsu, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0286-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172191PMC
October 2018

Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin.

Biochem Biophys Res Commun 2018 04 21;499(1):17-23. Epub 2018 Mar 21.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan; Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Shitsukawa, Ehime 791-0295, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.03.097DOI Listing
April 2018

Phytosphingosine is a novel activator of GPR120.

J Biochem 2018 Jul;164(1):27-32

Laboratory of Food Safety and Science, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, Saga 840-8502, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvy017DOI Listing
July 2018

The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.

J Cell Biol 2018 03 22;217(3):1015-1032. Epub 2018 Jan 22.

Department of Physiology, Vrije Universiteit University Medical Center, Amsterdam, Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201606055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839774PMC
March 2018

Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization.

Arterioscler Thromb Vasc Biol 2018 01 30;38(1):174-185. Epub 2017 Nov 30.

From the Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan (Y.I., M.S., S.N., S.T., Y.H., H.I., T.M., K.T., H.H.); Proteo-Science Center, Division of Cell Growth and Tumor Regulation, Ehime University Shitsukawa, Toon, Japan (T.S., H.N., S.H.); and Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Japan (T.S., S.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.117.310337DOI Listing
January 2018

Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells.

Biol Open 2017 Nov 15;6(11):1707-1719. Epub 2017 Nov 15.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Matsuyama 791-0295, Japan

View Article

Download full-text PDF

Source
http://bio.biologists.org/lookup/doi/10.1242/bio.029579
Publisher Site
http://dx.doi.org/10.1242/bio.029579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703617PMC
November 2017

Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis.

J Biochem 2017 Oct;162(4):237-245

Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvx051DOI Listing
October 2017

Mechanism of Proliferation of Cultured Human Corneal Endothelial Cells.

Cornea 2017 Nov;36 Suppl 1:S41-S45

Departments of *Ophthalmology;†Stem Cell Biology;‡Ophthalmology and Regenerative Medicine; and§Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001337DOI Listing
November 2017

The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.

Sci Rep 2017 02 20;7:42845. Epub 2017 Feb 20.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, Toon, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep42845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317005PMC
February 2017

Proteomics-based analysis of lung injury-induced proteins in a mouse model of common bile duct ligation.

Surgery 2017 06 28;161(6):1525-1535. Epub 2017 Jan 28.

Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surg.2016.12.017DOI Listing
June 2017

Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes.

Biochim Biophys Acta 2016 11 4;1863(11):2795-2808. Epub 2016 Sep 4.

Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Aachen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2016.09.002DOI Listing
November 2016

Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A).

J Biol Chem 2016 May 10;291(20):10490-500. Epub 2016 Mar 10.

From the Departments of Dermatology, Strategic Young Researcher Overseas Visiting Program for Accelerating Brain Circulation, Japan Society for the Promotion of Science (JSPS), 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan, Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.683201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865900PMC
May 2016

Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability.

J Dermatol Sci 2016 May 29;82(2):84-94. Epub 2016 Jan 29.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, Toon, Ehime 791-0295, Japan; Department of Biochemistry and Molecular Genetics, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2016.01.009DOI Listing
May 2016

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.

Sci Rep 2016 Feb 2;6:20209. Epub 2016 Feb 2.

Division of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, Toon, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep20209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735799PMC
February 2016

Rotation is the primary motion of paired human epidermal keratinocytes.

J Dermatol Sci 2015 Sep 10;79(3):194-202. Epub 2015 Jun 10.

Department of Biochemistry and Molecular Genetics, Graduate School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan; Division of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2015.05.008DOI Listing
September 2015

Cell motion predicts human epidermal stemness.

J Cell Biol 2015 Apr 20;209(2):305-15. Epub 2015 Apr 20.

Laboratory of Stem Cell Dynamics, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland Department of Experimental Surgery, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201409024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411274PMC
April 2015

Long‑term exposure to leptin enhances the growth of prostate cancer cells.

Int J Oncol 2015 Apr 23;46(4):1535-42. Epub 2015 Jan 23.

Department of Urology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2015.2845DOI Listing
April 2015

ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.

Am J Physiol Renal Physiol 2014 Sep 4;307(5):F551-9. Epub 2014 Jun 4.

Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.

View Article

Download full-text PDF

Source
http://ajprenal.physiology.org/content/ajprenal/early/2014/0
Web Search
http://ajprenal.physiology.org/content/ajprenal/307/5/F551.f
Web Search
http://ajprenal.physiology.org/cgi/doi/10.1152/ajprenal.0021
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00218.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154111PMC
September 2014

Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.

Oncol Lett 2014 Mar 19;7(3):674-678. Epub 2013 Dec 19.

Department of Urology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2013.1768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919892PMC
March 2014

Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.

Proc Natl Acad Sci U S A 2014 Jan 30;111(2):717-22. Epub 2013 Dec 30.

Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1313675111
Publisher Site
http://dx.doi.org/10.1073/pnas.1313675111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896180PMC
January 2014

Second harmonic generation reveals collagen fibril remodeling in fibroblast-populated collagen gels.

Cell Struct Funct 2013 18;38(2):227-36. Epub 2013 Oct 18.

Senior Research Fellow Center, Ehime University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1247/csf.13017DOI Listing
August 2015

Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells.

Oncol Rep 2013 Oct 6;30(4):1593-600. Epub 2013 Aug 6.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2013.2659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810215PMC
October 2013

Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation.

J Dermatol Sci 2013 Nov 13;72(2):81-6. Epub 2013 Jun 13.

Senior Research Fellow Center, Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan; Department of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2013.05.009DOI Listing
November 2013

Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells.

J Biochem 2013 Jul 18;154(1):67-76. Epub 2013 Apr 18.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
https://academic.oup.com/jb/article-lookup/doi/10.1093/jb/mv
Publisher Site
http://dx.doi.org/10.1093/jb/mvt030DOI Listing
July 2013

Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes.

Cancer Sci 2013 Jul 15;104(7):904-11. Epub 2013 May 15.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.12171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657214PMC
July 2013

Doxycycline-dependent inducible and reversible RNA interference mediated by a single lentivirus vector.

Biosci Biotechnol Biochem 2013 7;77(4):776-81. Epub 2013 Apr 7.

Functional Genomics Core Laboratory, Ehime University Proteo-Medicine Research Center (ProMRes), Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1271/bbb.120917DOI Listing
November 2013

Actin filament dynamics impacts keratinocyte stem cell maintenance.

EMBO Mol Med 2013 Apr;5(4):640-53

Laboratory of Stem Cell Dynamics, Ecole Polytechnique Fédérale de Lausanne EPFL, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/emmm.201201839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628097PMC
April 2013

Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.

Angiogenesis 2013 Jul 21;16(3):675-88. Epub 2013 Mar 21.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10456-013-9345-xDOI Listing
July 2013

Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes.

J Biol Chem 2013 Apr 21;288(15):10338-48. Epub 2013 Feb 21.

Department of Biochemistry and Molecular Genetics, Ehime University, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.417527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624417PMC
April 2013

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.

Nat Methods 2012 Oct 16;9(10):1021-9. Epub 2012 Sep 16.

Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.2172DOI Listing
October 2012

Lighting up by EMARS.

J Biochem 2012 Nov 25;152(5):381-2. Epub 2012 Aug 25.

Department of Cell Growth and Tumor Regulation, ProteoMedicine Research Center, Ehime University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvs096DOI Listing
November 2012

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.

Hepatol Res 2013 Apr 9;43(4):384-93. Epub 2012 Aug 9.

Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka Department of Biochemistry and Molecular Genetics, Ehime University, Graduate School of Medicine Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center (ProMRes), Ehime University, Ehime Kansai-Rosai Hospital, Hyogo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1872-034X.2012.01074.xDOI Listing
April 2013

Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion.

BMC Cancer 2012 May 30;12:205. Epub 2012 May 30.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-12-205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414754PMC
May 2012

Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner.

Biochem Biophys Res Commun 2012 Apr 16;420(4):721-6. Epub 2012 Mar 16.

Osaka University Graduate School of Medicine and Health Science, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0006291X1200492
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2012.03.045DOI Listing
April 2012

Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin.

Mol Biol Cell 2012 May 21;23(10):1964-75. Epub 2012 Mar 21.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

View Article

Download full-text PDF

Source
http://www.molbiolcell.org/doi/10.1091/mbc.e11-08-0683
Publisher Site
http://dx.doi.org/10.1091/mbc.E11-08-0683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350559PMC
May 2012

Important role of epiregulin in inflammatory responses during corneal epithelial wound healing.

Invest Ophthalmol Vis Sci 2012 Apr 30;53(4):2414-23. Epub 2012 Apr 30.

Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.11-8869DOI Listing
April 2012

Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding.

Biochem Biophys Res Commun 2012 Apr 7;420(2):315-20. Epub 2012 Mar 7.

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0006291X1200430
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2012.02.156DOI Listing
April 2012

A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.

PLoS One 2012 8;7(3):e33350. Epub 2012 Mar 8.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297637PMC
August 2012

Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer.

Cancer Sci 2012 Apr 20;103(4):708-15. Epub 2012 Feb 20.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1349-7006.2012.02204.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659380PMC
April 2012

The cytoplasmic tail of heparin-binding EGF-like growth factor regulates bidirectional intracellular trafficking between the plasma membrane and ER.

FEBS Open Bio 2012 26;2:339-44. Epub 2012 Sep 26.

Department of Biochemistry and Molecular Genetics, Graduate School of Medicine, Ehime University, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fob.2012.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642169PMC
May 2013

Overexpressed HER2 in NSCLC is a possible therapeutic target of EGFR inhibitors.

Anticancer Res 2011 Dec;31(12):4155-61

Biotechnology Research Group, Fundamental Research Department, Fujirebio Inc, Tokyo, Japan.

View Article

Download full-text PDF

Source
December 2011

Fibronectin regulates proteoglycan production balance in transforming growth factor-β1-induced chondrogenesis.

Int J Mol Med 2011 Nov 5;28(5):829-34. Epub 2011 Aug 5.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2011.766DOI Listing
November 2011

ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.

Exp Cell Res 2011 Aug 20;317(13):1851-9. Epub 2011 May 20.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2011.05.012DOI Listing
August 2011

Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands.

J Biochem 2011 Jul 24;150(1):15-22. Epub 2011 May 24.

Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center (ProMRes), Ehime University, Japan.

View Article

Download full-text PDF

Source
https://academic.oup.com/jb/article-lookup/doi/10.1093/jb/mv
Publisher Site
http://dx.doi.org/10.1093/jb/mvr068DOI Listing
July 2011

Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Wound Repair Regen 2011 Mar-Apr;19(2):229-40

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1524-475X.2010.00655.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076689PMC
June 2011

Spatiotemporally-regulated interaction between β1 integrin and ErbB4 that is involved in fibronectin-dependent cell migration.

J Biochem 2011 Mar 8;149(3):347-55. Epub 2011 Jan 8.

Department of Biochemistry, Kochi System Glycobiology Center, Kochi University Medical School, Nankoku, Kochi, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvq148DOI Listing
March 2011

[Epidermal growth factor (EGF)].

Nihon Rinsho 2010 Jul;68 Suppl 7:114-7

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine.

View Article

Download full-text PDF

Source
July 2010

TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.

Biochem Biophys Res Commun 2010 Nov 8;402(3):449-54. Epub 2010 Oct 8.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.09.130DOI Listing
November 2010

Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.

Invest Ophthalmol Vis Sci 2010 Nov 16;51(11):5630-9. Epub 2010 Jun 16.

Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Japan.

View Article

Download full-text PDF

Source
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
Publisher Site
http://dx.doi.org/10.1167/iovs.10-5158DOI Listing
November 2010

Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.

Biochem Biophys Res Commun 2010 Apr 11;394(3):685-90. Epub 2010 Mar 11.

Biotechnology Research Group, Fundamental Research Department, Fujirebio Inc., Tokyo 192-0031, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.03.052DOI Listing
April 2010

Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro.

Obesity (Silver Spring) 2010 Oct 28;18(10):1888-94. Epub 2010 Jan 28.

Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2010.2DOI Listing
October 2010

Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Mol Biol Cell 2009 Dec;20(24):5236-49

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e08-12-1256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793298PMC
December 2009

Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.

Eur J Pharm Sci 2009 Dec 3;38(5):504-11. Epub 2009 Oct 3.

Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2009.09.016DOI Listing
December 2009

Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling.

Mol Membr Biol 2009 Aug;26(5):279-92

Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Unversität Leipzig, Härtelstrasse 16-18, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09687680903191682DOI Listing
August 2009

Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Mol Cancer Res 2009 Sep 8;7(9):1572-81. Epub 2009 Sep 8.

Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

View Article

Download full-text PDF

Source
http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-08
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-08-0567DOI Listing
September 2009

Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells.

Int J Radiat Oncol Biol Phys 2009 Oct;75(2):475-81

Department of Radiation Oncology, Osaka University Graduate School of Medicine and Health Science, Suita, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2008.12.090DOI Listing
October 2009

Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.

Exp Cell Res 2009 Dec 6;315(20):3500-8. Epub 2009 Aug 6.

Clinic of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2009.07.029DOI Listing
December 2009

Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.

J Biol Chem 2009 May 4;284(18):12399-409. Epub 2009 Feb 4.

Department of Biochemistry and Molecular Genetics, Center for Regenerative Medicine (CEREM), Ehime University, Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M900463200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673307PMC
May 2009

Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.

J Cell Sci 2008 Nov;121(Pt 21):3608-18

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://jcs.biologists.org/cgi/doi/10.1242/jcs.031443
Publisher Site
http://dx.doi.org/10.1242/jcs.031443DOI Listing
November 2008

Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.

J Cell Biol 2008 Feb;180(4):763-9

Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.200710022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373455PMC
February 2008

Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.

Cancer Sci 2008 Feb;99(2):214-20

Department of Biochemistry and Molecular Genetics, Center for Regenerative Medicine (CEREM), Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1349-7006.2007.00676.xDOI Listing
February 2008