Publications by authors named "Shi-Yao Cheng"

17 Publications

  • Page 1 of 1

Dehydroepiandrosterone attenuates pulmonary artery and right ventricular remodeling in a rat model of pulmonary hypertension due to left heart failure.

Life Sci 2019 Feb 31;219:82-89. Epub 2018 Dec 31.

Cardiovascular Department of the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address:

Aim: Pulmonary hypertension due to left heart failure (PH-LHF) is the most common cause of pulmonary hypertension. However, therapies for PH-LHF are lacking. Therefore, we investigated the effects and potential mechanism of dehydroepiandrosterone (DHEA) treatment in an experimental model of PH-LHF.

Main Method: PH-LHF was induced in rats via ascending aortic banding. The rats then received daily DHEA from Day 1 to Day 63 for the prevention protocol or from Day 49 to Day 63 for the reversal protocol. Other ascending aortic banding rats were left untreated to allow development of PH and right ventricular (RV) failure. Sham ascending aortic banding rats served as controls.

Key Finding: Significant increases in mean pulmonary arterial pressure (mPAP) and right ventricular end-diastolic diameter (RVEDD) were observed in the PH-LHF group. Therapy with DHEA prevented LHF-induced PH and RV failure by preserving mPAP and preventing RV hypertrophy and pulmonary artery remodeling. In preexisting severe PH, DHEA attenuated most lung and RV abnormalities. The beneficial effects of DHEA in PH-LHF seem to result from depression of the STAT3 signaling pathway in the lung.

Significant: DHEA not only prevents the development of PH-LHF and RV failure but also rescues severe preexisting PH-LHF.
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http://dx.doi.org/10.1016/j.lfs.2018.12.056DOI Listing
February 2019

Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B.

Genet Test Mol Biomarkers 2016 Sep 8;20(9):535-43. Epub 2016 Jul 8.

1 Division of Digestive Diseases, Zhong Shan Hospital, Fu Dan University , Shanghai, China .

Aims: To investigate the clinical and genetic risk factors associated with hepatocellular carcinoma (HCC) in cirrhotic patients with chronic hepatitis B (CHB).

Methods: Nine hundred forty-nine Chinese Han patients with CHB were studied, including noncirrhotic patients without HCC (N = 234), cirrhotic patients without (N = 281) and with HCC (N = 434). Patients were genotyped for 10 candidate single nucleotide polymorphisms (SNPs) by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method.

Results: By multivariate logistic regression analysis adjusted for Child-Pugh scores, noneffective antiviral treatment, drinking history, family history of HCC, and age ≥50 years old were associated with HCC risk (odds ratio [OR] = 5.923, 2.456, 2.241, 1.955, respectively). Sixty-two of 170 cirrhotic patients who achieved sustained virological suppression by antiviral treatment developed HCC, with fatty liver disease, family history of HCC, and family history of hepatitis B virus (HBV) infection as the risk factors (OR = 11.646, 3.339, 2.537, respectively). The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in TLR4 and rs2853744 in SPP1. Polymorphisms of TLR4 rs2149356, AP3S2 rs2290351, STXBP5L rs2169302, MLEC rs7976497, and SOCS3 rs4969168 were associated with HCC risk in specific stratified analyses with gender, age, and drinking history in the cirrhotic patients.

Conclusions: Inadequate antiviral treatment, family history of HCC, drinking history, and age ≥50 years old are risk factors for HCC. Sustained suppression of HBV does not eliminate the risk of HCC. Specific host genetic factors may impact HCC development in Han Chinese cirrhotic patients with CHB, including SNPs in TLR4, SPP1, AP3S2, STXBP5L, MLEC, and SOCS3, which warrant further validation in additional cohorts.
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http://dx.doi.org/10.1089/gtmb.2016.0062DOI Listing
September 2016

The Effects and Mechanism of Atorvastatin on Pulmonary Hypertension Due to Left Heart Disease.

PLoS One 2016 7;11(7):e0157171. Epub 2016 Jul 7.

Department of Cardiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Pulmonary hypertension due to left heart disease (PH-LHD) is one of the most common forms of PH, termed group 2 PH. Atorvastatin exerts beneficial effects on the structural remodeling of the lung in ischemic heart failure. However, few studies have investigated the effects of atorvastatin on PH due to left heart failure induced by overload.

Methods: Group 2 PH was induced in animals by aortic banding. Rats (n = 20) were randomly divided into four groups: a control group (C), an aortic banding group (AOB63), an atorvastatin prevention group (AOB63/ATOR63) and an atorvastatin reversal group (AOB63/ATOR50-63). Atorvastatin was administered for 63 days after banding to the rats in the AOB63/ATOR63 group and from days 50 to 63 to the rats in the AOB63/ATOR50-63 group.

Results: Compared with the controls, significant increases in the mean pulmonary arterial pressure, pulmonary arteriolar medial thickening, biventricular cardiac hypertrophy, wet and dry weights of the right middle lung, percentage of PCNA-positive vascular smooth muscle cells, inflammatory infiltration and expression of RhoA and Rho-kinase II were observed in the AOB63 group, and these changes concomitant with significant decreases in the percentage of TUNEL-positive vascular smooth muscle cells. Treatment of the rats in the AOB63/ATOR63 group with atorvastatin at a dose of 10 mg/kg/day significantly decreased the mean pulmonary arterial pressure, right ventricular hypertrophy, pulmonary arteriolar medial thickness, inflammatory infiltration, percentage of PCNA-positive cells and pulmonary expression of RhoA and Rho-kinase II and significantly augmented the percentage of TUNEL-positive cells compared with the AOB63 group. However, only a trend of improvement in pulmonary vascular remodeling was detected in the AOB63/ATOR50-63 group.

Conclusions: Atorvastatin prevents pulmonary vascular remodeling in the PH-LHD model by down-regulating the expression of RhoA/Rho kinase, by inhibiting the proliferation and increasing the apoptosis of pulmonary arterial smooth muscle cells, and by attenuating the inflammation of pulmonary arteries.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157171PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936674PMC
July 2017

Two Fe3(μ3-S)2(CO)8 clusters with terminal N-heterocyclic carbenes.

Acta Crystallogr C Struct Chem 2014 Jun 6;70(Pt 6):528-32. Epub 2014 May 6.

College of Chemistry and Chemical Engineering, Yangzhou University, 180 Si Wang Ting Road, Yangzhou 225002, People's Republic of China.

The title compounds with terminal N-heterocyclic carbenes, namely octacarbonyl(imidazolidinylidene-κC(2))di-μ3-sulfido-triiron(II)(2 Fe-Fe), [Fe3(C3H6N2)(μ3-S)2(CO)8], (I), and octacarbonyl(1-methylimidazo[1,5-a]pyridin-3-ylidene-κC(3))di-μ3-sulfido-triiron(II)(2 Fe-Fe), [Fe3(C8H8N2)(μ3-S)2(CO)8], (II), have been synthesized. Each compound contains two Fe-Fe bonds and two S atoms above and below a triiron triangle. One of the eight carbonyl ligands deviates significantly from linearity. In (I), dimers generated by an N-H···S hydrogen bond are linked into [001] double chains by a second N-H···S hydrogen bond. These chains are packed by a C-H···O hydrogen bond to yield [101] sheets. In (II), dimers generated by an N-H···S hydrogen bond are linked by C-H···O hydrogen bonds to form [111] double chains.
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http://dx.doi.org/10.1107/S2053229614009310DOI Listing
June 2014

Two seven-membered heterocycles with 1,2-diaza ring N atoms: 3,5,7-triphenyl-1,2-diazacyclohepta-1(7),2-diene and 3,7-bis(2-hydroxyphenyl)-5-phenyl-1,2-diazacyclohepta-1(7),2-diene.

Acta Crystallogr C 2013 Oct 6;69(Pt 10):1177-80. Epub 2013 Sep 6.

College of Chemistry and Chemical Engineering, Yangzhou University, 180 SiWangTing Road, Yangzhou 225002, People's Republic of China.

The title compounds, 3,5,7-triphenyl-1,2-diazacyclohepta-1(7),2-diene, C23H20N2, (I), and 3,7-bis(2-hydroxyphenyl)-5-phenyl-1,2-diazacyclohepta-1(7),2-diene, C23H20N2O2, (II), constitute the first structurally characterized examples of seven-membered heterocycles with 1,2-diaza ring N atoms. Compound (I) crystallizes in the space group P1, with two independent molecules in the asymmetric unit that differ in the conformation of one of the phenyl rings, while (II) crystallizes in the space group C2/c. The C5N2 ring in each of (I) and (II) adopts a twist-boat conformation. Compound (I) exhibits neither C-H···π interactions nor π-π stacking interactions, whereas (II) shows both intramolecular O-H···N hydrogen bonds and a C-H···π interaction that joins the molecules into an infinite chain in the [010] direction.
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http://dx.doi.org/10.1107/S0108270113023792DOI Listing
October 2013

A novel hexairon cluster with one disulfide and two Ph2PCS(3-) ligands.

Acta Crystallogr C 2013 Jun 10;69(Pt 6):581-3. Epub 2013 May 10.

College of Chemistry and Chemical Engineering, Yangzhou University, 180 SiWangTing Road, Yangzhou 225002, People's Republic of China.

The title compound, hexadecacarbonylbis{μ3-[(diphenylphosphanyl)methanediidyl]sulfanido}-μ4-disulfido(2-)-hexairon(4 Fe-Fe), [Fe6(C13H10PS)2(S2)(CO)16], contains two inversion-related [Fe3(Ph2PCS)(CO)8] subclusters linked by an equatorial disulfide bond [S-S = 2.1490 (9) Å]. Each Ph2PCS(3-) ligand is coordinated to a triiron core in a μ3-κP:κ(2)C:κ(2)S fashion.
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http://dx.doi.org/10.1107/S0108270113009049DOI Listing
June 2013

Syntheses and crystal structures of neutral tetrairon complexes with the unique SCPPh2S ligand.

Chem Commun (Camb) 2013 Mar;49(22):2255-7

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

The novel reactions of cluster salts [(μ-RS)Fe(2)(CO)(6)(μ(4)-CS(2))Fe(2)(CO)(6)][Et(3)NH] with Ph(2)PCl, via the insertion of the PPh(2) group into an activated C-S bond, afford the unprecedented tetrairon complexes with the unique SCPPh(2)S ligand which is coordinated to (μ-RS)Fe(2)(CO)(6) and Fe(2)(CO)(6) units in a μ(4)-k(2)C:k(4)S,S' mode (R = Ph, CH(3)O(2)CCH(2)).
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http://dx.doi.org/10.1039/c3cc00169eDOI Listing
March 2013

μ(4)-Orthothio-carbonato-tetra-kis-[tri-carbonyl-iron(I)](2 Fe-Fe).

Acta Crystallogr Sect E Struct Rep Online 2011 Nov 12;67(Pt 11):m1534. Epub 2011 Oct 12.

The fused bis-butterfly-shaped title compound, [Fe(4)(CS(4))(CO)(12)], possesses an orthothio-carbonate (CS(4) (4-)) ligand that acts as a bridge between two Fe(2)(CO)(6) units. A short intra-molecular S⋯S contact [2.6984 (8) and 2.6977 (8) Å] occurs in each S(2)Fe(2)(CO)(6) fragment.
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http://dx.doi.org/10.1107/S1600536811041936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246959PMC
November 2011

1,1'-Bis(1-acetyl-5-methyl-1H-pyrazol-3-yl)ferrocene.

Acta Crystallogr Sect E Struct Rep Online 2011 Nov 12;67(Pt 11):m1533. Epub 2011 Oct 12.

The title compound, [Fe(C(11)H(11)N(2)O)(2)], crystallizes with two independent mol-ecules in the asymmetric unit which have have different conformations. In one mol-ecule, the two ferrocene cyclo-penta-dienyl rings are fully eclipsed and the two pyrazole rings are syn to each other; in the other, the two cyclo-penta-dienyl rings are synclinal and the pyrazole rings are anti. In both mol-ecules, the acetyl group attached to the pyrazole ring is oriented away from the iron-cyclo-penta-dienyl group of ferrocene.
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http://dx.doi.org/10.1107/S1600536811041924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246958PMC
November 2011

Undeca-carbonyl-μ(2)-methane-thiol-ato-μ(2)-[(pyridin-2-yl)methane-thiol-ato]-μ(4)-sulfido-tetra-iron(II)(2 Fe-Fe).

Acta Crystallogr Sect E Struct Rep Online 2011 Dec 16;67(Pt 12):m1763. Epub 2011 Nov 16.

The title compound, [Fe(4)(C(6)H(6)NS)(CH(3)S)S(CO)(11)], com-prises two butterfly-shaped sub-cluster cores, Fe(2)S(2)N and Fe(2)S(2), joined together by a spiro-type μ(4)-S atom. The (pyridin-2-yl)methane-thiol-ate ligand is attached to the Fe(2)(CO)(5) unit in a μ-κN:κ(2)S mode, and the methane-thiol-ate ligand is coordinated to the Fe(2)(CO)(6) unit in a μ-κ(2)S fashion.
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http://dx.doi.org/10.1107/S1600536811047751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238668PMC
December 2011

Monoclinic form of (Z)-1-ferrocenyl-3-(3-hy-droxy-anilino)but-2-en-1-one.

Acta Crystallogr Sect E Struct Rep Online 2011 Dec 16;67(Pt 12):m1762. Epub 2011 Nov 16.

The title compound, [Fe(C(5)H(5))(C(15)H(14)NO(2))], is a monoclinic polymorph of the previously reported triclinic form [Shi et al. (2006 ▶). Acta Cryst. C62, m407-m410]. The polymorphs feature the same strong intra-molecular N-H⋯O=C hydrogen bonds, but show different packing modes. The mol-ecules in the monoclinic form associate into double chains via O-H⋯O=C and (Cp)C-H⋯O-H inter-actions.
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http://dx.doi.org/10.1107/S1600536811047775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238667PMC
December 2011

Ethyl (Z)-4-ferrocenyl-2-(4-hy-droxy-anilino)-4-oxobutenoate.

Acta Crystallogr Sect E Struct Rep Online 2011 Dec 16;67(Pt 12):m1761. Epub 2011 Nov 16.

In the title compound, [Fe(C(5)H(5))(C(17)H(16)NO(4))], the O=C-C=C-N mean plane is twisted with respect to the mean planes of the benzene and substituted cyclo-penta-dienyl rings by 44.2 (2) and 13.8 (3)°, respectively. Furthermore, the O=C-C=C-N mean plane and the O=C-O(ester) plane make a dihedral angle of 55.5 (6)°. Consistent with this large dihedral angle, the linking C-C bond [1.507 (6) Å] does not show any (delocalized) double-bond character.
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http://dx.doi.org/10.1107/S1600536811047763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238666PMC
December 2011

(Z)-1-Phenyl-3-(3-pyridyl-meth-ylamino)-but-2-en-1-one.

Acta Crystallogr Sect E Struct Rep Online 2010 Oct 20;66(Pt 11):o2854. Epub 2010 Oct 20.

The reaction of 3-C(5)H(4)NCH(2)NH(2) and C(6)H(5)COCH(2)COCH(3) affords the title compound, C(16)H(16)N(2)O. The O=C-C=C-N portion is essentially planar [maximum deviation = 0.046 (2) Å] and is aligned at dihedral angles of 22.6 (1) and 78.9 (1)° to the phenyl and pyridyl rings, respectively. The N-H and O=C groups are linked by an intra-molecular hydrogen bond. In the crystal, C-H⋯O hydrogen bonds and C-H⋯π inter-actions occur.
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http://dx.doi.org/10.1107/S1600536810041127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009348PMC
October 2010

(E)-1-Ferrocenyl-3-(3-nitro-phen-yl)prop-2-en-1-one.

Acta Crystallogr Sect E Struct Rep Online 2008 Sep 6;64(Pt 10):m1241. Epub 2008 Sep 6.

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, People's Republic of China.

In the title compound, [Fe(C(5)H(5))(C(14)H(10)NO(3))], one cyclo-penta-diene ring is substituted and one is unsubstituted. The two rings are almost parallel and are eclipsed and ordered. The conjugated substituent is slightly twisted with respect to the cyclo-penta-diene ring. The crystal structure contains four inter-molecular C-H⋯O hydrogen-bonds in the range 3.324 (3)-3.539 (3) Å and one π(aryl ring)-π (Cp ring) stacking inter-action with a ring-centroid distance of 3.894 (2) Å.
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http://dx.doi.org/10.1107/S1600536808027815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959240PMC
September 2008

1-Acetyl-3-ferrocenyl-5-methyl-1H-pyrazole and 1-acetyl-5-ferrocenyl-3-(2-pyridyl)-1H-pyrazole.

Acta Crystallogr C 2006 Dec 10;62(Pt 12):m577-80. Epub 2006 Nov 10.

School of Chemistry, Yangzhou University, Yangzhou 225002, People's Republic of China.

Molecules of 1-acetyl-3-ferrocenyl-5-methyl-1H-pyrazole, [Fe(C5H5)(C11H11N2O)], form a centrosymmetric dimer generated by a combination of one C-H...pi(pyrazole) and one C-H...pi(cyclopentadienyl) interaction. The dimers are linked by C-H...pi interactions, involving the pyrazole rings as acceptors, into layers parallel to (10-1). Molecules of 1-acetyl-5-ferrocenyl-3-(2-pyridyl)-1H-pyrazole, [Fe(C5H5)(C15H12N3O)], are linked by C-H...O interactions into a chain running in the [010] direction. Two chains of this type passing through each unit cell are connected by O...pi(pyridyl) interactions into an [010] double chain.
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http://dx.doi.org/10.1107/S0108270106043599DOI Listing
December 2006

N,N'-Bis(2-pyridylmethyl)ferrocene-1,1'-diyldicarboxamide and N,N'-bis(3-pyridylmethyl)ferrocene-1,1'-diyldicarboxamide.

Acta Crystallogr C 2006 Nov 31;62(Pt 11):m559-62. Epub 2006 Oct 31.

School of Chemistry, Yangzhou University, Yangzhou 225002, People's Republic of China.

The molecules of N,N'-bis(2-pyridylmethyl)ferrocene-1,1'-diyldicarboxamide, [Fe(C12H11N2O)2], contain intramolecular N-H...N hydrogen bonds and are linked into sheets by three independent C-H...O hydrogen bonds. The molecules of the isomeric compound N,N'-bis(3-pyridylmethyl)ferrocene-1,1'-diyldicarboxamide lie across inversion centres, and the molecules are linked into sheets by a combination of N-H...N hydrogen bonds and pi-pi stacking interactions between pyridyl groups.
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http://dx.doi.org/10.1107/S0108270106041345DOI Listing
November 2006

(Z)-1-Ferrocenyl-3-(3-hydroxyanilino)but-2-en-1-one and (Z)-1-ferrocenyl-3-(4-hydroxyanilino)but-2-en-1-one.

Acta Crystallogr C 2006 Sep 11;62(Pt 9):m407-10. Epub 2006 Aug 11.

School of Chemistry, Yangzhou University, 130 XiMenWai Street, Yangzhou 225002, People's Republic of China.

The title compounds, both [Fe(C5H5)(C15H14NO2)], crystallize with Z'=2 in the centrosymmetric space group P-1. In each compound, there is an intramolecular N-H...O=C hydrogen bond, and pairs of intermolecular O-H...O=C hydrogen bonds link the molecules into chains, parallel to [110] in the 3-hydroxy compound and parallel to [101] in the 4-hydroxy compound.
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http://dx.doi.org/10.1107/S0108270106027314DOI Listing
September 2006
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