Sherif Abou-Elela - Université de Sherbrooke - Professor

Sherif Abou-Elela

Université de Sherbrooke

Professor

Sherbrooke, Quebec | Canada

Main Specialties: Biochemical Genetics, Biology, Oncology

ORCID logohttps://orcid.org/0000-0002-0630-3294

Sherif Abou-Elela - Université de Sherbrooke - Professor

Sherif Abou-Elela

Introduction

Sherif Abou Elela is a professor of microbiology at the University of Sherbrooke in Quebec,
Canada and a member of the oncology group at the university's Hospital Clinical Research
Centre. He is also the scientific director of the U de Sherbrooke RNomics Platform, and the
coordinator of the RiboClub. He has been funded by fellowship for his entire research career
and he is now Canada Chair in RNA biology and Cancer Genomics. Born in Egypt, Abou
Elela earned a bachelor's degree in zoology from the University of Qatar in 1988. Relocating
to Canada, he completed a Ph.D. in microbiology and genetics at the University of Guelph in
Ontario in 1994. From 1994 to 1997, he was a postdoctoral fellow at the RNA biology center
at the University of California Santa Cruz (UCSC). In 1997, Abou Elela joined the Sherbrooke
faculty, and in 2013, he was elevated to the school's Canada Research Chair in RNA Biology
and Cancer Genomics. Abou Elela's research projects have received more than $20 million in
grants from different sources including CIHR, NSERC, Genome Canada and Genome
Quebec. He holds three patents and has published more than 85 peer-reviewed journal
articles. Abou Elela's research is at the "forefront of RNA biology and its diagnostic and
therapeutic applications." His research group "aims to understand the basic mechanisms that
control the synthesis and stability of RNA in eukaryotic cells in order to understand how genes
are regulated." Their current focus is on identifying novel markers for cancer.

Primary Affiliation: Université de Sherbrooke - Sherbrooke, Quebec , Canada

Specialties:

Education

Jun 1998
UCSC
Post Doc.
Sep 1994
University of Guelph
Ph. D.

Publications

66Publications

574Reads

1Profile Views

Reducing the structure bias of RNA-Seq reveals a large number of non-annotated non-coding RNA.

Nucleic Acids Res 2020 Mar;48(5):2271-2286

Département de biochimie et génomique fonctionnelle, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.

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http://dx.doi.org/10.1093/nar/gkaa028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049693PMC
March 2020
9.112 Impact Factor

Differential expression of duplicated ribosomal protein genes modifies ribosome composition in response to stress.

Nucleic Acids Res 2020 02;48(4):1954-1968

Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.

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http://dx.doi.org/10.1093/nar/gkz1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038994PMC
February 2020
9.112 Impact Factor

snoDB: an interactive database of human snoRNA sequences, abundance and interactions.

Nucleic Acids Res 2020 Jan;48(D1):D220-D225

Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.

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http://dx.doi.org/10.1093/nar/gkz884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943035PMC
January 2020
2 Reads
9.112 Impact Factor

Introns: Good Day Junk Is Bad Day Treasure.

Trends Genet 2019 Dec 25;35(12):923-934. Epub 2019 Oct 25.

Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2019.09.010DOI Listing
December 2019
9.918 Impact Factor

CoCo: RNA-seq read assignment correction for nested genes and multimapped reads.

Bioinformatics 2019 Dec;35(23):5039-5047

Department of Biochemistry and RNA Group, Université de Sherbrooke, Sherbrooke, QC, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btz433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901076PMC
December 2019
6 Reads
4.981 Impact Factor

The cellular landscape of mid-size noncoding RNA.

Wiley Interdiscip Rev RNA 2019 07 6;10(4):e1530. Epub 2019 Mar 6.

Department of Microbiology and Infectious Disease, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

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http://dx.doi.org/10.1002/wrna.1530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619189PMC
July 2019
6.154 Impact Factor

Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression.

Commun Biol 2019 17;2:211. Epub 2019 Jun 17.

Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8 Canada.

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http://dx.doi.org/10.1038/s42003-019-0441-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572803PMC
June 2019

Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation.

Wiley Interdiscip Rev RNA 2019 05 11;10(3):e1521. Epub 2018 Dec 11.

Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland.

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http://dx.doi.org/10.1002/wrna.1521DOI Listing
May 2019
5 Reads
6.154 Impact Factor

Introns are mediators of cell response to starvation.

Nature 2019 01 16;565(7741):612-617. Epub 2019 Jan 16.

RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

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http://dx.doi.org/10.1038/s41586-018-0859-7DOI Listing
January 2019
42.351 Impact Factor

Simultaneous sequencing of coding and noncoding RNA reveals a human transcriptome dominated by a small number of highly expressed noncoding genes.

RNA 2018 07 27;24(7):950-965. Epub 2018 Apr 27.

Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.

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http://dx.doi.org/10.1261/rna.064493.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004057PMC
July 2018
3 Reads
4.936 Impact Factor

The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate.

Nucleic Acids Res 2016 09 1;44(16):7911-21. Epub 2016 Jun 1.

Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Pavillon de recherche appliquée sur le cancer, Sherbrooke, Québec J1E 4K8, Canada

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http://dx.doi.org/10.1093/nar/gkw507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027489PMC
September 2016
1 Read
9.112 Impact Factor

Introns regulate the production of ribosomal proteins by modulating splicing of duplicated ribosomal protein genes.

Nucleic Acids Res 2016 05 3;44(8):3878-91. Epub 2016 Mar 3.

Université de Sherbrooke Centre of Excellence in RNA Biology, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada

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http://dx.doi.org/10.1093/nar/gkw140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856989PMC
May 2016
16 Reads
9.112 Impact Factor

Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing.

Cancer Treat Res 2013 ;158:41-94

Département de microbiologie et d'infectiologie, Faculté de Médecine et des sciences de la santé, Université de Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1007/978-3-642-31659-3_3DOI Listing
April 2016
19 Reads

Preservation of Gene Duplication Increases the Regulatory Spectrum of Ribosomal Protein Genes and Enhances Growth under Stress.

Cell Rep 2015 Dec 10;13(11):2516-2526. Epub 2015 Dec 10.

Université de Sherbrooke Centre of Excellence in RNA Biology, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.033DOI Listing
December 2015
3 Reads
7.207 Impact Factor

Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals.

PLoS Genet 2015 Feb 13;11(2):e1005000. Epub 2015 Feb 13.

Université de Sherbrooke Centre of Excellence in RNA Biology, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1005000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334505PMC
February 2015
3 Reads

Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency.

Nucleic Acids Res 2014 Sep 29;42(15):10073-85. Epub 2014 Jul 29.

Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada

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http://nar.oxfordjournals.org/content/early/2014/07/29/nar.g
Web Search
http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku664
Publisher Site
http://dx.doi.org/10.1093/nar/gku664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150776PMC
September 2014
14 Reads
9.112 Impact Factor

Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection.

Mol Cell 2014 May 3;54(3):431-44. Epub 2014 Apr 3.

Biomolecular Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019767PMC
May 2014
2 Reads
14.018 Impact Factor

Redirecting splicing with bifunctional oligonucleotides.

Nucleic Acids Res 2014 Apr 26;42(6):e40. Epub 2013 Dec 26.

Laboratory of Functional Genomics and Research Centre on RNA Biology of the Université de Sherbrooke, Sherbrooke, Quebec J1E 4K8, Canada, Department of Biochemistry, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec J1E 4K8, Canada and Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec J1E 4K8, Canada.

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http://dx.doi.org/10.1093/nar/gkt1287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973305PMC
April 2014
16 Reads
9.112 Impact Factor

MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.

Nat Commun 2013 ;4:2480

1] CNRS, Institut de Génétique Moléculaire de Montpellier, Montpellier F-34293, France [2] Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK [3] Université Montpellier 2, F-34293 Montpellier cedex 5, France [4] Université Montpellier 1, F-34094 Montpellier cedex 5, France [5].

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http://dx.doi.org/10.1038/ncomms3480DOI Listing
April 2014
107 Reads
10.742 Impact Factor

Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.

RNA 2013 Jul 20;19(7):992-1002. Epub 2013 May 20.

RNA Group, Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec J1E 4K8, Canada.

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http://dx.doi.org/10.1261/rna.037663.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683933PMC
July 2013
6 Reads
4.936 Impact Factor

RNA-dependent regulation of the cell wall stress response.

Nucleic Acids Res 2012 Aug 10;40(15):7507-17. Epub 2012 May 10.

RNA Group, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de santé, Université de Sherbrooke, Pavillon de recherche appliquée sur cancer, Sherbrooke, Québec, J1E 4K8, Canada.

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http://dx.doi.org/10.1093/nar/gks411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424562PMC
August 2012
3 Reads
9.112 Impact Factor

Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway.

Nucleic Acids Res 2012 Jul 29;40(12):5625-36. Epub 2012 Feb 29.

RNA Group, Department of Microbiology and Infectious Diseases, Faculty of Medicine, Université de Sherbrooke, 3001, 12e Ave Nord, Sherbrooke, Quebec, J1H 5N4, Canada.

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http://dx.doi.org/10.1093/nar/gks200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384322PMC
July 2012
1 Read
9.112 Impact Factor

Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression.

Nucleic Acids Res 2012 Apr 19;40(8):3663-75. Epub 2011 Dec 19.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A8, Canada.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkr1238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333888PMC
April 2012
4 Reads
9.112 Impact Factor

Detection and characterization of transcription termination.

Methods Mol Biol 2012 ;809:593-607

RNA Group/Groupe ARN, Département de Microbiologie & Infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada.

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http://dx.doi.org/10.1007/978-1-61779-376-9_38DOI Listing
March 2012
1 Read

Regulation of conditional gene expression by coupled transcription repression and RNA degradation.

Nucleic Acids Res 2012 Jan 20;40(2):871-83. Epub 2011 Sep 20.

RNA Group, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5N4.

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http://dx.doi.org/10.1093/nar/gkr759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258148PMC
January 2012
1 Read
9.112 Impact Factor

Reporter mRNAs cleaved by Rnt1p are exported and degraded in the cytoplasm.

Nucleic Acids Res 2011 Nov 5;39(21):9357-67. Epub 2011 Aug 5.

Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkr627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241649PMC
November 2011
3 Reads
9.112 Impact Factor

Introns within ribosomal protein genes regulate the production and function of yeast ribosomes.

Cell 2011 Oct;147(2):320-31

Laboratoire de génomique fonctionnelle de l'Université de Sherbrooke, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1016/j.cell.2011.08.044DOI Listing
October 2011
32.242 Impact Factor

PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.

Hum Mol Genet 2011 Jun 5;20(11):2116-30. Epub 2011 Mar 5.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddr094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090192PMC
June 2011
17 Reads
6.393 Impact Factor

Short RNA duplexes guide sequence-dependent cleavage by human Dicer.

RNA 2010 Dec 25;16(12):2464-73. Epub 2010 Oct 25.

RNA group/Groupe ARN, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1261/rna.2346510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995407PMC
December 2010
3 Reads
4.936 Impact Factor

High-throughput quantification of splicing isoforms.

RNA 2010 Feb 28;16(2):442-9. Epub 2009 Dec 28.

Universite de Sherbrooke, Departement de Microbiologie et d'Infectiologie Sherbrooke, Quebec J1H 5N4, Canada.

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http://dx.doi.org/10.1261/rna.1877010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811672PMC
February 2010
24 Reads
4.936 Impact Factor

Yeast RNase III triggers polyadenylation-independent transcription termination.

Mol Cell 2009 Oct;36(1):99-109

RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

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http://dx.doi.org/10.1016/j.molcel.2009.07.029DOI Listing
October 2009
3 Reads
14.018 Impact Factor

Control of alternative splicing through siRNA-mediated transcriptional gene silencing.

Nat Struct Mol Biol 2009 Jul 21;16(7):717-24. Epub 2009 Jun 21.

Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.

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http://dx.doi.org/10.1038/nsmb.1620DOI Listing
July 2009
16 Reads

Cancer-associated regulation of alternative splicing.

Nat Struct Mol Biol 2009 Jun 17;16(6):670-6. Epub 2009 May 17.

Laboratoire de génomique fonctionnelle de l'Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1038/nsmb.1608DOI Listing
June 2009
19 Reads

Comment on "When good transcripts go bad: artifactual RT-PCR 'splicing' and genome analysis".

Bioessays 2008 Nov;30(11-12):1256; author reply 1257-8

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http://dx.doi.org/10.1002/bies.20844DOI Listing
November 2008
6 Reads
4.730 Impact Factor

Multiple and specific mRNA processing targets for the major human hnRNP proteins.

Mol Cell Biol 2008 Oct 21;28(19):6033-43. Epub 2008 Jul 21.

Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, 3001, 12th Avenue Nord, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1128/MCB.00726-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547008PMC
October 2008
11 Reads
4.777 Impact Factor

Yeast ribonuclease III uses a network of multiple hydrogen bonds for RNA binding and cleavage.

Biochemistry 2008 Aug 23;47(33):8514-26. Epub 2008 Jul 23.

Groupe ARN/RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://pubs.acs.org/doi/abs/10.1021/bi800238u
Publisher Site
http://dx.doi.org/10.1021/bi800238uDOI Listing
August 2008
2 Reads
3.015 Impact Factor

A G-tract element in apoptotic agents-induced alternative splicing.

Nucleic Acids Res 2008 Jun 24;36(10):3320-31. Epub 2008 Apr 24.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College. Kunming, China.

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http://dx.doi.org/10.1093/nar/gkn207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425498PMC
June 2008
4 Reads
9.112 Impact Factor

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes.

Mol Cancer Ther 2008 Jun;7(6):1398-409

Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0192DOI Listing
June 2008
3 Reads
5.683 Impact Factor

Deletion of many yeast introns reveals a minority of genes that require splicing for function.

Mol Biol Cell 2008 May 20;19(5):1932-41. Epub 2008 Feb 20.

Laboratoire de génomique fonctionnelle de l'Université de Sherbrooke, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

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http://dx.doi.org/10.1091/mbc.e07-12-1254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366882PMC
May 2008
8 Reads
4.466 Impact Factor

Multiple alternative splicing markers for ovarian cancer.

Cancer Res 2008 Feb;68(3):657-63

Laboratoire de génomique fonctionnelle de l'Université de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2580DOI Listing
February 2008
23 Reads
9.329 Impact Factor

Deletion of Rnt1p alters the proportion of open versus closed rRNA gene repeats in yeast.

Mol Cell Biol 2008 Jan 8;28(2):619-29. Epub 2007 Nov 8.

Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, 3001 12 Ave. Nord, Sherbrooke, Québec, Canada.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01805-07
Publisher Site
http://dx.doi.org/10.1128/MCB.01805-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223425PMC
January 2008
4 Reads
4.777 Impact Factor

Short RNA guides cleavage by eukaryotic RNase III.

PLoS One 2007 May 30;2(5):e472. Epub 2007 May 30.

Groupe ARN (RNA Group), Laboratoire de Génomique Fonctionnelle (Laboratory for Functional Genomics), Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000472PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868780PMC
May 2007
5 Reads
3.234 Impact Factor

RNase III-dependent regulation of yeast telomerase.

J Biol Chem 2007 Feb 11;282(7):4373-81. Epub 2006 Dec 11.

RNA Group, Département de Microbiologie et d'Infectiologie, Facultéde Médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1074/jbc.M607145200DOI Listing
February 2007
3 Reads
4.573 Impact Factor

Modern origin of numerous alternatively spliced human introns from tandem arrays.

Proc Natl Acad Sci U S A 2007 Jan 8;104(3):882-6. Epub 2007 Jan 8.

Laboratoire de Génomique Fonctionnelle de Sherbrooke, Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, PQ, Canada.

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http://dx.doi.org/10.1073/pnas.0604777104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783408PMC
January 2007
1 Read
9.809 Impact Factor

Characterization of the reactivity determinants of a novel hairpin substrate of yeast RNase III.

J Mol Biol 2006 Oct 16;363(2):332-44. Epub 2006 Aug 16.

Groupe ARN/RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.

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http://dx.doi.org/10.1016/j.jmb.2006.08.028DOI Listing
October 2006
4.333 Impact Factor

Structure of an AAGU tetraloop and its contribution to substrate selection by yeast RNase III.

J Mol Biol 2006 Oct 16;363(2):322-31. Epub 2006 Aug 16.

Laboratoire de RMN, ICSN-CNRS 1 ave de la terrasse, 91190 Gif-sur-Yvette France.

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http://dx.doi.org/10.1016/j.jmb.2006.08.029DOI Listing
October 2006
27 Reads
4.333 Impact Factor

A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures.

Mutat Res 2006 Jul 19;606(1-2):92-105. Epub 2006 May 19.

Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Que. J1H 5N4, Canada.

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http://dx.doi.org/10.1016/j.mrgentox.2006.03.006DOI Listing
July 2006
3 Reads
3.680 Impact Factor

Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals.

BMC Biotechnol 2006 Jan 13;6. Epub 2006 Jan 13.

Département de Microbiologie et d'Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1186/1472-6750-6-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379639PMC
January 2006
8 Reads
2.034 Impact Factor

Free uptake of cell-penetrating peptides by fission yeast.

FEBS Lett 2005 Aug;579(21):4873-8

Centre de Génomique Fonctionnelle de Sherbrooke, Département de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbooke, Sherbooke, Que., Canada.

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http://dx.doi.org/10.1016/j.febslet.2005.07.064DOI Listing
August 2005
19 Reads
3.169 Impact Factor

Genome-wide prediction and analysis of yeast RNase III-dependent snoRNA processing signals.

Mol Cell Biol 2005 Apr;25(8):2981-94

Université de Sherbrooke, Département de Microbiologie et d'Infectiologie, 3001 12e Ave nord, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1128/MCB.25.8.2981-2994.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069626PMC
April 2005
6 Reads
4.777 Impact Factor

RNase III-mediated silencing of a glucose-dependent repressor in yeast.

Curr Biol 2005 Jan;15(2):140-5

Groupe ARN/RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1016/j.cub.2004.12.001DOI Listing
January 2005
2 Reads
9.571 Impact Factor

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.

RNA 2004 Dec 3;10(12):1946-56. Epub 2004 Nov 3.

Section of Biochemistry and Molecular Biology, Vrije Universiteit, de Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1261/rna.7155904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370683PMC
December 2004
2 Reads
4.936 Impact Factor

Cell cycle-dependent nuclear localization of yeast RNase III is required for efficient cell division.

Mol Biol Cell 2004 Jul 16;15(7):3015-30. Epub 2004 Apr 16.

RNA Group/Groupe ARN, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1091/mbc.e04-03-0183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC452560PMC
July 2004
1 Read
4.466 Impact Factor

A phylogenetically based secondary structure for the yeast telomerase RNA.

Curr Biol 2004 Jul;14(13):1148-58

Groupe ARN/RNA Group, Department of Microbiology and Infectious Diseases, Faculty of Medicine, Université de Sherbrooke, 3001 12th Avenue N., Sherbrooke, QC J1H 5N4, Canada.

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http://dx.doi.org/10.1016/j.cub.2004.05.054DOI Listing
July 2004
18 Reads
9.571 Impact Factor

Molecular requirements for duplex recognition and cleavage by eukaryotic RNase III: discovery of an RNA-dependent DNA cleavage activity of yeast Rnt1p.

J Mol Biol 2004 Apr;338(2):401-18

Groupe ARN/RNA Group, Département de microbiologie et d'infectiologie, faculté de médecine, Université de Sherbrooke, Sherbrooke, Que., Canada J1H 5N4.

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http://dx.doi.org/10.1016/j.jmb.2004.02.059DOI Listing
April 2004
4.333 Impact Factor

Evaluation of the RNA determinants for bacterial and yeast RNase III binding and cleavage.

J Biol Chem 2004 Jan 27;279(3):2231-41. Epub 2003 Oct 27.

Groupe ARN/RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1074/jbc.M309324200DOI Listing
January 2004
1 Read
4.573 Impact Factor

Reprogramming alternative pre-messenger RNA splicing through the use of protein-binding antisense oligonucleotides.

J Biol Chem 2003 Dec 30;278(50):50031-9. Epub 2003 Sep 30.

Département de microbiologie et d'infectiologie, RNA/RNP Group, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

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http://dx.doi.org/10.1074/jbc.M308897200DOI Listing
December 2003
1 Read
4.573 Impact Factor

Sequence dependence of substrate recognition and cleavage by yeast RNase III.

J Mol Biol 2003 Apr;327(5):985-1000

Groupe ARN/RNA Group, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, 3001 12e Avenue Nord, J1H 5N4, Sherbrooke, Que., Canada.

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http://dx.doi.org/10.1016/s0022-2836(03)00231-6DOI Listing
April 2003
4 Reads
4.333 Impact Factor

A physical interaction between Gar1p and Rnt1pi is required for the nuclear import of H/ACA small nucleolar RNA-associated proteins.

Mol Cell Biol 2002 Jul;22(13):4792-802

Groupe ARN, Département de Microbiologie et d'Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133895PMC
http://dx.doi.org/10.1128/mcb.22.13.4792-4802.2002DOI Listing
July 2002
4 Reads
4.777 Impact Factor

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