Shengying Li

Shengying Li

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Shengying Li

Shengying Li

Publications by authors named "Shengying Li"

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54Publications

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AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.

Org Lett 2018 08 2;20(16):4854-4857. Epub 2018 Aug 2.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China.

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August 2018

Deciphering the late steps of rifamycin biosynthesis.

Nat Commun 2018 Jun 14;9(1):2342. Epub 2018 Jun 14.

Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, 266101, China.

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June 2018

The molecular basis for lipase stereoselectivity.

Appl Microbiol Biotechnol 2018 Apr 3;102(8):3487-3495. Epub 2018 Mar 3.

Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong, 266101, China.

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April 2018

In vitro oxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases.

Biotechnol Biofuels 2017 7;10:208. Epub 2017 Sep 7.

Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, 266101 Shandong China.

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September 2017

Improving the Secretory Expression of an -Galactosidase from Aspergillus niger in Pichia pastoris.

PLoS One 2016 22;11(8):e0161529. Epub 2016 Aug 22.

Shandong Provincial Key Laboratory of Synthetic Biology, and CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, China.

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August 2017

Expansion of chemical space for natural products by uncommon P450 reactions.

Nat Prod Rep 2017 08;34(9):1061-1089

Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China.

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August 2017

Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics.

BMC Biotechnol 2017 07 4;17(1):59. Epub 2017 Jul 4.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588-0304, USA.

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July 2017

Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system.

Proc Natl Acad Sci U S A 2017 06 12;114(26):E5129-E5137. Epub 2017 Jun 12.

Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China;

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June 2017

Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from .

J Microbiol Biotechnol 2017 May;27(5):956-964

Ocean College, Zhejiang University, Dinghai, Zhoushan, Zhejiang 316021, P.R. China.

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May 2017

Complete elucidation of the late steps of bafilomycin biosynthesis in .

J Biol Chem 2017 04 14;292(17):7095-7104. Epub 2017 Mar 14.

From the Shandong Provincial Key Laboratory of Synthetic Biology, and CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101,

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April 2017

Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleT.

Sci Rep 2017 03 9;7:44258. Epub 2017 Mar 9.

Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China.

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March 2017

In vitro reconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins.

J Ind Microbiol Biotechnol 2017 02 25;44(2):161-166. Epub 2016 Nov 25.

Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, China.

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February 2017

Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.

Tetrahedron Lett 2016 Dec 19;57(52):5919-5923. Epub 2016 Nov 19.

Shandong Provincial Key Laboratory of Synthetic Biology, and CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China.

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December 2016

Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation in Corynebacterium glutamicum.

J Biol Chem 2016 Mar 27;291(12):6583-94. Epub 2016 Jan 27.

From the CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology and

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March 2016

Domain Characterization of Cyclosporin Regio-Specific Hydroxylases in Rare Actinomycetes.

J Microbiol Biotechnol 2015 Oct;25(10):1634-9

Department of Biological Engineering, Inha University, Incheon 402-751, Republic of Korea.

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October 2015

Characteristics of human umbilical cord mesenchymal stem cells during ex vivo expansion.

Mol Med Rep 2015 Sep 25;12(3):4320-4325. Epub 2015 Jun 25.

Department of Physiology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

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September 2015

Reconstitution of the In Vitro Activity of the Cyclosporine-Specific P450 Hydroxylase from Sebekia benihana and Development of a Heterologous Whole-Cell Biotransformation System.

Appl Environ Microbiol 2015 Sep 6;81(18):6268-75. Epub 2015 Jul 6.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, China

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September 2015

Metabolic engineering of 2-phenylethanol pathway producing fragrance chemical and reducing lignin in Arabidopsis.

Plant Cell Rep 2015 Aug 21;34(8):1331-42. Epub 2015 Apr 21.

Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China,

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August 2015

Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.

ACS Chem Biol 2015 May 26;10(5):1340-51. Epub 2015 Feb 26.

‡Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.

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May 2015

Extraction of human genomic DNA from whole blood using a magnetic microsphere method.

Int J Nanomedicine 2014 8;9:3781-9. Epub 2014 Aug 8.

Clinical Laboratory, Tianjin Children's Hospital, Tianjin, People's Republic of China.

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March 2015

Functional characterization of MpaG', the O-methyltransferase involved in the biosynthesis of mycophenolic acid.

Chembiochem 2015 Mar 28;16(4):565-9. Epub 2015 Jan 28.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101 (China).

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March 2015

Assembly of lipase and P450 fatty acid decarboxylase to constitute a novel biosynthetic pathway for production of 1-alkenes from renewable triacylglycerols and oils.

Biotechnol Biofuels 2015 26;8:34. Epub 2015 Feb 26.

Key Laboratory of Biofuels, and Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 266101 Qingdao, Shandong China.

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March 2015

Lettuce glycoside B ameliorates cerebral ischemia reperfusion injury by increasing nerve growth factor and neurotrophin-3 expression of cerebral cortex in rats.

Indian J Pharmacol 2014 Jan-Feb;46(1):63-8

Student Union, The Affiliated Middle School of Henan Normal University, Jian She Dong Lu, Xinxiang, Henan, China.

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October 2014

Polydimethylsiloxane: a general matrix for high-performance chromatographic NMR spectroscopy.

Angew Chem Int Ed Engl 2014 Oct 4;53(43):11592-5. Epub 2014 Sep 4.

Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China).

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October 2014

Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123.

Fitoterapia 2014 Jul 10;96:146-51. Epub 2014 May 10.

School of Life Sciences, Shandong University, Jinan, Shandong 250100, PR China. Electronic address:

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July 2014

Engineering self-sufficient aldehyde deformylating oxygenases fused to alternative electron transfer systems for efficient conversion of aldehydes into alkanes.

Chem Commun (Camb) 2014 Apr;50(33):4299-301

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China.

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April 2014

Integrated lipase production and in situ biodiesel synthesis in a recombinant Pichia pastoris yeast: an efficient dual biocatalytic system composed of cell free enzymes and whole cell catalysts.

Biotechnol Biofuels 2014 Apr 8;7(1):55. Epub 2014 Apr 8.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No, 189 Songling Road, Qingdao, Shandong 266101, China.

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April 2014

New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.

J Am Chem Soc 2014 Mar 25;136(9):3640-6. Epub 2014 Feb 25.

CAS Key Laboratory of Biofuels, and Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao, Shandong 266101, China.

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March 2014

Hydrogen peroxide-independent production of α-alkenes by OleTJE P450 fatty acid decarboxylase.

Biotechnol Biofuels 2014 Feb 24;7(1):28. Epub 2014 Feb 24.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No, 189 Songling Road, Qingdao, Shandong 266101, China.

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February 2014

A novel and robust recombinant Pichia pastoris yeast whole cell biocatalyst with intracellular overexpression of a Thermomyces lanuginosus lipase: preparation, characterization and application in biodiesel production.

Bioresour Technol 2014 Jan 18;151:43-8. Epub 2013 Oct 18.

Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, China. Electronic address:

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January 2014

Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Chembiochem 2013 Feb 29;14(3):301-6. Epub 2013 Jan 29.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, PR China.

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February 2013

Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B.

Org Lett 2013 Jan 18;15(1):22-5. Epub 2012 Dec 18.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

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January 2013

Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids.

J Am Chem Soc 2012 Jan 28;134(2):788-91. Epub 2011 Dec 28.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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January 2012

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.

Nat Chem 2011 Jul 17;3(8):628-33. Epub 2011 Jul 17.

Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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July 2011

STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S.

Heterocycles 2010 Dec;82(1):461-472

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

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December 2010

Refraction corrected transmission ultrasound computed tomography for application in breast imaging.

Med Phys 2010 May;37(5):2233-46

Department of Computer Science, Stony Brook University, Stony Brook, New York 11794-4400, USA.

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May 2010

Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.

Chembiochem 2010 Mar;11(4):564-72

Life Sciences Institute and Departments of Medicinal Chemistry, Microbiology, Immunology and Chemistry, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, USA.

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March 2010

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase.

Proc Natl Acad Sci U S A 2009 Nov 15;106(44):18463-8. Epub 2009 Oct 15.

Department of Medicinal Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2009

Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.

J Nat Prod 2009 Nov;72(11):2076-9

Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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November 2009

Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.

Chembiochem 2009 May;10(8):1297-301

Life Sciences Institute, Department of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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May 2009

Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.

J Biol Chem 2009 Feb 4;284(9):5723-30. Epub 2009 Jan 4.

Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2009

Physical-space refraction-corrected transmission ultrasound computed tomography made computationally practical.

Med Image Comput Comput Assist Interv 2008 ;11(Pt 2):280-8

Stony Brook University, Stony Brook, NY, USA.

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December 2008

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.

J Am Chem Soc 2007 Oct 4;129(43):12940-1. Epub 2007 Oct 4.

Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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October 2007

Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase.

J Biol Chem 2007 Apr 1;282(17):12765-72. Epub 2007 Mar 1.

Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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April 2007

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.

J Biol Chem 2006 Sep 6;281(36):26289-97. Epub 2006 Jul 6.

Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA.

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September 2006