Publications by authors named "Shengjie Jin"

10 Publications

  • Page 1 of 1

Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase.

Biomed Pharmacother 2021 Jul 3;139:111610. Epub 2021 May 3.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation. Therefore, NSM and ASM have broad prospects in clinical treatments, especially in cancer, cardiovascular diseases (such as atherosclerosis), nervous system diseases (such as Alzheimer's disease), respiratory diseases (such as chronic obstructive pulmonary disease) and the phenotype of dwarfisms in adolescents, playing a complex regulatory role. This review focuses on the physiological functions of NSM and ASM and summarizes their roles in certain diseases and their potential applications in therapy.
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http://dx.doi.org/10.1016/j.biopha.2021.111610DOI Listing
July 2021

Identification of CDC20 as an immune infiltration-correlated prognostic biomarker in hepatocellular carcinoma.

Invest New Drugs 2021 May 3. Epub 2021 May 3.

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, 98 West Nantong Rd, 225009, Yangzhou, Jiangsu, China.

Hepatocellular carcinoma (HCC) is a malignancy with a poor prognosis. E3 ubiquitin-protein ligases play essential roles in HCC, such as regulating progression, migration, and metastasis. We aimed to explore a hub E3 ubiquitin-protein ligase gene and verify its association with prognosis and immune cell infiltration in HCC. Cell division cycle 20 (CDC20) was identified as a hub E3 ubiquitin-protein ligase in HCC by determining the intersecting genes in a protein-protein interaction (PPI) network of differentially expressed genes (DEGs) using HCC data from the International Cancer Genome Consortium (ICGC) and the gene list of 919 E3 ubiquitin-protein ligases. DEGs and their correlations with clinicopathological features were explored in The Cancer Genome Atlas (TCGA), ICGC, and Gene Expression Omnibus (GEO) databases via the Wilcoxon signed-rank test. The prognostic value of CDC20 was illustrated by Kaplan-Meier (K-M) curves and Cox regression analyses. Subsequently, the correlation between CDC20 and immune infiltration was demonstrated via the Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA). CDC20 expression was significantly higher in HCC than in normal tissues (all P < 0.05). High CDC20 expression predicted a poor prognosis and might be an independent risk factor in HCC (P < 0.05). Additionally, CDC20 was correlated with the immune infiltration of CD8 + T cells, T cells (general), monocytes, and exhausted T cells. This study reveals the potential prognostic value of CDC20 in HCC and demonstrates that CDC20 may be an immune-associated therapeutic target in HCC because of its correlation with immune infiltration.
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http://dx.doi.org/10.1007/s10637-021-01126-1DOI Listing
May 2021

Evidence of Potts-Nematic Superfluidity in a Hexagonal sp^{2} Optical Lattice.

Phys Rev Lett 2021 Jan;126(3):035301

State Key Laboratory of Surface Physics, Institute of Nanoelectronics and Quantum Computing, Department of Physics, Fudan University, Shanghai 200438, China.

As in between liquid and crystal phases lies a nematic liquid crystal, which breaks rotation with preservation of translation symmetry, there is a nematic superfluid phase bridging a superfluid and a supersolid. The nematic order also emerges in interacting electrons and has been found to largely intertwine with multiorbital correlation in high-temperature superconductivity, where Ising nematicity arises from a four-fold rotation symmetry C_{4} broken down to C_{2}. Here, we report an observation of a three-state (Z_{3}) quantum nematic order, dubbed "Potts-nematicity", in a system of cold atoms loaded in an excited band of a hexagonal optical lattice described by an sp^{2}-orbital hybridized model. This Potts-nematic quantum state spontaneously breaks a three-fold rotation symmetry of the lattice, qualitatively distinct from the Ising nematicity. Our field theory analysis shows that the Potts-nematic order is stabilized by intricate renormalization effects enabled by strong interorbital mixing present in the hexagonal lattice. This discovery paves a way to investigate quantum vestigial orders in multiorbital atomic superfluids.
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http://dx.doi.org/10.1103/PhysRevLett.126.035301DOI Listing
January 2021

GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.

Bioengineered 2021 Dec;12(1):30-43

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University , Yangzhou, Jiangsu, P.R. China.

Globally, hepatocellular carcinoma (HCC) is one of the most common causes of cancer-associated mortalities. It has a high rate of metastasis and recurrence, which predict a poor prognosis. G-protein-coupled receptor (GPCR)-kinase interacting protein-1 (GIT1) is a multifunctional scaffold protein that mediates the progression of various tumors. Studies have correlated GIT1 with HCC, however, these correlations have not been fully elucidated. Therefore, we aimed at evaluating the expression of GIT1 in HCC tissues and cells, and to investigate its role and potential mechanisms in HCC progression. The expression levels of GIT1 in HCC tissues and other cancers was determined by using the Oncomine and TCGA databases. Functional analysis of GIT1 in HCC was evaluated through and experiments, whereby, HCC cells were transfected with synthetically overexpressed and short hairpin RNA (shRNA) lentivirus-mediated plasmids. Kaplan-Meier and Cox regression methods were used to establish the associations between GIT1 and clinical outcomes of 158 HCC patients. GIT1 was found to be elevated in HCC tissues where it promoted the invasion, migration, and proliferation of HCC cells. Moreover, the overexpression of GIT1 prompted epithelial-mesenchymal transition (EMT) by activating extracellular regulated kinase 1/2 (ERK1/2) pathway, which was shown to be reversed by SCH772984, a specific ERK1/2 inhibitor. GIT1 was also found to be associated with malignant features of HCC, leading to a poorer prognosis. In conclusion, GIT1 promotes HCC progression by inducing EMT and may reflect the course of HCC patients.
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http://dx.doi.org/10.1080/21655979.2020.1855914DOI Listing
December 2021

Observation of a Dynamical Sliding Phase Superfluid with P-Band Bosons.

Phys Rev Lett 2018 Dec;121(26):265301

School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China.

Sliding phases have been long sought after in the context of coupled XY models, as they are of relevance to various many-body systems such as layered superconductors, freestanding liquid-crystal films, and cationic lipid-DNA complexes. Here we report an observation of a dynamical sliding phase superfluid that emerges in a nonequilibrium setting from the quantum dynamics of a three-dimensional ultracold atomic gas loaded into the P band of a one-dimensional optical lattice. A shortcut loading method is used to transfer atoms into the P band at zero quasimomentum within a very short time duration. The system can be viewed as a series of "pancake"-shaped atomic samples. For this far-out-of-equilibrium system, we find an intermediate time window with a lifetime around tens of milliseconds, where the atomic ensemble exhibits robust superfluid phase coherence in the pancake directions, but no coherence in the lattice direction, which implies a dynamical sliding phase superfluid. The emergence of the sliding phase is attributed to a mechanism of cross-dimensional energy transfer in our proposed phenomenological theory, which is consistent with experimental measurements. This experiment potentially opens up a novel venue to search for exotic dynamical phases by creating high-band excitations in optical lattices.
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http://dx.doi.org/10.1103/PhysRevLett.121.265301DOI Listing
December 2018

Progress of immune checkpoint therapy in the clinic (Review).

Oncol Rep 2019 Jan 24;41(1):3-14. Epub 2018 Oct 24.

Department of Hepatobiliary Surgery, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.

Cancer cells can escape antitumor immune responses by exploiting inhibitory immune checkpoints. Immune checkpoint therapy, mainly including anti‑CTLA‑4 therapy and anti‑PD‑1/PD‑L1 therapy, can enhance antitumor immune responses by blocking the inhibitory signals of the immune system. This therapy has produced clinical advances in a fraction of patients. Deeper insight into the tumor microenvironment and immune checkpoint inhibitors will improve this therapy. Here, we review immune checkpoint inhibitors that prevent tumor immune escape and recent clinical studies of immune checkpoint therapy. We also compare the efficacy of different combination immunotherapies, describe how the relationship between the gut microbiome and immune system can determine the therapeutic outcomes for immune checkpoint inhibitors and introduce several novel immune checkpoints that are potential targets for antitumor immunotherapy in the future.
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http://dx.doi.org/10.3892/or.2018.6819DOI Listing
January 2019

A Novel Technique for Synchronous Laparoscopic Splenectomy and Azygoportal Disconnection With Hepatectomy.

Surg Innov 2018 Jun 13;25(3):218-223. Epub 2018 Mar 13.

1 Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China.

Background: Liver resection was not formerly recommended in patients with both hepatocellular carcinoma (HCC) and portal hypertension because of difficult perioperative bleeding control and postoperative liver failure. Splenectomy is a proven method with which to overcome these problems. To investigate the safety and feasibility of synchronous laparoscopic splenectomy and azygoportal disconnection with hepatectomy (LSDH) for treatment of portal hypertension accompanied with HCC, we describe a clinical cohort of 10 patients who underwent a new technique of synchronous LSDH.

Methods: A cohort of 10 cirrhotic patients with HCC, esophageal/gastric variceal bleeding, and hypersplenism received LSDH. A 6-port method was used for LSDH. This procedure comprises 5 steps: laparoscopic splenectomy, intraoperative splenic blood salvage, laparoscopic azygoportal disconnection, laparoscopic partial hepatectomy, and removal of spleen and liver specimens. Intraoperative autologous cell salvage was performed before hepatectomy.

Results: LSDH was successful in all patients. There was no conversion to open operations. The operative time was 220.5 ± 19.8 minutes, blood loss was 264.0 ± 160.3 mL, and postoperative hospital stay was 10.2 ± 1.8 days.

Conclusions: Selective synchronous LSDH is a feasible, effective, and safe surgical procedure with satisfactory short-term efficacy. It is a promising minimally invasive treatment option for patients with cirrhotic HCC and portal hypertension.
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http://dx.doi.org/10.1177/1553350618759151DOI Listing
June 2018

Modified Laparoscopic Pyloroplasty During Laparoscopic Splenectomy and Azygoportal Disconnection for the Prevention of Postoperative Gastroparesis.

Surg Innov 2017 Aug 13;24(4):328-335. Epub 2017 Mar 13.

1 Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China.

Background: Gastroparesis is a common complication after splenectomy and azygoportal disconnection, remaining a chronic debilitating disorder with considerable treatment challenges. To minimize postoperative gastroparesis, we have developed a new modified laparoscopic pyloroplasty (LP) technique for use during laparoscopic splenectomy and azygoportal disconnection (LSD).

Methods: We retrospectively evaluated the outcomes of 31 cirrhotic patients with portal hypertensive bleeding and secondary hypersplenism who underwent synchronous LSD with modified LP (n = 14) or LSD without modified LP (n = 17) between January 2015 and August 2015. Perioperative variables were compared.

Results: LSD with and without modified LP were successful in all patients. Operation time was significantly longer for LSD with modified LP than LSD without modified LP ( P = .001). However, the LSD with modified LP group had significantly reduced incidences of bloating 1 month postoperatively ( P < .05), nausea ( P < .05), and bloating ( P < .05) 3 months postoperatively, gastric retention 3 months postoperatively ( P < .0001), and prokinetic use at 1 month ( P = .009) and 3 months postoperatively ( P < .05) compared with the LSD without modified LP group. Gastric emptying scintigraphy showed that the mean time required to empty 50% of the ingested meal was significantly shorter in the LSD with modified LP group than in the LSD without modified LP group at 3 months postoperatively (74.3 ± 19.1 vs 261.7 ± 61.0 minutes, P < .0001).

Conclusions: Modified LP during LSD was feasible, effective, and safe, and significantly reduced short-term symptoms of postoperative gastroparesis.
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http://dx.doi.org/10.1177/1553350617697186DOI Listing
August 2017

Excitation of atoms in an optical lattice driven by polychromatic amplitude modulation.

Opt Express 2015 Apr;23(8):10064-74

We investigate the mutiphoton process between different Bloch states in an amplitude modulated optical lattice. In the experiment, we perform the modulation with more than one frequency components, which includes a high degree of freedom and provides a flexible way to coherently control quantum states. Based on the study of single frequency modulation, we investigate the collaborative effect of different frequency components in two aspects. Through double frequency modulations, the spectrums of excitation rates for different lattice depths are measured. Moreover, interference between two separated excitation paths is shown, emphasizing the influence of modulation phases when two modulation frequencies are commensurate. Finally, we demonstrate the application of the double frequency modulation to design a large-momentum-transfer beam splitter. The beam splitter is easy in practice and would not introduce phase shift between two arms.
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http://dx.doi.org/10.1364/OE.23.010064DOI Listing
April 2015

A new technique for laparoscopic splenectomy and azygoportal disconnection.

Surg Innov 2014 Jun 26;21(3):256-62. Epub 2013 Jun 26.

Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu Province, China

Background: Laparoscopic splenectomy and azygoportal disconnection (LSD) using many different surgical techniques has become increasingly popular for treatment of cirrhotic patients with bleeding portal hypertension and secondary hypersplenism. Surgical procedures with the least possible impairment are consistently expected by both surgeons and patients. Here, we report a clinical cohort of 10 patients who underwent LSD with a new technique and present the advantages of less impairment during performance of this new technique.

Methods: A cohort of 10 cirrhotic patients with bleeding portal hypertension and secondary hypersplenism treated with LSD were studied. During the procedure, an electromechanical morcellator allowed for easy extraction of the entire massive splenic tissue without a cumbersome intracorporeal bag, enlarged incision, or hand-assisted incision. Various perioperative data were recorded.

Results: LSD was successful in all patients. There was no conversion to open operations or significant perioperative complications. The operative time was 288.0 ± 53.9 minutes, the spleen removal time was 39.3 ± 15.1 minutes, and blood loss was 240.0 ± 217.1 mL.

Conclusions: This new technique involving the use of an electromechanical morcellator provides expedient recovery and minimal postoperative pain and scarring. LSD with this technique is a feasible, effective, and safe surgical procedure, and embodies all the benefits of minimally invasive surgery for cirrhotic patients with bleeding portal hypertension and hypersplenism.
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http://dx.doi.org/10.1177/1553350613492587DOI Listing
June 2014