Publications by authors named "Sheng-Nan Wu"

100Publications

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of or and in the Stimulation of .

Front Pharmacol 2020 21;11:1091. Epub 2020 Jul 21.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

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http://dx.doi.org/10.3389/fphar.2020.01091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385287PMC
July 2020

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na and K Currents.

Molecules 2020 Jul 4;25(13). Epub 2020 Jul 4.

Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/molecules25133062DOI Listing
July 2020

Melatonin Suppressed the Heat Stress-Induced Damage in Wheat Seedlings by Modulating the Antioxidant Machinery.

Plants (Basel) 2020 Jun 28;9(7). Epub 2020 Jun 28.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling 712100, China.

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http://dx.doi.org/10.3390/plants9070809DOI Listing
June 2020

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07.

Molecules 2020 Jun 24;25(12). Epub 2020 Jun 24.

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

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http://dx.doi.org/10.3390/molecules25122907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355731PMC
June 2020

Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from , of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K Current.

Int J Mol Sci 2020 Jun 15;21(12). Epub 2020 Jun 15.

Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms21124260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352210PMC
June 2020

Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2[H-1]-one), on hyperpolarization-activated cation current: An additional but distinctive target.

Eur J Pharmacol 2020 Sep 7;882:173237. Epub 2020 Jun 7.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2020.173237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276140PMC
September 2020

Glibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue.

Psychoneuroendocrinology 2020 Aug 24;118:104712. Epub 2020 May 24.

Department of Physiology and Pharmacology, Graduate Institute of Biomedical Sciences, Chang-Gung University, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2020.104712DOI Listing
August 2020

Effectiveness in the inhibition of dapagliflozin and canagliflozin on M-type K current and α-methylglucoside-induced current in pituitary tumor (GH) and pheochromocytoma PC12 cells.

Eur J Pharmacol 2020 Jul 27;879:173141. Epub 2020 Apr 27.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan; Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2020.173141DOI Listing
July 2020

Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium Currents.

Int J Mol Sci 2020 Mar 31;21(7). Epub 2020 Mar 31.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms21072416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177279PMC
March 2020

Differential Inhibitory Actions of Multitargeted Tyrosine Kinase Inhibitors on Different Ionic Current Types in Cardiomyocytes.

Int J Mol Sci 2020 Feb 29;21(5). Epub 2020 Feb 29.

Department of Physiology, National Cheng Kung University Medical College 70101, Tainan, Taiwan.

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http://dx.doi.org/10.3390/ijms21051672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084345PMC
February 2020

Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of -Kaurane-Type Diterpenoids from .

Int J Mol Sci 2020 Feb 13;21(4). Epub 2020 Feb 13.

Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms21041268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072998PMC
February 2020

High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BK-Channel Activity and Inhibits or .

Biomolecules 2020 Jan 25;10(2). Epub 2020 Jan 25.

Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

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http://dx.doi.org/10.3390/biom10020188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072225PMC
January 2020

Characterization of Effectiveness in Concerted Inhibition and Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid.

Int J Mol Sci 2020 Jan 5;21(1). Epub 2020 Jan 5.

Department of Physiology, National Cheng Kung University Medical College, No. 1, University Road, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms21010357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981816PMC
January 2020

A novel missense COL10A1 mutation: c.2020G>A; p. Gly674Arg linked with the bowed legs stature in the Schmid metaphyseal chondrodysplasia-affected Chinese lineage.

Bone Rep 2020 Jun 13;12:100240. Epub 2019 Dec 13.

Department of Endocrinology and Metabolism, Henan provincial key laboratory of children's genetics and metabolic diseases, Henan children's hospital (Children's hospital affiliated to Zhengzhou University), No-33, Longhu Waihuan East road, Zhengzhou 450018, China.

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http://dx.doi.org/10.1016/j.bonr.2019.100240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950639PMC
June 2020

Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K Currents in Pituitary Cells and Hippocampal Neurons.

Int J Mol Sci 2019 Dec 23;21(1). Epub 2019 Dec 23.

Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms21010117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982048PMC
December 2019

Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action.

Int J Mol Sci 2019 Nov 29;20(23). Epub 2019 Nov 29.

Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms20236027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928729PMC
November 2019

Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Triterpenoids, the Main Active Constitutents of Spores.

Molecules 2019 Nov 22;24(23). Epub 2019 Nov 22.

Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/molecules24234256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930560PMC
November 2019

The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents.

Biomolecules 2019 10 22;9(10). Epub 2019 Oct 22.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

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http://dx.doi.org/10.3390/biom9100638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843791PMC
October 2019

High Effectiveness in Actions of Carfilzomib on Delayed-Rectifier K Current and on Spontaneous Action Potentials.

Front Pharmacol 2019 7;10:1163. Epub 2019 Oct 7.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

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http://dx.doi.org/10.3389/fphar.2019.01163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791059PMC
October 2019

Characterization of Perturbing Actions by Verteporfin, a Benzoporphyrin Photosensitizer, on Membrane Ionic Currents.

Front Chem 2019 22;7:566. Epub 2019 Aug 22.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.3389/fchem.2019.00566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714490PMC
August 2019

[Correlation between serum microRNA-122 and insulin resistance in obese children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Sep;21(9):910-914

Department of Endocrinology and Inherited Metabolic Disease, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390255PMC
September 2019

Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of I , I , and I unlinked to interaction with opioid receptors.

Drug Dev Res 2019 09 13;80(6):846-856. Epub 2019 Jul 13.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1002/ddr.21568DOI Listing
September 2019

Differential suppression of delayed-rectifier and inwardly rectifier K currents by a group of ent-kaurane-type diterpenoids from Croton tonkinensis, in microglial cells.

Eur J Pharmacol 2019 Aug 24;856:172414. Epub 2019 May 24.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.172414DOI Listing
August 2019

MST3 is involved in ENaC-mediated hypertension.

Am J Physiol Renal Physiol 2019 07 10;317(7):F30-F42. Epub 2019 Apr 10.

School of Pharmacy, China Medical University , Taichung , Taiwan.

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http://dx.doi.org/10.1152/ajprenal.00455.2018DOI Listing
July 2019

Concerted suppression of I and activation of I by ivabradine, an HCN-channel inhibitor, in pituitary cells and hippocampal neurons.

Brain Res Bull 2019 07 3;149:11-20. Epub 2019 Apr 3.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan; Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.016DOI Listing
July 2019

Evidence for Effective Multiple K-Current Inhibitions by Tolvaptan, a Non-peptide Antagonist of Vasopressin V Receptor.

Front Pharmacol 2019 18;10:76. Epub 2019 Feb 18.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

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http://dx.doi.org/10.3389/fphar.2019.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401633PMC
February 2019

Bisoprolol, Known to Be a Selective β₁-Receptor Antagonist, Differentially but Directly Suppresses I and I in Pituitary Cells and Hippocampal Neurons.

Int J Mol Sci 2019 Feb 2;20(3). Epub 2019 Feb 2.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

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http://dx.doi.org/10.3390/ijms20030657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386942PMC
February 2019

The biochemical and electrophysiological profiles of amniotic fluid-derived stem cells following Wnt signaling modulation cardiac differentiation.

Cell Death Discov 2019 28;5:59. Epub 2019 Jan 28.

5Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Rd, East District, Tainan, Taiwan.

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http://www.nature.com/articles/s41420-019-0143-0
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http://dx.doi.org/10.1038/s41420-019-0143-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349909PMC
January 2019

The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity.

Mol Neurobiol 2019 Aug 8;56(8):5497-5506. Epub 2019 Jan 8.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1007/s12035-018-1457-2DOI Listing
August 2019

[Protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1020-1023

Department of Endocrinology and Inherited Metabolism, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389498PMC
December 2018

Parecoxib, a selective blocker of cyclooxygenase-2, directly inhibits neuronal delayed-rectifier K current, M-type K current and Na current.

Eur J Pharmacol 2019 Feb 6;844:95-101. Epub 2018 Dec 6.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan; Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.12.005DOI Listing
February 2019

The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures.

Cell Physiol Biochem 2018 2;50(1):150-168. Epub 2018 Oct 2.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1159/000493965DOI Listing
November 2018

Pioglitazone, a PPAR-γ Activator, Stimulates BK but Suppresses IK in Hippocampal Neurons.

Front Pharmacol 2018 29;9:977. Epub 2018 Aug 29.

Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.3389/fphar.2018.00977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123368PMC
August 2018

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration.

Front Neurosci 2018 15;12:563. Epub 2018 Aug 15.

Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan.

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http://dx.doi.org/10.3389/fnins.2018.00563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104168PMC
August 2018

Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid-Induced Differentiation in Motor Neuron-Like NSC-34 Cells.

Cell Physiol Biochem 2018 16;48(6):2374-2388. Epub 2018 Aug 16.

Department of Physiology, Tainan, Taiwan.

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http://dx.doi.org/10.1159/000492653DOI Listing
September 2018

Multiple Actions of Rotenone, an Inhibitor of Mitochondrial Respiratory Chain, on Ionic Currents and Miniature End-Plate Potential in Mouse Hippocampal (mHippoE-14) Neurons.

Cell Physiol Biochem 2018 11;47(1):330-343. Epub 2018 May 11.

Department of Physiology, National Cheng Kung University, College of Medicine, Tainan, Taiwan.

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http://dx.doi.org/10.1159/000489810DOI Listing
August 2018

Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes.

Clin Exp Pharmacol Physiol 2018 08 3;45(8):797-807. Epub 2018 May 3.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

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http://dx.doi.org/10.1111/1440-1681.12943DOI Listing
August 2018

Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH cells and in olfactory sensory (Rolf B1.T) neurons.

Biochem Pharmacol 2018 05 23;151:79-88. Epub 2018 Feb 23.

Department of Physiology, National Cheng Kung University Medical College, 70101 Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.02.027DOI Listing
May 2018

Stimulatory Action of Telmisartan, an Antagonist of Angiotensin II Receptor, on Voltage-Gated Na⁺ Current: Experimental and Theoretical Studies.

Chin J Physiol 2018 Feb;61(1):1-13

Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan, Republic of China.

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http://dx.doi.org/10.4077/CJP.2018.BAG516DOI Listing
February 2018

Differential regulation of tefluthrin and telmisartan on the gating charges of I activation and inactivation as well as on resurgent and persistent I in a pituitary cell line (GH).

Toxicol Lett 2018 Mar 3;285:104-112. Epub 2018 Jan 3.

Department of Medicine, Shanghai Medical College, Fudan University, Shanghai City, China. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.01.002DOI Listing
March 2018

Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration.

J Neurochem 2018 02 15;144(4):483-497. Epub 2018 Jan 15.

Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1111/jnc.14282DOI Listing
February 2018

The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K currents in insulin-secreting cells.

Eur J Pharmacol 2018 Jan 7;819:233-241. Epub 2017 Dec 7.

Department of Physiology, National Cheng Kung University Medical College, Tainan 701, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.12.004DOI Listing
January 2018

Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity.

Neurotox Res 2018 07 29;34(1):1-15. Epub 2017 Nov 29.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1007/s12640-017-9844-4DOI Listing
July 2018

Huntington Mice Demonstrate Diminished Pain Response in Inflammatory Pain Model.

Anesth Analg 2018 02;126(2):661-669

Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.

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http://dx.doi.org/10.1213/ANE.0000000000002419DOI Listing
February 2018

Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells.

Cell Physiol Biochem 2017 14;41(5):2053-2066. Epub 2017 Apr 14.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1159/000475436DOI Listing
June 2017

Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels.

J Cell Physiol 2017 Dec 10;232(12):3409-3421. Epub 2017 Apr 10.

Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.

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http://dx.doi.org/10.1002/jcp.25788DOI Listing
December 2017

Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells.

BMC Neurosci 2017 01 3;18(1). Epub 2017 Jan 3.

Department of Physiology, National Cheng Kung University Medical College, No. 1, University Road, Tainan City, 70101, Taiwan.

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http://dx.doi.org/10.1186/s12868-016-0320-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210182PMC
January 2017

[Comparison of TaqMan and Allglo probe in fluorescence quantitative RT-PCR detection of simian immunodeficiency virus].

Nan Fang Yi Ke Da Xue Xue Bao 2016 Nov;36(11):1496-1501

Institute of Tropical Medicine, Guangzhou University of TCM, Guangzhou 510405, China.E-mail:

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November 2016

Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population.

Front Genet 2016 20;7:108. Epub 2016 Jun 20.

Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.

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http://dx.doi.org/10.3389/fgene.2016.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913099PMC
July 2016

Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels.

J Biomed Sci 2016 May 21;23(1):47. Epub 2016 May 21.

Center for Neuropsychiatric Research, National Health Research Institutes, 35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.

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http://dx.doi.org/10.1186/s12929-016-0259-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875746PMC
May 2016

Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel.

Sci Rep 2016 Mar 10;6:22864. Epub 2016 Mar 10.

Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1038/srep22864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785403PMC
March 2016

Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes.

Cell Rep 2015 Sep 10;12(12):1960-7. Epub 2015 Sep 10.

Institute of Clinical Medicine, National Cheng Kung University, Tainan 704, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Division of Cardiovascular Surgery, National Taiwan University Hospital, Taipei 100, Taiwan. Electronic address:

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http://www.cell.com/cms/attachment/2038220585/2052459956/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500927
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http://dx.doi.org/10.1016/j.celrep.2015.08.042DOI Listing
September 2015

Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells.

Br J Pharmacol 2015 Nov 25;172(21):5110-22. Epub 2015 Oct 25.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

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http://dx.doi.org/10.1111/bph.13276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687803PMC
November 2015

The potent activation of Ca(2+)-activated K(+) current by NVP-AUY922 in the human pancreatic duct cell line (PANC-1) possibly independent of heat shock protein 90 inhibition.

J Pharmacol Sci 2015 Apr 20;127(4):404-13. Epub 2015 Feb 20.

National Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng Li Road, Tainan 70456, Taiwan; Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138, Shengli Road, Tainan 70456, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2015.02.009DOI Listing
April 2015

Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines.

Eur J Pharmacol 2015 Jul 2;758:177-87. Epub 2015 Apr 2.

Department of Physiology, National Cheng Kung University Medical College, No. 1 University Road, Tainan City 70101, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.065DOI Listing
July 2015

Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: an experimental and theoretical study.

Kaohsiung J Med Sci 2015 Jan 22;31(1):9-17. Epub 2014 Nov 22.

Department of Pharmacology, Kaohsiung Medical University, Kaohsiung City, Taiwan.

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http://dx.doi.org/10.1016/j.kjms.2014.10.006DOI Listing
January 2015

Reversal by ranolazine of doxorubicin-induced prolongation in the inactivation of late sodium current in rat dorsal root ganglion neurons.

Pain Med 2015 May 13;16(5):1032-4. Epub 2015 Jan 13.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1111/pme.12681DOI Listing
May 2015

Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7).

J Membr Biol 2015 Feb 2;248(1):103-15. Epub 2014 Nov 2.

Department of Physiology, National Cheng Kung University Medical College, No. 1 University Road, Tainan City, 70101, Taiwan,

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http://dx.doi.org/10.1007/s00232-014-9747-8DOI Listing
February 2015

Evaluation of microvasculature at the auditory midbrain--the benefits of sectioning at a tangential angle.

Microsc Res Tech 2015 Jan 28;78(1):105-10. Epub 2014 Oct 28.

Department of Anesthesia, China Medical University- An Nan Hospital, Tainan, Taiwan; Department of Anesthesia, China Medical University, Taichung, Taiwan; Department of Anesthesia, Taishan Medical University, Taian, Shangdong, People's Republic of China; Department of Anesthesia, Nanshan branch of Qilu Hospital, Shangdong University, People's Republic of China.

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http://dx.doi.org/10.1002/jemt.22450DOI Listing
January 2015

High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells.

Eur J Pharmacol 2014 Sep 11;738:332-41. Epub 2014 Jun 11.

Department of Physiology, National Cheng Kung University Medical College, No. 1, University Road, Tainan City 70101, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.05.059DOI Listing
September 2014

Stimulation of electroporation-induced inward currents in glioblastoma cell lines by the heat shock protein inhibitor AUY922.

Clin Exp Pharmacol Physiol 2014 Oct;41(10):830-7

National Institute of Cancer Research, National Health Research Institutes, Tainan City, Taiwan; Division of Hematology/Oncology, Department of Internal Medicine, Tainan City, Taiwan.

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http://dx.doi.org/10.1111/1440-1681.12273DOI Listing
October 2014

Effects of midazolam on ion currents and membrane potential in differentiated motor neuron-like NSC-34 and NG108-15 cells.

Eur J Pharmacol 2014 Feb 27;724:152-60. Epub 2013 Dec 27.

Department of Physiology, National Cheng Kung University, 1# University Road, Tainan City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2013.12.034DOI Listing
February 2014

Corticosteroids for viral myocarditis.

Cochrane Database Syst Rev 2013 Oct 18(10):CD004471. Epub 2013 Oct 18.

Intensive Care Unit, Shenzhen People's Hospital, The Second Affiliated Hospital of Ji Nan University, 1017 Dong Men Bei Lu, Luo Hu District, Shenzhen City, Guangdong, China, 518020.

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http://dx.doi.org/10.1002/14651858.CD004471.pub3DOI Listing
October 2013

[Diagnosis and treatment of isolated methylmalonic acidemia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2013 Oct;30(5):589-93

Department of Pediatric Endocrinology, Genetic and Metabolic Diseases, Shanghai Institute of Pediatric Research, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 210092, P. R. China. Email:

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2013.05.018DOI Listing
October 2013

Identification of minuscule inward currents as precursors to membrane electroporation-induced currents: real-time prediction of pore appearance.

Cell Physiol Biochem 2013 27;32(2):402-16. Epub 2013 Aug 27.

Department of Anesthesia, Tainan Municipal An Nan Hospital, China Medical University, Tainan City.

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http://dx.doi.org/10.1159/000354447DOI Listing
April 2014

The inhibition of inwardly rectifying K+ channels by memantine in macrophages and microglial cells.

Cell Physiol Biochem 2013 21;31(6):938-51. Epub 2013 Jun 21.

Department of Physiology, School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.

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http://dx.doi.org/10.1159/000350112DOI Listing
February 2014

Pregabalin attenuates excitotoxicity in diabetes.

PLoS One 2013 13;8(6):e65154. Epub 2013 Jun 13.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065154PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681790PMC
January 2014

[Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia].

Zhonghua Yi Xue Za Zhi 2013 Feb;93(8):561-5

Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

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February 2013

Inhaled unfractionated heparin improves abnormalities of alveolar coagulation, fibrinolysis and inflammation in endotoxemia-induced lung injury rats.

Chin Med J (Engl) 2013 Jan;126(2):318-24

Department of Intensive Care Unit, Peking University Third Hospital, Beijing 100191, China.

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January 2013

Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit.

Neurotoxicology 2012 Oct;33(5):1058-66

Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung city, Taiwan.

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http://dx.doi.org/10.1016/j.neuro.2012.05.006DOI Listing
October 2012

[The effects of three dosages of nebulized unfractionated heparin on alveolar coagulation and tissue inflammation injury in endotoxin-induced acute lung injury rat model].

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2012 Oct;24(10):612-5

Department of Critical Care Medicine, Peking University, Beijing, China.

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October 2012

Possible effects of reduced conductance in delayed-rectifier K+ current on neuronal firing.

Mov Disord 2012 Oct 2;27(12):1581-2; author reply 1583. Epub 2012 Oct 2.

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http://dx.doi.org/10.1002/mds.25205DOI Listing
October 2012

Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells.

Evid Based Complement Alternat Med 2012 22;2012:148403. Epub 2012 Jul 22.

Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

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http://dx.doi.org/10.1155/2012/148403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408763PMC
August 2012

Evidence for mitoxantrone-induced block of inwardly rectifying K(+) channels expressed in the osteoclast precursor RAW 264.7 cells differentiated with lipopolysaccharide.

Cell Physiol Biochem 2012 1;30(3):687-701. Epub 2012 Aug 1.

Department of Nursing, Chung Jen College of Nursing, Health Sciences and Management, Chiayi city, Taiwan.

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http://dx.doi.org/10.1159/000341449DOI Listing
December 2012

The effects of magnetite (Fe₃O₄) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH₃) cells and in RAW 264.7 macrophages.

Int J Nanomedicine 2012 27;7:1687-96. Epub 2012 Mar 27.

Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.

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http://dx.doi.org/10.2147/IJN.S28798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357052PMC
December 2012

Catheter ablation for paroxysmal and persistent atrial fibrillation.

Cochrane Database Syst Rev 2012 Apr 18(4):CD007101. Epub 2012 Apr 18.

Intensive Care Unit, Shenzhen People’s Hospital, The Second Affiliated Hospital of JiNan University, Shenzhen City,

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http://dx.doi.org/10.1002/14651858.CD007101.pub2DOI Listing
April 2012

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells.

Eur J Pharm Sci 2012 Aug 24;46(5):415-25. Epub 2012 Mar 24.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.ejps.2012.03.004DOI Listing
August 2012

The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K⁺ current and membrane potential in HL-1 murine atrial cardiomyocytes.

Eur J Pharmacol 2012 May 21;683(1-3):1-9. Epub 2012 Feb 21.

Department of Anesthesia, Chi-Mei Medical Center, Tainan City, Taiwan.

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http://dx.doi.org/10.1016/j.ejphar.2012.02.012DOI Listing
May 2012

The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K⁺ current in pituitary tumor (GH₃) cells.

Arch Toxicol 2012 May;86(5):713-23

Department of Physiology, National Cheng Kung University Medical College, No. 1 University Road, Tainan City 70101, Taiwan.

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http://dx.doi.org/10.1007/s00204-012-0805-7DOI Listing
May 2012

Cholesterol depletion with (2-hydroxypropyl)- β-cyclodextrin modifies the gating of membrane electroporation-induced inward current in pituitary tumor GH3 cells: experimental and analytical studies.

Cell Physiol Biochem 2011 15;28(5):959-68. Epub 2011 Dec 15.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1159/000335809DOI Listing
April 2012

Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.

Psychopharmacology (Berl) 2012 Jun 13;221(4):575-87. Epub 2011 Dec 13.

Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan.

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http://dx.doi.org/10.1007/s00213-011-2603-yDOI Listing
June 2012

Investigations into the correlation properties of membrane electroporation-induced inward currents: prediction of pore formation.

Cell Biochem Biophys 2012 Jan;62(1):211-20

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1007/s12013-011-9284-3DOI Listing
January 2012

Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

Life Sci 2011 Nov 8;89(19-20):691-701. Epub 2011 Sep 8.

Department of Anaesthesiology, Chi-Mei Medical Center, Tainan City, Taiwan.

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http://dx.doi.org/10.1016/j.lfs.2011.08.013DOI Listing
November 2011

Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage.

Chin J Physiol 2010 Dec;53(6):423-9

Department of Anesthesiology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, China.

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http://dx.doi.org/10.4077/cjp.2010.amm026DOI Listing
December 2010

Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.

Toxicology 2011 Oct 18;289(1):11-8. Epub 2011 Jul 18.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1016/j.tox.2011.07.003DOI Listing
October 2011

[Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model].

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2011 Apr;23(4):239-42

Department of Anesthesiology, Peking University People's Hospital, Beijing 100044, China.

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April 2011

Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7.

J Membr Biol 2011 May 29;241(1):11-20. Epub 2011 Mar 29.

Department of Physiology, National Cheng Kung University Medical College, No. 1, University Road, Tainan, 70101, Taiwan,

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http://dx.doi.org/10.1007/s00232-011-9358-6DOI Listing
May 2011

Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells.

Biochem Biophys Res Commun 2011 Feb 22;405(3):508-13. Epub 2011 Jan 22.

Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1016/j.bbrc.2011.01.066DOI Listing
February 2011

Functional role of the activity of ATP-sensitive potassium channels in electrical behavior of hippocampal neurons: experimental and theoretical studies.

J Theor Biol 2011 Mar 8;272(1):16-25. Epub 2010 Dec 8.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan.

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http://dx.doi.org/10.1016/j.jtbi.2010.12.003DOI Listing
March 2011

Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH₃ pituitary tumor cells.

Toxicology 2011 Feb 20;280(1-2):1-9. Epub 2010 Nov 20.

College of Medical and Health Sciences, Fooyin University, Ta-Liao, Kaohsiung County, Taiwan.

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http://dx.doi.org/10.1016/j.tox.2010.10.010DOI Listing
February 2011