Publications by authors named "Sheng Wang"

1,946 Publications

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Identifying potential prognosis markers in hepatocellular carcinoma integrated bioinformatics analysis and biological experiments.

Front Genet 2022 19;13:942454. Epub 2022 Jul 19.

Department of Hematology, Linyi Central Hospital, Yishui, Shandong, China.

Hepatocellular carcinoma is one kind of clinical common malignant tumor with a poor prognosis, and its pathogenesis remains to be clarified urgently. This study was performed to elucidate key genes involving HCC by bioinformatics analysis and experimental evaluation. We identified common differentially expressed genes (DEGs) based on gene expression profile data of GSE60502 and GSE84402 from the Gene Expression Omnibus (GEO) database. Gene Ontology enrichment analysis (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, REACTOME pathway enrichment analysis, and Gene Set Enrichment Analysis (GSEA) were used to analyze functions of these genes. The protein-protein interaction (PPI) network was constructed using Cytoscape software based on the STRING database, and Molecular Complex Detection (MCODE) was used to pick out two significant modules. Hub genes, screened by the CytoHubba plug-in, were validated by Gene Expression Profiling Interactive Analysis (GEPIA) and the Human Protein Atlas (HPA) database. Then, the correlation between hub genes expression and immune cell infiltration was evaluated by Tumor IMmune Estimation Resource (TIMER) database, and the prognostic values were analyzed by Kaplan-Meier plotter. Finally, biological experiments were performed to illustrate the functions of RRM2. Through integrated bioinformatics analysis, we found that the upregulated DEGs were related to cell cycle and cell division, while the downregulated DEGs were associated with various metabolic processes and complement cascade. RRM2, MAD2L1, MELK, NCAPG, and ASPM, selected as hub genes, were all correlated with poor overall prognosis in HCC. The novel RRM2 inhibitor osalmid had anti-tumor activity, including inhibiting proliferation and migration, promoting cell apoptosis, blocking cell cycle, and inducing DNA damage of HCC cells. The critical pathways and hub genes in HCC progression were screened out, and targeting RRM2 contributed to developing new therapeutic strategies for HCC.
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http://dx.doi.org/10.3389/fgene.2022.942454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343963PMC
July 2022

Propofol enhances stem-like properties of glioma via GABAR-dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism.

Stem Cell Res Ther 2022 Aug 4;13(1):398. Epub 2022 Aug 4.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), No. 17, Lujiang Road, Hefei, 230001, Anhui, China.

Background: Propofol is a commonly used anesthetic. However, its effects on glioma growth and recurrence remain largely unknown.

Methods: The effect of propofol on glioma growth was demonstrated by a series of in vitro and in vivo experiments (spheroidal formation assay, western blotting, and xenograft model). The acyl-biotin exchange method and liquid chromatography-mass spectrometry assays identified palmitoylation proteins mediated by the domain containing the Asp-His-His-Cys family. Western blotting, co-immunoprecipitation, quantitative real-time polymerase chain reaction, co-immunoprecipitation, chromatin immunoprecipitation, and luciferase reporter assays were used to explore the mechanisms of the γ-aminobutyric acid receptor (GABAR)/Src/ZDHHC5/EZH2 signaling axis in the effects of propofol on glioma stem cells (GSCs).

Results: We found that treatment with a standard dose of propofol promoted glioma growth in nude mice compared with control or low-dose propofol. Propofol-treated GSCs also led to larger tumor growth in nude mice than did vector-treated tumors. Mechanistically, propofol enhances the stem-like properties of gliomas through GABAR to increase Src expression, thereby enhancing the palmitoylation of ZDHHC5-mediated EZH2 and Oct4 expression.

Conclusion: These results demonstrate that propofol may promote glioma growth through the GABAR-Src-ZDHHC5-EZH2 mechanism and are helpful in guiding the clinical use of propofol to obtain a better patient prognosis after the surgical resection of tumors.
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http://dx.doi.org/10.1186/s13287-022-03087-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351178PMC
August 2022

LncRNA/miRNA/mRNA ceRNA network analysis in spinal cord injury rat with physical exercise therapy.

PeerJ 2022 29;10:e13783. Epub 2022 Jul 29.

Medical College of Nantong University, Department of Anatomy, Nantong, China.

Noncoding RNAs have been implicated in the pathophysiology of spinal cord injury (SCI), including cell death, glial scar formation, axonal collapse and demyelination, and inflammation. The evidence suggests that exercise therapy is just as effective as medical treatment in SCI. However, studies of competing endogenous RNA (ceRNA)-mediated regulation mechanisms in the therapy of SCI with exercise are rare. The focus of this research was to investigate the effect of exercise therapy on the expression levels of long noncoding RNA (lncRNA), microRNA (miRNA), and mRNA in rats with SCI. The RNA-seq technology has been used to examine the differentially expressed circRNAs (DECs), lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs) between SCI and exercise therapy rats. The ceRNA network was established using interactions between miRNAs and mRNAs, as well as between miRNAs and lncRNAs/circRNAs. The Database for Annotation, Visualization, and Integrated Discovery was used to anticipate the underlying functions of mRNAs. Our current study identified 76 DELs, 33 DEMs, and 30 DEGs between groups of SCI rats and exercise therapy rats. Subsequently, these newly discovered ceRNA interaction axes could be important targets for the exercise treatment of SCI.
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http://dx.doi.org/10.7717/peerj.13783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341448PMC
July 2022

A User-Friendly Platform for Single-Cell Raman Spectroscopy Analysis.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jul 28;282:121686. Epub 2022 Jul 28.

Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

The optimization of Raman instruments greatly expands our understanding of single-cell Raman spectroscopy. The improvement in the speed and sensitivity of the instrument and the implementation of advanced data mining methods help to reveal the complex chemical and biological information within the Raman spectral data. Here we introduce a new Matlab Graphical User-Friendly Interface (GUI), named "CELL IMAGE" for the analysis of cellular Raman spectroscopy data. The three main steps of data analysis embedded in the GUI include spectral processing, pattern recognition and model validation. Various well-known methods are available to the user of the GUI at each step of the analysis. Herein, a new subsampling optimization method is integrated into the GUI to estimate the minimum number of spectral collection points. The introduction of the signal-to-noise ratio (SNR) of the analyte in the binomial statistical model means the new subsampling model is more sophisticated and suitable for complicated Raman cell data. These embedded methods allow "CELL IMAGE" to transform spectral information into biological information, including single-cell visualization, cell classification and biomolecular/ drug quantification.
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http://dx.doi.org/10.1016/j.saa.2022.121686DOI Listing
July 2022

Stability of Perovskite Light-Emitting Diodes: Existing Issues and Mitigation Strategies Related to both Material and Device Aspects.

Adv Mater 2022 Aug 3:e2205217. Epub 2022 Aug 3.

Key Laboratory of Advanced Display and System Applications of Ministry of Education, Shanghai University, Shanghai, 200072, P. R. China.

Metal halide perovskites combine excellent electronic and optical properties such as defect tolerance and high photoluminescence efficiency with the benefits of low-cost, large area, solution-based processing. Composition- and dimension-tunable properties of perovskites have already been utilized in bright and efficient light-emitting diodes (LEDs). At the same time, there are still great challenges ahead to achieve operational and spectral stability of these devices. In this review, we consider the origins of instability of perovskite materials, and reasons for their degradation in LEDs. We then review the strategies on improving the stability of perovskite materials such as compositional engineering, dimensionality control, defect passivation, suitable encapsulation matrices, and fabrication of core/shell perovskite nanocrystals. For improvement of the operational stability of perovskite LEDs, we consider use of inorganic charge transport layers, optimization of charge balance, and proper thermal management. We conclude this review with a detailed account of the current challenges and a perspective on the key approaches and opportunities on how to reach the goal of stable, bright and efficient perovskite LEDs. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202205217DOI Listing
August 2022

Cooperative NHC and Photoredox Catalysis for the Synthesis of 1,4-Dicarbonyl Compounds via Diacylation of Alkenes.

Org Lett 2022 Aug 3. Epub 2022 Aug 3.

School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Anhui, 230000, P. R. China.

An intermolecular 1,2-diacylation of alkenes is disclosed via cooperative N-heterocyclic carbene and photoredox catalysis under the mediation of PPh and CsCO. This protocol provides a practical approach for construction of 1,4-dicarbonyl compounds toward novel diketone and pharmaceutical derivatives. Furthermore, the regioselective dicarbonyl compounds can be synthesized by adding acyl azolium salt. Mechanistic investigations suggest that the process was a critical radical/radical cross coupling of ketyl radicals with benzylic C-radicals.
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http://dx.doi.org/10.1021/acs.orglett.2c02108DOI Listing
August 2022

Electromembrane extraction of nicotine in inhaled aerosols from tobacco cigarettes, electronic cigarettes, and heated tobacco products.

J Chromatogr B Analyt Technol Biomed Life Sci 2022 Jul 26;1208:123391. Epub 2022 Jul 26.

Institute of Business Scientific, Henan Academy of Sciences, Wenhua Road #87, Zhengzhou, Henan 450003, PR China. Electronic address:

Heated tobacco products and electronic cigarettes are considered as alternatives to traditional tobacco cigarettes. However, it is crucial to monitor and compare the nicotine concentration in inhaled aerosols from these tobacco products, owing to the addictive nature and adverse effects of nicotine on human health. This study aimed to provide an electromembrane extraction (EME) combined liquid chromatography method to extract and determine nicotine in different inhaled aerosols. EME showed high extraction efficiency, selectivity, and sample clean-up capability. Under the optimal parameters, the linear range for nicotine was 0.1-200 mg L (r > 0.9998), and the limit of detection was 0.02 mg L. Good precision was obtained with the intra- and inter-day relative standard deviations of 2.2 % and 2.8 %, respectively. Repeatability was satisfactory (<7.7 %), and recoveries ranged from 81.0 % to 112.8 %. Finally, this method has been successfully used for the determination and comparison of nicotine in aerosols from these three tobacco products.
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http://dx.doi.org/10.1016/j.jchromb.2022.123391DOI Listing
July 2022

Iron-modified biochar-based bilayer permeable reactive barrier for Cr(VI) removal.

J Hazard Mater 2022 Jul 19;439:129636. Epub 2022 Jul 19.

China Northeast Municipal Engineering Design and Research Institute Co., Ltd., Changchun 130021, China.

Iron (Fe)-modified biochar (FeBC) has been developed to remove hexavalent chromium (Cr(VI)) from groundwater and is suitable for use in permeable reactive barriers (PRBs). However, Cr(VI) removal behavior and chemical processes in FeBC-based PRBs are not fully understood, and the potential for Fe release has not been addressed. In this study, three FeBC-based PRBs were assessed in column experiments for 563 days with respect to their ability to remove Cr(VI). Bilayer column filled with FeBC+limestone and BC+limestone in two separate layers (FeBC_Ca_BC) showed the best performance in terms of Cr(VI) removal with a low treatment cost. The corrosion of FeBC was mainly related to pH and Cr(VI) concentration rather than flow rate. Leached Fe was attenuated by BC and limestone and reutilized in FeBC_Ca_BC. Cr(VI) was reduced to Cr(III) and then adsorbed or precipitated on the biochars. Cr and Fe formed inner-sphere complexes and then transformed from double corner sharing to edge sharing. During the reaction, Cr penetrated from the surface to the interior of the biochars and became a more stable species. This study provides evidence of the effectiveness of a new combination of biochars for Cr(VI) removal and insights into the reaction mechanisms.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129636DOI Listing
July 2022

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines.

Molecules 2022 Jul 22;27(15). Epub 2022 Jul 22.

Department of Chemistry, Xihua University, Chengdu 610039, China.

Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, highly toxic reaction reagents or hazardous reaction conditions. Herein, an efficient route from halogenated amides to piperidines and pyrrolidines was disclosed. In this method, amide activation, reduction of nitrile ions, and intramolecular nucleophilic substitution were integrated in a one-pot reaction. The reaction conditions were mild and no metal catalysts were used. The synthesis of a variety of N-substituted and some C-substituted piperidines and pyrrolidines became convenient, and good yields were obtained.
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http://dx.doi.org/10.3390/molecules27154698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331508PMC
July 2022

Hippocampal semaphorin 3B improves depression-like behaviours in mice by upregulating synaptic plasticity and inhibiting neuronal apoptosis.

J Neurochem 2022 Jul 26. Epub 2022 Jul 26.

Hebei Key Laboratory of Neurophysiology, Shijiazhuang, China.

Depression is a global health problem, and there is a pressing need for a better understanding of its pathogenesis. Semaphorin 3B (Sema 3B) is an important axon guidance molecule that is primarily expressed in neurons and contributes to synaptic plasticity. Our previous studies using a high-throughput microarray assay suggested that Sema 3B expression was tremendously decreased during the development of depression, but the specific role and mechanisms of Sema 3B in depression are still unknown. Herein, we report that levels of Sema 3B protein are decreased in the hippocampus and serum of chronic mild stress (CMS)-treated mice. Increasing the levels of Sema 3B, either by injecting AAV-Sema 3B into the hippocampus or by injecting recombinant Sema 3B protein into the lateral ventricles, alleviated CMS-induced depression-like behaviours and enhanced the resistance to acute stress by increasing dendritic spine density in hippocampal neurons. In contrast, interfering with the function of Sema 3B by injecting anti-Sema 3B antibody into the lateral ventricles decreased the resistance to acute stress. In vitro, corticosterone (CORT) treatment decreased the survival rate and protein levels of Sema 3B and synapse-associated proteins in HT22 cells. Overexpression of Sema 3B improved the decreased survival rate caused by CORT by inhibiting apoptosis and increasing levels of synaptic-associated proteins, and knockdown of Sema 3B reduces the cellular resistance to CORT and the levels of synapse-associated proteins. These findings represent the first evidence for the neuroprotective mechanism of Sema 3B against stresses, suggesting that Sema 3B could be a promising novel target for the prevention and treatment of depression.
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http://dx.doi.org/10.1111/jnc.15680DOI Listing
July 2022

A Novel NDT Scanning System Based on Line Array Fast Neutron Detector and D-T Neutron Source.

Materials (Basel) 2022 Jul 15;15(14). Epub 2022 Jul 15.

Institute of Nuclear Physics and Chemistry, Mianyang 621900, China.

A novel non-destructive testing scanning system based on a large-size line array fast neutron detector and compact D-T neutron source has been constructed. The scanning range is up to 1000 mm, and the resolution is better than 1 mm. The fast neutron detection subsystem consists of a polypropylene zinc sulfide scintillator embedded with wavelength-shifting fibers, coupled with a light lens and a scientific CCD camera. With a new rotating tritium target, the lifetime of the compact D-T neutron source could achieve ten hours. The experimental results indicate that the scanning method based on line array fast neutron detector and D-T neutron source is feasible and enables the detection of slits on the order of 0.5 mm in width. Fast neutron tomography has been realized by this detection system too.
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http://dx.doi.org/10.3390/ma15144946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319683PMC
July 2022

The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus.

Cell Reprogram 2022 Jul 25. Epub 2022 Jul 25.

Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, China.

Mesenchymal stem cells (MSCs) exist in many tissues and can differentiate into cells of multiple lineages, such as adipocytes, osteoblasts, or chondrocytes. MSC administration has demonstrated therapeutic potential in various degenerative and inflammatory diseases (, graft-vs.-host disease, multiple sclerosis, Crohn's disease, organ fibrosis, and diabetes mellitus [DM]). The mechanisms involved in the therapeutic effects of MSCs are multifaceted. Generally, implanted MSCs can migrate to sites of injury, where they establish an anti-inflammatory and regenerative microenvironment in damaged tissues. In addition, MSCs can modulate innate and adaptive immune responses through immunosuppressive mechanisms that involve immune cells, inflammatory cytokines, chemokines, and immunomodulatory factors. DM has a high prevalence worldwide; it also contributes to a high rate of mortality worldwide. MSCs offer a promising therapeutic agent to prevent or repair damage from DM and diabetic complications through properties such as multilineage differentiation, homing, promotion of angiogenesis, and immunomodulation (, prevention of oxidative stress, fibrosis, and cell death). In this study, we review current findings regarding the immunomodulatory and regenerative mechanisms of MSCs, as well as their therapeutic applications in DM and DM-related complications.
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http://dx.doi.org/10.1089/cell.2022.0039DOI Listing
July 2022

Multiplexed Massively Parallel Sequencing of Plastomes Provides Insights Into the Genetic Diversity, Population Structure, and Phylogeography of Wild and Cultivated .

Front Plant Sci 2022 7;13:923600. Epub 2022 Jul 7.

National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Root rot has been a major problem for cultivated populations of var. in recent years. var. , the closest wild relative of var. , has a scattered distribution across southwestern China and is an important wild resource. Genetic diversity is associated with greater evolutionary potential and resilience of species or populations and is important for the breeding and conservation of species. Here, we conducted multiplexed massively parallel sequencing of the plastomes of 227 accessions of wild and cultivated using 111 marker pairs to study patterns of genetic diversity, population structure, and phylogeography among wild and cultivated populations. Wild and cultivated resources diverged approximately 2.83 Mya. The cultivated resources experienced a severe genetic bottleneck and possess highly mixed germplasm. However, high genetic diversity has been retained in the wild resources, and subpopulations in different locations differed in genotype composition. The significant divergence in the genetic diversity of wild and cultivated resources indicates that they require different conservation strategies. Wild resources require conservation strategies aiming to expand population sizes while maintaining levels of genetic diversity; by contrast, germplasm resource nurseries with genotypes of cultivated resources and planned distribution measures are needed for the conservation of cultivated resources to prevent cultivated populations from undergoing severe genetic bottlenecks. The results of this study provide comprehensive insights into the genetic diversity, population structure, and phylogeography of and will facilitate future breeding and conservation efforts.
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http://dx.doi.org/10.3389/fpls.2022.923600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302112PMC
July 2022

Microwave-based soil moisture improves estimates of vegetation response to drought in China.

Sci Total Environ 2022 Jul 21:157535. Epub 2022 Jul 21.

Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies, School of Atmospheric Sciences, Sun Yat-sen University, Guangzhou 510275, China.

The increased frequency and severity of drought has heightened concerns over the risk of hydraulic vegetative stress and premature mortality of ecosystems globally. Unfortunately, most land surface models (LSMs) continue to underestimate ecosystem resilience to drought - which degrades the credibility of model-predicted ecohydrological responses to climate change. This study investigates the response of vegetation gross productivity to water-stress conditions using microwave-based vegetation optical depth (VOD) and soil moisture retrievals. Based on the estimated isohydric/anisohydric spectrum, we find that vegetation at isohydric state exhibits a larger decrease in gross primary productivity and higher water use efficiency than anisohydric vegetation due to their more rigorous stomatal control and higher tolerance of carbon starvation risk. In addition, the introduction of microwave soil moisture improves the accuracy of isohydricity/anisohydricity estimates compared to those obtained using microwave VOD alone (i.e., increases their Spearman rank correlation versus the benchmark of Global Biodiversity Information Facility dataset from 0.12 to 0.63). Results of this study provide clear justification for the use of microwave-based soil moisture retrievals to enhance stomatal conductance parameterization within LSMs.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157535DOI Listing
July 2022

[Development of bio-jet fuel production technology: a review].

Sheng Wu Gong Cheng Xue Bao 2022 Jul;38(7):2477-2488

Research Institute of Petroleum Processing, Sinopec, Beijing 100083, China.

Due to the large amount of greenhouse gas emissions and the high dependence on fossil fuels, the sustainable development of aviation industry has attracted worldwide attention. Bio-jet fuel is considered to be a promising alternative to traditional aviation fuel. This article summarizes the representative technological route, development status, opportunities and challenges faced by the development of bio-jet fuel industry. So far, several bio-jet fuel production technologies have been certified by the American Society for Testing and Materials (ASTM). Hydroprocessed esters and fatty acids is currently the most mature process that can be fully commercialized. Considering economic characteristics and technology maturity, Fischer-Tropsch is promising in near term.
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http://dx.doi.org/10.13345/j.cjb.210934DOI Listing
July 2022

Comprehensive analysis of mutations in NSCLC patients in a real-world setting.

Ther Adv Med Oncol 2022 16;14:17588359221112474. Epub 2022 Jul 16.

Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, No.241, Huaihai West Road, Shanghai 200032, China.

Background: Aberrant mesenchymal-epithelial transition/hepatocyte growth factor (MET/HGF) regulation presented in a wide variety of human cancers. exon 14 skipping, copy number gain (CNG), and kinase domain mutations/arrangements were associated with increased MET activity, and considered to be oncogenic drivers of non-small cell lung cancers (NSCLCs).

Methods: We retrospectively analyzed 564 patients with MET alterations. alterations were classified into structural mutations or small mutations. CNG, exon 14 skipping, gain of function (GOF) mutations, and kinase domain rearrangement were defined as actionable mutations.

Results: Six hundred thirty-two mutations were identified including 199 CNG, 117 exon 14 skipping, 12 GOF mutations, and 2 actionable fusions. Higher percentage of structural alterations (CNG + fusion) were detected in advanced NSCLC patients. Moreover, CNG was enriched while exon 14 skipping was rare in epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI)-treated advanced NSCLC patients. Ten of the 12 GOF mutations were also in EGFR-TKI-treated patients. Fifteen (68.1%) of the 22 patients treated with crizotinib or savolitinib had a partial response. Interestingly, one patient had a great response to savolitinib with a novel exon 14 skipping mutation identified after failure of immune-checkpoint inhibitor.

Conclusions: Half of the alterations were actionable mutations. CNG, exon 14 skipping and GOF mutations had different distribution in different clinical scenario but all defined a molecular subgroup of NSCLCs for which MET inhibition was active.
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http://dx.doi.org/10.1177/17588359221112474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290171PMC
July 2022

Developmental Trends and Research Hotspots in Bronchoscopy Anesthesia: A Bibliometric Study.

Front Med (Lausanne) 2022 30;9:837389. Epub 2022 Jun 30.

Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: This study discusses the developmental trends and research hotspots in bronchoscopy anesthesia in the past six decades.

Methods: The original and review articles published from 1975 to June 2021 related to bronchoscopy anesthesia were retrieved from the Web of Science Core Collection (WoSCC). Three different scientometric tools (CiteSpace, VOSviewer, and Bibliometrix) were used for this comprehensive analysis.

Results: There was a substantial increase in the research on bronchoscopy anesthesia in recent years. A total of 1,270 publications were retrieved up to June 25, 2021. Original research articles were 1,152, and reviews were 118, including 182 randomized controlled trials (RCTs). These publications were cited a total of 25,504 times, with a mean of 20.08 citations per publication. The US had the largest number of publications (27.6%) and the highest H-index of 44. The sum of publications from China ranked second (11.5%), with an H-index of 17. Keyword co-occurrence and references co-citation visual analysis showed that the use of sedatives such as dexmedetomidine in the process of bronchoscopy diagnosis and treatment was gradually increasing, indicating that bronchoscopy anesthesia was further progressing toward safety and comfort.

Conclusion: Based on a bibliometric analysis of the publications over the past decades, a comprehensive analysis indicated that the research of bronchoscopy anesthesia is in a period of rapid development and demonstrated the improvement of medical instruments and surgical options that have significantly contributed to the field of bronchoscopy anesthesia. The data would provide future directions for clinicians and researchers in relation to bronchoscopy anesthesia.
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http://dx.doi.org/10.3389/fmed.2022.837389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279861PMC
June 2022

Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.

Front Aging 2021 29;2:757801. Epub 2021 Sep 29.

Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, United States.

O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification process that senses nutrient availability and cellular stress and regulates diverse biological processes that are involved in neurodegenerative diseases and provide potential targets for therapeutics development. However, very little is known of the networks involved in the brain that are responsive to changes in the O-GlcNAc proteome. Pharmacological increase of protein O-GlcNAcylation by Thiamet G (TG) has been shown to decrease tau phosphorylation and neurotoxicity, and proposed as a therapy in Alzheimer's disease (AD). However, acute TG exposure impairs learning and memory, and protein O-GlcNAcylation is increased in the aging rat brain and in Parkinson's disease (PD) brains. To define the cortical O-GlcNAc proteome that responds to TG, we injected young adult mice with either saline or TG and performed mass spectrometry analysis for detection of O-GlcNAcylated peptides. This approach identified 506 unique peptides corresponding to 278 proteins that are O-GlcNAcylated. Of the 506 unique peptides, 85 peptides are elevated by > 1.5 fold in O-GlcNAcylation levels in response to TG. Using pathway analyses, we found TG-dependent enrichment of O-GlcNAcylated synaptic proteins, trafficking, Notch/Wnt signaling, HDAC signaling, and circadian clock proteins. Significant changes in the O-GlcNAcylation of DNAJC6/AUXI, and PICALM, proteins that are risk factors for PD and/or AD respectively, were detected. We compared our study with two key prior O-GlcNAc proteome studies using mouse cerebral tissue and human AD brains. Among those identified to be increased by TG, 15 are also identified to be increased in human AD brains compared to control, including those involved in cytoskeleton, autophagy, chromatin organization and mitochondrial dysfunction. These studies provide insights regarding neurodegenerative diseases therapeutic targets.
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http://dx.doi.org/10.3389/fragi.2021.757801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261315PMC
September 2021

Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma.

J Oncol 2022 29;2022:1399697. Epub 2022 Jun 29.

Department of Hematology, First People's Hospital of Linping District, Hangzhou 311100, Zhejiang, China.

Objective: The aim of this study was to explore the relationship between the Hedgehog signaling pathway and drug resistance in multiple myeloma.

Methods: The human myeloma cell line RPMI 8266 was taken as the research object. An azithromycin (AZM)-resistant cell line RPMI 8226/R was constructed, and GENT61 was used to block the Hedgehog signaling pathway. Cells were rolled into RPMI 8226/S (S group), RPMI 8226/R (R group), GENT61+RPMI 8226/S (GENT61+S group), and GENT61+RPMI 8226/R (GENT61+R group). The proliferation of cells in each group was assessed, and the expression of patched homolog 1 (PTCH1), zinc finger-containing transcription factors 1 (GLI1), GLI2, hair-division associated enhancer 1 (Hes1), and sonic hedgehog factor (SHH) in each group was detected. Interleukin (IL)-6 and vascular endothelial growth factor (VEGF) were measured.

Results: Compared with the S group, the expression levels of PTCH1, GLI2, Hes1, and SHH and the contents of IL-6 and VEGF in the group were greatly increased, while the expression level of GLI1 was notably decreased ( < 0.05). Compared with the group, the GENT61+R group greatly increased cell proliferation inhibition. However, the expression levels of PTCH1, GLI2, Hes1, and SHH, and the contents of IL-6 and VEGF were notably decreased, while GLI1 expression levels were greatly increased ( < 0.05).

Conclusion: AZM-resistant multiple myeloma was closely associated with the Hedgehog signaling pathway activation, and blocking the Hedgehog signaling pathway can be used as a therapeutic target to improve drug resistance in multiple myeloma.
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http://dx.doi.org/10.1155/2022/1399697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259296PMC
June 2022

Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway.

Front Genet 2022 16;13:906326. Epub 2022 Jun 16.

Department of Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang, China.

As a malignant tumor, pancreatic cancer is difficult to detect in its early stage. Pancreatic cancer progresses rapidly and has a short survival time. Most cases have metastasized to distant organs before diagnosis. The mechanism of induction of pancreatic cancer is not fully understood. In this study, bioinformatics predicted ATP binding cassette subfamily A member 12 () expression in pancreatic tissues and performed survival analysis, risk assessment, and enrichment analysis. The expression of in 30 pairs of clinical samples was detected by immunohistochemistry and we analyzed its correlation with clinical information. Both reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis were used to detect mRNA and protein expression in cell lines. Two different siRNAs and SW1990 cell line were used to construct pancreatic cancer cell models with knockdown. Cell viability was evaluated by cell counting kit-8 (CCK-8) and EdU proliferation assays. Wound healing assays and Transwell assays were used to measure the ability of cell migration and invasion. Flow cytometry was used to investigate the effect of on the proliferation cycle and apoptosis of pancreatic cancer. Western blot analysis detected changes in apoptosis, migration, and other pathway proteins in SW1990 cells after transfection. is highly expressed in pancreatic cancer tissues and cells. After was knocked down, the proliferation, invasion, and migration of SW1990 cells were significantly reduced, and apoptosis was increased. The changes in pathway proteins suggested that may regulate the progression of pancreatic cancer through the AKT pathway. We found that is differentially expressed in pancreatic tissues and cells. can also affect the biological behavior of pancreatic cancer cells effectively, which may serve as a new target for pancreatic cancer diagnosis and treatment.
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http://dx.doi.org/10.3389/fgene.2022.906326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243331PMC
June 2022

CCL25 Inhibition Alleviates Sepsis-Induced Acute Lung Injury and Inflammation.

Infect Drug Resist 2022 25;15:3309-3321. Epub 2022 Jun 25.

Department of Emergency, Changhai Hospital, The Naval Medical University, Shanghai, People's Republic of China.

Purpose: Acute lung injury (ALI) is a common clinical syndrome with high mortality. The chemokine ligand 25 (CCL25) is involved in inflammation, leukocyte trafficking and immunoregulation. However, the role and mechanism of CCL25 in ALI are not fully understood yet. The aim of this study was to explore the relationship between acute lung injury and CCL25.

Patients And Methods: In this study, we first examined chemokine expression in sepsis patients and found that serum CCL25 expression levels were relatively high in sepsis patients compared to healthy individuals. Based on this, we designed in vitro and in vivo experiments to verify the validity of the theory. In vitro, we used lipopolysaccharide-stimulated human pulmonary microvascular endothelial cells (HPMECs). In vivo, we established male C57BL/6 mice cecal ligation puncture (CLP) model of sepsis.

Results: In vitro, we used lipopolysaccharide-stimulated human pulmonary microvascular endothelial cells (HPMECs) and found significantly higher expression of CCL25 by enzyme-linked immunosorbent assay. Inhibition of CCL25 resulted in a significant decrease in the expression of inflammatory cytokines in HPMECs. In addition, we found that CCL25 promoted increased endothelial permeability by reducing the expression of tight junction proteins and was associated with activation of the P38 MAPK pathway by measuring the transepithelial electrical resistance and fluorescence intensity of fluorescein isothiocyanate. Results from luciferase assays and chromatin immunoprecipitation assays showed that inhibition of NF-κB activity in HPMECs decreased CCL25 expression, but addition of recombinant CCL25 increased cell permeability and inflammatory cytokine expression. In vivo, we established male C57BL/6 mice cecal ligation puncture (CLP) model of sepsis. We found that inhibition of CCL25 significantly reduced inflammatory cytokine expression in a CLP-induced sepsis model, thereby alleviating lung tissue damage in mice.

Conclusion: Our study suggests that CCL25 contributed to the development of ALI by modulating the functions of microvascular endothelial cells.
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http://dx.doi.org/10.2147/IDR.S352544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241997PMC
June 2022

Associations between general trait anxiety, trait social anxiety and cardiovascular responses to social and non-social stressors.

J Psychosom Res 2022 Jun 22;160:110979. Epub 2022 Jun 22.

School of Business, Xi'an Technology and Business College, China.

Objective: The present study sought to examine whether anxiety propensity dimensions (general trait anxiety vs. trait social anxiety) interact with stressor types (tasks with social vs. non-social challenges) to determine cardiovascular stress responses.

Methods: A 2 × 3 mixed-factorial experimental design was employed. The State-Trait Anxiety Inventory, the Social Performance and Social Interaction Anxiety Scales were administered to 233 participants, who engaged in a stress task with either social or non-social challenges during which their cardiovascular data were continuously collected.

Results: General trait anxiety negatively predicted heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) reactivity (β = -0.16, p = 0.001; β = -0.17, p = 0.001; β = -0.18, p < 0.001), and positively predicted HR, SBP, DBP recovery (β = 0.16, p = 0.012; β = 0.15, p = 0.014; β = 0.15, p = 0.011), regardless of stress types. Social performance anxiety (β = -0.23, p = 0.002; β = -0.25, p = 0.001; β = -0.24, p = 0.001) and social interaction anxiety (β = -0.22, p < 0.001; β = -0.25, p < 0.001; β = -0.22, p < 0.001) only negatively predicted HR, SBP, DBP reactivity to the stress task with social challenges. No associations were observed between trait social anxiety and cardiovascular recovery from the stress task with social or non-social challenges.

Conclusions: These findings suggest that different trait anxiety dimensions interact with stressor types in affecting cardiovascular stress responses, which have different health implications.
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http://dx.doi.org/10.1016/j.jpsychores.2022.110979DOI Listing
June 2022

The Species Identification and Genomic Analysis of : A Novel Pathogenic Bacterium Isolated From a Critically Ill Patient With Bloodstream Infection.

Front Microbiol 2022 14;13:919169. Epub 2022 Jun 14.

Department of Critical Care Medicine, School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Since the first strain related to Thermicanaceae was reported in 1999, almost no literature on Thermicanaceae is available, particularly its genomics. We recently isolated a novel pathogenic bacterium, the strain DYY3, from the blood sample of a critically ill patient. The morphological, physiological, and biochemical characteristics of strain DYY3 were presented in this study, and the virulence factor genes and antibiotic resistance of DYY3 were also determined. Interestingly, the average nucleotide identity (ANI) and core-genes average amino acid identity (cAAI) analysis indicated that strain DYY3 was genus novel and species novel. Moreover, phylogenetic analysis based on both 16S rRNA gene and whole genomic core gene sequences suggested that strain DYY3 belonged to the family Thermicanaceae, and this novel taxon was thus named gen. nov., sp. nov. Besides, both the whole genome-based phylogenetic tree and amino acid identity analysis indicated that , , , and the newly discovered species should belong to Thermicanaceae at the family level, and was the closest species to . We also constructed the first high-quality genome in the family Thermicanaceae using the next-generation sequencing (NGS) and single-molecule real-time (SMRT) sequencing technologies, which certainly contributed to further genomics studies and metagenomic-based pathogenic detection in the future.
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http://dx.doi.org/10.3389/fmicb.2022.919169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237643PMC
June 2022

Development and validation of a prognostic model for esophageal carcinoma based on immune microenvironment using system bioinformatics.

Cancer Med 2022 Jun 30. Epub 2022 Jun 30.

Department of Oncology, Zhongda Hospital, Southeast University, Nanjing, China.

Esophageal cancer (EC) is an aggressive malignancy that accounts for numerous cancer-related deaths worldwide. The multimodal combination therapy approach can be potentially used to treat EC effectively. However, distinct biomarker of significant specificity are still needed to develop individualized treatment strategies and provide accurate prognostic predictions. Therefore, we aimed to investigate the associated genes subtypes identified were, IFN-γDominant, Inflammatory, Lymphocyte Depleted, etc. and construct a risk model based on these genes to predict the overall survival (OS) of patients suffering from EC. Three immune subtypes were defined in the Cancer Genome Atlas (TCGA) cohort with different tumor microenvironment (TME) and clinical outcomes based on radio-differentiated immune genes. Subsequently, a risk model of immune characteristics included the immune cell infiltration levels and pathway activity was developed based on the genomic changes between the subtypes. In the TCGA dataset, as well as in subgroup analysis with different stages, gender, age, and pathological type, a high-risk score was identified as an adverse factor for OS using the method of the univariate Cox regression analysis and tROC analysis. Furthermore, it was observed that the high-risk group was characterized by depleted immunophenotype, active cell metabolism, and a high tumor mutation burden (TMB). The low-risk group was characterized by high TME abundance and active immune function. Differences in the biological genotypes may account for the differences in the prognosis and treatment response. Extensive research was carried out, and the results revealed that the low-risk group exhibited a significant level of therapeutic advantage in the field of immunotherapy. A risk model was developed based on the immune characteristics. It can be used to optimize risk stratification for patients suffering from EC. The results can potentially help provide new perspectives on treatment methods.
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http://dx.doi.org/10.1002/cam4.4985DOI Listing
June 2022

Lean non-alcoholic fatty liver disease (Lean-NAFLD) and the development of metabolic syndrome: a retrospective study.

Sci Rep 2022 Jun 29;12(1):10977. Epub 2022 Jun 29.

School of Nursing, Hangzhou Normal University, No.2318 Yuhangtang Road, Hangzhou, 311121, Zhejiang Province, China.

Lean NAFLD is a special phenotypic closely correlated with metabolic syndrome (MS). The aim of this study is to investigate the MS development and the gender differences in lean NAFLD population. Participants were divided into 4 groups by BMI and NAFLD status. Descriptive analysis was performed to characterize baseline information. A total of 18,395 subjects were participated, and 1524 incident cases of MS were documented. Then, Kaplan-Meier curves were used to present the MS outcomes in different groups, and the NAFLD was found to be a riskier factor than obesity for MS. Subgroup analysis showed significantly higher MS incidence in female than male among lean NAFLD group, which is different from other groups. Although with higher prevalence in male, lean NAFLD seems to be a more harmful phenotype for females according to the TG, ALT and GGT levels. The logistic regressive analysis was performed to show the impact of NAFLD status and BMI changes on MS risk. Lean non-NAFLD subjects merely developed to NAFLD with no BMI status changes exhibited highest MS risk (ORs = 1.879, 95% CI 1.610-2.292) than that with both BMI increase and NAFLD development (ORs = 1.669, 95% CI 1.325-2.104). It also suggests the metabolic specificity of this population.
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http://dx.doi.org/10.1038/s41598-022-14701-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243064PMC
June 2022

A case report: Anesthetic management for open-heart surgery in a child with congenital insensitivity to pain with anhidrosis.

Paediatr Anaesth 2022 Sep 7;32(9):1070-1072. Epub 2022 Jul 7.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, China.

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare disease also known as hereditary sensory and autonomic neuropathy. CIPA is characterized by a lack of pain sensitivity and impaired development of sweat glands. Surgery is required for patients with self-mutilation and skeletal developmental disorders. Due to the disease's rarity and intricacy, anesthesia poses its challenges. Although there have been a few cases of CIPA patients receiving surgery and anesthesia, the number is very limited. Here, we report a case of a child with CIPA who underwent open-heart surgery and discuss the anesthetic considerations. We conclude that patients with CIPA undergoing open-heart surgery require some opioids, that muscle relaxants and volatile anesthetics should be used with extreme caution, and that airway management and temperature control require special attention.
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http://dx.doi.org/10.1111/pan.14515DOI Listing
September 2022

Automatic Grading Assessments for Knee MRI Cartilage Defects via Self-ensembling Semi-supervised Learning with Dual-Consistency.

Med Image Anal 2022 08 18;80:102508. Epub 2022 Jun 18.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Knee cartilage defects caused by osteoarthritis are major musculoskeletal disorders, leading to joint necrosis or even disability if not intervened at early stage. Deep learning has demonstrated its effectiveness in computer-aided diagnosis, but it is time-consuming to prepare a large set of well-annotated data by experienced radiologists for model training. In this paper, we propose a semi-supervised framework to effectively use unlabeled data for better evaluation of knee cartilage defect grading. Our framework is developed based on the widely-used mean-teacher classification model, by designing a novel dual-consistency strategy to boost the consistency between the teacher and student models. The main contributions are three-fold: (1) We define an attention loss function to make the network focus on the cartilage regions, which can both achieve accurate attention masks and boost classification performance simultaneously; (2) Besides enforcing the consistency of classification results, we further design a novel attention consistency mechanism to ensure the focusing of the student and teacher networks on the same defect regions; (3) We introduce an aggregation approach to ensemble the slice-level classification outcomes for deriving the final subject-level diagnosis. Experimental results show that our proposed method can significantly improve both classification and localization performances of knee cartilage defects. Our code is available on https://github.com/King-HAW/DC-MT.
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http://dx.doi.org/10.1016/j.media.2022.102508DOI Listing
August 2022

Phylogenomics and Genetic Diversity of and Its Allies (, Boraginaceae) in China.

Front Plant Sci 2022 9;13:920826. Epub 2022 Jun 9.

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

is a traditional medicine with pleiotropic properties that has been used for several 100 years. There are five species of in China, and the two species and are the source plants of according to the Chinese Pharmacopoeia. Molecular markers that permit species identification and facilitate studies of the genetic diversity and divergence of the wild populations of these two source plants have not yet been developed. Here, we sequenced the chloroplast genomes of 56 samples of five species using genome skimming methods. The chloroplast genomes exhibited quadripartite structures with lengths from 149,539 and 152,040 bp. Three variable markers (, , and ) were identified, and these markers exhibited more variable sites than universal chloroplast markers. The phylogenetic relationships among the five species were completely resolved using the whole chloroplast genome sequences. arose during the Oligocene and diversified in the middle Miocene; this coincided with two geological events during the late Oligocene and early Miocene: warming and the progressive uplift of Tianshan and the Himalayas. Our analyses revealed that and have high levels of genetic diversity and comprise two and three subclades, respectively. The two clades of exhibited significant genetic differences and diverged at 10.18 Ma in the middle Miocene. Three clades of diverged in the Pleistocene. The results provided new insight into evolutionary history of species and promoted the conservation and exploitation of and
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http://dx.doi.org/10.3389/fpls.2022.920826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218939PMC
June 2022

Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.

BMC Anesthesiol 2022 06 24;22(1):197. Epub 2022 Jun 24.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.

Background: Laryngeal mask airways have been widely used in clinical practice. The aim of this study was to investigate whether the remifentanil requirement for facilitation of i-gel insertion in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) surgery was different from that in non-PD (NPD) patients undergoing intracranial surgery.

Study Design: An up-and-down sequential allocation trial.

Methods: Male patients aged between 40 and 64 years old were enrolled. The first patient in each group (PD and NPD) group received an effect-site concentration (Ce) of remifentanil (Minto pharmacokinetic model) of 4.0 ng.ml during a target-controlled infusion (TCI) of 3.5 μg.ml propofol (Marsh pharmacokinetic model). The next dose of remifentanil was determined by the response of the previous patient. The Ce of remifentanil required for i-gel insertion in 50% of patients (EC) was estimated by the modified Dixon's up-and-down method and by probit analysis.

Results: The PD group included 24 patients and the NPD group included 23. The EC of remifentanil for i-gel insertion during a TCI of 3.5 μg.ml propofol estimated by the modified Dixon's up-and-down method in PD patients (2.38 ± 0.65 ng.ml) was significantly lower than in NPD patients (3.21 ± 0.49 ng.ml) (P = 0.03). From the probit analysis, the EC and EC (effective Ce in 95% of patients) of remifentanil were 1.95 (95% CI 1.52-2.36) ng.ml and 3.12 (95% CI 2.53-5.84) ng.ml in PD patients and 2.85 (95% CI 2.26-3.41) ng.ml and 4.57 (95% CI 3.72-8.54) ng.ml in NPD patients, respectively.

Conclusions: The remifentanil requirement for successful i-gel insertion is reduced in male PD patients undergoing DBS implantation during propofol TCI induction. Clinicians should closely monitor the remifentanil requirement in patients with PD.

Trial Registration: Registered at http://www.chictr.org.cn ( ChiCTR1900021760 ).
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http://dx.doi.org/10.1186/s12871-022-01735-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229424PMC
June 2022

Study on Characteristics of the Light-Initiated High Explosive-Based Pulse Laser Initiation.

Materials (Basel) 2022 Jun 9;15(12). Epub 2022 Jun 9.

Department of Nuclear Science and Technology, Xi'an Jiaotong University, No. 28, Xianning West Road, Xi'an 710049, China.

The silver acetylene silver nitrate loading technology of the light initiated high explosive, as one of important means to simulate the structural response of powerful pulsed X-ray, adopts the pulse laser initiation. It has advantages of improvement of practical control, heterogenous loading realization and simultaneous loading timeliness. In this paper, the physical and mathematical models of hot spot initiation and photochemical initiation of energetic materials under the action of laser are firstly established, and then the laser initiation mechanism of the light initiated high explosive is specifically analyzed, and the laser initiation experiment is conducted based on the optical adsorption property of the light initiated high explosive. From this study, the laser initiation thresholds of 193 nm, 266 nm, 532 nm, 1064 nm wavelengths are given, and they are 5.07 mJ/mm, 6.77 mJ/mm, 7.21 mJ/mm and 10.61 mJ/mm, respectively, and the complete detonation process is verified by detonation velocity. This work technically supports the study of pulse laser initiation process, mechanism and explosion loading rule as well as the loading technology of the light initiated high explosive to simulate the structural response of X ray.
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http://dx.doi.org/10.3390/ma15124100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231334PMC
June 2022
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