Publications by authors named "Shen Zhang"

264 Publications

Re-evaluating Transarterial Chemoembolization Failure/Refractoriness: A Survey by Chinese College of Interventionalists.

J Clin Transl Hepatol 2021 Aug 8;9(4):521-527. Epub 2021 Apr 8.

Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background And Aims: The recognition of transarterial chemoembolization (TACE) failure/refractoriness among Chinese clinicians remains unclear. Using an online survey conducted by the Chinese College of Interventionalists (CCI), the aim of this study was to explore the recognition of TACE failure/refractoriness and review TACE application for hepatocellular carcinoma (HCC) treatment in clinical practice.

Methods: From 27 August 2020 to 30 August 2020 during the CCI 2020 annual meeting, a survey with 34 questions was sent by email to 264 CCI clinicians in China with more than 10 years of experience using TACE for HCC treatment.

Results: A total of 257 clinicians participated and responded to the survey. Most participants agreed that the concept of "TACE failure/refractoriness" has scientific and clinical significance (n=191, 74.3%). Nearly half of these participants chose TACE-based combination treatment as subsequent therapy after so-called TACE failure/refractoriness (n=88, 46.1%). None of the existing TACE failure/refractoriness definitions were widely accepted by the participants; thus, it is necessary to re-define this concept for the treatment of HCC in China (n=235, 91.4%). Most participants agreed that continuing TACE should be performed for patients with preserved liver function, presenting portal vein tumor thrombosis (n=242, 94.2%) or extrahepatic spread (n=253, 98.4%), after the previous TACE treatment to control intrahepatic lesion(s).

Conclusions: There is an obvious difference in the recognition of TACE failure/refractoriness among Chinese clinicians based on existing definitions. Further work should be carried out to re-define TACE failure/refractoriness.
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http://dx.doi.org/10.14218/JCTH.2021.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369015PMC
August 2021

Age-dependent characteristics and prognostic factors of pediatric anti-N-methyl-d-aspartate receptor encephalitis in a Chinese single-center study.

Eur J Paediatr Neurol 2021 Jul 9;34:67-73. Epub 2021 Jul 9.

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China. Electronic address:

Objective: To describe the clinical features and prognosis of pediatric anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis from a single center in northern China.

Methods: The clinical and laboratory characteristics of hospitalized patients with anti-NMDAR encephalitis, stratified by age, were retrospectively studied. Risk factors including relapse and long-term (follow-up ≥1 year) outcomes were analyzed.

Results: A total of 273 patients were included between November 2011 and December 2019, and the average age of onset was 7.5 ± 4.0 years (0.5-15.8 years). Of them, 159(58.2%) were female, and the proportion of females increased with age. Seizures were the most common initial symptom. Movement disorders(86.1%) and psychiatric(82.4%) symptoms were most frequent in the acute phase. In the acute stage, the incidence of movement disorders decreased with age (χ = 10.676, p = 0.011), while the proportion of psychiatric symptoms increased with age (χ = 21.85, p < 0.001) The recurrence rate was 9.6% (24/250). Demyelination was an independent risk factor for relapse (p = 0.006, OR = 5.877, 95% CI: 1.658-20.835). Among the 210 patients who were followed up for more than one year, 28 patients had a poor prognosis (mRS ≥3). Onset age (p = 0.038,OR = 0.844, 95% CI: 0.720-0.991), precursor of viral encephalitis (p = 0.007,OR = 9.876, 95% CI: 1.878-51.940), and ICU admission (p = 0.023,OR = 5.924, 95% CI: 1.280-27.064) significantly affected the prognosis. The mortality rate was 2.9%.

Conclusions: The characteristics of anti-NMDAR encephalitis in children are age-dependent. Early-onset, the precursor of viral encephalitis, and ICU admission may indicate poor prognosis. Demyelination may be a risk factor for recurrence.
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http://dx.doi.org/10.1016/j.ejpn.2021.07.004DOI Listing
July 2021

Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat.

Sci Rep 2021 Aug 6;11(1):16034. Epub 2021 Aug 6.

College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.

How top-down influence affects neuronal activity and information encoding in the primary visual cortex (V1) remains elusive. This study examined changes of neuronal excitability and contrast sensitivity in cat V1 cortex after top-down influence of area 7 (A7) was modulated by transcranial direct current stimulation (tDCS). The neuronal excitability in V1 cortex was evaluated by visually evoked field potentials (VEPs), and contrast sensitivity (CS) was assessed by the inverse of threshold contrast of neurons in response to visual stimuli at different performance accuracy. We found that the amplitude of VEPs in V1 cortex lowered after top-down influence suppression with cathode-tDCS in A7, whereas VEPs in V1 did not change after sham-tDCS in A7 and nonvisual cortical area 5 (A5) or cathode-tDCS in A5 and lesioned A7. Moreover, the mean CS of V1 neurons decreased after cathode-tDCS but not sham-tDCS in A7, which could recover after tDCS effect vanished. Comparisons of neuronal contrast-response functions showed that cathode-tDCS increased the stimulus contrast required to generate the half-maximum response, with a weakly-correlated reduction in maximum response but not baseline response. Therefore, top-down influence of A7 enhanced neuronal excitability in V1 cortex and improved neuronal contrast sensitivity by both contrast gain and response gain.
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http://dx.doi.org/10.1038/s41598-021-95407-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346540PMC
August 2021

Foot and Ankle Kinematics During Activities Measured by Using a Dual Fluoroscopic Imaging System: A Narrative Review.

Front Bioeng Biotechnol 2021 19;9:693806. Epub 2021 Jul 19.

School of Kinesiology, Shanghai University of Sport, Shanghai, China.

Foot and ankle joints are complicated anatomical structures that combine the tibiotalar and subtalar joints. They play an extremely important role in walking, running, jumping and other dynamic activities of the human body. The kinematic analysis of the foot and ankle helps deeply understand the movement characteristics of these structures, as well as identify abnormal joint movements and treat related diseases. However, the technical deficiencies of traditional medical imaging methods limit studies on foot and ankle biomechanics. During the last decade, the dual fluoroscopic imaging system (DFIS) has enabled the accurate and noninvasive measurements of the dynamic and static activities in the joints of the body. Thus, this method can be utilised to quantify the movement in the single bones of the foot and ankle and analyse different morphological joints and complex bone positions and movement patterns within these organs. Moreover, it has been widely used in the field of image diagnosis and clinical biomechanics evaluation. The integration of existing single DFIS studies has great methodological reference value for future research on the foot and ankle. Therefore, this review evaluated existing studies that applied DFIS to measure the kinematics of the foot and ankle during various activities in healthy and pathologic populations. The difference between DFIS and traditional biomechanical measurement methods was shown. The advantages and shortcomings of DFIS in practical application were further elucidated, and effective theoretical support and constructive research direction for future studies on the human foot and ankle were provided.
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http://dx.doi.org/10.3389/fbioe.2021.693806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327092PMC
July 2021

Nr5a homologues in the ricefield eel Monopterus albus: Alternative splicing, tissue-specific expression, and differential roles on the activation of cyp19a1a promoter in vitro.

Gen Comp Endocrinol 2021 Oct 26;312:113871. Epub 2021 Jul 26.

Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China; Guangdong Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, Sun Yat-Sen University, Guangzhou, China. Electronic address:

Nr5a (Fushi tarazu factor 1, Ftz-F1) homologues belong to the nuclear receptor superfamily, and are involved in the regulation of reproduction in vertebrates. Four genes encoding Nr5a homologues were present in the genome of ricefield eel, which are designated as nr5a1a, nr5a1b, nr5a2, and nr5a5 in the present study. Alternatively spliced transcripts were identified for nr5a1a and nr5a1b genes. Sequence analysis indicated that nr5a5 is possibly a paralog of nr5a2, and nr5a1b is lost during evolution in some teleosts including tilapia and medaka. Ricefield eel nr5a genes exhibit tissue-specific expression patterns, with nr5a1a and nr5a1b resembling that of the SF-1/Ad4BP (NR5A1) subfamily, and nr5a2 and nr5a5 resembling that of the NR5A2/LRH/FTF subfamily. Transcriptomic analysis revealed parallel expression profiles of nr5a1a, foxl2, and cyp19a1a in ovarian follicles during vitellogenesis, with peak values at the late vitellogenic stage. Real-time PCR indicated that the expression levels of nr5a1a and foxl2 in gonads were decreased significantly during the sexual transition from female to the late intersexual stage. In vitro transient transfection assay showed that Nr5a1a up-regulated ricefield eel cyp19a1a promoter activities synergistically with Foxl2. However, Nr5a1b, Nr5a2, and Nr5a5 could neither activate ricefield eel cyp19a1a promoter alone nor enhance the stimulatory effects of Foxl2 on cyp19a1a promoter activities. Collectively, the above data suggest that Nr5a homologues may have diverse and differential roles in the tissues of ricefield eels. The up-regulation of gonadal nr5a1a and foxl2 during vitellogenesis may be important for the ovarian development whereas their down-regulation during the sexual transition period may be important for the sex change process of ricefield eels, possibly through the regulation of cyp19a1a gene expression.
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http://dx.doi.org/10.1016/j.ygcen.2021.113871DOI Listing
October 2021

Molecular dynamics investigation of the stopping power of warm dense hydrogen for electrons.

Phys Rev E 2021 Jun;103(6-1):063215

Department of Physics, National University of Defense Technology, Changsha 410073, China.

A variety of theoretical models have been proposed to calculate the stopping power of charged particles in matter, which is a fundamental issue in many fields. However, the approximation adopted in these theories will be challenged under warm dense matter conditions. Molecular dynamics (MD) simulation is a good way to validate the effectiveness of these models. We investigate the stopping power of warm dense hydrogen for electrons with projectile energies ranging from 400-10000 eV by means of an electron force field (eFF) method, which can effectively avoid the Coulomb catastrophe in conventional MD calculations. It is found that the stopping power of warm dense hydrogen decreases with increasing temperature of the sample at those high projectile velocities. This phenomenon could be explained by the effect of electronic structure dominated by bound electrons, which is further explicated by a modified random phase approximation (RPA) model based on local density approximation proper to inhomogeneous media. Most of the models extensively accepted by the plasma community, e.g., Landau-Spitzer model, Brown-Preston-Singleton model and RPA model, cannot well address the effect caused by bound electrons so that their predictions of stopping power contradict our result. Therefore, the eFF simulations of this paper reveals the important role played by the bound electrons on stopping power in warm dense plasmas.
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http://dx.doi.org/10.1103/PhysRevE.103.063215DOI Listing
June 2021

Comparing the efficacy of two different temperature stimulation in warm acupuncture on acute low back pain: A randomized controlled trial.

Integr Med Res 2022 Mar 26;11(1):100748. Epub 2021 May 26.

Shanghai Pudong Hospital of Traditional Chinese Medicine, Shanghai, China.

Background: Warm acupuncture, a combination of the mechanical stimulation of acupuncture and thermal stimulation of moxibustion, is commonly used in treating acute low back pain (LBP). This trial aimed to compare the efficacy of stronger (above 43°C) and weaker (above 40°C) heat stimulation in warm acupuncture on the function and pain in patients with acute LBP due to lumbosacral disc degeneration (LDD).

Methods: One hundred and fifty-nine adults were randomly assigned to receive warm acupuncture treatment with silver needle (SvN) or with stainless steel needle (SSN) (1:1). Both groups received a 3-week therapy with 3 sessions per week. The primary outcome was the modified Oswestry Disability Index at week 4. The secondary outcomes included average pain, three physical sign tests and adverse events. Participants were followed up at week 16 and week 28 after randomization.

Results: The LBP related disability and pain intensity significantly relieved more in the SvN warm acupuncture group than in the SSN group, in both the short and long term (<0.001). The between-groups difference in physical signs showed statistical significance only in the short term ( = 0.024), but not in long term ( = 0.081;  = 0.069).

Conclusion: Compared with warm acupuncture with stainless-steel needle at above 40°C, warm acupuncture with silver needle at above 43°C relieved more disability and pain in patients with acute LBP due to LDD.

Study Registration: Chinese Clinical Trial Registry (ChiCTR1800019051).
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http://dx.doi.org/10.1016/j.imr.2021.100748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217681PMC
March 2022

Output tracking for nonlinear systems subject to unmodeled sluggish actuator dynamics via model-based extended state observer.

ISA Trans 2021 Jun 23. Epub 2021 Jun 23.

Qian Xuesen Laboratory of Space Technology, China Academy of Space Technology, Beijing, 100094, China.

We propose an output tracking control approach for a class of uncertain, nonlinear systems with unmodeled, sluggish actuator dynamics. The normal extended state observer (ESO) is modified with a nominal model of the largely unknown actuator dynamics. The total disturbance is redefined to include the uncertainties of the actuator dynamics. The feedback law is correspondingly designed to cancel the estimated total disturbance. The closed-loop system is guaranteed with bounded stability through theoretical analysis. The proposed controller is extensively validated and compared to normal active disturbance rejection control (ADRC), nonlinear dynamic inversion control (NDIC), and L adaptive control by a numerical example, and a practical application to both the attitude control and velocity control of a hypersonic vehicle, where the deflection of the elevator and the thrust variation of the scramjet engine are considered.
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http://dx.doi.org/10.1016/j.isatra.2021.06.028DOI Listing
June 2021

[Progress on in vivo ankle biomechanics based on dual fluoroscopic imaging technology].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2021 Jun;38(3):602-608

Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, P.R. China.

The technical deficiencies in traditional medical imagining methods limit the study of ankle biomechanics. A dual fluoroscopic imaging system (DFIS) provides accurate and non-invasive measurements of dynamic and static activities in joints of the body. This approach can be used to quantify the movement in the single bones of the ankle and analyse different morphological and complex bone positions and movement patterns within these organs and has been widely used in the field of image diagnosis and evaluation of clinical biomechanics. This paper reviews the applications of DFIS that were used to measure the kinematics of the ankle in the field of clinical and sports medicine. The advantages and shortcomings of DFIS in the practical application are summarised. We further put forward effective research programs for understanding the movement as well as injury mechanism of the ankle , and provide constructive research direction for future study.
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http://dx.doi.org/10.7507/1001-5515.202006009DOI Listing
June 2021

A comprehensive nano-interpenetrating semiconducting photoresist toward all-photolithography organic electronics.

Sci Adv 2021 Jun 18;7(25). Epub 2021 Jun 18.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.

Owing to high resolution, reliability, and industrial compatibility, all-photolithography is a promising strategy for industrial manufacture of organic electronics. However, it receives limited success due to the absence of a semiconducting photoresist with high patterning resolution, mobility, and performance stability against photolithography solution processes. Here, we develop a comprehensive semiconducting photoresist with nano-interpenetrating structure. After photolithography, nanostructured cross-linking networks interpenetrate with continuous phases of semiconducting polymers, enabling submicrometer patterning accuracy and compact molecular stacking with high thermodynamic stability. The mobility reaches the highest values of photocrosslinkable organic semiconductors and maintains almost 100% after soaking in developer and stripper for 1000 min. Owing to the comprehensive performance, all-photolithography is achieved, which fabricates organic inverters and high-density transistor arrays with densities up to 1.1 × 10 units cm and 1 to 4 orders larger than conventional printing processes, opening up a new approach toward manufacturing highly integrated organic circuits and systems.
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http://dx.doi.org/10.1126/sciadv.abg0659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213218PMC
June 2021

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Outcomes in Patients With Unresectable Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Plus Sorafenib.

Front Mol Biosci 2021 28;8:624366. Epub 2021 May 28.

Department of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

To investigate the predictive value of inflammatory biomarkers in patients with unresectable hepatocellular carcinoma (HCC) for outcomes following the combination treatment of transarterial chemoembolization (TACE) plus sorafenib. A total of 314 (270 male and 44 female) treatment-naïve patients with unresectable HCC treated by TACE plus sorafenib between January 2011 and December 2018 were enrolled in the retrospective study. The primary outcome was overall survival (OS). The secondary outcome was progression-free survival (PFS). Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were obtained within 3-7 days before the initial TACE and the median value of the NLR and PLR was considered as the cut-off value. The median value of NLR and PLR was 2.42 and 100, respectively. The median OS and PFS of the entire cohort were 18.7 months (95% CI: 16.8-20.6) and 9.1 months (95% CI: 8.5-9.8), respectively. The low NLR and PLR group showed improved OS and PFS compared with the high NLR and PLR group [21.8 months (95% CI: 15.2-28.5) vs. 15.4 months (95% CI: 12.4-18.3), < 0.0001; 21.6 months (95% CI: 15.8-27.5) vs. 14.9 months (95% CI: 11.9-17.8), = 0.00027, respectively]. In addition, the low NLR and PLR group also provided a longer PFS than the high NLR and PLR group [10.4 months (95% CI: 8.9-12.0) vs. 8.1 months (95% CI: 7.1-9.2), = 0.00022; 10.3 months (95% CI: 8.6-11.9) vs. 8.2 months (95% CI: 7.2-9.2), < 0.0001, respectively]. High NLR and PLR at baseline were predictive factors of poor OS ( = 0.02 and = 0.004) and PFS ( = 0.045 and = 0.005). This study showed the prognostic value of quantitative inflammatory biomarkers in correlation with OS and PFS in unresectable HCC patients undergoing TACE plus sorafenib treatment.
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http://dx.doi.org/10.3389/fmolb.2021.624366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194392PMC
May 2021

Highly fluorescent carbon dots from coix seed for the determination of furazolidone and temperature.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 19;260:119969. Epub 2021 May 19.

College of Arts, Taiyuan University of Technology, Taiyuan 030024, Shanxi, PR China. Electronic address:

In this work, blue emission fluorescent carbon dots (CDs) were fabricated by using the hydrothermal strategy from coix seed for the first time. We found that the prepared CDs possessed many excellent characteristics including excitation-dependent properties, good solubility and strong photostability. The optimal excitation and emission wavelength of CDs were 363 and 435 nm, respectively. Unbelievably, the fluorescence of CDs was selectively and effectively quenched with the addition of furazolidone (Fu). The quenching mechanisms might be assumed to the static quenching and inner filter effect (IFE). Based on this principle, a novel fluorescence probe was developed for the determination of Fu. At the same time, the proposed probe showed excellent sensitivity and selectivity towards Fu with a wide linear range from 0.5 to 100 μM, and the corresponding detection limit was 0.096 μM. Moreover, the CDs also could be applied for the sensing of temperature. The practical application of the CDs for Fu detection in real samples was also confirmed with the satisfactory recoveries changing from 96.6% to 108.5%, which provided huge possibility in the field of medical analysis.
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http://dx.doi.org/10.1016/j.saa.2021.119969DOI Listing
November 2021

Development and validation of a novel mRNA signature for predicting early relapse in non-small cell lung cancer.

Jpn J Clin Oncol 2021 Aug;51(8):1277-1286

Department of abdominal oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, China.

Background: Recurrence after initial primary resection is still a major and ultimate cause of death for non-small cell lung cancer patients. We attempted to build an early recurrence associated gene signature to improve prognostic prediction of non-small cell lung cancer.

Methods: Propensity score matching was conducted between patients in early relapse group and long-term survival group from The Cancer Genome Atlas training series (N = 579) and patients were matched 1:1. Global transcriptome analysis was then performed between the paired groups to identify tumour-specific mRNAs. Finally, using LASSO Cox regression model, we built a multi-gene early relapse classifier incorporating 40 mRNAs. The prognostic and predictive accuracy of the signature was internally validated in The Cancer Genome Atlas patients.

Results: A total of 40 mRNAs were finally identified to build an early relapse classifier. With specific risk score formula, patients were classified into a high-risk group and a low-risk group. Relapse-free survival was significantly different between the two groups in both discovery (HR: 3.244, 95% CI: 2.338-4.500, P < 0.001) and internal validation series (HR 1.970, 95% CI 1.181-3.289, P = 0.009). Further analysis revealed that the prognostic value of this signature was independent of tumour stage, histotype and epidermal growth factor receptor mutation (P < 0.05). Time-dependent receiver operating characteristic analysis showed that the area under receiver operating characteristic curve of this signature was higher than TNM stage alone (0.771 vs 0.686, P < 0.05). Further, decision curve analysis curves analysis at 1 year revealed the considerable clinical utility of this signature in predicting early relapse.

Conclusions: We successfully established a reliable signature for predicting early relapse in stage I-III non-small cell lung cancer.
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http://dx.doi.org/10.1093/jjco/hyab075DOI Listing
August 2021

Resting-state brain networks in neonatal hypoxic-ischemic brain damage: a functional near-infrared spectroscopy study.

Neurophotonics 2021 Apr 14;8(2):025007. Epub 2021 May 14.

Beihang University, School of Biological Science and Medical Engineering, Beijing, China.

There is an emerging need for convenient and continuous bedside monitoring of full-term newborns with hypoxic-ischemic brain damage (HIBD) to determine whether early intervention is required. Functional near-infrared spectroscopy (fNIRS)-based resting-state brain network analysis, which could provide an effective evaluation method, remains to be extensively studied. Our study aims to verify the feasibility of fNIRS-based resting-state brain networks for evaluating brain function in infants with HIBD to provide a new and effective means for clinical research in neonatal HIBD. Thirteen neonates with HIBD were scanned using fNIRS in the resting state. The brain network properties were explored to attempt to extract effective features as recognition indicators. Compared with healthy controls, newborns with HIBD showed decreased brain functional connectivity. Specifically, there were severe losses of long-range functional connectivity of the contralateral parietal-temporal lobe, contralateral parietal-frontal lobe, and contralateral parietal lobe. The node degree showed a widespread decrease in the left frontal middle gyrus, left superior frontal gyrus dorsal, and right central posterior gyrus. However, newborns with HIBD showed a significantly higher local network efficiency (* ). Subsequently, network indicators based on small-worldness, local efficiency, modularity, and normalized clustering coefficient were extracted for HIBD identification with the accuracy observed as 79.17%. Our findings indicate that fNIRS-based resting-state brain network analysis could support early HIBD diagnosis.
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http://dx.doi.org/10.1117/1.NPh.8.2.025007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119736PMC
April 2021

Clinical analysis and a novel risk predictive nomogram for 155 adult patients with hemophagocytic lymphohistiocytosis.

Ann Hematol 2021 Sep 12;100(9):2181-2193. Epub 2021 May 12.

Department and Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Recently, more and more attention has been paid on adult hemophagocytic lymphohistiocytosis (HLH), a disease with complicated symptoms and high mortality. In order to analyze the clinical characteristics and prediction risk factors of mortality, we designed a retrospective study with 1-year follow-up and included 155 patients admitted to Tongji Hospital diagnosed as HLH. One hundred seven patients formed the training cohort for nomogram development, and 48 patients formed the validation cohort to confirm the model's performance. All patients' clinical characteristics, laboratory results, medical records, and prognosis were analyzed. Among all the 107 patients in the training cohort, 46 were male and 61 were female, with the median age of 49.0 (IQR 31.0-63.0). The 1-year mortality rate was 43.9% (47/107) and 45.8% (22/48) in the training and validation cohort, respectively. And further multivariate logistic regression analysis in the training cohort showed that male (odds ratio 5.534, 95% CI 1.507-20.318, p = 0.010), altered mental status (11.876, 1.882-74.947, p = 0.008), serum ferritin ≥ 31,381 μg/L (8.273, 1.855-36.883, p = 0.006), and IL-6 ≥ 18.59 pg/mL (19.446, 1.527-247.642, p = 0.022) were independent risk factor of mortality. A nomogram included the four prediction factors mentioned above was also tabled to help clinicians evaluate the probability of poor outcome. Area under the receiver operating characteristic curve (AUROC) analysis, calibration curves, and decision curve analysis (DCA) certify the accuracy and the clinical usefulness of the nomogram. Our research reveals that male, altered mental status, serum ferritin ≥ 31,381 µg/L, and IL-6 ≥ 18.59 pg/mL are four independent predictors for poor prognosis. Doctors should pay more attention to patients with altered mental status, high serum ferritin, and IL-6 level, who have a higher risk of death.
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http://dx.doi.org/10.1007/s00277-021-04551-7DOI Listing
September 2021

Novel luteolin sensor of tannic acid-stabilized copper nanoclusters with blue-emitting fluorescence.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Oct 30;259:119887. Epub 2021 Apr 30.

College of Arts, Taiyuan University of Technology, Jinzhong, 030600, Shanxi, China. Electronic address:

In this work, the fluorescent copper nanoclusters (Cu NCs) were firstly adopted to detect luteolin with excellent performance. The blue-emitting Cu NCs was successfully prepared through a facile one-pot approach by protection of tannic acid (TA) and chemical reduction of ascorbic acid (AA). The water-soluble nanoclusters possessed uniform size and displayed good stability. The TA-Cu NCs showed maximum luminescence at 434 nm when excited at 366 nm. Based on the static quenching and inner filter effect (IFE) mechanism, the TA-Cu NCs was efficiently and selectively quenched by luteolin. The detection limit was 0.12 μM and linear relationship existed in the range of 0.2-100 μM. Moreover, the TA-Cu NCs probe was successfully employed to detect luteolin in bovine serum samples with satisfactory recoveries. This novel platform was expected to expand the possible detection method based on fluorescence properties.
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http://dx.doi.org/10.1016/j.saa.2021.119887DOI Listing
October 2021

Retraction Note: A fast, high-affinity fluorescent serotonin biosensor engineered from a tick lipocalin.

Nat Methods 2021 May;18(5):575

Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1038/s41592-021-01148-wDOI Listing
May 2021

The Associations of Built Environment with Older People Recreational Walking and Physical Activity in a Chinese Small-Scale City of Yiwu.

Int J Environ Res Public Health 2021 03 8;18(5). Epub 2021 Mar 8.

Faculty of Sport Science, Research Academy of Grand Health, Ningbo University, Ningbo 315211, China.

Physical activity would bring in plenty of health benefits, especially recreational physical activity (RPA). Previous studies have suggested that built environment would affect older people's recreational walking (RW) and RPA, but how the effects exist in a small-scale Chinese city remains unclear. Two hundred and fifty-two older participants were recruited in the city of Yiwu using cross-sectional survey of random samples in 2019. RW and RPA level of participants and perceived scores of built environments were collected using the International Physical Activity Questionnaire and Neighborhood Environment Walkability Scale, respectively. Linear regression analysis was conducted to investigate the association of built environment with older people's RW and RPA. The results showed that two main factors affecting older people's RW and RPA were residential density and aesthetics. Additionally, access to services was related to RW, and street connectivity was correlated with RPA. The associations of RW with built environment varied slightly with demographic variables included in the regression model. All the results suggested that lower residential density, better aesthetics environment, and higher street connectivity would motivate older people to engage more in RW and RPA. The better access to services encourages only RW, not RPA, in older people. These findings would be helpful for policy decision makers in the urban construction process in Yiwu. More studies are needed to enlarge the scientific evidence base about small-scale cities in China.
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http://dx.doi.org/10.3390/ijerph18052699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967424PMC
March 2021

Glucose isomerization catalyzed by swollen cellulose derived aluminum-hydrochar.

Sci Total Environ 2021 Jul 22;777:146037. Epub 2021 Feb 22.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Since efficient isomerization of glucose to fructose is vital for valorizing cellulose fraction of biomass to value-added chemicals, an approach of engineering aluminum-hydrochar catalyst by impregnating aluminum on swollen cellulose derived hydrochar has been studied. The results showed that Al-hydrochar calcinated at 300°C achieved fructose yield of 26.3% in acetone/HO reaction medium. It was found that the amorphous Al structures with nano-size on the surface of the carbon microspheres were the major contributor of the catalytic activity on glucose to fructose isomerization, while the formation of Al crystal had an inhibition effect on glucose isomerization. The deactivation study of Al-hydrochar catalysts showed the exfoliation of colloidal carbon containing aluminum active catalytic sites. This finding provides a novel strategy for efficient isomerization of glucose by Al-hydrochar prepared through hydrothermal carbonization and mild calcination activation process.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146037DOI Listing
July 2021

The role of cell wall polysaccharides disassembly in Lasiodiplodia theobromae-induced disease occurrence and softening of fresh longan fruit.

Food Chem 2021 Jul 15;351:129294. Epub 2021 Feb 15.

Institute of Postharvest Technology of Agricultural Products, College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; Key Laboratory of Postharvest Biology of Subtropical Special Agricultural Products (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, Fujian 350002, China. Electronic address:

Cell wall polysaccharides in fruits act a pivotal role in their resistance to fungal invasion. Lasiodiplodia theobromae (Pat.) Griff. & Maubl. is a primary pathogenic fungus causing the spoilage of fresh longan fruit. In this study, the influences of L. theobromae inoculation on the disassembly of cell wall polysaccharides in pericarp of fresh longans and its association with L. theobromae-induced disease and softening development were investigated. In contrast to the control, samples with L. theobromae infection showed more severe disease development, lower firmness, lower amounts of cell wall materials, covalent-soluble pectin, ionic-soluble pectin, cellulose and hemicellulose, whereas higher value of water-soluble pectin, higher activities of cell wall polysaccharide-disassembling enzymes (cellulase, β-galactosidase, polygalacturonase and pectinesterase). These findings revealed that cell wall polysaccharides disassembly induced by enzymatic manipulation was an essential pathway for L. theobromae to infect harvested longans, and thus led to the disease occurrence and fruit softening.
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http://dx.doi.org/10.1016/j.foodchem.2021.129294DOI Listing
July 2021

A fast, high-affinity fluorescent serotonin biosensor engineered from a tick lipocalin.

Nat Methods 2021 03 25;18(3):258-261. Epub 2021 Feb 25.

Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.

Serotonin (5-HT) is an important signaling monoamine and neurotransmitter. We report structure-guided engineering of a green fluorescent, genetically encoded serotonin sensor (G-GESS) from a 5-HT-binding lipocalin in the soft tick Argas monolakensis. G-GESS shows fast response kinetics and high affinity, specificity, brightness and photostability. We used G-GESS to image 5-HT dynamics in cultured cells, brain slices and behaving mice.
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http://dx.doi.org/10.1038/s41592-021-01078-7DOI Listing
March 2021

Finite-temperature density-functional-theory investigation on the nonequilibrium transient warm-dense-matter state created by laser excitation.

Phys Rev E 2021 Jan;103(1-1):013210

Institut für Theoretische Physik und Astrophysik, Christian-Albrechts-Universität zu Kiel, Leibnizstraße 15, 24098 Kiel, Germany.

We present a finite-temperature density-functional-theory investigation of the nonequilibrium transient electronic structure of warm dense Li, Al, Cu, and Au created by laser excitation. Photons excite electrons either from the inner shell orbitals or from the valence bands according to the photon energy, and give rise to isochoric heating of the sample. Localized states related to the 3d orbital are observed for Cu when the hole lies in the inner shell 3s orbital. The electrical conductivity for these materials at nonequilibrium states is calculated using the Kubo-Greenwood formula. The change of the electrical conductivity, compared to the equilibrium state, is different for the case of holes in inner shell orbitals or the valence band. This is attributed to the competition of two factors: the shift of the orbital energies due to reduced screening of core electrons, and the increase of chemical potential due to the excitation of electrons. The finite-temperature effect of both the electrons and the ions on the electrical conductivity is discussed in detail. This work is helpful to better understand the physics of laser excitation experiments of warm dense matter.
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http://dx.doi.org/10.1103/PhysRevE.103.013210DOI Listing
January 2021

A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite.

Cell Chem Biol 2021 Jan 27. Epub 2021 Jan 27.

Department of Chemistry, University of California, Riverside, Riverside, CA 92521, USA; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA; Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA; Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA; The UVA Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address:

Peroxynitrite is a reactive nitrogen species (RNS) that plays critical roles in signal transduction, stress response, and numerous human diseases. Advanced molecular tools that permit the selective, sensitive, and noninvasive detection of peroxynitrite are essential for understanding its pathophysiological functions. Here, we present pnGFP-Ultra, a high-performance, reaction-based, genetically encodable biosensor for imaging peroxynitrite in live cells. pnGFP-Ultra features a p-boronophenylalanine-modified chromophore as the sensing moiety and exhibits a remarkable ~110-fold fluorescence turn-on response toward peroxynitrite while displaying virtually no cross-reaction with other reactive oxygen/nitrogen species. To facilitate the expression of pnGFP-Ultra in mammalian cells, we engineered an efficient noncanonical amino acid (ncAA) expression system that is broadly applicable to the mammalian expression of ncAA-containing proteins. pnGFP-Ultra robustly detected peroxynitrite production in activated macrophages and primary glial cells. pnGFP-Ultra fills an important technical gap and represents a valuable addition to the molecular toolbox for probing RNS biology.
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http://dx.doi.org/10.1016/j.chembiol.2021.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313648PMC
January 2021

The Effect of the Built Environment on Older Men's and Women's Leisure-Time Physical Activity in the Mid-Scale City of Jinhua, China.

Int J Environ Res Public Health 2021 01 25;18(3). Epub 2021 Jan 25.

Faculty of Sport Science, Research Academy of Grand Health, Ningbo University, Ningbo 315211, China.

Physical activity has been suggested to be beneficial in preventing disease and improving body function in older people. Older people's leisure-time physical activity (LTPA) is affected by various factors, especially environmental factors. However, the differences in the association between older people's LTPA and the built environment in different sex groups remain unclear. Perceived built environment scores and older people's LTPA were collected for 240 older people in Jinhua using the Neighborhood Environment Walkability Scale and International Physical Activity Questionnaire, respectively. A linear regression method was used to analyze the associations between older people's LTPA and the built environment in men, women, and all participants. The results showed that land use mix diversity was associated with LTPA in older people for both sexes. In men, LTPA was also associated with access to services. However, in women, LTPA was associated with residential density, street connectivity, and crime safety. The relationship varied when demographic variables were incorporated into the regression analysis. Those results indicated that a shorter perceived distance from home to destination would motivate older people to engage more in LTPA. Older people's LTPA was affected by various built environment factors according to different sex groups. Women's LTPA was generally more sensitive to the built environment. More studies are needed to confirm the association between LTPA in older people and the built environment in men and women in mid- or small-sized Chinese cities in the future.
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http://dx.doi.org/10.3390/ijerph18031039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908135PMC
January 2021

A Narrative Review of Injury Incidence, Location, and Injury Factor of Elite Athletes in Snowsport Events.

Front Physiol 2020 8;11:589983. Epub 2021 Jan 8.

School of Kinesiology, Shanghai University of Sport, Shanghai, China.

Snowsport athletes face a high injury risk both during training and in competitions. Reducing injury incidence is crucial for athletes to achieve breakthroughs. This narrative review aimed to summarize and analyze injury data of elite athletes in snowsports and provide references for injury prevention and health security for these athletes and their coaches. A total of 39 studies that investigated snowsport injury were analyzed in the present study. On the basis of injury data of elite athletes in snowsports events, this narrative review focused on four aspects, namely, injury incidence, severity, location and causes. The findings of this review were as follows. (1) The highest injury incidence was recorded in freestyle skiing, followed by alpine skiing and snowboarding, the majority of which were moderate and severe injuries. (2) The proportion of injury in competitions and during training was similar. However, more injuries occurred in official training during the Winter Olympic Games; by contrast, injury proportion was higher in competitions during World Cup/World Championships. (3) The most commonly and severely injured body parts were the knees (29.9%), head and face (12.1%), shoulders and clavicula (10.5%), and lower back (8.9%). The most common injury types were joint and ligament injury (41.5%), fracture and bone stress (24.4%), concussion (11.1%), and muscle/tendon injury (10.7%). (4) The main causes of snowsport injury were collisions, falls, and non-contact injuries. Snowsport injury was also influenced by the skill level of the athletes, gender, course setup and equipment. Future studies should further explore the influence of event characteristics and intrinsic and extrinsic risk factors on snowsport injury. An injury or trauma reconstruction may be developed to predict athletic injuries and provide effective prevention strategies.
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http://dx.doi.org/10.3389/fphys.2020.589983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820716PMC
January 2021

Characterization of Feedback Neurons in the High-Level Visual Cortical Areas That Project Directly to the Primary Visual Cortex in the Cat.

Front Neuroanat 2020 8;14:616465. Epub 2021 Jan 8.

College of Life Sciences, Anhui Normal University, Wuhu, China.

Previous studies indicate that top-down influence plays a critical role in visual information processing and perceptual detection. However, the substrate that carries top-down influence remains poorly understood. Using a combined technique of retrograde neuronal tracing and immunofluorescent double labeling, we characterized the distribution and cell type of feedback neurons in cat's high-level visual cortical areas that send direct connections to the primary visual cortex (V1: area 17). Our results showed: (1) the high-level visual cortex of area 21a at the ventral stream and PMLS area at the dorsal stream have a similar proportion of feedback neurons back projecting to the V1 area, (2) the distribution of feedback neurons in the higher-order visual area 21a and PMLS was significantly denser than in the intermediate visual cortex of area 19 and 18, (3) feedback neurons in all observed high-level visual cortex were found in layer II-III, IV, V, and VI, with a higher proportion in layer II-III, V, and VI than in layer IV, and (4) most feedback neurons were CaMKII-positive excitatory neurons, and few of them were identified as inhibitory GABAergic neurons. These results may argue against the segregation of ventral and dorsal streams during visual information processing, and support "reverse hierarchy theory" or interactive model proposing that recurrent connections between V1 and higher-order visual areas constitute the functional circuits that mediate visual perception. Also, the corticocortical feedback neurons from high-level visual cortical areas to the V1 area are mostly excitatory in nature.
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http://dx.doi.org/10.3389/fnana.2020.616465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820340PMC
January 2021

Integrated analyses of miRNA and mRNA profiles in leukocytes and serums in traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome and Pi-wei damp-heat syndrome resulting from chronic atrophic gastritis.

Chin Med 2021 Jan 6;16(1). Epub 2021 Jan 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.

Background: To investigate the microRNA (miRNA)-gene interactions underlying leukocyte functions and characteristics, especially the potential serum biomarkers, implicated in the traditional Chinese medicine (TCM)-defined Pi-qi-deficiency syndrome (PQDS) and Pi-wei damp-heat syndrome (PDHS) resulting from chronic atrophic gastritis (CAG).

Methods: Using RNA/miRNA-sequencing approach, compared with healthy control population, we identified the PDHS- or PQDS-specific miRNAs and genes in leukocytes or serums, especially the Zheng (syndrome)-specific miRNA-gene interactions, and further decoded their functions and pathways.

Results: Despite being the TCM-defined Zhengs resulting from the same disease of CAG, the Zheng-specific genes and miRNAs were not same. The PDHS-specific leukocyte genes were mainly involved in defense and immune responses, including NOD-like receptor signaling and several synapses-related pathways. The expression upregulation of PDHS-specific genes enriched in the neutrophil degranulation pathway, indicated the enhanced leukocyte degranulation activation. The PQDS-specific genes in leukocytes were implicated in inflammatory response, extracellular matrix (ECM) organization and collagen catabolism. They could be enriched in MAPK and IL17 signaling and helper T cell differentiation pathways, especially the pathways associated with cell-to-cell adhesion/junction and communication such as cell adhesion molecules, ECM organization and ECM-receptor interaction, probably contributing to the characteristics and functions of leukocytes. Also, the experimentally-supported miRNA-gene interactions, concerned with COL4A2, COL26A1, SPP1 and PROCR, were implicated in the regulation of pathways related to cell-to-cell adhesion/junction and communication, suggesting the potential roles of the PQDS-specific miRNA-gene interactions for the characteristic and functional changes of leukocytes. Interestingly, the PQDS-specific miRNAs in the serums and the corresponding leukocytes, seemed to have the common roles in contributing to the characteristics and functions of leukocytes. Importantly, the hsa-miR-122-5p could be a potential biomarker, capable of being contained and carried in plasma exosomes and much higher expression in both the leukocytes and corresponding serums in the CAG patients with PQDS rather than PDHS.

Conclusions: These results may provide new insights into the characteristic and functional changes of leukocytes in the two Zhengs, PDHS and PQDS, especially the miRNA-mediated gene regulation underlying leukocyte characteristics and functions, with potential leukocyte and serum biomarkers for future application in integrative medicine. Trial registration ClinicalTrials.gov, NCT02915393. Registered on September 17, 2016.
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http://dx.doi.org/10.1186/s13020-020-00416-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788792PMC
January 2021

Prognostic Performance of Albumin-Bilirubin Grade With Artificial Intelligence for Hepatocellular Carcinoma Treated With Transarterial Chemoembolization Combined With Sorafenib.

Front Oncol 2020 18;10:525461. Epub 2020 Dec 18.

Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Purpose: To establish albumin-bilirubin (ALBI) grade-based and Child-Turcotte-Pugh (CTP) grade-based nomograms, as well as to develop an artificial neural network (ANN) model to compare the prognostic performance and discrimination of these two grades for hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) combined with sorafenib as an initial treatment.

Methods: This multicenter retrospective study included patients from three hospitals between January 2013 and August 2018. In the training cohort, independent risk factors associated with overall survival (OS) were identified by univariate and multivariate analyses. The nomograms and ANN were established and then validated in two validation cohorts.

Results: A total of 504 patients (319, 61, and 124 patients from hospitals A, B, and C, respectively) were included. The median OS was 15.2, 26.9, and 14.8 months in the training cohort and validation cohorts 1 and 2, respectively (P = 0.218). In the training cohort, both ALBI grade and CTP grade were identified as independent risk factors. The ALBI grade-based and CTP grade-based nomograms were established separately and showed similar prognostic performance and discrimination when validated in the validation cohorts (C-index in validation cohort 1: 0.799 vs. 0.779, P = 0.762; in validation cohort 2: 0.700 vs. 0.693, P = 0.803). The ANN model showed that the ALBI grade had higher importance in survival prediction than the CTP grade.

Conclusions: The ALBI grade and CTP grade have comparable prognostic performance for HCC patients treated with TACE combined with sorafenib. ALBI grades 1 and 2 have the potential to act as a stratification factor for clinical trials on the combination therapy of TACE and systemic therapy.
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http://dx.doi.org/10.3389/fonc.2020.525461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775577PMC
December 2020

Top-down influence affects the response adaptation of V1 neurons in cats.

Brain Res Bull 2021 02 14;167:89-98. Epub 2020 Dec 14.

College of Life Sciences, Anhui Normal University, Wuhu, Anhui, 241000, China. Electronic address:

The visual system lowers its perceptual sensitivity to a prolonged presentation of the same visual signal. This brain plasticity, called visual adaptation, is generally attributed to the response adaptation of neurons in the visual cortex. Although well-studied in the neurons of the primary visual cortex (V1), the contribution of high-level visual cortical regions to the response adaptation of V1 neurons is unclear. In the present study, we measured the response adaptation strength of V1 neurons before and after the top-down influence of the area 21a (A21a), a higher-order visual cortex homologous to the primate V4 area, was modulated with a noninvasive tool of transcranial direct current stimulation (tDCS). Our results showed that the response adaptation of V1 neurons enhanced significantly after applying anode (a-) tDCS in A21a when compared with that before a-tDCS, whereas the response adaptation of V1 neurons weakened after cathode (c-) tDCS relative to before c-tDCS in A21a. By contrast, sham (s-) tDCS in A21a had no significant impact on the response adaptation of V1 neurons. Further analysis indicated that a-tDCS in A21a significantly increased both the initial response (IR) of V1 neurons to the first several (five) trails of visual stimulation and the plateau response (PR) to the prolonged visual stimulation; the increase in PR was lower than in IR, which caused an enhancement in response adaptation. Conversely, c-tDCS significantly decreased both IR and PR of V1 neurons; the reduction in PR was smaller than in IR, which resulted in a weakness in response adaptation. Furthermore, the tDCS-induced changes of V1 neurons in response and response adaptation could recover after tDCS effect vanished, but did not occur after the neuronal activity in A21a was silenced by electrolytic lesions. These results suggest that the top-down influence of A21a may alter the response adaptation of V1 neurons through activation of local inhibitory circuitry, which enhances network inhibition in the V1 area upon an increased top-down input, weakens inhibition upon a decreased top-down input, and thus maintains homeostasis of V1 neurons in response to the long-presenting visual signals.
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http://dx.doi.org/10.1016/j.brainresbull.2020.12.007DOI Listing
February 2021
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