Shelli R McAlpine

Shelli R McAlpine

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Shelli R McAlpine

Shelli R McAlpine

Publications by authors named "Shelli R McAlpine"

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Delivering bioactive cyclic peptides that target Hsp90 as prodrugs.

J Enzyme Inhib Med Chem 2019 Dec;34(1):728-739

a School of Chemistry, University of New South Wales , Sydney , Australia.

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http://dx.doi.org/10.1080/14756366.2019.1580276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407599PMC
December 2019

C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway.

Cell Physiol Biochem 2019 ;53(3):480-495

School of Medicine and Health, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, Australia,

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http://dx.doi.org/10.33594/000000152DOI Listing
December 2019

Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype.

Chem Commun (Camb) 2019 Apr;55(31):4515-4518

School of Chemistry, University of New South Wales, Gate 2 High street, Dalton 219, Sydney, Australia.

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http://dx.doi.org/10.1039/c9cc00890jDOI Listing
April 2019

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery.

J Med Chem 2019 01 20;62(2):742-761. Epub 2018 Dec 20.

Department of Chemistry , University of New South Wales , Sydney , New South Wales 2052 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01436DOI Listing
January 2019

Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity.

Chem Commun (Camb) 2019 Jan;55(6):846-849

School of Chemistry, Gate 2 High street, Dalton 219, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1039/c8cc07576jDOI Listing
January 2019

Hsp90 Mediates Membrane Deformation and Exosome Release.

Mol Cell 2018 09;71(5):689-702.e9

VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.016DOI Listing
September 2018

Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d-Amino Acids.

Org Lett 2018 02 24;20(3):506-509. Epub 2018 Jan 24.

School of Chemistry, University of New South Wales , Sydney NSW 2051, Australia.

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http://dx.doi.org/10.1021/acs.orglett.7b03363DOI Listing
February 2018

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

ACS Med Chem Lett 2017 Apr 6;8(4):401-406. Epub 2017 Mar 6.

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392768PMC
April 2017

How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?

ChemMedChem 2017 03 27;12(5):353-357. Epub 2017 Feb 27.

School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1002/cmdc.201600595DOI Listing
March 2017

Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors.

Chemistry 2017 Feb 20;23(9):2010-2013. Epub 2017 Jan 20.

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1002/chem.201604807DOI Listing
February 2017

A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.

Prostate 2016 12 16;76(16):1546-1559. Epub 2016 Aug 16.

School of Medicine and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1002/pros.23239DOI Listing
December 2016

Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors.

Chemistry 2016 Dec 11;22(51):18572-18582. Epub 2016 Nov 11.

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1002/chem.201603464DOI Listing
December 2016

Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?

ChemMedChem 2016 Apr 25;11(8):881-92. Epub 2016 Jan 25.

Department of Chemistry, University of New South Wales, Gate 2 High Street, Dalton F12, Sydney, NSW, 2008, Australia.

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http://dx.doi.org/10.1002/cmdc.201500572DOI Listing
April 2016

Heat-shock protein 90 inhibitors: will they ever succeed as chemotherapeutics?

Future Med Chem 2015 ;7(2):87-90

Department of Chemistry, The University of New South Wales, Sydney, Australia, 2052.

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http://dx.doi.org/10.4155/fmc.14.154DOI Listing
November 2015

Synthesis of the Natural Product Marthiapeptide A.

Org Lett 2015 Nov 15;17(21):5149-51. Epub 2015 Oct 15.

School of Chemistry, The University of New South Wales , Gate 2 High Street, Sydney 2052, Australia.

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http://dx.doi.org/10.1021/acs.orglett.5b02574DOI Listing
November 2015

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach.

Bioorg Med Chem Lett 2015 Sep 20;25(17):3409-14. Epub 2015 Jun 20.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.06.052DOI Listing
September 2015

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

J Exp Med 2015 Jul 29;212(8):1239-54. Epub 2015 Jun 29.

Transplantation Immunology Group, Immunology Division, Cancer Bioinformatics, Cancer Division, B Cell Biology, Immunology Division, and Beta Cell Regeneration, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia

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http://dx.doi.org/10.1084/jem.20150218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516791PMC
July 2015

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts.

Org Biomol Chem 2015 Jun;13(22):6299-312

School of Women's and Children's Health, UNSW Australia, Sydney 2052, Australia.

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http://xlink.rsc.org/?DOI=C5OB00779H
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http://dx.doi.org/10.1039/c5ob00779hDOI Listing
June 2015

Predicting the unpredictable: Recent structure-activity studies on peptide-based macrocycles.

Bioorg Chem 2015 Jun 1;60:74-97. Epub 2015 May 1.

University of New South Wales, School of Chemistry, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bioorg.2015.04.009DOI Listing
June 2015

The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents.

Bioorg Med Chem Lett 2015 Jan 29;25(2):249-53. Epub 2014 Nov 29.

Department of Chemistry, University of New South Wales, Kensington, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.055DOI Listing
January 2015

Chemically accessible hsp90 inhibitor that does not induce a heat shock response.

ACS Med Chem Lett 2014 Jul 13;5(7):771-6. Epub 2014 May 13.

The University of New South Wales , Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/ml500114pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094262PMC
July 2014

Dimerization of a heat shock protein 90 inhibitor enhances inhibitory activity.

Org Biomol Chem 2014 Feb 10;12(5):765-73. Epub 2013 Dec 10.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1039/c3ob41722kDOI Listing
February 2014

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response.

Bioorg Med Chem Lett 2014 Jan 1;24(2):661-6. Epub 2013 Dec 1.

Department of Chemistry, University of New South Wales, Kensington, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547841PMC
January 2014

Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.

Bioorg Med Chem Lett 2013 Sep 3;23(17):4862-6. Epub 2013 Jul 3.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.082DOI Listing
September 2013

Mechanistic studies of sanguinamide B derivatives: a unique inhibitor of eukaryotic ribosomes.

Org Lett 2013 Sep 3;15(18):4638-41. Epub 2013 Sep 3.

School of Chemistry, The University of New South Wales , Kensington, NSW 2052 Australia.

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http://pubs.acs.org/doi/10.1021/ol401749p
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http://dx.doi.org/10.1021/ol401749pDOI Listing
September 2013

Total synthesis and biological activity of natural product Urukthapelstatin A.

Org Lett 2013 Jul 2;15(14):3574-7. Epub 2013 Jul 2.

Department of Chemistry and Biochemistry, 5500 Campanile Drive, San Diego State University, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/ol401412vDOI Listing
July 2013

Effectively delivering a unique hsp90 inhibitor using star polymers.

ACS Med Chem Lett 2013 Jul;4(10)

Department of Chemistry, University of New South Wales, Sydney, NSW 2052 Australia.

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http://pubs.acs.org/doi/10.1021/ml400082b
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http://dx.doi.org/10.1021/ml400082bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873631PMC
July 2013

A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.

Bioorg Med Chem Lett 2013 May 14;23(9):2527-31. Epub 2013 Mar 14.

Department of Chemistry, University of New South Wales, Kensington, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2013.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735625PMC
May 2013

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.

Bioorg Med Chem Lett 2013 Apr 13;23(7):1923-8. Epub 2013 Feb 13.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2013.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602338PMC
April 2013

A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity.

Medchemcomm 2013 Feb 29;4(2):406-410. Epub 2012 Nov 29.

School of Chemistry, 219 Dalton, Gate 2 High Street, University of New South Wales, Sydney, NSW, 2052, Australia. Tel: +61-4-1672-8896.

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http://xlink.rsc.org/?DOI=C2MD20291C
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http://dx.doi.org/10.1039/C2MD20291CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601786PMC
February 2013

Halting metastasis through CXCR4 inhibition.

Bioorg Med Chem Lett 2013 Jan 12;23(1):20-5. Epub 2012 Nov 12.

Department of Chemistry, University of New South Wales, Sydney NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.138DOI Listing
January 2013

Solid phase versus solution phase synthesis of heterocyclic macrocycles.

Molecules 2013 Jan 16;18(1):1111-21. Epub 2013 Jan 16.

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.3390/molecules18011111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269862PMC
January 2013

Synthesis, structure-activity analysis, and biological evaluation of sanguinamide B analogues.

J Org Chem 2012 Dec 16;77(23):10596-616. Epub 2012 Nov 16.

School of Chemistry, Gate 2 High Street, Dalton 219, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/jo3017499DOI Listing
December 2012

Progress towards the synthesis of Urukthapelstatin A and two analogues.

Tetrahedron Lett 2012 Aug 29;53(32):4065-4069. Epub 2012 May 29.

Department of Chemistry and Biochemistry, 5500 Campanile Dr., San Diego State University, San Diego, CA 92182-1030 USA.

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http://dx.doi.org/10.1016/j.tetlet.2012.05.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431499PMC
August 2012

An Hsp90 modulator that exhibits a unique mechanistic profile.

Bioorg Med Chem Lett 2012 May 11;22(9):3287-90. Epub 2012 Mar 11.

Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2012.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337333PMC
May 2012

Total synthesis of trans,trans-Sanguinamide B and conformational isomers.

Org Lett 2012 Mar 22;14(5):1198-201. Epub 2012 Feb 22.

Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/ol203290nDOI Listing
March 2012

Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.

ACS Chem Biol 2011 Dec 17;6(12):1357-66. Epub 2011 Oct 17.

School of Chemistry, University of New South Wales, Kensington, Australia.

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http://dx.doi.org/10.1021/cb200203mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241894PMC
December 2011

A small molecule that preferentially binds the closed conformation of Hsp90.

Bioorg Med Chem Lett 2011 Dec 29;21(23):7068-71. Epub 2011 Sep 29.

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.09.096DOI Listing
December 2011

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.

Bioorg Med Chem Lett 2011 Aug 25;21(16):4716-9. Epub 2011 Jun 25.

Department of Chemistry and Biochemistry, 5500 Campanile Drive, San Diego State University, San Diego, CA 92182-1030, United States.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155875PMC
August 2011

Macrocyclic inhibitors of hsp90.

Curr Top Med Chem 2010 ;10(14):1380-402

Department of Chemistry and Biochemistry, San Diego State University, CA 92182-1030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105290PMC
http://dx.doi.org/10.2174/156802610792232088DOI Listing
February 2011

Histone Deacetylase Inhibitors: Synthesis of Cyclic Tetrapeptides and their Triazole Analogues.

Tetrahedron Lett 2010 Aug;51(33):4357-4360

Department of Chemistry and Biochemistry, 5500 Campanile Dr., San Diego State University, San Diego, CA 92182-1030.

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http://dx.doi.org/10.1016/j.tetlet.2010.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941989PMC
August 2010

Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.

ACS Med Chem Lett 2010 Jan;1(1):4-8

Department of Chemistry and Biochemistry, 5500 Campanile Road, San Diego State University, San Diego, CA 92182-1030.

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http://dx.doi.org/10.1021/ml900003tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922868PMC
January 2010

Conformationally based design of macrocycles as antitumor agents.

Curr Opin Drug Discov Devel 2008 Jul;11(4):544-52

San Diego State University, Department of Chemistry and Biochemistry, 5500 Campanile Drive, San Diego, CA 92182, USA.

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July 2008

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.

Bioorg Med Chem Lett 2008 Apr 20;18(8):2549-54. Epub 2008 Mar 20.

Department of Chemistry and Biochemistry, 5500 Campanile Drive, San Diego State University, San Diego, CA 92182, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593638PMC
April 2008

Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines.

J Med Chem 2008 Feb 11;51(3):530-44. Epub 2008 Jan 11.

Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045-7582, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm070731a
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http://dx.doi.org/10.1021/jm070731aDOI Listing
February 2008

Synthesis and cytotoxicity of a new class of potent decapeptide macrocycles.

Org Lett 2008 Jan 21;10(2):177-80. Epub 2007 Dec 21.

Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Road, 208 CSL, San Diego State University, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/ol702403rDOI Listing
January 2008

Identification of Sansalvamide a analog potent against pancreatic cancer cell lines.

Bioorg Med Chem Lett 2007 Sep 19;17(18):5072-7. Epub 2007 Jul 19.

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X070081
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http://dx.doi.org/10.1016/j.bmcl.2007.07.025DOI Listing
September 2007

Scaffold targeting drug-resistant colon cancers.

J Med Chem 2007 May 6;50(9):1999-2002. Epub 2007 Apr 6.

Department of Chemistry and Biochemistry, 5500 Campanile Road, San Diego State University, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/jm070088sDOI Listing
May 2007

Synthesis of second-generation sansalvamide A derivatives: novel templates as potential antitumor agents.

J Org Chem 2007 Mar 22;72(6):1980-2002. Epub 2007 Feb 22.

Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/jo061830jDOI Listing
March 2007

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC.

Bioorg Med Chem 2006 Jul 11;14(14):4731-9. Epub 2006 Apr 11.

Department of Chemistry and Biochemisty, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-1030, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.03.028DOI Listing
July 2006

Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives.

Chem Commun (Camb) 2006 Mar 1(9):1033-4. Epub 2006 Feb 1.

Department of Chemistry and Biochemistry, San Diego State University, CA 92182-1030, USA.

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http://dx.doi.org/10.1039/b517434aDOI Listing
March 2006

Synthesis and cytotoxicity of novel sansalvamide A derivatives.

Org Lett 2005 Aug;7(16):3481-4

Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Road, 208 CSL, San Diego State University, San Diego, CA 92182-1030, USA.

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http://dx.doi.org/10.1021/ol051161gDOI Listing
August 2005

Understanding diseases via receptor regulation.

Chem Biol 2004 Feb;11(2):157-8

Department of Chemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.02.004DOI Listing
February 2004

Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.

Org Lett 2003 Jan;5(2):109-12

Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Drive, 208 CSL, San Diego State University, San Diego, California 92182-1030, USA.

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http://dx.doi.org/10.1021/ol020204fDOI Listing
January 2003

Binding Studies of Adamantanecarboxylic Acid and a Naphthyl-Bound beta-Cyclodextrin by Variable Temperature (1)H NMR.

J Org Chem 1996 Nov;61(23):8307-8309

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90024.

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http://dx.doi.org/10.1021/jo9613794DOI Listing
November 1996