Shelley B Bull

Shelley B Bull

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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

J Am Soc Nephrol 2019 Oct 19;30(10):2000-2016. Epub 2019 Sep 19.

Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts;

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http://dx.doi.org/10.1681/ASN.2019030218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779358PMC
October 2019

Integrating epigenetic, genetic, and phenotypic data to uncover gene-region associations with triglycerides in the GOLDN study.

BMC Proc 2018 17;12(Suppl 9):57. Epub 2018 Sep 17.

1Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Ave, Toronto, ON M5G 1X5 Canada.

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http://dx.doi.org/10.1186/s12919-018-0142-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157034PMC
September 2018

Model-Free Linkage Analysis of a Binary Trait.

Methods Mol Biol 2017 ;1666:343-373

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60 Murray St., Box 18, Toronto, ON, Canada, M5T 3L9.

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http://dx.doi.org/10.1007/978-1-4939-7274-6_17DOI Listing
May 2018

Two-phase designs for joint quantitative-trait-dependent and genotype-dependent sampling in post-GWAS regional sequencing.

Genet Epidemiol 2018 02 14;42(1):104-116. Epub 2017 Dec 14.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/gepi.22099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814750PMC
February 2018

Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure.

Genet Epidemiol 2017 Feb 25;41(2):108-121. Epub 2016 Nov 25.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/gepi.22024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245123PMC
February 2017

Identification of low frequency and rare variants for hypertension using sparse-data methods.

BMC Proc 2016 11;10(Suppl 7):389-395. Epub 2016 Oct 11.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, ON M5T 3L9 Canada.

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http://dx.doi.org/10.1186/s12919-016-0061-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133522PMC
October 2016

Clique-Based Clustering of Correlated SNPs in a Gene Can Improve Performance of Gene-Based Multi-Bin Linear Combination Test.

Biomed Res Int 2015 4;2015:852341. Epub 2015 Aug 4.

Prosserman Centre for Health Research, The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9 ; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.

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http://www.hindawi.com/journals/bmri/2015/852341/
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http://dx.doi.org/10.1155/2015/852341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539439PMC
June 2016

Validation of Intratumoral T-bet+ Lymphoid Cells as Predictors of Disease-Free Survival in Breast Cancer.

Cancer Immunol Res 2016 Jan 6;4(1):41-8. Epub 2015 Nov 6.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0051DOI Listing
January 2016

Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event.

Genet Epidemiol 2015 Nov 28;39(7):518-28. Epub 2015 Sep 28.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1002/gepi.21920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609263PMC
November 2015

The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy.

Hum Genet 2015 Feb 7;134(2):247-57. Epub 2014 Dec 7.

Genetics and Genome Biology Program, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Rm 12.9835, 686 Bay Street, Toronto, ON, M5G 0A4, Canada,

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http://dx.doi.org/10.1007/s00439-014-1517-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291513PMC
February 2015

Multiphase analysis by linkage, quantitative transmission disequilibrium, and measured genotype: systolic blood pressure in complex Mexican American pedigrees.

BMC Proc 2014 17;8(Suppl 1):S108. Epub 2014 Jun 17.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario M5T 3L9, Canada ; Dalla Lana School of Public Health, Health Sciences Building, 155 College Street, University of Toronto, Toronto, Ontario M5T 3M7, Canada.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143726PMC
December 2014

Bivariate genetic association analysis of systolic and diastolic blood pressure by copula models.

BMC Proc 2014 17;8(Suppl 1):S72. Epub 2014 Jun 17.

Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7, Canada.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143670PMC
December 2014

An exploration of heterogeneity in genetic analysis of complex pedigrees: linkage and association using whole genome sequencing data in the MAP4 region.

BMC Proc 2014 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S107. Epub 2014 Jun 17.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario M5T 3L9, Canada.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143705PMC
December 2014

A note on the efficiencies of sampling strategies in two-stage Bayesian regional fine mapping of a quantitative trait.

Genet Epidemiol 2014 Nov 1;38(7):599-609. Epub 2014 Aug 1.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gepi.21845DOI Listing
November 2014

A 2-step strategy for detecting pleiotropic effects on multiple longitudinal traits.

Front Genet 2014 20;5:357. Epub 2014 Oct 20.

Division of Biostatistics, Yale School of Public Health New Haven, CT, USA.

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http://dx.doi.org/10.3389/fgene.2014.00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202779PMC
November 2014

Distinguishing luminal breast cancer subtypes by Ki67, progesterone receptor or TP53 status provides prognostic information.

Mod Pathol 2014 Apr 20;27(4):554-61. Epub 2013 Sep 20.

1] Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada [2] Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada [3] Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada [4] Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/modpathol.2013.153DOI Listing
April 2014

Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification.

PLoS Genet 2013 8;9(8):e1003609. Epub 2013 Aug 8.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1003609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738448PMC
March 2014

Killer-cell immunoglobulin-like receptor gene polymorphisms and susceptibility to psoriatic arthritis.

Rheumatology (Oxford) 2014 Feb 31;53(2):233-9. Epub 2013 Oct 31.

Psoriatic Arthritis Program, Toronto Western Research Institute, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, 399 Bathurst Street, Room 1E-410, Toronto, ON, Canada M5T 2S8.

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http://dx.doi.org/10.1093/rheumatology/ket296DOI Listing
February 2014

Gene-based multiple regression association testing for combined examination of common and low frequency variants in quantitative trait analysis.

Front Genet 2013 12;4:233. Epub 2013 Nov 12.

Department of Mathematics Education, Seoul National University Seoul, South Korea ; Interdisciplinary Program in Bioinformatics, Seoul National University Seoul, South Korea.

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http://dx.doi.org/10.3389/fgene.2013.00233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824159PMC
November 2013

Human leukocyte antigen alleles and susceptibility to psoriatic arthritis.

Hum Immunol 2013 Oct 2;74(10):1333-8. Epub 2013 Aug 2.

Psoriatic Arthritis Program, Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.humimm.2013.07.014DOI Listing
October 2013

Cumulative meta-analysis for genetic association: when is a new study worthwhile?

Hum Hered 2012 21;74(2):61-70. Epub 2012 Dec 21.

School of Kinesiology and Health Science, York University, and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1159/000345604DOI Listing
September 2013

Insights from mixture cure modeling of molecular markers for prognosis in breast cancer.

J Clin Oncol 2013 Jun 29;31(16):2047-54. Epub 2013 Apr 29.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2012.46.6615DOI Listing
June 2013

Elevated expression of podocalyxin is associated with lymphatic invasion, basal-like phenotype, and clinical outcome in axillary lymph node-negative breast cancer.

Breast Cancer Res Treat 2013 Feb 4;137(3):709-19. Epub 2013 Jan 4.

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada.

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http://link.springer.com/10.1007/s10549-012-2392-y
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http://dx.doi.org/10.1007/s10549-012-2392-yDOI Listing
February 2013

New susceptibility loci associated with kidney disease in type 1 diabetes.

PLoS Genet 2012 Sep 20;8(9):e1002921. Epub 2012 Sep 20.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

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http://pure.qub.ac.uk/portal/files/2407268/New_Susceptibilit
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http://dx.plos.org/10.1371/journal.pgen.1002921
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http://dx.doi.org/10.1371/journal.pgen.1002921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447939PMC
September 2012

Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study.

Ann Rheum Dis 2012 Aug 14;71(8):1361-5. Epub 2012 May 14.

Center for Prognosis Studies in the Rheumatic Diseases,Toronto Western Hospital, University of Toronto Psoriatic Arthritis Clinic, Toronto, Canada.

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http://dx.doi.org/10.1136/annrheumdis-2012-201308DOI Listing
August 2012

Does familial clustering of risk factors for long-term diabetic complications leave any place for genes that act independently?

J Cardiovasc Transl Res 2012 Aug 23;5(4):388-98. Epub 2012 Jun 23.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12265-012-9385-4DOI Listing
August 2012

Strategies for genetic association analyses combining unrelated case-control individuals and family trios.

Am J Epidemiol 2012 Jul 9;176(1):70-9. Epub 2012 May 9.

Maternal-Infant Care Research Centre, Mount Sinai Hospital, 700 University Avenue, Suite 8-500, Toronto, Ontario M5G 1X6, Canada.

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http://dx.doi.org/10.1093/aje/kwr494DOI Listing
July 2012

Gene network modular-based classification of microarray samples.

BMC Bioinformatics 2012 Jun 25;13 Suppl 10:S17. Epub 2012 Jun 25.

Department of Computer Science and Engineering, York University, Toronto, M3J 1P3, Canada.

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http://dx.doi.org/10.1186/1471-2105-13-S10-S17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314572PMC
June 2012

Model-free linkage analysis of a binary trait.

Methods Mol Biol 2012 ;850:317-45

Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-555-8_17DOI Listing
May 2012

Two-phase stratified sampling designs for regional sequencing.

Genet Epidemiol 2012 May 28;36(4):320-32. Epub 2012 Mar 28.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto ON, Canada.

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http://dx.doi.org/10.1002/gepi.21624DOI Listing
May 2012

Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis.

Ann Rheum Dis 2012 Jan 6;71(1):50-5. Epub 2011 Sep 6.

Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada.

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http://ard.bmj.com/content/71/1/50.full.pdf
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http://ard.bmj.com/cgi/doi/10.1136/ard.2011.155044
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http://dx.doi.org/10.1136/ard.2011.155044DOI Listing
January 2012

Are quantitative trait-dependent sampling designs cost-effective for analysis of rare and common variants?

BMC Proc 2011 Nov 29;5 Suppl 9:S111. Epub 2011 Nov 29.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Prosserman Centre for Health Research, 60 Murray Street, Box 18, Toronto, ON M5T 3L9, Canada.

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https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561
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http://dx.doi.org/10.1186/1753-6561-5-S9-S111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287835PMC
November 2011

Two-stage study designs combining genome-wide association studies, tag single-nucleotide polymorphisms, and exome sequencing: accuracy of genetic effect estimates.

BMC Proc 2011 Nov 29;5 Suppl 9:S64. Epub 2011 Nov 29.

Dalla Lana School of Public Health, University of Toronto, Health Sciences Building, 155 College Street, Toronto, ON M5T 3M7, Canada.

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http://dx.doi.org/10.1186/1753-6561-5-S9-S64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287903PMC
November 2011

A flexible genome-wide bootstrap method that accounts for ranking and threshold-selection bias in GWAS interpretation and replication study design.

Stat Med 2011 Jul 3;30(15):1898-912. Epub 2011 May 3.

Dalla Lana School of Public Health, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1002/sim.4228DOI Listing
July 2011

BR-squared: a practical solution to the winner's curse in genome-wide scans.

Hum Genet 2011 May 19;129(5):545-52. Epub 2011 Jan 19.

Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s00439-011-0948-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074069PMC
May 2011

Regression models, scan statistics and reappearance probabilities to detect regions of association between gene expression and copy number.

Stat Med 2011 May 21;30(10):1157-78. Epub 2011 Feb 21.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/sim.4193DOI Listing
May 2011

CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the breast cancer family registry.

Cancer 2011 Apr 2;117(7):1350-9. Epub 2010 Nov 2.

Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital and the Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cncr.25642
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http://dx.doi.org/10.1002/cncr.25642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116977PMC
April 2011

CUBN is a gene locus for albuminuria.

Authors:
Carsten A Böger Ming-Huei Chen Adrienne Tin Matthias Olden Anna Köttgen Ian H de Boer Christian Fuchsberger Conall M O'Seaghdha Cristian Pattaro Alexander Teumer Ching-Ti Liu Nicole L Glazer Man Li Jeffrey R O'Connell Toshiko Tanaka Carmen A Peralta Zoltán Kutalik Jian'an Luan Jing Hua Zhao Shih-Jen Hwang Ermeg Akylbekova Holly Kramer Pim van der Harst Albert V Smith Kurt Lohman Mariza de Andrade Caroline Hayward Barbara Kollerits Anke Tönjes Thor Aspelund Erik Ingelsson Gudny Eiriksdottir Lenore J Launer Tamara B Harris Alan R Shuldiner Braxton D Mitchell Dan E Arking Nora Franceschini Eric Boerwinkle Josephine Egan Dena Hernandez Muredach Reilly Raymond R Townsend Thomas Lumley David S Siscovick Bruce M Psaty Bryan Kestenbaum Talin Haritunians Sven Bergmann Peter Vollenweider Gerard Waeber Vincent Mooser Dawn Waterworth Andrew D Johnson Jose C Florez James B Meigs Xiaoning Lu Stephen T Turner Elizabeth J Atkinson Tennille S Leak Knut Aasarød Frank Skorpen Ann-Christine Syvänen Thomas Illig Jens Baumert Wolfgang Koenig Bernhard K Krämer Olivier Devuyst Josyf C Mychaleckyj Cosetta Minelli Stephan J L Bakker Lyudmyla Kedenko Bernhard Paulweber Stefan Coassin Karlhans Endlich Heyo K Kroemer Reiner Biffar Sylvia Stracke Henry Völzke Michael Stumvoll Reedik Mägi Harry Campbell Veronique Vitart Nicholas D Hastie Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Ozren Polasek Gary Curhan Florian Kronenberg Inga Prokopenko Igor Rudan Johan Arnlöv Stein Hallan Gerjan Navis Afshin Parsa Luigi Ferrucci Josef Coresh Michael G Shlipak Shelley B Bull Nicholas J Paterson H-Erich Wichmann Nicholas J Wareham Ruth J F Loos Jerome I Rotter Peter P Pramstaller L Adrienne Cupples Jacques S Beckmann Qiong Yang Iris M Heid Rainer Rettig Albert W Dreisbach Murielle Bochud Caroline S Fox W H L Kao

J Am Soc Nephrol 2011 Mar;22(3):555-70

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1681/ASN.2010060598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060449PMC
March 2011

Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traits.

Genet Epidemiol 2010 Jul;34(5):502-11

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/gepi.20506DOI Listing
July 2010

Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.

Genet Epidemiol 2010 Feb;34(2):107-18

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada.

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http://dx.doi.org/10.1002/gepi.20438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811772PMC
February 2010

Application of bivariate mixed counting process models to genetic analysis of rheumatoid arthritis severity.

BMC Proc 2007 18;1 Suppl 1:S120. Epub 2007 Dec 18.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, Box #18, Lebovic Building, 5th Floor, Prosserman Centre, Toronto, Ontario M5T 3L9, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367476PMC
http://dx.doi.org/10.1186/1753-6561-1-S1-S120DOI Listing
December 2009

One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies.

BMC Proc 2007 18;1 Suppl 1:S137. Epub 2007 Dec 18.

Department of Genome Sciences, University of Washington, 1705 Northeast Pacific Street #K-357, Box 357730, Seattle, Washington 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367501PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s137DOI Listing
December 2009

Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data.

BMC Proc 2007 18;1 Suppl 1:S78. Epub 2007 Dec 18.

Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, 610 University Avenue, Room 15-507, Toronto, Ontario, Canada M5G 2M9.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367509PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s78DOI Listing
December 2009

Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.

BMC Proc 2009 Dec 15;3 Suppl 7:S103. Epub 2009 Dec 15.

Dalla Lana School of Public Health, University of Toronto, 6th Floor, Health Sciences Building, 155 College Street, Toronto, Ontario M5T 3M7 Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795874PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s103DOI Listing
December 2009

Region-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes.

BMC Proc 2009 Dec 15;3 Suppl 7:S127. Epub 2009 Dec 15.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario M5T 3L9, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795900PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s127DOI Listing
December 2009

Transmission-ratio distortion in the Framingham Heart Study.

BMC Proc 2009 Dec 15;3 Suppl 7:S51. Epub 2009 Dec 15.

Program in Genetics and Genome Biology, Hospital for Sick Children, 101 College Street, TMDT East Tower, Toronto, ON M5G 1X8 Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795951PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s51DOI Listing
December 2009

Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.

Breast Cancer Res Treat 2009 Sep 18;117(1):183-91. Epub 2008 Jun 18.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10549-008-0087-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727582PMC
September 2009

Combining case-control and case-trio data from the same population in genetic association analyses: overview of approaches and illustration with a candidate gene study.

Am J Epidemiol 2009 Sep 27;170(5):657-64. Epub 2009 Jul 27.

Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, 1110 Pine Avenue West, Montreal, Quebec H3A1A3, Canada.

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https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/
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http://dx.doi.org/10.1093/aje/kwp180DOI Listing
September 2009

A Bayesian segmentation approach to ascertain copy number variations at the population level.

Bioinformatics 2009 Jul 23;25(13):1669-79. Epub 2009 Apr 23.

Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btp270DOI Listing
July 2009

JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer.

Breast Cancer Res Treat 2008 Oct 8;111(3):439-48. Epub 2007 Nov 8.

Department of Surgical Oncology, University of Toronto, Toronto, ON, Canada, M5G 2M9.

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http://dx.doi.org/10.1007/s10549-007-9805-3DOI Listing
October 2008

EM-random forest and new measures of variable importance for multi-locus quantitative trait linkage analysis.

Bioinformatics 2008 Jul 21;24(14):1603-10. Epub 2008 May 21.

Department of Public Health Sciences, University of Toronto, Toronto M5T3M7, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btn239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638262PMC
July 2008

Type of TP53 mutation and ERBB2 amplification affects survival in node-negative breast cancer.

Breast Cancer Res Treat 2007 Nov 13;105(3):255-65. Epub 2007 Jan 13.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray St., Room: 6-303-O, Toronto, ON, Canada, M5T 3L9.

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http://dx.doi.org/10.1007/s10549-006-9452-0DOI Listing
November 2007

Ethnic differences in relative risk of idiopathic calcium nephrolithiasis in North America.

J Urol 2007 Nov 17;178(5):1992-7; discussion 1997. Epub 2007 Sep 17.

Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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November 2007

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.

J Hypertens 2007 Oct;25(10):2074-81

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1097/HJH.0b013e3282a9be1bDOI Listing
October 2007

Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study.

Diabetes 2007 Aug 18;56(8):2161-8. Epub 2007 May 18.

Program in Genetics and Genome Biology, Hospital of Sick Children Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.2337/db07-0376DOI Listing
August 2007

A hierarchical clustering method for estimating copy number variation.

Biostatistics 2007 Jul 23;8(3):632-53. Epub 2006 Oct 23.

Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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https://academic.oup.com/biostatistics/article-lookup/doi/10
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http://dx.doi.org/10.1093/biostatistics/kxl035DOI Listing
July 2007

Locus-specific heritability estimation via the bootstrap in linkage scans for quantitative trait loci.

Hum Hered 2006 12;62(2):84-96. Epub 2006 Oct 12.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1159/000096096DOI Listing
June 2007

COPS3 amplification and clinical outcome in osteosarcoma.

Cancer 2007 May;109(9):1870-6

Fred A. Litwin Centre for Cancer Genetics, Mount Sinai Hospital, and University Musculoskeletal Oncology Unit, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.22595DOI Listing
May 2007

Confidence intervals for multinomial logistic regression in sparse data.

Stat Med 2007 Feb;26(4):903-18

Samuel Lunenfeld Research Institute, Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Ont., Canada M5G 1X5.

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http://dx.doi.org/10.1002/sim.2518DOI Listing
February 2007

Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast.

Genes Chromosomes Cancer 2006 Nov;45(11):1007-17

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/gcc.20368DOI Listing
November 2006

Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies.

Genet Epidemiol 2006 Sep;30(6):519-30

Department of Public Health Sciences, University of Toronto, and Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/gepi.20164DOI Listing
September 2006

High urinary calcium excretion and genetic susceptibility to hypertension and kidney stone disease.

J Am Soc Nephrol 2006 Sep 19;17(9):2567-75. Epub 2006 Jul 19.

Department of Medicine, Division of Nephrology, Mount Sinai Hospital, Room 435, 600 University Avenue, Toronto, Ont M5G1X5, Canada.

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http://dx.doi.org/10.1681/ASN.2005121309DOI Listing
September 2006

Fine mapping by linkage and association in nuclear family and case-control designs.

Genet Epidemiol 2005 ;29 Suppl 1:S48-58

Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gepi.20110DOI Listing
April 2006

Application of reliability coefficients in cDNA microarray data analysis.

Stat Med 2006 Mar;25(6):1051-66

Prosserman Center for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1002/sim.2254DOI Listing
March 2006

Validity, efficiency, and robustness of a family-based test of association.

Genet Epidemiol 2006 Jan;30(1):62-76

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/gepi.20125DOI Listing
January 2006

Tests for the presence of two linked disease susceptibility genes.

Genet Epidemiol 2005 Dec;29(4):389-401

Department of Public Health Sciences, University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1002/gepi.20094
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December 2005

Resampling methods to reduce the selection bias in genetic effect estimation in genome-wide scans.

BMC Genet 2005 Dec 30;6 Suppl 1:S24. Epub 2005 Dec 30.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866762PMC
December 2005

Recursive partitioning models for linkage in COGA data.

BMC Genet 2005 Dec 30;6 Suppl 1:S38. Epub 2005 Dec 30.

Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866747PMC
December 2005

Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals.

BMC Genet 2005 Dec 30;6 Suppl 1:S62. Epub 2005 Dec 30.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866720PMC
December 2005

Reduction of selection bias in genomewide studies by resampling.

Genet Epidemiol 2005 May;28(4):352-67

Department of Public Health Sciences, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/gepi.20068DOI Listing
May 2005

Simultaneous localization of two linked disease susceptibility genes.

Genet Epidemiol 2005 Jan;28(1):33-47

Department of Public Health Sciences, University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1002/gepi.20033
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http://dx.doi.org/10.1002/gepi.20033DOI Listing
January 2005

Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives.

Hum Hered 2003 ;56(1-3):94-106

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada.

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https://www.karger.com/Article/FullText/73737
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http://dx.doi.org/10.1159/000073737DOI Listing
July 2004

The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer.

J Clin Oncol 2004 Jan;22(1):86-96

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1200/JCO.2004.09.128DOI Listing
January 2004

Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure.

BMC Genet 2003 Dec 31;4 Suppl 1:S23. Epub 2003 Dec 31.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.

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http://dx.doi.org/10.1186/1471-2156-4-S1-S23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866458PMC
December 2003

Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure.

BMC Genet 2003 Dec 31;4 Suppl 1:S84. Epub 2003 Dec 31.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, 5th Floor, Toronto, Ontario, M5G 1X5, Canada.

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http://dx.doi.org/10.1186/1471-2156-4-S1-S84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866524PMC
December 2003

Is 'stage of change' related to knowledge of health effects and support for tobacco control?

Addict Behav 2002 Jan-Feb;27(1):49-61

Ontario Tobacco Research Unit, Centre for Health Promotion, University of Toronto, Canada.

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http://dx.doi.org/10.1016/s0306-4603(00)00162-3DOI Listing
November 2002

High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension.

Nephrol Dial Transplant 2002 Feb;17(2):253-9

First Department of Medicine, Semmelweis University, 2/a Koranyi S.u., H-1083 Budapest, Hungary.

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http://dx.doi.org/10.1093/ndt/17.2.253DOI Listing
February 2002

Regression models for allele sharing: analysis of accumulating data in affected sib pair studies.

Stat Med 2002 Feb;21(3):431-44

Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Department of Public Health Sciences, University of Toronto Suite 850, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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February 2002