Shawn M Davidson

Shawn M Davidson

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Shawn M Davidson

Shawn M Davidson

Publications by authors named "Shawn M Davidson"

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Critical Functions of the Lysosome in Cancer Biology.

Annu Rev Pharmacol Toxicol 2017 01 12;57:481-507. Epub 2016 Oct 12.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; email: ,

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http://dx.doi.org/10.1146/annurev-pharmtox-010715-103101DOI Listing
January 2017

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Cell Metab 2016 11 13;24(5):716-727. Epub 2016 Oct 13.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102768PMC
November 2016

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Proc Natl Acad Sci U S A 2016 09 6;113(38):E5598-607. Epub 2016 Sep 6.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912; Institute for Brain Science, Brown University, Providence, RI 02912; Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, East Providence, RI 02915;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035873PMC
http://dx.doi.org/10.1073/pnas.1609221113DOI Listing
September 2016

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Science 2016 09;353(6304):1161-5

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaf5171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245791PMC
September 2016

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Cell Metab 2016 08 28;24(2):324-31. Epub 2016 Jul 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367626PMC
August 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Cell Metab 2016 Mar 4;23(3):517-28. Epub 2016 Feb 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)00041-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311600041
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http://dx.doi.org/10.1016/j.cmet.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785096PMC
March 2016

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Cell 2016 Feb;164(5):884-95

Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819986PMC
February 2016

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Cancer Metab 2015 29;3. Epub 2015 Apr 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Dana-Farber Cancer Institute, Boston, MA 02215 USA ; Broad Institute, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1186/s40170-015-0131-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414297PMC
April 2015

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.

Cancer Res 2014 Jun 22;74(12):3317-31. Epub 2014 Apr 22.

Authors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, CaliforniaAuthors' Affiliations: Novartis Institutes for Biomedical Research; Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Departments of Bioengineering and Pharmacology; and Moores Cancer Center, University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0772-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885639PMC
June 2014

METabolic adaptations in the tumor MYCroenvironment.

Cell Metab 2012 Feb;15(2):131-3

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.01.005DOI Listing
February 2012