Shaun M K McKinnie

Shaun M K McKinnie

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Shaun M K McKinnie

Shaun M K McKinnie

Publications by authors named "Shaun M K McKinnie"

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18Publications

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Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.

Angew Chem Int Ed Engl 2019 Jun 13;58(25):8394-8399. Epub 2019 May 13.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1002/anie.201901571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555645PMC
June 2019

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.

Angew Chem Int Ed Engl 2019 Jun 10;58(25):8454-8457. Epub 2019 May 10.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://doi.wiley.com/10.1002/anie.201902910
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http://dx.doi.org/10.1002/anie.201902910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574125PMC
June 2019

Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases.

Methods Enzymol 2018 2;604:405-424. Epub 2018 Apr 2.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205230PMC
April 2019

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

Eur J Med Chem 2019 Mar 18;166:119-124. Epub 2019 Jan 18.

Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, Alberta, T6G 2G2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.040DOI Listing
March 2019

Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives.

Org Biomol Chem 2019 Mar;17(13):3416-3423

Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.

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http://xlink.rsc.org/?DOI=C8OB03109F
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http://dx.doi.org/10.1039/c8ob03109fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437001PMC
March 2019

Total Enzyme Syntheses of Napyradiomycins A1 and B1.

J Am Chem Soc 2018 Dec 14;140(51):17840-17845. Epub 2018 Dec 14.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , La Jolla , California 92093 , United States.

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http://dx.doi.org/10.1021/jacs.8b10134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491662PMC
December 2018

Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca Dynamics.

Environ Sci Technol 2018 May 20;52(9):5469-5478. Epub 2018 Apr 20.

Department of Molecular Biosciences, School of Veterinary Medicine , University of California , Davis , California 95616 , United States.

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http://dx.doi.org/10.1021/acs.est.8b00512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195434PMC
May 2018

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.

Biochim Biophys Acta Mol Basis Dis 2017 08 4;1863(8):1942-1950. Epub 2016 Nov 4.

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada; Department of Physiology, University of Alberta, Edmonton, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.007DOI Listing
August 2017

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

J Med Chem 2017 07 7;60(14):6408-6427. Epub 2017 Jul 7.

Department of Chemistry, University of Alberta , 11227 Saskatchewan Drive NW, Edmonton, Alberta T6G 2G2, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00723DOI Listing
July 2017

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Hypertension 2016 08 23;68(2):365-77. Epub 2016 May 23.

From the Division of Cardiology, Department of Medicine (W.W., B.M., G.Y.O.), Mazankowski Alberta Heart Institute (W.W., B.M., G.Y.O.), Department of Chemistry, Faculty of Science (S.M.K.M., T.M., J.C.V.), and Division of Nephrology, Department of Medicine (M.F., A.G.M.), University of Alberta, Edmonton, AB, Canada; Department of Zoology, RBC College, West Bengal State University, West Bengal, India (M.P.); INSERM, Laboratory of Central Neuropeptides and Regulations of Water Balance and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, College de France, Paris, France (C.L.-C.); Department of Biotechnology, Indian Institute of Technology, Roorkee, India (S.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06892DOI Listing
August 2016

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides.

Chembiochem 2016 08 5;17(16):1495-8. Epub 2016 Jul 5.

Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, Alberta, T6G 2G2, Canada.

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http://dx.doi.org/10.1002/cbic.201600244DOI Listing
August 2016

Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds.

Bioorg Med Chem 2014 Jan 9;22(1):523-30. Epub 2013 Nov 9.

The Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, 85 Lomb Memorial Drive, Rochester, NY 14623-5603, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130092
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http://dx.doi.org/10.1016/j.bmc.2013.10.055DOI Listing
January 2014

The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S.

J Am Chem Soc 2012 Feb 24;134(4):2008-11. Epub 2012 Jan 24.

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.

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http://pubs.acs.org/doi/10.1021/ja211088m
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http://dx.doi.org/10.1021/ja211088mDOI Listing
February 2012

Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2.

Angew Chem Int Ed Engl 2008 ;47(49):9472-5

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

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http://dx.doi.org/10.1002/anie.200802919DOI Listing
December 2008