Shaun M Cowley

Shaun M Cowley

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Shaun M Cowley

Shaun M Cowley

Publications by authors named "Shaun M Cowley"

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24Publications

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Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription.

Essays Biochem 2019 04 23;63(1):97-107. Epub 2019 Apr 23.

Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K.

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http://dx.doi.org/10.1042/EBC20180061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484784PMC
April 2019

Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.

Biochem J 2018 12 14;475(24):3921-3932. Epub 2018 Dec 14.

Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.

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http://dx.doi.org/10.1042/BCJ20170314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295471PMC
December 2018

Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.

Sci Rep 2018 10 2;8(1):14689. Epub 2018 Oct 2.

Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester, LE1 7RH, United Kingdom.

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http://www.nature.com/articles/s41598-018-32942-w
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http://dx.doi.org/10.1038/s41598-018-32942-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168491PMC
October 2018

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

Stem Cell Reports 2018 04;10(4):1369-1383

CRUK Stem Cell Biology Group, CRUK Manchester Institute, 555 Wilmslow Road, Manchester M20 4GJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998800PMC
April 2018

OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.

Mol Cell 2016 08 4;63(4):647-661. Epub 2016 Aug 4.

Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; MTA-DE "Lendulet" Immunogenomics Research Group, University of Debrecen, 4032 Debrecen, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.039DOI Listing
August 2016

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.

Nat Commun 2016 04 25;7:11262. Epub 2016 Apr 25.

Henry Wellcome Laboratories of Structural Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK.

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http://dx.doi.org/10.1038/ncomms11262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848466PMC
April 2016

Differential requirements of singleplex and multiplex recombineering of large DNA constructs.

PLoS One 2015 8;10(5):e0125533. Epub 2015 May 8.

Department of Biochemistry, University of Leicester, Leicester, LE1 9HN, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125533PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425527PMC
February 2016

Class I HDACs share a common mechanism of regulation by inositol phosphates.

Mol Cell 2013 Jul 20;51(1):57-67. Epub 2013 Jun 20.

Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, UK.

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http://dx.doi.org/10.1016/j.molcel.2013.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710971PMC
July 2013

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts.

Biochem Soc Trans 2013 Jun;41(3):741-9

Department of Biochemistry, University of Leicester, Henry Welcome Building, Lancaster Road, Leicester LE1 9HN, U.K.

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http://dx.doi.org/10.1042/BST20130010DOI Listing
June 2013

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Mol Cell Biol 2010 Oct 16;30(20):4851-63. Epub 2010 Aug 16.

Department of Biochemistry, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00521-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950538PMC
October 2010

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Proc Natl Acad Sci U S A 2010 May 19;107(18):8242-7. Epub 2010 Apr 19.

Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1000478107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889513PMC
May 2010

The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

Mol Cell Biol 2005 Aug;25(16):6990-7004

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109-1024, USA.

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http://dx.doi.org/10.1128/MCB.25.16.6990-7004.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190252PMC
August 2005

HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.

Nat Struct Mol Biol 2004 Aug 4;11(8):738-46. Epub 2004 Jul 4.

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208-3500, USA.

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http://dx.doi.org/10.1038/nsmb798DOI Listing
August 2004

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.

Genes Dev 2003 May 14;17(9):1101-14. Epub 2003 Apr 14.

Division of Basic Sciences and Divison of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1101/gad.1066903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196053PMC
May 2003

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

Proc Natl Acad Sci U S A 2002 Oct 27;99(21):13425-30. Epub 2002 Sep 27.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1073/pnas.172511699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129689PMC
October 2002