Publications by authors named "Shashanka Dhanuka"

2 Publications

  • Page 1 of 1

A rare case of bilateral synchronous renal tumors with different histology successfully treated with bilateral partial nephrectomy.

J Cancer Res Ther 2021 Apr-Jun;17(2):593-595

Department of Biomedical Engineering, MIET, Bhubaneswar, Odisha, India.

Renal cell carcinoma (RCC) accounts for about 85% of all renal neoplasms, 60% of which are diagnosed incidentally. Most are unilateral, but bilateral tumors, synchronous or asynchronous, have been found in 2%-4% of reported sporadic cases. The occurrence of synchronous bilateral renal neoplasms with different histology in the same individual is very rare. We report one such case in a 45-year-old male patient, who was successfully managed by performing bilateral partial nephrectomy in two sittings. The histopathological examination revealed different histology on each side. Both preservations of renal parenchyma and tumor eradication should be considered in bilateral synchronous sporadic RCC before formulating a therapeutic regime. Management by nephron-sparing surgery approach performed in a staged manner offers adequate cancer-specific survival while ensuring good renal function.
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http://dx.doi.org/10.4103/jcrt.JCRT_605_18DOI Listing
June 2021

Tissue engineered indigenous pericardial patch urethroplasty: A promising solution to a nagging problem.

Asian J Urol 2020 Jan 6;7(1):56-60. Epub 2019 Jun 6.

Department of Urology, Nilratan Sircar Medical College and Hospital, Kolkata, India.

Objective: Urethral stricture is a highly prevalent disease and has a continued rising incidence. The global burden of disease keeps rising as there are significant rates of recurrence with the existing management options with the need for additional repeat procedures. Moreover, the existing treatment options are associated with significant morbidity in the patient. Long segment urethral strictures are most commonly managed by augmentation urethroplasty. We explored the potential for the application of an acellular tissue engineered bovine pericardial patch in augmentation urethroplasty in a series of our patients suffering from urethral stricture disease. The decreased morbidity due to the avoidance of harvest of buccal mucosa, decreased operative time and satisfactory postoperative results make it a promising option for augmentation urethroplasty.

Methods: Nine patients with long segment anterior urethral strictures (involving penile and/or bulbar urethra and stricture length >4 cm) were included in the study after proper informed consent was obtained. Acellular tissue engineered indigenous bovine pericardial patch was used for urethroplasty using dorsal onlay technique.

Results: A total of nine patients underwent tissue engineered indigenous pericardial patch urethroplasty for long segment urethral strictures, mostly catheter injury induced or associated with balanitis xerotica obliterans. Median follow-up was 8 months (range: 2-12 months). Out of nine patients, eight (88.9%) were classified as success and one (11.1%) was classified as failure.

Conclusion: Our study brings a product of tissue engineering, already being used in the cardiovascular surgery domain, into the urological surgery operating room with satisfactory results achieved using standard operating techniques of one stage urethroplasty.
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http://dx.doi.org/10.1016/j.ajur.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962739PMC
January 2020
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