Publications by authors named "Shashank M Patil"

4 Publications

  • Page 1 of 1

A Perspective on the Effective Conduction of Functional-based Coaching Program on Diabetic Indonesian Communities.

Oman Med J 2021 Jul 1;36(4):e281. Epub 2021 Jul 1.

Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Karnataka, India.

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http://dx.doi.org/10.5001/omj.2021.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254870PMC
July 2021

Azadirachta indica A. Juss (neem) as a contraceptive: An evidence-based review on its pharmacological efficiency.

Phytomedicine 2021 Jul 19;88:153596. Epub 2021 May 19.

Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, JSS Technical Institutional Campus, Mysore, 570006, Karnataka, India.

Background: Azadirachta indica A. Juss. is an Indian medicinal plant with innumerable pharmacological properties. Studies have proven that the phytochemicals from neem possess remarkable contraceptive abilities with limited knowledge on its mechanism of action.

Purpose: The present review aims to summarize the efficiency of A. indica treatment as a contraceptive.

Methods: The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used. Published scientific articles on antifertility, antispermatogenic, antiovulation, hormone altering, contraceptive, and abortifacient activities of A. indica were collected from reputed Journals from 1980 to 2020 using electronic databases. Specific keywords search was completed to collect numerous articles with unique experiment design and significant results. This was followed by the selection of the requisite articles based on the criteria designed by the authors. Data extraction was based on the common research elements included in the articles.

Results: A total of 27 studies were considered for reviewing, which included key pharmacological investigations. In the beginning, authors evaluated a number of publications on the contraceptive properties of A. indica, in which it was revealed that most of the publications were made between 2005 and 2009. All the collected articles were categorised and reviewed as antifertility, antispermatogenic, antiovulation, hormone altering, contraceptive, and abortifacient. Authors also assessed studies based on the plant parts used for pharmacological evaluations including leaves, seeds, stem-bark, and flowers. The article was primarily divided into different sections based on the previous works of authors on phytochemistry and pharmacological review articles.

Conclusion: Although A. indica is not reported with the complete alleviation of reproductive system in both male and female animal models, studies have proven its efficacy as a contraceptive. Extracts and phytochemicals from neem neither reduced the libido nor retarded the growth of secondary sexual characters, thus indicating only a temporary and reversible contraceptive activity. However, there is a dearth for clinical studies to prove the efficacy of A. indica as a herbal contraceptive.
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http://dx.doi.org/10.1016/j.phymed.2021.153596DOI Listing
July 2021

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Linn.

Heliyon 2021 May 18;7(5):e07054. Epub 2021 May 18.

Departments of Clinical Sciences, Kansas State University, Manhattan, KS, 66506-5606, USA.

Linn. is a medicinal and culinary herb from the Southern European region known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities since the Egyptian era. The reported pharmacological activities of L. include antibacterial, antioxidant, anti-inflammatory, antiviral, and anti-cancerous activities. In this review, a comprehensive approach is put forth to scrutinize and report the available data on phytochemistry, ethnopharmacology, pharmacology, and toxicology of the plant. The different extracts and essential oil obtained from the plant have been assessed and reported to treat ailments like microbial infections, inflammation, non-communicable diseases like cancer, and sexually transmitted diseases like HIV-1 and Herpes. The literature review has also indicated the use of volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides in pharmacotherapy. Applications of these compounds including antidiabetic, anti-Alzheimer's, cardio, neuro and hepatoprotective, anti-osteoporosis, sedative, immunomodulatory, antioxidant, anti-tyrosinase, antispasmodic, antinociceptive, gastroprotective, anticonvulsant, antihypertensive, antidepressant, anti-amnesia, and anti-helminthic activities have been mentioned. Further, based on research gaps, recommendations have been provided to evaluate L. systematically to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety.
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http://dx.doi.org/10.1016/j.heliyon.2021.e07054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141878PMC
May 2021

The COVID-19 Vaccine Saga: A Perspective.

J Res Pharm Pract 2020 Oct-Dec;9(4):218-219. Epub 2021 Jan 11.

Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

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http://dx.doi.org/10.4103/jrpp.JRPP_20_100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067902PMC
January 2021