Sharon J Diskin

Sharon J Diskin

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Sharon J Diskin

Publications by authors named "Sharon J Diskin"

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Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma.

Am J Hum Genet 2019 Sep 29;105(3):658-668. Epub 2019 Aug 29.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Oncology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731370PMC
September 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 Apr 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

Differences in Genomic Profiles and Outcomes between Thoracic and Adrenal Neuroblastoma.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Childrens Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/jnci/djz027DOI Listing
February 2019

Graphical Interpretation and Analysis of Proteins and their Ontologies (GiaPronto): A One-Click Graph Visualization Software for Proteomics Data Sets.

Mol Cell Proteomics 2018 07 8;17(7):1426-1431. Epub 2017 Nov 8.

From the ‡Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1074/mcp.TIR117.000438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030729PMC
July 2018

Genetic susceptibility to neuroblastoma: current knowledge and future directions.

Cell Tissue Res 2018 05 27;372(2):287-307. Epub 2018 Mar 27.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00441-018-2820-3DOI Listing
May 2018

The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma.

J Cell Mol Med 2017 Dec 30;21(12):3224-3230. Epub 2017 Jun 30.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/jcmm.13226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706517PMC
December 2017

Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma.

J Natl Cancer Inst 2017 10;109(10)

Affiliations of authors: Section of Hematology/Oncology, Department of Pediatrics (EAH, MAA, ADS, SLV, SLC), Section of Genetic Medicine, Department of Medicine (BES), and Institute for Genomics and Systems Biology, Center for Data Intensive Science (BES), University of Chicago, Chicago, IL; Division of Oncology and Center for Childhood Cancer Research and Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA (ZV, MD, LM, JMM, SJD); Department of Pediatrics and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (JMM, SJD); Department of Pediatrics, Hofstra-Northwell School of Medicine and The Feinstein Institute for Medical Research, Manhasset, NY (KO).

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http://dx.doi.org/10.1093/jnci/djx093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279278PMC
October 2017

Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project.

Eur J Cancer 2017 02 26;72:177-185. Epub 2016 Dec 26.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258837PMC
February 2017

LIN28B: an orchestrator of oncogenic signaling in neuroblastoma.

Cell Cycle 2016 ;15(6):772-4

a Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/15384101.2015.1137712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845945PMC
December 2016

A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group.

Cancer Causes Control 2016 10 19;27(10):1209-18. Epub 2016 Aug 19.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Campus Box 7435, 2106 McGavran-Greenberg Hall, Chapel Hill, NC, 27599-7435, USA.

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http://dx.doi.org/10.1007/s10552-016-0799-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025391PMC
October 2016

Imaging genomics in cancer research: limitations and promises.

Br J Radiol 2016 11;89(1061):20151030. Epub 2016 Feb 11.

4 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1259/bjr.20151030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985482PMC
September 2016

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Cell Metab 2015 Dec 17;22(6):1009-19. Epub 2015 Sep 17.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818967PMC
December 2015

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.

Cancer Cell 2015 Nov 17;28(5):599-609. Epub 2015 Oct 17.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643330PMC
November 2015

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.

Cancer Res 2015 Aug 22;75(15):3155-66. Epub 2015 Jun 22.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526355PMC
August 2015

CODEX: a normalization and copy number variation detection method for whole exome sequencing.

Nucleic Acids Res 2015 Mar 23;43(6):e39. Epub 2015 Jan 23.

Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1093/nar/gku1363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381046PMC
March 2015

Rare variants in TP53 and susceptibility to neuroblastoma.

J Natl Cancer Inst 2014 Apr 14;106(4):dju047. Epub 2014 Mar 14.

Affiliations of authors: Division of Oncology (SJD, MDi, DAO, KC, KRB, MRR, JMM), Center for Childhood Cancer Research (SJD, MDi, DAO, KC, KRB, MRR, JMM), Center for Applied Genomics (HH), and Division of Genetics (HH, MDe) Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics (SJD, DAO, KRB, HH, MDe, JMM), Abramson Cancer Center (SJD, JMM), Genomics and Computational Biology, Biomedical Graduate Studies (SJD, DAO, JMM), and Department of Biostatistics and Epidemiology (MDe), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (SJD, HH, MDe, JMM); Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Naples, Italy (MC, AI); Ceinge-Biotecnologie Avanzate, Naples, Italy (MC, AI); University of Rome "La Sapienza," Department of Molecular Medicine, Rome, Italy (MDe).

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http://jnci.oxfordjournals.org/content/early/2014/03/14/jnci
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju047
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http://dx.doi.org/10.1093/jnci/dju047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982892PMC
April 2014

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.

Clin Cancer Res 2013 Nov 17;19(22):6173-82. Epub 2013 Sep 17.

Authors' Affiliations: Division of Oncology and Center for Childhood Cancer Research; Division of Pathology, Children's Hospital of Philadelphia; Department of Pediatrics; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-1675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844928PMC
November 2013

Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.

Int J Cancer 2013 Feb 28;132(3):E149-57. Epub 2012 Sep 28.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1002/ijc.27781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706358PMC
February 2013

Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival.

J Natl Cancer Inst 2013 Feb 14;105(4):302-9. Epub 2012 Dec 14.

Section of Genetic Medicine, University of Chicago, 900 E 57th St, Rm 3220F, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/jnci/djs503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691940PMC
February 2013

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.

Nat Genet 2012 Oct 2;44(10):1126-30. Epub 2012 Sep 2.

Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.nature.com/articles/ng.2387
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http://dx.doi.org/10.1038/ng.2387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459292PMC
October 2012

Replication of neuroblastoma SNP association at the BARD1 locus in African-Americans.

Cancer Epidemiol Biomarkers Prev 2012 Apr 10;21(4):658-63. Epub 2012 Feb 10.

Division of Human Genetics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-11-0830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319325PMC
April 2012

Genetics and genomics of neuroblastoma.

Cancer Treat Res 2010 ;155:65-84

CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy.

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http://link.springer.com/10.1007/978-1-4419-6033-7_4
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http://dx.doi.org/10.1007/978-1-4419-6033-7_4DOI Listing
September 2010

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy.

Genome Res 2009 Feb 13;19(2):276-83. Epub 2009 Jan 13.

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1101/gr.075671.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652209PMC
February 2009

Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms.

Nucleic Acids Res 2008 Nov 10;36(19):e126. Epub 2008 Sep 10.

Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/nar/gkn556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577347PMC
November 2008

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.

Mol Cancer Res 2008 May;6(5):735-42

Division of Oncology, Children's Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760152PMC
May 2008

Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.

Genes Chromosomes Cancer 2007 Oct;46(10):936-49

Division of Oncology, Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1002/gcc.20477
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http://dx.doi.org/10.1002/gcc.20477DOI Listing
October 2007

Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays.

PLoS Genet 2007 Aug;3(8):e143

Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0030143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950957PMC
August 2007

The Plasmodium genome database.

Nature 2002 Oct;419(6906):490-2

Department of Biology and Genetics, Center for Bioinformatics and Genomics Institute, University of Pennsylvania, Philadelphia, 19104-6018, USA.

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http://dx.doi.org/10.1038/419490aDOI Listing
October 2002