Sharon Glynn

The Role of Nitric Oxide in Cancer: Master Regulator or NOt?

Authors:

Faizan H Khan Eoin Dervan Dibyangana D Bhattacharyya Jake D McAuliffe Katrina M Miranda Sharon A Glynn

Int J Mol Sci 2020 Dec 10;21(24). Epub 2020 Dec 10.

Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway (NUIG), H91 YR71 Galway, Ireland.

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December 2020

The role of extracellular matrix in tumour angiogenesis: the throne has NOx servants.

Authors:

Amir M Alsharabasy Sharon A Glynn Abhay Pandit

Biochem Soc Trans 2020 Nov 5. Epub 2020 Nov 5.

CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland, Galway, Ireland.

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November 2020

Diabetes Mellitus and Gender Have a Negative Impact on the Outcome of Hip Fracture Surgery-A Pilot Study.

Authors:

Adam S Galbraith Clara Sanz-Nogués Sharon Glynn Cynthia M Coleman Colin Murphy

J Orthop Res 2020 04 14;38(4):834-842. Epub 2019 Nov 14.

Department of Trauma & Orthopaedics, Galway University Hospital, Newcastle Road, Galway, Ireland.

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April 2020

Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy.

Authors:

Elaine M Walsh Aliaa Shalaby Mark O'Loughlin Nessa Keane Mark J Webber Michael J Kerin Maccon M Keane Sharon A Glynn Grace M Callagy

Breast Cancer Res Treat 2019 Feb 28;174(1):1-13. Epub 2018 Nov 28.

Discipline of Pathology, Lambe Institute for Translational Research, NUI Galway, Costello Road, Galway, Ireland.

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February 2019

Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study.

Breast Cancer Res Treat 2018 Aug 17;171(1):1-9. Epub 2018 May 17.

Discipline of Pathology, National University of Ireland, Galway, Ireland.

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August 2018

Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration.

Authors:

Sarah M Ridge Dibyangana Bhattacharyya Eoin Dervan Serika D Naicker Amy J Burke J M Murphy Karen O'leary John Greene Aideen E Ryan Francis J Sullivan Sharon A Glynn

Int J Cancer 2018 05 4;142(10):2056-2067. Epub 2018 Jan 4.

Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.

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May 2018

Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways.

Authors:

Pablo Garrido Aliaa Shalaby Elaine M Walsh Nessa Keane Mark Webber Maccon M Keane Francis J Sullivan Michael J Kerin Grace Callagy Aideen E Ryan Sharon A Glynn

Oncotarget 2017 Oct 26;8(46):80568-80588. Epub 2017 Jul 26.

Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Republic of Ireland.

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October 2017

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.

Authors:

Debashree Basudhar Sharon A Glynn Madison Greer Veena Somasundaram Jae Hong No David A Scheiblin Pablo Garrido William F Heinz Aideen E Ryan Jonathan M Weiss Robert Y S Cheng Lisa A Ridnour Stephen J Lockett Daniel W McVicar Stefan Ambs David A Wink

Proc Natl Acad Sci U S A 2017 12 27;114(49):13030-13035. Epub 2017 Oct 27.

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702;

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December 2017

Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.

Authors:

Amy J Burke Pablo Garrido Carol Johnson Francis J Sullivan Sharon A Glynn

Antioxid Redox Signal 2017 06 22;26(18):1078-1090. Epub 2017 Mar 22.

1 Prostate Cancer Institute, School of Medicine, National University of Ireland Galway , Galway, Ireland .

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June 2017

Mesenchymal stem cells: key players in cancer progression.

Authors:

Sarah M Ridge Francis J Sullivan Sharon A Glynn

Mol Cancer 2017 02 1;16(1):31. Epub 2017 Feb 1.

Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, Costello Road, Galway, Ireland.

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February 2017

Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression.

Authors:

Debashree Basudhar Veena Somasundaram Graciele Almeida de Oliveira Aparna Kesarwala Julie L Heinecke Robert Y Cheng Sharon A Glynn Stefan Ambs David A Wink Lisa A Ridnour

Antioxid Redox Signal 2017 06 7;26(18):1044-1058. Epub 2016 Sep 7.

1 Cancer and Inflammation Program, National Cancer Institute-Frederick , Frederick, Maryland.

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June 2017

Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel.

Authors:

Amy J Burke Husnain Ali Enda O'Connell Francis J Sullivan Sharon A Glynn

Anticancer Res 2016 Feb;36(2):633-41

Prostate Cancer Institute, National University of Ireland Galway, Galway, Ireland Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland Apoptosis Research Centre, National University of Ireland Galway, Galway, Ireland

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February 2016

An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers.

Cancer Res 2016 Mar 30;76(5):1055-1065. Epub 2015 Dec 30.

Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

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March 2016

Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes.

Authors:

Elaine M Walsh Maccon M Keane David A Wink Grace Callagy Sharon A Glynn

Crit Rev Oncog 2016 ;21(5-6):333-351

Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.

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January 2016

The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer.

Authors:

David A Wink Lisa A Ridnour Robert Cheng Christopher W Switzer Sharon Glynn Stefan Ambs

Redox Biol 2015 08 30;5:413. Epub 2015 Dec 30.

LHC, CCR, NCI, Bethesda MD, USA.

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August 2015

Signaling and stress: The redox landscape in NOS2 biology.

Authors:

Douglas D Thomas Julie L Heinecke Lisa A Ridnour Robert Y Cheng Aparna H Kesarwala Christopher H Switzer Daniel W McVicar David D Roberts Sharon Glynn Jon M Fukuto David A Wink Katrina M Miranda

Free Radic Biol Med 2015 Oct 24;87:204-25. Epub 2015 Jun 24.

Department of Chemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA. Electronic address:

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October 2015

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy.

Authors:

Shane Deegan Izabela Koryga Sharon A Glynn Sanjeev Gupta Adrienne M Gorman Afshin Samali

Biochem Biophys Res Commun 2015 Jan 2;456(1):305-11. Epub 2014 Dec 2.

Apoptosis Research Centre, National University of Ireland Galway, Ireland; School of Natural Sciences, National University of Ireland Galway, Ireland. Electronic address:

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January 2015

Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.

Authors:

Robert Y S Cheng Debashree Basudhar Lisa A Ridnour Julie L Heinecke Aparna H Kesarwala Sharon Glynn Christopher H Switzer Stefan Ambs Katrina M Miranda David A Wink

Nitric Oxide 2014 Dec 19;43:17-28. Epub 2014 Aug 19.

Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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December 2014

Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

Authors:

Ronan F Downey Francis J Sullivan Feng Wang-Johanning Stefan Ambs Francis J Giles Sharon A Glynn

Int J Cancer 2015 Sep 17;137(6):1249-57. Epub 2014 Jun 17.

Prostate Cancer Institute, National University of Ireland Galway, Galway, Ireland.

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September 2015

Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers.

Authors:

Tiffany A Wallace Ronan F Downey Caleb J Seufert Aaron Schetter Tiffany H Dorsey Carol A Johnson Radoslav Goldman Christopher A Loffredo Peisha Yan Francis J Sullivan Francis J Giles Feng Wang-Johanning Stefan Ambs Sharon A Glynn

Carcinogenesis 2014 Sep 23;35(9):2074-83. Epub 2014 May 23.

Prostate Cancer Institute, Biosciences Research Building, National University of Ireland Galway, Dangan, Corrib Village, Galway, Ireland,

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September 2014

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.

Authors:

Julie L Heinecke Lisa A Ridnour Robert Y S Cheng Christopher H Switzer Michael M Lizardo Chand Khanna Sharon A Glynn S Perwez Hussain Howard A Young Stefan Ambs David A Wink

Proc Natl Acad Sci U S A 2014 Apr 14;111(17):6323-8. Epub 2014 Apr 14.

Radiation Biology Branch, Tumor and Metastasis Biology Section, Pediatric Oncology Branch, and Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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April 2014

Development and progress of Ireland's biobank network: Ethical, legal, and social implications (ELSI), standardized documentation, sample and data release, and international perspective.

Biopreserv Biobank 2013 Feb;11(1):3-11

1 St. James's Hospital , Dublin, Ireland .

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February 2013

The yin and yang of nitric oxide in cancer progression.

Authors:

Amy J Burke Francis J Sullivan Francis J Giles Sharon A Glynn

Carcinogenesis 2013 Mar 25;34(3):503-12. Epub 2013 Jan 25.

Prostate Cancer Institute, National University of Ireland Galway, Dublin, Ireland.

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March 2013

Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.

Authors:

Lisa A Ridnour Robert Y S Cheng Christopher H Switzer Julie L Heinecke Stefan Ambs Sharon Glynn Howard A Young Giorgio Trinchieri David A Wink

Clin Cancer Res 2013 Mar 27;19(6):1340-6. Epub 2012 Dec 27.

Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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March 2013

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.

Authors:

Christopher H Switzer Robert Y-S Cheng Lisa A Ridnour Sharon A Glynn Stefan Ambs David A Wink

Breast Cancer Res 2012 Sep 12;14(5):R125. Epub 2012 Sep 12.

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September 2012

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation.

Authors:

Lisa A Ridnour Kimberly M Barasch Alisha N Windhausen Tiffany H Dorsey Michael M Lizardo Harris G Yfantis Dong H Lee Christopher H Switzer Robert Y S Cheng Julie L Heinecke Ernst Brueggemann Harry B Hines Chand Khanna Sharon A Glynn Stefan Ambs David A Wink

PLoS One 2012 5;7(9):e44081. Epub 2012 Sep 5.

Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America.

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February 2013

S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer.

Authors:

Christopher H Switzer Sharon A Glynn Robert Y-S Cheng Lisa A Ridnour Jeffrey E Green Stefan Ambs David A Wink

Mol Cancer Res 2012 Sep 9;10(9):1203-15. Epub 2012 Aug 9.

Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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September 2012

Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer.

Authors:

Jing Zhao Kiera Rycaj Shanshan Geng Ming Li Joshua B Plummer Bingnan Yin Hong Liu Xu Xu Yinchun Zhang Yanfang Yan Sharon A Glynn Tiffany H Dorsey Stefan Ambs Gary L Johanning Lin Gu Feng Wang-Johanning

Genes Cancer 2011 Sep;2(9):914-22

Cancer Institute and Hospital of Tianjin Medical University, Tianjin, China.

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September 2011

Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Authors:

Christopher H Switzer Robert Y-S Cheng Lisa A Ridnour Margaret C Murray Valerio Tazzari Anna Sparatore Piero Del Soldato Harry B Hines Sharon A Glynn Stefan Ambs David A Wink

Cancer Res 2012 May 21;72(9):2394-404. Epub 2012 Mar 21.

Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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May 2012

Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors.

Authors:

Feng Wang-Johanning Kiera Rycaj Joshua B Plummer Ming Li Bingnan Yin Katherine Frerich Jeremy G Garza Jianjun Shen Kevin Lin Peisha Yan Sharon A Glynn Tiffany H Dorsey Kelly K Hunt Stefan Ambs Gary L Johanning

J Natl Cancer Inst 2012 Feb 12;104(3):189-210. Epub 2012 Jan 12.

Department of Veterinary Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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February 2012

S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer.

Authors:

Christopher H Switzer Lisa A Ridnour Robert Cheng Julie Heinecke Amy Burke Sharon Glynn Stefan Ambs David A Wink

For Immunopathol Dis Therap 2012 ;3(2):117-124

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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January 2012

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.

Authors:

Christopher H Switzer Sharon A Glynn Lisa A Ridnour Robert Y-S Cheng Michael P Vitek Stefan Ambs David A Wink

Trends Pharmacol Sci 2011 Nov 4;32(11):644-51. Epub 2011 Sep 4.

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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November 2011

Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer.

Authors:

Stefan Ambs Sharon A Glynn

Cell Cycle 2011 Feb 15;10(4):619-24. Epub 2011 Feb 15.

Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI); Bethesda, MD USA.

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February 2011

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

Authors:

Wilmarie Flores-Santana Debra J Salmon Sonia Donzelli Christopher H Switzer Debashree Basudhar Lisa Ridnour Robert Cheng Sharon A Glynn Nazareno Paolocci Jon M Fukuto Katrina M Miranda David A Wink

Antioxid Redox Signal 2011 May 16;14(9):1659-74. Epub 2011 Mar 16.

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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May 2011

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.

Authors:

Sharon A Glynn Robyn L Prueitt Lisa A Ridnour Brenda J Boersma Tiffany M Dorsey David A Wink Julie E Goodman Harris G Yfantis Dong H Lee Stefan Ambs

BMC Cancer 2010 Nov 15;10:626. Epub 2010 Nov 15.

Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, Maryland (MD), USA.

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November 2010

Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.

Authors:

Sharon A Glynn Brenda J Boersma Tiffany H Dorsey Ming Yi Harris G Yfantis Lisa A Ridnour Damali N Martin Christopher H Switzer Robert S Hudson David A Wink Dong H Lee Robert M Stephens Stefan Ambs

J Clin Invest 2010 Nov 18;120(11):3843-54. Epub 2010 Oct 18.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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November 2010

A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.

Authors:

Sharon A Glynn Brenda J Boersma Tiffany M Howe Hege Edvardsen Stephanie B Geisler Julie E Goodman Lisa A Ridnour Per E Lønning Anne-Lise Børresen-Dale Bjorn Naume Vessela N Kristensen Stephen J Chanock David A Wink Stefan Ambs

Clin Cancer Res 2009 Jun 9;15(12):4165-73. Epub 2009 Jun 9.

Laboratory of Human Carcinogenesis, Center for Cancer Research, Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA.

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June 2009