Sharon E Murphy

Sharon E Murphy

UNVERIFIED PROFILE

Are you Sharon E Murphy?   Register this Author

Register author
Sharon E Murphy

Sharon E Murphy

Publications by authors named "Sharon E Murphy"

Are you Sharon E Murphy?   Register this Author

100Publications

1699Reads

13Profile Views

Urinary cotinine is as good a biomarker as serum cotinine for cigarette smoking exposure and lung cancer risk prediction.

Cancer Epidemiol Biomarkers Prev 2019 Nov 4. Epub 2019 Nov 4.

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-0653DOI Listing
November 2019

Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers.

J Expo Sci Environ Epidemiol 2019 Aug 12. Epub 2019 Aug 12.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41370-019-0159-9DOI Listing
August 2019

Web-Delivered Multimedia Training Materials for the Self-Collection of Dried Blood Spots: A Formative Project.

JMIR Form Res 2018 Nov 5;2(2):e11025. Epub 2018 Nov 5.

Department of Epidemiology, School of Public Health, Boston University, Boston, MA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/11025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334672PMC
November 2018

In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.

Anal Chem 2018 10 4;90(20):11863-11872. Epub 2018 Oct 4.

Masonic Cancer Center , University of Minnesota , 2231 Sixth Street Southeast , Minneapolis , Minnesota 55455 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b01881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644709PMC
October 2018

Misclassification of self-reported smoking in adult survivors of childhood cancer.

Pediatr Blood Cancer 2018 09 1;65(9):e27240. Epub 2018 Jun 1.

Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105425PMC
September 2018

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers.

Chem Res Toxicol 2018 03 28;31(3):168-175. Epub 2018 Feb 28.

Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine , University of Southern California , Los Angeles , California 90089 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.7b00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058729PMC
March 2018

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.

PLoS One 2017 25;12(5):e0178435. Epub 2017 May 25.

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444837PMC
September 2017

Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.

Cancer Epidemiol Biomarkers Prev 2017 07 6;26(7):1093-1099. Epub 2017 Mar 6.

Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-16-0920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500430PMC
July 2017

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.

Addiction 2017 01 2;112(1):156-167. Epub 2016 Nov 2.

Duluth Medical Research Institute, University of Minnesota Medical School, Duluth, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/add.13603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249662PMC
January 2017

Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.

Authors:
Sharon E Murphy

Chem Res Toxicol 2017 01 22;30(1):410-419. Epub 2016 Nov 22.

Department of Biochemistry, Molecular Biology, and Biophysics and Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.6b00387DOI Listing
January 2017

Estimations and predictors of non-compliance in switchers to reduced nicotine content cigarettes.

Addiction 2016 12 1;111(12):2208-2216. Epub 2016 Aug 1.

University of California, San Francisco, Department of Medicine and Bioengineering and Therapeutic Sciences, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/add.13519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203964PMC
December 2016

Effects of Monoamine Oxidase Inhibition on the Reinforcing Properties of Low-Dose Nicotine.

Neuropsychopharmacology 2016 08 9;41(9):2335-43. Epub 2016 Mar 9.

Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/npp.2016.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946064PMC
August 2016

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Drug Metab Dispos 2016 Mar 7;44(3):422-7. Epub 2016 Jan 7.

Department of Medicinal Chemistry, College of Pharmacy (S.C.N., P.L., J.P., C.X.), Masonic Cancer Center (L.B.W., S.G.C., P.U., S.S.H., S.E.M.), and Department of Biochemistry, Molecular Biology and Biophysics (L.B.W., S.E.M.), University of Minnesota, Minneapolis, Minnesota

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.115.068387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767383PMC
March 2016

Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity.

Carcinogenesis 2016 Mar 27;37(3):269-279. Epub 2016 Jan 27.

Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, University of Minnesota , 2231 6th Street SE, 2-127 CCRB, Minneapolis, MN 55455 , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgw012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014092PMC
March 2016

Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry.

Chem Res Toxicol 2016 Mar 12;29(3):390-7. Epub 2016 Feb 12.

Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.5b00521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155587PMC
March 2016

Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.

PLoS One 2015 25;10(3):e0120023. Epub 2015 Mar 25.

Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373935PMC
February 2016

Benzene oxide is a substrate for glutathione S-transferases.

Chem Biol Interact 2015 Dec 7;242:390-5. Epub 2015 Nov 7.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Medicinal Chemistry Graduate Program, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695229PMC
December 2015

Randomized Trial of Reduced-Nicotine Standards for Cigarettes.

N Engl J Med 2015 Oct;373(14):1340-9

From the Departments of Psychology (E.C.D., R.L.D., S.S.D., T.L.) and Medicine (H.T.), University of Pittsburgh, Pittsburgh; the Center for Alcohol and Addiction Studies, Brown University, Providence, RI (J.W.T.); the Division of Biostatistics, School of Public Health (J.S.K., C.T.L.), the Departments of Biochemistry, Molecular Biology, and Biophysics (S.E.M.) and Psychiatry (D.K.H.) and the Masonic Cancer Center (J.S.K., S.G.C., S.S.H., J.J., C.T.L., S.E.M., D.K.H.), University of Minnesota, Minneapolis, and the University of Minnesota Medical School, Duluth (M.A.) - all in Minnesota; the Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco (N.L.B.); the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (R.G.V., M.L.S.), and National Institute on Drug Abuse, Bethesda (I.D.M.) - both in Maryland; the Department of Behavioral Science, University of Texas M.D. Anderson Cancer Center, Houston (P.M.C., J.D.R.); the Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL (D.J.D.); the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC (F.J.M.); and the Department of Psychiatry, Perelman School of Medicine, and Abramson Cancer Center, University of Pennsylvania, Philadelphia (A.A.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMsa1502403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642683PMC
October 2015

Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation.

Cancer Epidemiol Biomarkers Prev 2015 Aug 26;24(8):1239-46. Epub 2015 May 26.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-14-1381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526326PMC
August 2015

Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans.

Chem Res Toxicol 2015 Jul 7;28(7):1508-16. Epub 2015 Jul 7.

∥University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.5b00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473163PMC
July 2015

Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine.

Anal Chem 2015 Feb 14;87(3):1514-7. Epub 2015 Jan 14.

Masonic Cancer Center, University of Minnesota , 2231 6th Street SE, 2-148 CCRB, Minneapolis, Minnesota 55455, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac504047jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315695PMC
February 2015

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.

Cancer Epidemiol Biomarkers Prev 2015 Jan 7;24(1):119-27. Epub 2014 Oct 7.

Department of Biochemistry, Molecular Biology, and Biophysics and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-14-0815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294952PMC
January 2015

Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.

Carcinogenesis 2014 Nov 18;35(11):2526-33. Epub 2014 Sep 18.

Cancer Research Center of Hawai'i, University of Hawai'i, Honolulu, HI 96813, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgu191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216060PMC
November 2014

Prenatal tobacco exposure and cotinine in newborn dried blood spots.

Pediatrics 2014 Jun 12;133(6):e1632-8. Epub 2014 May 12.

Masonic Cancer Center, University of Minnesota, Minneapolis, MinnesotaMedicine, University of Minnesota, Minneapolis, Minnesota; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2013-3118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035592PMC
June 2014

Cotinine and trans 3'-hydroxycotinine in dried blood spots as biomarkers of tobacco exposure and nicotine metabolism.

J Expo Sci Environ Epidemiol 2013 Sep-Oct;23(5):513-8. Epub 2013 Feb 27.

Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jes.2013.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048618PMC
March 2014

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.

Pharmacogenet Genomics 2013 Dec;23(12):706-16

aDepartment of Psychiatry, Washington University School of Medicine, St Louis, Missouri bDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919513PMC
December 2013

The detection of biomarkers of tobacco smoke exposure in wound fluid: a pilot study.

Plast Reconstr Surg 2013 Nov;132(5):892e-894e

Department of Otolaryngology-Head and Neck Surgery Department of Biochemistry, Molecular Biology, and Biophysics, and Masonic Cancer Center Department of Otolaryngology-Head and Neck Surgery Masonic Cancer Center Department of Medicine University of Minnesota Minneapolis, Minn.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0b013e3182a4c642DOI Listing
November 2013

Dose-response effects of spectrum research cigarettes.

Nicotine Tob Res 2013 Jun 22;15(6):1113-21. Epub 2012 Nov 22.

Department of Psychiatry, University of Minnesota, Minneapolis, MN 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ntr/nts247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646652PMC
June 2013

Reduced nicotine content cigarettes and nicotine patch.

Cancer Epidemiol Biomarkers Prev 2013 Jun 19;22(6):1015-24. Epub 2013 Apr 19.

Tobacco Research, University of Minnesota, Minneapolis, MN 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-12-1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681886PMC
June 2013

A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele.

Pharmacogenet Genomics 2013 Mar;23(3):107-16

Department of Psychiatry bTissue Procurement Core, Laboratory for Translational Pathology, Washington University School of Medicine, St Louis, Missouri 63119, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32835caf7dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919506PMC
March 2013

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Pharmacogenet Genomics 2013 Feb;23(2):62-8

Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32835c3b48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583063PMC
February 2013

CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion.

J Pharmacol Exp Ther 2012 Nov 6;343(2):307-15. Epub 2012 Aug 6.

Department of Biochemistry, Molecular Biology, and Biophysics, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.112.195255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477218PMC
November 2012

Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol.

Chem Biol Interact 2012 May 1;197(2-3):87-92. Epub 2012 Apr 1.

Department of Biochemistry, Molecular Biology, and Biophysics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00092797120006
Publisher Site
http://dx.doi.org/10.1016/j.cbi.2012.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362486PMC
May 2012

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Cancer Prev Res (Phila) 2011 Nov 25;4(11):1752-60. Epub 2011 Oct 25.

Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-11-0366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357110PMC
November 2011

Common polymorphisms in FMO1 are associated with nicotine dependence.

Pharmacogenet Genomics 2011 Jul;21(7):397-402

Departments of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63119, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e328346886fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248052PMC
July 2011

Abstinence and relapse rates following a college campus-based quit & win contest.

J Am Coll Health 2010 Jan-Feb;58(4):365-72

Department of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07448480903380268DOI Listing
February 2011

Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study.

Cancer Epidemiol Biomarkers Prev 2011 Jan 10;20(1):91-100. Epub 2010 Nov 10.

University of Minnesota Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-10-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063713PMC
January 2011

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1423-31. Epub 2010 May 25.

Department of Biochemistry, Molecular Biology, and Biophysics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-09-0959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882998PMC
June 2010

Nicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype.

J Pharmacol Exp Ther 2010 Jan 28;332(1):202-9. Epub 2009 Sep 28.

Department of Biochemistry, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.15985
Publisher Site
http://dx.doi.org/10.1124/jpet.109.159855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802474PMC
January 2010

Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines.

Drug Metab Dispos 2009 Mar 12;37(3):665-71. Epub 2008 Dec 12.

Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota,Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.108.025072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680511PMC
March 2009

Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.

Cancer Epidemiol Biomarkers Prev 2008 Dec 24;17(12):3526-35. Epub 2008 Nov 24.

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-08-0424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599805PMC
December 2008

Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers.

Cancer Epidemiol Biomarkers Prev 2008 Dec;17(12):3337-43

University of Minnesota Transdisciplinary Tobacco Use Research Center, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-08-0307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547466PMC
December 2008

Stability of the nicotine metabolite ratio in ad libitum and reducing smokers.

Cancer Epidemiol Biomarkers Prev 2008 Jun;17(6):1396-400

University of Minnesota, Transdisciplinary Tobacco Use Research Center, 2701 University Avenue South East, Suite 201, Minneapolis, MN 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-08-0242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765478PMC
June 2008

CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

J Pharmacol Exp Ther 2007 Nov 1;323(2):570-8. Epub 2007 Aug 1.

Wadsworth Center, New York State Department of Health, and School of Public Health, State University at New York, Albany, New York 12201-0509, USA.

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.107.12706
Publisher Site
http://dx.doi.org/10.1124/jpet.107.127068DOI Listing
November 2007

Developing the science base for reducing tobacco harm.

Nicotine Tob Res 2007 Nov;9 Suppl 4:S537-53

University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/ntr/article-lookup/doi/10.1080/1462
Publisher Site
http://dx.doi.org/10.1080/14622200701679040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222243PMC
November 2007

Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Sep 29;857(1):1-8. Epub 2007 Jun 29.

University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2007.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234036PMC
September 2007

Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers.

Cancer Epidemiol Biomarkers Prev 2007 Aug;16(8):1567-72

Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, 420 Delaware Street Southeast, MMC 806, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-07-0227DOI Listing
August 2007

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke.

Cancer Epidemiol Biomarkers Prev 2006 May;15(5):988-92

The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-05-0596DOI Listing
May 2006

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism.

J Pharmacol Exp Ther 2006 Jan 27;316(1):295-303. Epub 2005 Sep 27.

The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street S.E., Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.105.091306DOI Listing
January 2006

Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6.

Drug Metab Dispos 2005 Dec 20;33(12):1760-4. Epub 2005 Sep 20.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis 55455, USA.

View Article

Download full-text PDF

Source
http://dmd.aspetjournals.org/content/early/2005/09/30/dmd.10
Web Search
http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.105.006718
Publisher Site
http://dx.doi.org/10.1124/dmd.105.006718DOI Listing
December 2005

Identification of N-(hydroxymethyl) norcotinine as a major product of cytochrome P450 2A6, but not cytochrome P450 2A13-catalyzed cotinine metabolism.

Chem Res Toxicol 2005 Dec;18(12):1792-8

The Cancer Center and the Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx0501381DOI Listing
December 2005

Relationships between cigarette consumption and biomarkers of tobacco toxin exposure.

Cancer Epidemiol Biomarkers Prev 2005 Dec;14(12):2963-8

Section of General Internal Medicine (111-0), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-04-0768DOI Listing
December 2005

Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymes.

Drug Metab Dispos 2005 Aug 28;33(8):1166-73. Epub 2005 Apr 28.

The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.105.004549DOI Listing
August 2005

Smokeless tobacco topography and toxin exposure.

Nicotine Tob Res 2005 Jun;7(3):469-74

Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis 55414, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14622200500135640DOI Listing
June 2005

Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes.

Cancer Epidemiol Biomarkers Prev 2005 Mar;14(3):693-8

Transdiciplinary Tobacco Use Research and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-04-0542DOI Listing
March 2005

Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

Chem Res Toxicol 2005 Feb;18(2):95-110

Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/tx049847p
Publisher Site
http://dx.doi.org/10.1021/tx049847pDOI Listing
February 2005

Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.

Chem Res Toxicol 2005 Jan;18(1):61-9

University of Minnesota, The Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx0497696DOI Listing
January 2005

A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers.

Cancer Epidemiol Biomarkers Prev 2004 Oct;13(10):1617-23

Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
October 2004

Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products.

J Natl Cancer Inst 2004 Jun;96(11):844-52

University of Minnesota Transdisciplinary Tobacco Use Research Center and Cancer Center, Minneapolis 55414, USA.

View Article

Download full-text PDF

Source
http://www.ihra.net/files/2011/07/13/Hatsukami_-_Carcinogen_
Web Search
http://dx.doi.org/10.1093/jnci/djh163DOI Listing
June 2004

Effects of reduced cigarette smoking on levels of 1-hydroxypyrene in urine.

Cancer Epidemiol Biomarkers Prev 2004 May;13(5):834-42

Transdisciplinary Tobacco Use Research Center and Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
May 2004

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.

J Natl Cancer Inst 2004 Jan;96(2):107-15

Transdisciplinary Tobacco Use Research Center and College of Pharmacy, University of Minnesota, Minneapolis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djh016DOI Listing
January 2004

Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats.

Cancer Lett 2003 Dec;202(1):1-9

College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2003.07.004DOI Listing
December 2003

N-glucuronidation of trans-3'-hydroxycotinine by human liver microsomes.

Chem Res Toxicol 2003 Dec;16(12):1502-6

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx034173oDOI Listing
December 2003

Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons.

Cancer Epidemiol Biomarkers Prev 2003 Dec;12(12):1544-6

Division of Epidemiology, Comprehensive Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA.

View Article

Download full-text PDF

Source
December 2003