Sharon C Cunningham

Sharon C Cunningham

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Sharon C Cunningham

Sharon C Cunningham

Publications by authors named "Sharon C Cunningham"

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19Publications

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Efficient editing of OTC-deficient patient-derived primary human hepatocytes.

JHEP Rep 2020 Feb 27;2(1):100065. Epub 2019 Dec 27.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

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http://dx.doi.org/10.1016/j.jhepr.2019.100065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005564PMC
February 2020

Prevention of Cholestatic Liver Disease and Reduced Tumorigenicity in a Murine Model of PFIC Type 3 Using Hybrid AAV-piggyBac Gene Therapy.

Hepatology 2019 Dec 26;70(6):2047-2061. Epub 2019 Jun 26.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.

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http://dx.doi.org/10.1002/hep.30773DOI Listing
December 2019

Insights into Gene Therapy for Urea Cycle Defects by Mathematical Modeling.

Hum Gene Ther 2019 11 17;30(11):1385-1394. Epub 2019 Jul 17.

Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health and Sydney Children's Hospitals Network, The University of Sydney, Westmead, Australia.

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http://dx.doi.org/10.1089/hum.2019.053DOI Listing
November 2019

AAV-Mediated Gene Delivery to the Mouse Liver.

Methods Mol Biol 2019 ;1937:213-219

Gene Therapy Research Unit, Children's Medical Research Institute, The University of Sydney, Faculty of Medicine and Health and Sydney Children's Hospitals Network, Westmead, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-4939-9065-8_12DOI Listing
July 2019

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Nat Genet 2017 Aug 19;49(8):1267-1273. Epub 2017 Jun 19.

Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/ng.3893DOI Listing
August 2017

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice.

Mol Ther 2015 Sep 25;23(9):1434-43. Epub 2015 May 25.

Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1038/mt.2015.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817885PMC
September 2015

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.

Hepatology 2015 Aug 23;62(2):417-28. Epub 2015 May 23.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1002/hep.27842DOI Listing
August 2015

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Nature 2014 Feb 25;506(7488):382-6. Epub 2013 Dec 25.

Stanford University, School of Medicine, Departments of Pediatrics and Genetics, 269 Campus Drive, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature12875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939040PMC
February 2014

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice.

Mol Ther 2013 Oct 2;21(10):1823-31. Epub 2013 Jul 2.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Sydney, Australia.

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http://dx.doi.org/10.1038/mt.2013.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808136PMC
October 2013

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

J Inherit Metab Dis 2012 Jul 9;35(4):641-5. Epub 2012 Mar 9.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia.

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http://dx.doi.org/10.1007/s10545-012-9467-0DOI Listing
July 2012

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.

Mol Ther 2011 May 8;19(5):854-9. Epub 2011 Mar 8.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2011.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098641PMC
May 2011

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation.

Mol Ther 2009 Sep 30;17(9):1548-54. Epub 2009 Jun 30.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/mt.2009.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835267PMC
September 2009

AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.

Mol Ther 2009 Aug 21;17(8):1340-6. Epub 2009 Apr 21.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, New South Wales, Australia.

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http://www.nature.com/doifinder/10.1038/mt.2009.88
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http://dx.doi.org/10.1038/mt.2009.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835243PMC
August 2009

Gene delivery to the juvenile mouse liver using AAV2/8 vectors.

Mol Ther 2008 Jun 15;16(6):1081-8. Epub 2008 Apr 15.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, Westmead, Australia.

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http://dx.doi.org/10.1038/mt.2008.72DOI Listing
June 2008

Gene Delivery to the Juvenile Mouse Liver Using AAV2/8 Vectors.

Mol Ther 2008 Jun 8;16(6):1081-1088. Epub 2016 Dec 8.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Wentworthville, Westmead, Australia; Discipline of Paediatrics and Child Health, University of Sydney, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1038/mt.2008.72DOI Listing
June 2008

AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.

Vaccine 2007 Jan 9;25(6):1014-22. Epub 2006 Oct 9.

Gene Therapy Research Unit, Children's Medical Research Institute and The Children's Hospital at Westmead, Westmead, Australia.

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http://dx.doi.org/10.1016/j.vaccine.2006.09.072DOI Listing
January 2007

Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors.

Hum Gene Ther 2005 Aug;16(8):947-56

Gene Therapy Research Unit, The Children's Hospital at Westmead and Children's Medical Research Institute, Sydney, NSW, Australia.

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http://dx.doi.org/10.1089/hum.2005.16.947DOI Listing
August 2005