Shaoying Lu

Shaoying Lu

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Shaoying Lu

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Genetically Encoded FRET Biosensor for Visualizing EphA4 Activity in Different Compartments of the Plasma Membrane.

ACS Sens 2019 Feb 16;4(2):294-300. Epub 2019 Jan 16.

Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acssensors.8b00465DOI Listing
February 2019

Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Submembrane Localization.

ACS Sens 2019 01 9;4(1):76-86. Epub 2019 Jan 9.

Department of Bioengineering , University of California at San Diego , La Jolla , California 92093 , United States.

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http://pubs.acs.org/doi/10.1021/acssensors.8b00896
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http://dx.doi.org/10.1021/acssensors.8b00896DOI Listing
January 2019

Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface.

Cell Chem Biol 2018 04 27;25(4):370-379.e4. Epub 2018 Jan 27.

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910193PMC
April 2018

MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2.

PLoS One 2017 8;12(12):e0189490. Epub 2017 Dec 8.

Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722343PMC
January 2018

MicroRNA-1297 contributes to tumor growth of human breast cancer by targeting PTEN/PI3K/AKT signaling.

Oncol Rep 2017 Oct 7;38(4):2435-2443. Epub 2017 Aug 7.

Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

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https://www.spandidos-publications.com/10.3892/or.2017.5884
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http://dx.doi.org/10.3892/or.2017.5884DOI Listing
October 2017

Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.

Nat Commun 2017 09 7;8(1):477. Epub 2017 Sep 7.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

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http://dx.doi.org/10.1038/s41467-017-00569-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589908PMC
September 2017

A CD44-specific peptide, RP-1, exhibits capacities of assisting diagnosis and predicting prognosis of gastric cancer.

Oncotarget 2017 May;8(18):30063-30076

Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P.R.China.

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http://dx.doi.org/10.18632/oncotarget.16275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444726PMC
May 2017

In-situ coupling between kinase activities and protein dynamics within single focal adhesions.

Sci Rep 2016 07 7;6:29377. Epub 2016 Jul 7.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/srep29377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935953PMC
July 2016

Screening and Identification of a Phage Display Derived Peptide That Specifically Binds to the CD44 Protein Region Encoded by Variable Exons.

J Biomol Screen 2016 Jan 30;21(1):44-53. Epub 2015 Sep 30.

Department of Gastroenterology, the First Affiliated Hospital of Medical School, Xian Jiaotong University, Xi'an, China

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http://dx.doi.org/10.1177/1087057115608604DOI Listing
January 2016

Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.

Nano Lett 2015 Aug 27;15(8):5025-32. Epub 2015 Jul 27.

§Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acs.nanolett.5b01047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675668PMC
August 2015

Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment.

Sci Rep 2015 Aug 11;5:12963. Epub 2015 Aug 11.

1] Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [2] Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093-0435.

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http://dx.doi.org/10.1038/srep12963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531316PMC
August 2015

Prolonged mechanical stretch initiates intracellular calcium oscillations in human mesenchymal stem cells.

PLoS One 2014 20;9(10):e109378. Epub 2014 Oct 20.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Bioengineering and Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109378PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203723PMC
July 2015

Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.

Oncol Rep 2015 Jun 9;33(6):3038-44. Epub 2015 Apr 9.

The First People's Hospital of Xianyang City, Xianyang, Shaanxi 712000, P.R. China.

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http://dx.doi.org/10.3892/or.2015.3908DOI Listing
June 2015

Single-cell imaging of mechanotransduction in endothelial cells.

Prog Mol Biol Transl Sci 2014 ;126:25-51

Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-394624-9.00002-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665391PMC
April 2015

3D traction stresses activate protease-dependent invasion of cancer cells.

Biophys J 2014 Dec 2;107(11):2528-37. Epub 2014 Dec 2.

Department of Bioengineering, University of California-San Diego, La Jolla, California; Institute of Engineering in Medicine, University of California-San Diego, La Jolla, California; IFOM-inStem Joint Research Laboratory, Bangalore, India. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255420PMC
December 2014

RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.

Sci Rep 2014 Nov 12;4:7008. Epub 2014 Nov 12.

1] Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [2] Department of Integrative and Molecular Physiology, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [3] Department of Bioengineering, University of California at San Diego, CA 92093, USA.

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http://dx.doi.org/10.1038/srep07008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228346PMC
November 2014

The regulation of β-adrenergic receptor-mediated PKA activation by substrate stiffness via microtubule dynamics in human MSCs.

Biomaterials 2014 Sep 24;35(29):8348-8356. Epub 2014 Jun 24.

Neuroscience Program, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2014.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144871PMC
September 2014

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells.

Sci Rep 2014 Aug 12;4:6024. Epub 2014 Aug 12.

1] Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA [2] Institute of Engineering in Medicine University of California, San Diego, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/srep06024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129417PMC
August 2014

Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells.

Sci Rep 2014 Jul 24;4:5756. Epub 2014 Jul 24.

1] Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093-0435 [2] Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [3] Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [4] Center of Biophysics and Computational Biology, Beckman Institute for Advanced Science and Technology, Department of Molecular and Integrative Physiology and, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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http://www.nature.com/articles/srep05756
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http://dx.doi.org/10.1038/srep05756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108961PMC
July 2014

The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET.

PLoS One 2013 27;8(8):e72233. Epub 2013 Aug 27.

Biomaterials and Live Cell Imaging Institute, Chongqing University of Science and technology, Chongqing, People's Republic of China ; Beckman Institute for Advanced Science and Technology, Center for Biophysics and Computational Biology, Department of Integrative and Molecular Physiology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754985PMC
May 2014

Genetically encoded fluorescent biosensors for live-cell imaging of MT1-MMP protease activity.

Methods Mol Biol 2014 ;1071:163-74

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

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http://dx.doi.org/10.1007/978-1-62703-622-1_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550515PMC
April 2014

The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation.

Biomaterials 2014 Mar 4;35(9):2868-77. Epub 2014 Jan 4.

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, United States; Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925146PMC
March 2014

Screening and identification of a specific peptide binding to hepatocellular carcinoma cells from a phage display peptide library.

J Pept Sci 2014 Mar 30;20(3):196-202. Epub 2014 Jan 30.

Department of Cell Biology, College of Life Sciences, Shaanxi Normal University, 199 South Chang'an Road, Xi'an, 710062, China.

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http://dx.doi.org/10.1002/psc.2599DOI Listing
March 2014

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

Nat Commun 2013 ;4:2037

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1038/ncomms3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412PMC
December 2013

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

Proc Natl Acad Sci U S A 2013 Nov 12;110(48):19372-7. Epub 2013 Nov 12.

Neuroscience Program, Department of Mechanical Science and Engineering, and Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.

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http://dx.doi.org/10.1073/pnas.1307405110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845171PMC
November 2013

Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.

PLoS One 2013 13;8(3):e58569. Epub 2013 Mar 13.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058569PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596289PMC
September 2013

The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions.

Biomaterials 2013 May 7;34(15):3807-15. Epub 2013 Mar 7.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2013.01.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602290PMC
May 2013

Visualization of Src and FAK activity during the differentiation process from HMSCs to osteoblasts.

PLoS One 2012 10;7(8):e42709. Epub 2012 Aug 10.

Biomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials Engineering, Chongqing University of Science and technology, Chongqing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416797PMC
March 2013

FRET imaging of calcium signaling in live cells in the microenvironment.

Integr Biol (Camb) 2013 Feb;5(2):431-8

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1039/c2ib20264fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165894PMC
February 2013

Cadherin point mutations alter cell sorting and modulate GTPase signaling.

J Cell Sci 2012 Jul 14;125(Pt 14):3299-309. Epub 2012 Apr 14.

Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1242/jcs.087395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516376PMC
July 2012

Computational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cells.

PLoS One 2011 27;6(6):e21293. Epub 2011 Jun 27.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124492PMC
December 2011

Bone Physiology, Biomaterial and the Effect of Mechanical/Physical Microenvironment on MSC Osteogenesis: A Tribute to Shu Chien's 80th Birthday.

Cell Mol Bioeng 2011 Dec;4(4):579-590

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801 ; Center for Biophysics and Computational Biology, Department of Integrative and Molecular Physiology, Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL 61801.

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http://dx.doi.org/10.1007/s12195-011-0204-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288028PMC
December 2011

Two distinct phases of calcium signalling under flow.

Cardiovasc Res 2011 Jul 1;91(1):124-33. Epub 2011 Feb 1.

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1093/cvr/cvr033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112016PMC
July 2011

Live Cell Imaging of Src/FAK Signaling by FRET.

Cell Mol Bioeng 2011 Jun;2(4):138-147

Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s12195-011-0161-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157646PMC
June 2011

Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy.

Clin Cancer Res 2010 Aug;16(15):3822-4

Department of Bioengineering & Beckman Institute for Advanced Science and Technology, Neuroscience Program, Center of Biophysics and Computational Biology, Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 405 N. Mathews Avenue, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913312PMC
August 2010

Hypoxia-inducible factor-1alpha modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer.

Oncol Rep 2010 Jul;24(1):97-104

Department of General Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, PR China.

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July 2010

Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases.

Cell Mol Bioeng 2009 Sep;2(3):341-350

Department of Bioengineering and The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1007/s12195-009-0069-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790296PMC
September 2009

In vivo cancer biomarkers of esophageal neoplasia.

Cancer Biomark 2008 ;4(6):341-50

Department of General Surgery, First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an Shaanxi, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226753PMC
March 2009

Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells.

J Cell Physiol 2009 Feb;218(2):285-93

Neuroscience Program, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1002/jcp.21598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592496PMC
February 2009

Differential RhoA dynamics in migratory and stationary cells measured by FRET and automated image analysis.

PLoS One 2008 30;3(12):e4082. Epub 2008 Dec 30.

Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603592PMC
February 2009

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

Chem Biol 2009 Jan;16(1):48-57

Neuroscience Program, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647969PMC
January 2009

The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging.

PLoS Comput Biol 2008 Jul 25;4(7):e1000127. Epub 2008 Jul 25.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517613PMC
July 2008

Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.

J Biol Chem 2008 Jun 25;283(25):17740-8. Epub 2008 Apr 25.

Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M709872200
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http://dx.doi.org/10.1074/jbc.M709872200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427332PMC
June 2008