Shaorui Chen

Shaorui Chen

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Shaorui Chen

Publications by authors named "Shaorui Chen"

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Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways.

Pharmacol Res 2019 Jun 7;147:104307. Epub 2019 Jun 7.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104307DOI Listing
June 2019

Poly(ADP-ribose) polymerase 1 induces cardiac fibrosis by mediating mammalian target of rapamycin activity.

J Cell Biochem 2019 Apr 11;120(4):4813-4826. Epub 2019 Jan 11.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/jcb.26649DOI Listing
April 2019

Crystallinity-dependent capacity of a LiBC anode material in Li-ion batteries.

Phys Chem Chem Phys 2018 Nov;20(44):28176-28184

State Key Laboratory on Marine Resource Utilization in South China Sea, Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources, College of Materials Science and Chemical Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China.

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http://dx.doi.org/10.1039/c8cp05561kDOI Listing
November 2018

Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors.

Mol Neurobiol 2018 Jun 3;55(6):5393-5407. Epub 2017 Oct 3.

Department of Anesthesiology (XZ, YZ), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China.

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http://dx.doi.org/10.1007/s12035-017-0780-3DOI Listing
June 2018

SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.

Mol Cell Endocrinol 2018 01 1;460:1-13. Epub 2017 Jun 1.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China; National and Local Joint Engineering Laboratory of Druggabilitiy Assessment and Evaluation, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03037207173030
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http://dx.doi.org/10.1016/j.mce.2017.04.027DOI Listing
January 2018

Calcium Signal Pathway is Involved in Prostaglandin E2 Induced Cardiac Fibrosis in Cardiac Fibroblasts.

J Pharm Pharm Sci 2018 ;21(1):326-339

Department of Pharmacy, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, People's Republic of China. Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China.

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http://dx.doi.org/10.18433/jpps29322DOI Listing
January 2018

Receptor-interacting protein 140 overexpression impairs cardiac mitochondrial function and accelerates the transition to heart failure in chronically infarcted rats.

Transl Res 2017 02 31;180:91-102.e1. Epub 2016 Aug 31.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; National and Local United Engineering Laboratory of Druggability and New Drug Evaluation, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2016.08.005DOI Listing
February 2017

Store-Operated Ca Entry (SOCE) contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts.

J Pharmacol Sci 2016 Nov 30;132(3):171-180. Epub 2016 May 30.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, Guangdong, China; National and Local Joint Engineering Laboratory of Druggabilitiy Assessment and Evaluation, Sun Yat-sen University, Guangzhou 510006, Guangdong, China; Guangdong Provincial Engineering Laboratory of Druggability and New Drugs Evaluation, China; Guangzhou Key Laboratory of Druggability Assessment for Biologically Active Compounds, China. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2016.05.008DOI Listing
November 2016

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.

Exp Cell Res 2016 10 14;347(2):261-73. Epub 2016 Jul 14.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China; National and Local Joint Engineering Laboratory of Druggability Assessment and Evaluation, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.07.006DOI Listing
October 2016

Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis.

J Cell Mol Med 2016 07 17;20(7):1381-91. Epub 2016 Mar 17.

Department of Clinical Pharmacy, GuangDong Pharmaceutical University, Guangzhou, China.

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http://dx.doi.org/10.1111/jcmm.12828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929297PMC
July 2016

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.

Transl Res 2016 06 10;172:96-112.e6. Epub 2016 Mar 10.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2016.03.002DOI Listing
June 2016

Autophagy activation attenuates angiotensin II-induced cardiac fibrosis.

Arch Biochem Biophys 2016 Jan 10;590:37-47. Epub 2015 Nov 10.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.11.001DOI Listing
January 2016

Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).

Br J Pharmacol 2015 Dec 27;172(23):5661-75. Epub 2015 Feb 27.

Department of Pharmacology and Toxicology, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of Construction Foundation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1111/bph.13068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667869PMC
December 2015

Advanced glycation end products induced immune maturation of dendritic cells controls heart failure through NF-κB signaling pathway.

Arch Biochem Biophys 2015 Aug 8;580:112-20. Epub 2015 Jul 8.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Engineering Laboratory of Guangdong Province for Druggability and New Drug Evaluation, China. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.07.003DOI Listing
August 2015

Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.

J Cell Mol Med 2015 Jul 8;19(7):1672-88. Epub 2015 Mar 8.

Department of Clinical Pharmacy, GuangDong Pharmaceutical University, Guangzhou, China.

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http://doi.wiley.com/10.1111/jcmm.12541
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http://dx.doi.org/10.1111/jcmm.12541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511364PMC
July 2015

Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.

Life Sci 2015 Mar 28;124:41-9. Epub 2015 Jan 28.

Department of Clinical Pharmacy, GuangDong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.01.015DOI Listing
March 2015

SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg(2+) efflux and Ca(2+) signaling in cardiac fibroblasts.

Arch Biochem Biophys 2014 Dec 27;564:74-82. Epub 2014 Sep 27.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China; National and Local Joint Engineering Laboratory of Druggabilitiy Assessment and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2014.09.013DOI Listing
December 2014

Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4.

J Cardiovasc Pharmacol 2014 Jul;64(1):28-37

*Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; and †Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/FJC.0000000000000086DOI Listing
July 2014

Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinone IIA from Danshen in a mouse model of atherosclerosis.

Int J Cardiol 2014 Jul 26;174(3):878-80. Epub 2014 Apr 26.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University (Higher Education Mega Center), 132 E. Wai-huan Rd., Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2014.04.226DOI Listing
July 2014

The p65 subunit of NF-κB involves in RIP140-mediated inflammatory and metabolic dysregulation in cardiomyocytes.

Arch Biochem Biophys 2014 Jul 10;554:22-7. Epub 2014 May 10.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00039861140015
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http://dx.doi.org/10.1016/j.abb.2014.05.005DOI Listing
July 2014

C/EBPβ knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NFκB.

Mol Cell Endocrinol 2014 Jun 2;390(1-2):18-25. Epub 2014 Apr 2.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.03.007DOI Listing
June 2014

TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx.

Cell Calcium 2014 May 11;55(5):252-60. Epub 2014 Mar 11.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2014.02.019DOI Listing
May 2014

BIG1, a brefeldin A-inhibited guanine nucleotide-exchange factor, is required for GABA-gated Cl⁻ influx through regulation of GABAA receptor trafficking.

Mol Neurobiol 2014 Apr 3;49(2):808-19. Epub 2013 Oct 3.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132, Waihuan East Road, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.

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http://dx.doi.org/10.1007/s12035-013-8558-8DOI Listing
April 2014

Inhibitory effect of ethyl acetate extract of Aristolochia yunnanensis on cardiac fibrosis through extracellular signal-regulated kinases 1/2 and transforming growth factor β/small mother against decapentaplegic signaling pathways.

Transl Res 2014 Feb 4;163(2):160-70. Epub 2013 Oct 4.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2013.09.013DOI Listing
February 2014

COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3.

Mol Cell Endocrinol 2014 Feb 26;382(2):998-1006. Epub 2013 Nov 26.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Higher Education Mega Center, Guangzhou 510006, Guangdong, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.11.012DOI Listing
February 2014

Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1.

Biochem Biophys Res Commun 2014 Feb 22;444(3):346-53. Epub 2014 Jan 22.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.01.045DOI Listing
February 2014

The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells.

Psychopharmacology (Berl) 2013 Jul 15;228(1):129-41. Epub 2013 Mar 15.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

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http://link.springer.com/content/pdf/10.1007/s00213-013-3017
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http://link.springer.com/10.1007/s00213-013-3017-9
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http://dx.doi.org/10.1007/s00213-013-3017-9DOI Listing
July 2013

Nifedipine inhibits angiotensin II-induced cardiac fibrosis via downregulating Nox4-derived ROS generation and suppressing ERK1/2, JNK signaling pathways.

Pharmazie 2013 Jun;68(6):435-41

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

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June 2013

BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function.

Arterioscler Thromb Vasc Biol 2013 Feb 6;33(2):e31-8. Epub 2012 Dec 6.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132, East Wai-Huan Rd, College Town, Guangzhou 510006, PR China.

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http://dx.doi.org/10.1161/ATVBAHA.112.300720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578215PMC
February 2013

Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes.

Mol Cell Endocrinol 2012 Oct 5;362(1-2):11-8. Epub 2012 Apr 5.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1016/j.mce.2012.03.023DOI Listing
October 2012

Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress.

Eur J Pharmacol 2012 Jan 9;674(2-3):359-64. Epub 2011 Nov 9.

Department of Pharmacy, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

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http://dx.doi.org/10.1016/j.ejphar.2011.10.040DOI Listing
January 2012

Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake.

Cytotechnology 2010 Oct 16;62(5):473-81. Epub 2010 Nov 16.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University (Higher Education Mega Center), 132 East Wai-huan Road, 510006, Guangzhou, People's Republic of China.

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http://link.springer.com/10.1007/s10616-010-9290-0
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http://dx.doi.org/10.1007/s10616-010-9290-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993859PMC
October 2010

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Neurosci Lett 2009 Mar 13;452(2):90-5. Epub 2009 Jan 13.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.

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http://dx.doi.org/10.1016/j.neulet.2009.01.013DOI Listing
March 2009

Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway.

Exp Brain Res 2009 Feb 21;193(1):109-18. Epub 2008 Oct 21.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.

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http://link.springer.com/content/pdf/10.1007/s00221-008-1600
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http://link.springer.com/10.1007/s00221-008-1600-9
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http://dx.doi.org/10.1007/s00221-008-1600-9DOI Listing
February 2009

Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway.

Mol Cell Biochem 2008 Oct 4;317(1-2):189-96. Epub 2008 Jul 4.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, 74 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

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http://dx.doi.org/10.1007/s11010-008-9848-8DOI Listing
October 2008

Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.

Transl Res 2008 Feb 28;151(2):79-87. Epub 2007 Dec 28.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1016/j.trsl.2007.11.005DOI Listing
February 2008

Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.

Vascul Pharmacol 2007 Jun 23;46(6):427-38. Epub 2007 Jan 23.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, PR China.

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http://dx.doi.org/10.1016/j.vph.2007.01.001DOI Listing
June 2007

Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.

Pharmacol Res 2007 May 2;55(5):408-17. Epub 2007 Feb 2.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, People's Republic of China.

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http://dx.doi.org/10.1016/j.phrs.2007.01.016DOI Listing
May 2007

PPARbeta/delta activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts.

Arch Biochem Biophys 2007 Apr 16;460(1):25-32. Epub 2007 Feb 16.

Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, PR China.

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http://dx.doi.org/10.1016/j.abb.2007.01.028DOI Listing
April 2007