Shane Atwell

Shane Atwell

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Shane Atwell

Shane Atwell

Publications by authors named "Shane Atwell"

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27Publications

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Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.

J Chem Theory Comput 2018 May 3;14(5):2721-2732. Epub 2018 Apr 3.

Department of Biochemistry and Molecular Biology , University of Chicago , Chicago , Illinois 60637 , United States.

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http://dx.doi.org/10.1021/acs.jctc.7b01170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317529PMC
May 2018

Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.

Bioorg Med Chem Lett 2018 02 31;28(4):612-617. Epub 2018 Jan 31.

Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.01.037DOI Listing
February 2018

Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody.

Protein Sci 2016 11 9;25(11):2028-2036. Epub 2016 Sep 9.

Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285.

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http://doi.wiley.com/10.1002/pro.3023
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http://dx.doi.org/10.1002/pro.3023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079263PMC
November 2016

Computationally Designed Bispecific Antibodies using Negative State Repertoires.

Structure 2016 Apr 17;24(4):641-651. Epub 2016 Mar 17.

Department of Biochemistry, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Campus Box 7260, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27514, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866497PMC
April 2016

Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure.

Mol Pharm 2016 Mar 18;13(3):915-23. Epub 2016 Feb 18.

Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00817DOI Listing
March 2016

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1.

Protein Sci 2010 Oct;19(10):1917-31

Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294-4400, USA.

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http://dx.doi.org/10.1002/pro.479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998726PMC
October 2010

Protein production and purification.

Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases.

Angew Chem Int Ed Engl 2003 Dec;42(48):5971-3

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/anie.200352117DOI Listing
December 2003