Publications by authors named "Shan-Shan Yao"

18 Publications

  • Page 1 of 1

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

Cell Rep 2021 Jun;35(12):109281

Shanghai Key Laboratory of Metabolic Remodeling and Disease, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, and Shanghai Qi Zhi Institute, Shanghai, China; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. Electronic address:

Obesity has become a global pandemic. Identification of key factors in adipogenesis helps to tackle obesity and related metabolic diseases. Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced obesity. Although typically recognized as a component of the CUL4-RING E3 ubiquitin ligase complex, DDB1 stimulates adipogenesis independently of CUL4. A DDB1 mutant that does not bind CUL4A or CUL4B fully restores adipogenesis in DDB1-deficient cells. Ddb1 mice show delayed postnatal development of white adipose tissues and are protected from diet-induced obesity. Mechanistically, by interacting with BRWD3, DDB1 is recruited to acetylated histones in the proximal promoters of ELK1 downstream immediate early response genes and facilitates the release of paused RNA polymerase II, thereby activating the transcriptional cascade in adipogenesis. Our findings have uncovered a CUL4-independent function of DDB1 in promoting the transcriptional cascade of adipogenesis, development of adipose tissues, and onset of obesity.
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http://dx.doi.org/10.1016/j.celrep.2021.109281DOI Listing
June 2021

A cross-sectional seroepidemiology study of seven major enteroviruses causing HFMD in Guangdong, China.

J Infect 2021 Jul 16;83(1):119-145. Epub 2021 Apr 16.

National Institutes for Food and Drug Control, No.31, Huatuo Street, Beijing, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2021.04.011DOI Listing
July 2021

Effect of water-soluble thiourea formaldehyde (WTF) on soil contaminated with high copper (Ⅱ) concentration.

J Hazard Mater 2021 05 7;409:124929. Epub 2021 Jan 7.

Tianjin TEDA Greening Group Co., Ltd., China.

It is very important to seek a heavy metal soil stabilization/solidification (S/S) agent that has less risk of secondary release and has less impact on the soil. This study explored the repair effect of a new resin repair agent water-soluble thiourea-formaldehyde (WTF), and its stability under indigenous biodegradation and compared the repair effect with sodium sulfide (NaS) and hydroxyapatite (HAP). Diethylene triamine pentaacetic acid leaching experiments show that WTF can effectively solidify/stabilize 97.9-84.7% of Cu. At the same time, heavy metal speciation analysis experiments show that WTF does indeed convert the exchangeable Cu in the soil into a non-exchangeable form. Research on soil organic matter, biological carbon and enzyme activity after remediation shows that WTF has a more positive effect on soil function, compared with HAP and NaS. Experiments using indigenous microorganisms to decompose the precipitation formed by WTF and Cu show that under the condition of less impact on soil microorganisms, the risk of secondary release of heavy metals caused by soil microorganisms after WTF remediation is less. These findings provide valuable experience for understanding the role of resin structure in preventing the secondary release of heavy metals and restoring soil function.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124929DOI Listing
May 2021

Vision impairment, vision correction, and cognitive decline among middle-aged and older Chinese: results from the China health and retirement longitudinal study.

Aging Ment Health 2020 Oct 16:1-8. Epub 2020 Oct 16.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objectives: To investigate the associations between vision impairment (VI), vision correction (VC), and cognitive function.

Method: We included 20,677 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (2011-2015). Participants were grouped into no VI, distance VI (DVI) only, near VI (NVI) only, or both distance and near VI (DNVI), and VI(+)/VC(-), VI(+)/VC(+), VI(-)/VC(-), or VI(-)/VC(+) further at baseline. Cognitive function at baseline and subsequently every two years was applied as a dependent variable in a generalized estimating equation model.

Results: DVI only, NVI only, and DNVI had significantly worse cognitive function over time than no VI (all  < .05). DNVI had significantly worse cognitive function over time than DVI only and NVI only (all  < .001). VI(+)/VC(+), VI(-)/VC(-), and VI(-)/VC(+) had significantly better cognitive function over time than VI(+)/VC(-) (all  < .05). VI(-)/VC(+) had significantly better cognitive function over time than VI(+)/VC(+) and VI(-)/VC(-) (all  < .05).

Conclusion: Cognitive function was worse in middle-aged and older Chinese with VI, especially in those with DNVI. VC was associated with better cognitive function over time regardless of the status of vision.
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http://dx.doi.org/10.1080/13607863.2020.1828271DOI Listing
October 2020

Self-reported vision impairment, vision correction, and depressive symptoms among middle-aged and older Chinese: Findings from the China health and retirement longitudinal study.

Int J Geriatr Psychiatry 2021 01 13;36(1):86-95. Epub 2020 Oct 13.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objective: To investigate associations between vision impairment (VI), vision correction (VC) and depressive symptoms among middle-aged and older Chinese.

Methods: 22 203 participants aged ≥45 years from China Health and Retirement Longitudinal Study 2011 to 2015 were divided into four self-reported VI categories: no VI, distance VI (DVI) only, near VI (NVI) only, and both distance and near VI (DNVI); and four self-reported VI/VC subgroups: VI(+)/VC(-), VI(+)/VC(+), VI(-)/VC(-) and VI(-)/VC(+). Depressive symptoms were evaluated by 10-item Center for Epidemiological Studies Depression Scale (CESD-10).

Results: Compared with no VI, DVI only (OR = 2.12, 95% CI: 1.95, 2.31), NVI only (OR = 1.51, 95% CI: 1.39, 1.63) and DNVI (OR = 2.75, 95% CI: 2.47, 3.07) were associated with higher odds of depressive symptoms. Compared with VI(+)/VC(-), VI(+)/VC(+) (OR = 0.91, 95% CI: 0.83, 0.98), VI (-)/VC(-) (OR = 0.50, 95% CI: 0.48, 0.53) and VI(-)/VC(+) (OR = 0.49, 95% CI: 0.47, 0.54) were associated with lower odds of depressive symptoms. Compared with no VI at baseline, baseline DNVI was significantly associated with higher odds of depressive symptoms after two (OR = 1.48, 95% CI: 1.16, 1.88) and four (OR = 1.32, 95% CI: 1.04, 1.68) years. Baseline depressive symptoms were significantly associated with higher odds of VI after two (OR = 1.53, 95% CI: 1.34, 1.74) and four (OR = 1.54, 95% CI: 1.34, 1.76) years.

Conclusion: Adults with DNVI were more likely to report depressive symptoms in the future and those with depressive symptoms were more likely to report VI in the future. VC might be a protective factor for preventing depressive symptoms among adults with VI.
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http://dx.doi.org/10.1002/gps.5398DOI Listing
January 2021

Associations between Multimorbidity and Physical Performance in Older Chinese Adults.

Int J Environ Res Public Health 2020 06 24;17(12). Epub 2020 Jun 24.

Medical Informatics Center, Peking University, Beijing 100191, China.

: Evidence on the association between physical performance and multimorbidity is scarce in Asia. This study aimed to identify multimorbidity patterns and their association with physical performance among older Chinese adults. : Individuals aged ≥60 years from the China Health and Retirement Longitudinal Study 2011-2015 ( = 10,112) were included. Physical performance was measured by maximum grip strength (kg) and average gait speed (m/s) categorized as fast (>0.8 m/s), median (>0.6-0.8 m/s), and slow (≤0.6 m/s). Multimorbidity patterns were explored using exploratory factor analysis. Generalized estimating equation was conducted. : Four multimorbidity patterns were identified: cardio-metabolic, respiratory, mental-sensory, and visceral-arthritic. An increased number of chronic conditions was associated with decreased normalized grip strength (NGS). Additionally, the highest quartile of factor scores for cardio-metabolic (β = -0.06; 95% Confidence interval (CI) = -0.07, -0.05), respiratory (β = -0.03; 95% CI = -0.05, -0.02), mental-sensory (β = -0.04; 95% CI = -0.05, -0.03), and visceral-arthritic (β = -0.04; 95% CI = -0.05, -0.02) patterns were associated with lower NGS compared with the lowest quartile. Participants with ≥4 chronic conditions were 2.06 times more likely to have a slow gait speed. Furthermore, the odds ratios for the highest quartile of factor scores of four patterns with slow gait speed compared with the lowest quartile ranged from 1.26-2.01. : Multimorbidity was related to worse physical performance, and multimorbidity patterns were differentially associated with physical performance. A shift of focus from single conditions to the requirements of a complex multimorbid population was needed for research, clinical guidelines, and health-care services. Grip strength and gait speed could be targeted to routinely measure clinical performance among older adults with multimorbidity, especially mental-sensory disorders, in clinical settings.
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http://dx.doi.org/10.3390/ijerph17124546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344642PMC
June 2020

Associations Between Somatic Multimorbidity Patterns and Depression in a Longitudinal Cohort of Middle-Aged and Older Chinese.

J Am Med Dir Assoc 2020 09 9;21(9):1282-1287.e2. Epub 2020 Jan 9.

Medical Informatics Center, Peking University, Beijing, China. Electronic address:

Objectives: Depressive symptoms are commonly seen among patients with multiple chronic somatic conditions, or somatic multimorbidity (SMM); however, little is known about the relationships between depressive symptoms and different SMM combinations. Our study aimed to delineate the patterns of SMM and their longitudinal associations with depressive symptoms among a nationally representative sample of middle-aged and older Chinese adults.

Design: We employed a longitudinal design.

Setting And Participants: Older adults (N = 10,084) aged ≥45 years from the China Health and Retirement Longitudinal Study 2011-2015 participated (mean age = 57.7 years at baseline; 53.3% men).

Methods: Sixteen chronic somatic conditions were ascertained at baseline via questionnaires. Depression was assessed with the Center for Epidemiological Studies Depression Scale at baseline and during follow-up. Patterns of SMM were identified via exploratory factor analyses. Generalized estimating equations were used to evaluate the longitudinal associations between patterns of SMM and the presence of depressive symptoms at follow-up.

Results: Compared with participants with no somatic condition, those with 1, 2, and 3 or more somatic conditions had a 21%, 66%, and 111% greater risk, respectively, for the presence of depressive symptoms. Increased factor scores for 4 patterns identified, cardio-metabolic pattern [adjusted odds ratio (AOR) 1.12, 95% confidence interval (CI) 1.06, 1.20], respiratory pattern (AOR 1.25, 95% CI 1.17, 1.33), arthritic-digestive-visual pattern (AOR 1.29, 95% CI 1.22, 1.37), and hepatic-renal-skeletal pattern (AOR 1.09, 95% CI 1.02, 1.16), were all associated with a higher risk of having depressive symptoms.

Conclusions And Implications: All SMM patterns were independently associated with depression among middle-aged and older Chinese adults, with greater odds for people with comorbid arthritic-digestive-visual conditions and respiratory conditions. Clinical practitioners should treat the middle-aged and older population under a multiple-condition framework combining SMM and mental disorders.
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http://dx.doi.org/10.1016/j.jamda.2019.11.028DOI Listing
September 2020

A novel all-fiber-based LiFePO/LiTiO battery with self-standing nanofiber membrane electrodes.

Beilstein J Nanotechnol 2019 13;10:2229-2237. Epub 2019 Nov 13.

Institute for Advanced Materials, School of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, China.

Electrodes with high conductivity and flexibility are crucial to the development of flexible lithium-ion batteries. In this study, three-dimensional (3D) LiFePO and LiTiO fiber membrane materials were prepared through electrospinning and directly used as self-standing electrodes for lithium-ion batteries. The structure and morphology of the fibers, and the electrochemical performance of the electrodes and the full battery were characterized. The results show that the LiFePO and LiTiO fiber membrane electrodes exhibit good rate and cycle performance. In particular, the all-fiber-based gel-state battery composed of LiFePO and LiTiO fiber membrane electrodes can be charged/discharged for 800 cycles at 1C with a retention capacity of more than 100 mAh·g and a coulombic efficiency close to 100%. The good electrochemical performance is attributed to the high electronic and ionic conductivity provided by the 3D network structure of the self-standing electrodes. This design and preparation method for all-fiber-based lithium-ion batteries provides a novel strategy for the development of high-performance flexible batteries.
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http://dx.doi.org/10.3762/bjnano.10.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880811PMC
November 2019

Electrochemical Behaviors of Sulfurized-Polyacrylonitrile with Synthesized Polyacrylonitrile Precursors Based on the Radical Polymerization Through Monomer Acrylonitrile.

J Nanosci Nanotechnol 2020 Mar;20(3):1578-1588

Hunan Engineering Laboratory of Power Battery Cathode Materials, Changsha Research Institute of Mining and Metallurgy, Changsha 410012, P. R. China.

Polyacrylonitrile (PAN) precursors have been polymerized at different radical polymerization temperatures for preparing sulfurized-polyacrylonitrile (S-PAN) composite cathodes in rechargeable lithium sulfur battery. The physical properties of these composites have been investigated using X-ray diffraction, Fourier transform infrared spectrometry, Raman spectroscopy, Brunner-Emmet-Teller measurement and Gel permeation chromatography analysis. The electrochemical performance of the S-PAN composite cathodes made from the PAN precursor was investigated. The results showed that the molecular weight distribution of the PAN precursors affected the electrochemical performance of the S-PAN made from the PAN precursor. S-PAN composites derived from PAN with a narrower molecular weight distribution at 65 °C were exhibit the best electrochemical performance in lithium-sulfur battery.
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http://dx.doi.org/10.1166/jnn.2020.16950DOI Listing
March 2020

Prevalence and Patterns of Multimorbidity in a Nationally Representative Sample of Older Chinese: Results From the China Health and Retirement Longitudinal Study.

J Gerontol A Biol Sci Med Sci 2020 09;75(10):1974-1980

Department of Epidemiology and Biostatistics, School of Public Health, Beijing, China.

Background: Multimorbidity has become a prominent problem worldwide; however, few population-based studies have been conducted among older Chinese with multimorbidity. This study aimed to examine the prevalence of multimorbidity and explore its common patterns among a nationally representative sample of older Chinese.

Methods: This study used data from the China Health and Retirement Longitudinal Study and included 19,841 participants aged at least 50 years. The prevalence of individual chronic diseases and multimorbidity during 2011-2015 were evaluated among the entire cohort and according to residential regions and gender. The relationships between participants' demographic characteristics and multimorbidity were examined using logistic regression model. Patterns of multimorbidity were explored using hierarchical cluster analysis and association rule mining.

Results: Multimorbidity occurred in 42.4% of the participants. The prevalence of multimorbidity was higher among women (odds ratio [OR] = 1.31, 95% confidence interval [CI]: 1.13-1.51) and urban residents (OR = 1.14, 95% CI: 1.02-1.27) than their respective counterparts after accounting for potential confounders of age, education, smoking, and alcohol consumption. Hierarchical cluster analysis revealed four common multimorbidity patterns: the vascular-metabolic cluster, the stomach-arthritis cluster, the cognitive-emotional cluster, and the hepatorenal cluster. Regional differences were found in the distributions of stroke and memory-related disease. Most combinations of conditions and urban-rural difference in multimorbidity patterns from hierarchical cluster analysis were also observed in association rule mining.

Conclusion: The prevalence and patterns of multimorbidity vary by gender and residential regions among older Chinese. Women and urban residents are more vulnerable to multimorbidity. Future studies are needed to understand the mechanisms underlying the identified multimorbidity patterns and their policy and interventional implications.
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http://dx.doi.org/10.1093/gerona/glz185DOI Listing
September 2020

Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down-regulating microRNA-21.

Phytother Res 2019 Jun 16;33(6):1706-1716. Epub 2019 Apr 16.

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Celastrol could inhibit cancer cell growth in vitro. However, effect(s) of celastrol on gastric cancer is not well studied. Therefore, we investigated the effects of celastrol on human gastric cancer cell line MKN45 and the underlying mechanisms. We found that celastrol inhibited cell proliferation, migration, and invasion and induced cell apoptosis and G2/M cell cycle arrest (p < .05, p < .01, or p < .001). Under celastrol treatment, overexpression of microRNA-21 (miR-21) increased cell viability, migration, and invasion and inhibited cell apoptosis compared with negative control (p < .05, p < .01, or p < .001). In addition, the phosphorylation of PTEN was significantly up-regulated, whereas PI3K, AKT, p65, and IκBα phosphorylation was statistically decreased by celastrol (p < .05 or p < .01) and then further reversed by miR-21 overexpression (p < .05 or p < .01). On the other side, miR-21 silence showed contrary results (p < .05) as relative to miR-21 overexpression. In conclusion, celastrol inhibits proliferation, migration, and invasion and inactivates PTEN/PI3K/AKT and nuclear factor κB signaling pathways in MKN45 cells by down-regulating miR-21.
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http://dx.doi.org/10.1002/ptr.6359DOI Listing
June 2019

High-fat-diet-induced obesity upregulates the expression of lymphoid chemokines and promotes the formation of gastric lymphoid follicles after Helicobacter suis infection.

Pathog Dis 2017 11;75(8)

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, China.

Helicobacter suis colonizes the stomachs of a variety of animals, including humans, and is more likely than other Helicobacter species to induce gastric mucosa-associated lymphoid tissue lymphoma. Obesity is a low-grade chronic inflammatory state in which the induction of a chemokine network contributes to a variety of diseases. However, the effect of obesity on the development of gastric MALT in the presence of H. suis infection remains unclear. Here, we reveal that high-fat-diet-induced obesity upregulates the expression of lymphoid chemokines in the stomach and accelerates the H. suis infection-induced formation of gastric lymphoid follicles, potentially via a mechanism that involves the activation of the nuclear factor kappa B (NF-κB) signaling pathway. These findings provide novel insight into the pathogenesis of obesity-related diseases, especially those induced by Helicobacter infection.
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http://dx.doi.org/10.1093/femspd/ftx101DOI Listing
November 2017

Electrospinning preparation of oxygen-deficient nano TiO/carbon fibre membrane as a self-standing high performance anode for Li-ion batteries.

R Soc Open Sci 2017 Jul 12;4(7):170323. Epub 2017 Jul 12.

Changsha Research Institute of Mining and Metallurgy, Co. Ltd, Changsha 410012, China.

Improving the specific capacity and electronic conductivity of TiO can boost its practical application as a promising anode material for lithium ion batteries. In this work, a three-dimensional networking oxygen-deficient nano TiO/carbon fibre membrane was achieved by combining the electrospinning process with a hot-press sintering method and directly used as a self-standing anode. With the synergistic effects of three-dimensional conductive networks, surface oxygen deficiency, high specific surface area and high porosity, binder-free and self-standing structure, etc., the nano TiO/carbon fibre membrane electrode displays a high electrochemical reaction kinetics and a high specific capacity. The reversible capacity could be jointly generated from porous carbon, full-lithiation of TiO and interfacial lithium storage. At a current density of 100 mA g, the reversible discharge capacity can reach 464 mA h g. Even at 500 mA g, the discharge capacity still remains at 312 mA h g. Compared with pure carbon fibre and TiO powder, the TiO/C fibre membrane electrode also exhibits an excellent cycle performance with a discharge capacity of 209 mA h g after 700 cycles at the current density of 300 mA g, and the coulombic efficiency always remains at approximately 100%.
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http://dx.doi.org/10.1098/rsos.170323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541555PMC
July 2017

Fast throughput determination of 21 allergenic disperse dyes from river water using reusable three-dimensional interconnected magnetic chemically modified graphene oxide followed by liquid chromatography-tandem quadrupole mass spectrometry.

J Chromatogr A 2016 Jan 4;1431:36-46. Epub 2016 Jan 4.

Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, 315010, China; Ningbo Key Laboratory of Poison Research and Control, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, 315010, China. Electronic address:

We report the template-free fabrication of three-dimensional hierarchical nanostructures, i.e., three-dimensional interconnected magnetic chemically modified graphene oxide (3D-Mag-CMGO), through a simple and low-cost self-assembly process using one-pot reaction based on solvothermal method. The excellent properties of the 3D-Mag-CMGO are characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), FTIR, elementary analyzer (EA) and X-ray photoelectron spectroscopy (XPS). The easiness-to-handle of the magnetic dispersive solid phase extraction (Mag-dSPE) procedure is developed for preconcentration of 21 allergenic disperse dyes from river water. The obtained results show the higher extraction capacity of 3D-Mag-CMGO with recoveries between 80.0-112.0%. Furthermore, an ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS) method for determination of 21 allergenic disperse dyes in river at sub-ppt levels has been developed with pretreatment of the samples by Mag-dSPE. The limits of quantification (LOQs) for the allergenic disperse dyes are between 0.57-34.05ng/L. Validation results on linearity, specificity, trueness and precision, as well as on application to the analysis of 21 allergenic disperse dyes in fifty real samples demonstrate the applicability to environment monitoring analysis.
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http://dx.doi.org/10.1016/j.chroma.2015.12.089DOI Listing
January 2016

Xijiao Dihuang Decoction () and Rehmannia glutinosa Libosch. protect mice against lipopolysaccharide and tumor necrosis factor alpha-induced acute liver failure.

Chin J Integr Med 2019 Jun 26;25(6):446-453. Epub 2015 May 26.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.

Objective: To investigate the hepatoprotective effect of Xijiao Dihuang Decoction (, XJDHD) on lipopolysaccharide (LPS)- and tumor necrosis factor alpha (TNF-α)-induced acute liver failure (ALF) as well as the underlying mechanism of action, and to clarify the key herbs and components of XJDHD.

Methods: LPS/D-galactosamine (D-GalN) or TNF-α/D-GalN were intraperitoneally injected into C57BL/6J mice to induce ALF. Simultaneously, XJDHD or its individual herbs and components were orally administered. Survival rates, transaminase levels in serum, and hepatic histology were examined to evaluate the effects of XJDHD. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and real-time polymerase chain reaction were additionally performed to expound the mechanism underlying the anti-apoptotic activity of XJDHD.

Results: Oral administration of XJDHD protected mice from lethal liver failure induced by LPS and TNF-α, with notable amelioration of liver injury in histology and a significant decrease in transaminase levels in serum. XJDHD significantly inhibited apoptosis of hepatocytes and enhanced expression of the antiapoptosis genes, c-Flip, Iap1, Gadd45b and A20. In addition, Rehmannia glutinosa Libosch. was identified as the key herb of XJDHD and galactose as the effective component of Rehmannia glutinosa Libosch. that protects against ALF.

Conclusions: XJDHD inhibits TNF-α-induced apoptosis of hepatocytes by promoting the expression of nuclear factor κ B-regulated anti-apoptotic genes. Rehmannia glutinosa Libosch. is the effective herb of XJDHD and galactose is an active component in this protection.
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http://dx.doi.org/10.1007/s11655-015-2141-2DOI Listing
June 2019

Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors.

Anal Sci 2012 ;28(10):967-71

Ningbo Key Laboratory of Poison Research and Control, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China.

A reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed for the simultaneous determination of nine food additives, i.e., acesulfame, saccharin, caffeine, aspartame, benzoic acid, sorbic acid, stevioside, dehydroacetic acid and neotame in red wine. The effects of ion-suppressors, i.e., trifluoroacetic acid (TFA) and ammonium acetate (AmAc) on retention behavior of nine food additives in RP-HPLC separation were discussed in detail. The relationships between retention factors of solutes and volume percent of ion-suppressors in the mobile-phase systems of acetonitrile-TFA aqueous solution and acetonitrile-TFA-AmAc aqueous solution were quantitatively established, respectively. The results showed that the ion suppressors had not only an ion suppression effect, but also an organic modification effect on the acidic analytes. The baseline separation of nine food additives was completed by a gradient elution with acetonitrile-TFA(0.01%, v/v)-AmAc(2.5 mmol L(-1)) aqueous solution as the mobile phase. The recoveries were between 80.2 - 99.5% for all analytes with RSDs in the range of 1.5 - 8.9%. The linearities were in the range of 0.2 - 100.0 mg L(-1) with determination coefficients (r(2)) higher than 0.9991 for all analytes. The limits of quantification (LOQs) were between 0.53 - 0.99 mg L(-1). The applicability of the proposed method to detect and quantify food additives has been demonstrated in the analysis of 30 real samples.
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http://dx.doi.org/10.2116/analsci.28.967DOI Listing
March 2013

Luminescence studies on Ba₂ZnSi₂O₇: Eu(2+) phosphors crystals.

Luminescence 2010 Sep-Oct;25(5):399-402

State Key Laboratory of Materials Processing and Die and Mold Technology, College of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

A novel blue green-emitting phosphor, Ba₂ZnSi₂O₇: Eu(2+), was prepared by combustion synthesis method and an efficient bluish green emission under from ultraviolet to visible light was observed. The emission spectrum shows a single intensive band centered at 503 nm, which corresponds to the 4f(6)5d(1) → 4f(7) transition of Eu(2+). The excitation spectrum is a broad band extending from 260 to 465 nm, which matches the emission of ultraviolet light-emitting diodes (UV-LEDs). The effect of doped Eu(2+) concentration on the emission intensity of Ba₂ZnSi₂O₇: Eu(2+) was also investigated. The result indicates that Ba₂ZnSi₂O₇: Eu(2+) can be potentially useful as a UV radiation-converting phosphor for white light-emitting diodes.
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http://dx.doi.org/10.1002/bio.1168DOI Listing
February 2011

Flavor characteristics of lapsang souchong and smoked lapsang souchong, a special Chinese black tea with pine smoking process.

J Agric Food Chem 2005 Nov;53(22):8688-93

Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou, Zhejiang 310027, People's Republic of China.

The major volatile constituents of lapsang souchong, smoked lapsang souchong, and smoked souchong, a group of special black teas in China, were analyzed with GC and GC-MS analyses. Forty-nine constituents were identified. Longifolene and alpha-terpineol were the most abundant compounds in the aroma. Due to its special production process, the compounds longifolene, longicyclene, guaiacol, 4-methylguaiacol, 4-ethylguaiacol, etc., were identified only in this kind of black tea. The aroma constituents of tea origin decreased during the smoking process, whereas the pine terpenoids and the thermal pyrolysis products of the pine wood increased markedly. The pine material for smoking was also analyzed for the volatile constituents showing apparent selectivity of the tea leaves to absorb. There were apparent differences among the tea samples in the contents of aroma constituents. The characteristics of the aroma of the teas are discussed with their processes and the features of sensory qualities.
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http://dx.doi.org/10.1021/jf058059iDOI Listing
November 2005